{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:08:00Z","timestamp":1780546080041,"version":"3.54.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.yebeh.2026.111099","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:24:07Z","timestamp":1779236647000},"page":"111099","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Impact of antiseizure medications burden on patients\u2019 emotional states: an investigation of the interaction effects of urban\u2013rural differences"],"prefix":"10.1016","volume":"182","author":[{"given":"Jialin","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqin","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0606-561X","authenticated-orcid":false,"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2026.111099_b0005","series-title":"Epilepsy: a public health imperative","first-page":"171","year":"2023"},{"issue":"10172","key":"10.1016\/j.yebeh.2026.111099_b0010","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0140-6736(18)32596-0","article-title":"Epilepsy in adults","volume":"393","author":"Thijs","year":"2019","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.yebeh.2026.111099_b0015","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S1474-4422(15)00225-2","article-title":"Comorbidities of epilepsy: current concepts and future perspectives","volume":"15","author":"Keezer","year":"2016","journal-title":"Lancet Neurol"},{"issue":"s1","key":"10.1016\/j.yebeh.2026.111099_b0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1528-1167.2010.02907.x","article-title":"Depression and epilepsy: a bidirectional relation?","volume":"52","author":"Kanner","year":"2011","journal-title":"Epilepsia"},{"issue":"16","key":"10.1016\/j.yebeh.2026.111099_b0025","article-title":"Prevalence and risk factors of anxiety and depression in adult patients with epilepsy: a multicenter survey-based study","volume":"30","author":"Shi","year":"2023","journal-title":"Ther Adv Neurol Disord"},{"issue":"11","key":"10.1016\/j.yebeh.2026.111099_b0030","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1111\/epi.12377","article-title":"The role of stress as a trigger for epileptic seizures: a narrative review of evidence from human and animal studies","volume":"54","author":"Novakova","year":"2013","journal-title":"Epilepsia"},{"issue":"151","key":"10.1016\/j.yebeh.2026.111099_b0035","article-title":"The relationship between stress, anxiety, depression and medication adherence behavior in patients with epilepsy: a cross-sectional study","volume":"1","author":"Khatooni","year":"2024","journal-title":"Epilepsy Behav"},{"issue":"5","key":"10.1016\/j.yebeh.2026.111099_b0040","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.yebeh.2003.07.009","article-title":"The influence of comorbid depression on quality of life for people with epilepsy","volume":"4","author":"Cramer","year":"2003","journal-title":"Epilepsy Behav"},{"issue":"2","key":"10.1016\/j.yebeh.2026.111099_b0045","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/WCO.0000000000000431","article-title":"Depression in epilepsy","volume":"30","author":"Mula","year":"2017","journal-title":"Curr Opin Neurol"},{"issue":"3","key":"10.1016\/j.yebeh.2026.111099_b0050","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3988\/jcn.2014.10.3.175","article-title":"Depression and anxiety in people with epilepsy","volume":"10","author":"Kwon","year":"2014","journal-title":"J Clin Neurol"},{"issue":"1","key":"10.1016\/j.yebeh.2026.111099_b0055","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s42494-025-00223-5","article-title":"Psychiatric disorders with antiseizure medications in children: an analysis of the FDA adverse event reporting system database","volume":"7","author":"Gui","year":"2025","journal-title":"Acta Epileptol"},{"issue":"7","key":"10.1016\/j.yebeh.2026.111099_b0060","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2165\/00002018-200730070-00001","article-title":"Negative effects of antiepileptic drugs on mood in patients with epilepsy","volume":"30","author":"Mula","year":"2007","journal-title":"Drug Saf"},{"issue":"3","key":"10.1016\/j.yebeh.2026.111099_b0065","doi-asserted-by":"crossref","first-page":"317","DOI":"10.4103\/ijmr.IJMR_710_15","article-title":"Adverse effects & drug load of antiepileptic drugs in patients with epilepsy: monotherapy versus polytherapy","volume":"145","author":"Joshi","year":"2017","journal-title":"Indian J Med Res"},{"issue":"1","key":"10.1016\/j.yebeh.2026.111099_b0070","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12883-024-03670-8","article-title":"Psychiatric implications of anti-seizure medications in epileptic population","volume":"24","author":"Khalid","year":"2024","journal-title":"BMC Neurol"},{"issue":"163","key":"10.1016\/j.yebeh.2026.111099_b0075","article-title":"The association of polytherapy and psychiatric comorbidity in epilepsy","volume":"1","author":"Odhiambo","year":"2025","journal-title":"Epilepsy Behav"},{"issue":"162","key":"10.1016\/j.yebeh.2026.111099_b0080","article-title":"Impact of interaction among antiseizure medication polytherapy, clinical, sociodemographic and psychological factors on quality of life in patients with epilepsy: a systematic review","volume":"1","author":"Lozano-Garc\u00eda","year":"2025","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2026.111099_b0085","article-title":"A systematic literature review of health disparities among rural people with epilepsy (RPWE) in the United States and Canada","volume":"122","author":"Duke","year":"2021","journal-title":"Epilepsy Behav EB"},{"key":"10.1016\/j.yebeh.2026.111099_b0090","first-page":"10","article-title":"Perceived epilepsy-related stigma is linked to the socioeconomic status of the residence","volume":"26","author":"Hohmann","year":"2022","journal-title":"Front Public Health"},{"key":"10.1016\/j.yebeh.2026.111099_b0095","first-page":"15","article-title":"Felt stigma and associated factors in children and adolescents with epilepsy: a multicenter cross-sectional study in China","volume":"14","author":"Zhao","year":"2024","journal-title":"Front Neurol"},{"issue":"1","key":"10.1016\/j.yebeh.2026.111099_b0100","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s42494-024-00154-7","article-title":"Effects of stigma on the quality of life in patients with epilepsy","volume":"6","author":"Hu","year":"2024","journal-title":"Acta Epileptol"},{"issue":"4","key":"10.1016\/j.yebeh.2026.111099_b0105","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/epi.13670","article-title":"Operational classification of seizure types by the International League against Epilepsy: position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Fisher","year":"2017","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.yebeh.2026.111099_b0110","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S1474-4422(06)70415-X","article-title":"Rapid detection of major depression in epilepsy: a multicentre study","volume":"5","author":"Gilliam","year":"2006","journal-title":"Lancet Neurol"},{"issue":"47","key":"10.1016\/j.yebeh.2026.111099_b0115","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.yebeh.2015.03.012","article-title":"Validation of the Chinese version of the Neurological Disorders Depression Inventory for Epilepsy (C-NDDI-E) in West China","volume":"1","author":"Tong","year":"2015","journal-title":"Epilepsy Behav"},{"issue":"10","key":"10.1016\/j.yebeh.2026.111099_b0120","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: the GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch Intern Med"},{"issue":"35","key":"10.1016\/j.yebeh.2026.111099_b0125","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.yebeh.2014.04.005","article-title":"Validation of the generalized anxiety disorder-7 in people with epilepsy: a MEPSY study","volume":"1","author":"Seo","year":"2014","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2026.111099_b0130","unstructured":"Chongqing Municipal Bureau of Statistics. 2023 Statistical Communiqu\u00e9 of Chongqing on National Economic and Social Development [Internet]. 2024 Mar [cited 2026 Apr 25]. Available from: https:\/\/tjj.cq.gov.cn\/zwgk_233\/fdzdgknr\/tjxx\/sjzl_55471\/tjgb_55472\/202403\/t20240326_13084652_wap.html."},{"issue":"2","key":"10.1016\/j.yebeh.2026.111099_b0135","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/inm.12666","article-title":"Urban\u2013rural differences in mental health among Chinese patients with multiple chronic conditions","volume":"29","author":"Cheng","year":"2020","journal-title":"Int J Ment Health Nurs"},{"key":"10.1016\/j.yebeh.2026.111099_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2024.109665","article-title":"Risk factors for anxiety in patients with epilepsy: a meta-analysis","volume":"153","author":"Niu","year":"2024","journal-title":"Epilepsy Behav"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505026002209?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505026002209?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:37:49Z","timestamp":1780544269000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505026002209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":28,"alternative-id":["S1525505026002209"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2026.111099","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of antiseizure medications burden on patients\u2019 emotional states: an investigation of the interaction effects of urban\u2013rural differences","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2026.111099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111099"}}