{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:03:19Z","timestamp":1791975799281,"version":"4.4.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.yebeh.2026.111130","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:06:09Z","timestamp":1780059969000},"page":"111130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Early predictors for later epilepsy after therapeutic hypothermia for neonatal hypoxic\u2013ischemic encephalopathy"],"prefix":"10.1016","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9064-5205","authenticated-orcid":false,"given":"S.D.","family":"Calligaris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jozefkowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J. Martinez","family":"C\u00e1ceres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.I.","family":"Erripa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Reyes Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MN","family":"Nieves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.T.","family":"Mazzucchelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rugilo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Caraballo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2026.111130_b0005","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/dmcn.12726","article-title":"Early predictors of outcome in infants treated with hypothermia for hypoxic-ischemic encephalopathy","volume":"57","author":"Merchant","year":"2015","journal-title":"Dev Med Child Neurol"},{"issue":"23","key":"10.1016\/j.yebeh.2026.111130_b0010","doi-asserted-by":"crossref","first-page":"5571","DOI":"10.1113\/JP274949","article-title":"The fetus at the tipping point: modifying the outcome of fetal asphyxia","volume":"596","author":"Dhillon","year":"2018","journal-title":"J Physiol"},{"issue":"5","key":"10.1016\/j.yebeh.2026.111130_b0015","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1203\/00006450-199505000-00019","article-title":"Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet","volume":"37","author":"Thoresen","year":"1995","journal-title":"Pediatr Res"},{"issue":"15","key":"10.1016\/j.yebeh.2026.111130_b0020","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yebeh.2026.111130_b0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2431-8-17","article-title":"The TOBY Study. whole -body hypothermia for the treatment of perinatal asphyxia encephalopathy: a randomized controlled trial","volume":"8","author":"Azzopardi","year":"2008","journal-title":"BMC Pediatr"},{"issue":"5","key":"10.1016\/j.yebeh.2026.111130_b0030","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.siny.2010.02.002","article-title":"Synergistic neuroprotective therapies with hypothermia","volume":"15","author":"Cilio","year":"2010","journal-title":"Semin Fetal Neonatal Med"},{"issue":"9","key":"10.1016\/j.yebeh.2026.111130_b0035","doi-asserted-by":"crossref","first-page":"22368","DOI":"10.3390\/ijms160922368","article-title":"Neuroprotective strategies after Neonatal Hypoxic Ischemic Encephalopathy","volume":"16","author":"Dixon","year":"2015","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.yebeh.2026.111130_b0040","article-title":"Therapeutic hypothermia: a descriptive, cohort study conducted over 10 years at a tertiary care public hospital","volume":"122","author":"Nieves","year":"2024","journal-title":"Arch Argent Pediatr"},{"issue":"10","key":"10.1016\/j.yebeh.2026.111130_b0045","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.4103\/1673-5374.217338","article-title":"Effect of erythropoietin combined with hypothermia on serum tau protein levels and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy","volume":"12","author":"Lv","year":"2017","journal-title":"Neural Regen Res"},{"issue":"5","key":"10.1016\/j.yebeh.2026.111130_b0050","first-page":"2318","article-title":"The effects of monotherapy with erythropoietin in neonatal hypoxic-ischemic encephalopathy on neurobehavioral development: a systematic review and meta-analysis","volume":"25","author":"Liu","year":"2021","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"2","key":"10.1016\/j.yebeh.2026.111130_b0055","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1056\/NEJMoa2119660","article-title":"Trial of Erythropoietin for Hypoxic-Ischemic Encephalopathy in Newborns","volume":"387","author":"Wu","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yebeh.2026.111130_b0060","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress: A clinical and electroencephalographic study","volume":"33","author":"Sarnat","year":"1976","journal-title":"Arch Neurol"},{"key":"10.1016\/j.yebeh.2026.111130_b0065","unstructured":"Laptook AR, Shankaran S, Tyson JE, et al. Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death and Disability Among Newborns with Hypoxic-Ischemic Encephalopathy: A randomized clinical trial. JAMA.2017 Oct 24; 318 (16): 1550\u20131560. Doi: 10.101\/jama.2017.14972. PMID: 19067428: PMCID:PMC5783566."},{"issue":"1","key":"10.1016\/j.yebeh.2026.111130_b0070","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1542\/peds.2009-2938","article-title":"Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia","volume":"126","author":"Thoresen","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.yebeh.2026.111130_b0075","doi-asserted-by":"crossref","unstructured":"Hellstr\u00f6m-Westas L. Amplitude-integrated electroencephalography for seizure detection in newborn infants. Semin Fetal Neonatal Med. 2018 Jun;23(3):175-182. doi: 10.1016\/j.siny.2018.02.003. Epub 2018 Feb 13. PMID: 29472139.","DOI":"10.1016\/j.siny.2018.02.003"},{"issue":"3","key":"10.1016\/j.yebeh.2026.111130_b0080","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/epi.16815","article-title":"The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate","volume":"62","author":"Pressler","year":"2021","journal-title":"Epilepsia"},{"issue":"23","key":"10.1016\/j.yebeh.2026.111130_b0085","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1212\/01.wnl.0000295674.34193.9e","article-title":"Neonatal status epilepticus vs recurrent neonatal seizures: clinical findings and outcome","volume":"69","author":"Pisani","year":"2007","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.yebeh.2026.111130_b0090","doi-asserted-by":"crossref","first-page":"e459","DOI":"10.1542\/peds.2008-2190","article-title":"Early EEG findings in hypoxic-ischemic encephalopathy predict outcomes at 2 years","volume":"124","author":"Murray","year":"2009","journal-title":"Pediatrics"},{"issue":"33\u201340","key":"10.1016\/j.yebeh.2026.111130_b0095","first-page":"e2","article-title":"A Novel magnetic Resonance Imaging score Predicts Neurodevelopmental Outcome after Perinatal Asphyxia and Therapeutic Hypothermia","volume":"192","author":"Weeke","year":"2018","journal-title":"J Pediatr"},{"issue":"4","key":"10.1016\/j.yebeh.2026.111130_b0100","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/epi.12550","article-title":"ILAE official report: a practical clinical definition of epilepsy","volume":"55","author":"Fisher","year":"2014","journal-title":"Epilepsia"},{"issue":"9460","key":"10.1016\/j.yebeh.2026.111130_b0105","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","article-title":"Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicenter randomized trial","volume":"365","author":"Gluckman","year":"2005","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.yebeh.2026.111130_b0110","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1111\/epi.13914","article-title":"Reduced infancy and childhood epilepsy following hypothermia-treated neonatal encephalopathy","volume":"58","author":"Liu","year":"2017","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.yebeh.2026.111130_b0115","doi-asserted-by":"crossref","DOI":"10.1212\/CPJ.0000000000200370","article-title":"Individualized neuroprognostication in neonates with hypoxic-ischemic encephalopathy treated with hypothermia","volume":"15","author":"Van Steenis","year":"2025","journal-title":"Neurol Clin Pract"},{"key":"10.1016\/j.yebeh.2026.111130_b0120","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.pediatrneurol.2024.01.009","article-title":"Epilepsy Incidence and Developmental Outcomes After Early Discontinuation of Antiseizure Medication in Neonatal Hypoxic-Ischemic Encephalopathy","volume":"153","author":"Jagadish","year":"2024","journal-title":"Pediatr Neurol"},{"issue":"6","key":"10.1016\/j.yebeh.2026.111130_b0125","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1212\/WNL.0b013e31820af91a","article-title":"Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia","volume":"76","author":"Nash","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2026.111130_b0130","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.clinph.2022.09.005","article-title":"Poor aEEG background recovery after perinatal hypoxic ischemic encephalopathy predicts post neonatal epilepsy by age 4 years","volume":"143","author":"Nyman","year":"2022","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.yebeh.2026.111130_b0135","unstructured":"Glass HC, Shellhaas RA, Twanow JD, Kurth JB, Numis AL, Soul JS, et al. Duration of Antiseizure Medication Administration and Outcomes of Neonatal Seizures: The Neonatal Seizure Registry. JAMA Pediatr. 2021 Jul 1;175(7):705-712. doi: 10.1001\/jamapediatrics.2021.0112. PMID: 33683319; PMCID: PMC7941217."},{"issue":"2","key":"10.1016\/j.yebeh.2026.111130_b0140","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3233\/NPM-210849","article-title":"Editorial: Antiseizure medication for neonatal seizures: How long?","volume":"15","author":"Volpe","year":"2022","journal-title":"J Neonatal-Perinatal Med"},{"key":"10.1016\/j.yebeh.2026.111130_b0145","doi-asserted-by":"crossref","first-page":"106446","DOI":"10.1016\/j.eplepsyres.2020.106446","article-title":"Electroclinical pattern in the transition from West to Lennox-Gastaut syndrome","volume":"167","author":"Calvo","year":"2020","journal-title":"Epilepsy Res"},{"issue":"3","key":"10.1016\/j.yebeh.2026.111130_b0150","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/ped.12257","article-title":"Epilepsy and West syndrome in neonates with hypoxic-ischemic encephalopathy","volume":"56","author":"Inoue","year":"2014","journal-title":"Pediatr Int"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505026002519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505026002519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:42:11Z","timestamp":1780544531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505026002519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"alternative-id":["S1525505026002519"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2026.111130","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early predictors for later epilepsy after therapeutic hypothermia for neonatal hypoxic\u2013ischemic encephalopathy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2026.111130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111130"}}