{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:08:02Z","timestamp":1789013282093,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["20\/14642\\u20138"],"award-info":[{"award-number":["20\/14642\\u20138"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["21\/01098-0"],"award-info":[{"award-number":["21\/01098-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["422911\/2021-6"],"award-info":[{"award-number":["422911\/2021-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["141185\/2022\\u20138"],"award-info":[{"award-number":["141185\/2022\\u20138"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.yebeh.2026.111214","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T09:20:09Z","timestamp":1784712009000},"page":"111214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Temporal lobe epilepsy and depression: a dysfunctional lobe overshadows a sclerotic hippocampus"],"prefix":"10.1016","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9153-1370","authenticated-orcid":false,"given":"Thais Forner","family":"Batelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nath\u00e1lia Stela","family":"Vison\u00e1 de Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Silva","family":"Centeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian Salvadori","family":"Bittar Guaranha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao Pereira","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elza M\u00e1rcia","family":"Targas Yacubian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Eduardo","family":"Peixoto-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.yebeh.2026.111214_b0005","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/epi.12550","article-title":"ILAE official report: a practical clinical definition of epilepsy","volume":"55","author":"Fisher","year":"2014","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.yebeh.2026.111214_b0010","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: position paper of the ILAE commission for classification and terminology","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.yebeh.2026.111214_b0015","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/brain\/awx341","article-title":"Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study","volume":"141","author":"Whelan","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2026.111214_b0020","doi-asserted-by":"crossref","unstructured":"Kanner AM, Meador KJ. Remember..there is more to epilepsy than seizures! In Neurology 2015 (Vol. 85, Number 13, pp. 1094\u20131095). Lippincott Williams and Wilkins. doi: 10.1212\/WNL.0000000000001985.","DOI":"10.1212\/WNL.0000000000001985"},{"key":"10.1016\/j.yebeh.2026.111214_b0025","series-title":"Epilepsy and Behavior","article-title":"Psychiatric comorbidity in patients with epilepsy: Implications for diagnosis and treatment","author":"Devinsky","year":"2003"},{"key":"10.1016\/j.yebeh.2026.111214_b0030","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1528-1167.2005.463009.x","article-title":"Depression and mania in patients with epilepsy","volume":"46","author":"Schmitz","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2026.111214_b0035","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4139404","article-title":"Psychiatric assessment in patients with mild temporal lobe epilepsy","volume":"2019","author":"Bruni","year":"2019","journal-title":"Behav Neurol"},{"key":"10.1016\/j.yebeh.2026.111214_b0040","unstructured":"Lee GP. Neuropsychology of epilepsy and epilepsy surgery. 2010."},{"issue":"4","key":"10.1016\/j.yebeh.2026.111214_b0045","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1684\/epd.2010.0345","article-title":"Prevalence of psychiatric comorbidities in temporal lobe epilepsy: the value of structured psychiatric interviews","volume":"12","author":"Bragatti","year":"2010","journal-title":"Epileptic Disord"},{"issue":"7","key":"10.1016\/j.yebeh.2026.111214_b0050","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1007\/s11064-017-2331-8","article-title":"Can neurochemical changes of mood disorders explain the increase risk of epilepsy or its worse seizure control?","volume":"42","author":"Kanner","year":"2017","journal-title":"Neurochem Res"},{"issue":"6","key":"10.1016\/j.yebeh.2026.111214_b0055","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/13607863.2012.678478","article-title":"Depression, hippocampal volume changes, and cognitive decline in a clinical sample of older depressed outpatients and non-depressed controls","volume":"16","author":"Sawyer","year":"2012","journal-title":"Aging Ment Health"},{"issue":"11","key":"10.1016\/j.yebeh.2026.111214_b0060","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1176\/appi.ajp.161.11.1957","article-title":"Hippocampal volume and depression: a meta-analysis of MRI studies","volume":"161","author":"Videbech","year":"2004","journal-title":"Am J Psychiatry"},{"issue":"1","key":"10.1016\/j.yebeh.2026.111214_b0065","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12974-015-0266-z","article-title":"Mesial temporal lobe epilepsy with psychiatric comorbidities: a place for differential neuroinflammatory interplay","volume":"12","author":"Kandratavicius","year":"2015","journal-title":"J Neuroinflammation"},{"issue":"2","key":"10.1016\/j.yebeh.2026.111214_b0070","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.nbd.2009.11.001","article-title":"Comorbidity between epilepsy and depression: role of hippocampal interleukin-1\u03b2","volume":"37","author":"Mazarati","year":"2010","journal-title":"Neurobiol Dis"},{"issue":"17","key":"10.1016\/j.yebeh.2026.111214_b0075","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1056\/NEJMoa1703784","article-title":"Histopathological findings in brain tissue obtained during epilepsy surgery","volume":"377","author":"Blumcke","year":"2017","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.yebeh.2026.111214_b0080","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/epi.12220","article-title":"International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a task force report from the ILAE commission on diagnostic methods","volume":"54","author":"Bl\u00fcmcke","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2026.111214_b0085","doi-asserted-by":"crossref","DOI":"10.1002\/epi.70138","article-title":"Insulinlike growth factor 1 receptor correlates with verbal memory in ILAE type 2 hippocampal sclerosis","author":"Cruz","year":"2026","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.yebeh.2026.111214_b0090","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/nan.12150","article-title":"Review: hippocampal sclerosis in epilepsy: a neuropathology review","volume":"40","author":"Thom","year":"2014","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.yebeh.2026.111214_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107100","article-title":"Electroencephalogram alterations associated with psychiatric disorders in temporal lobe epilepsy with mesial sclerosis: a systematic review","volume":"108","author":"de Barros Louren\u00e7o","year":"2020","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2026.111214_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2024.109782","article-title":"Evaluating the prevalence and risk factors for depression in patients with temporal lobe epilepsy with hippocampal sclerosis: a cross-sectional multicenter study","volume":"154","author":"Aljafen","year":"2024","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2026.111214_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2023.107602","article-title":"Is depression in patients with temporal lobe epilepsy related to hippocampal sclerosis? A meta-analysis","volume":"225","author":"Cai","year":"2023","journal-title":"Clin Neurol Neurosurg"},{"issue":"2","key":"10.1016\/j.yebeh.2026.111214_b0110","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0920-1211(99)00117-5","article-title":"Depression in patients with temporal lobe epilepsy is related to mesial temporal sclerosis","volume":"39","author":"Quiske","year":"2000","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2026.111214_b0115","doi-asserted-by":"crossref","unstructured":"Kalin NH. The critical relationship between anxiety and depression. In Am J Psych. 2020 (Vol. 177, Number 5, pp. 365\u2013367). American Psychiatric Association. doi: 10.1176\/appi.ajp.2020.20030305.","DOI":"10.1176\/appi.ajp.2020.20030305"},{"issue":"1","key":"10.1016\/j.yebeh.2026.111214_b0120","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/brain\/118.1.105","article-title":"The clinical-pathogenic mechanisms of hippocampal neuron loss and surgical outcomes in temporal lobe epilepsy","volume":"118","author":"Mathern","year":"1995","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2026.111214_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscychresns.2021.111281","article-title":"A pioneering FreeSurfer volumetric study of a series of patients with mesial temporal lobe epilepsy and hippocampal sclerosis with comorbid depression","volume":"311","author":"de Figueiredo","year":"2021","journal-title":"Psych Res- Neuroimag"},{"issue":"2","key":"10.1016\/j.yebeh.2026.111214_b0130","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.yebeh.2012.01.007","article-title":"Depression and epilepsy: epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence","volume":"24","author":"Kanner","year":"2012","journal-title":"Epilepsy Behav"},{"issue":"6","key":"10.1016\/j.yebeh.2026.111214_b0135","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1111\/j.1471-4159.2007.04926.x","article-title":"Which clinical and experimental data link temporal lobe epilepsy with depression?","volume":"103","author":"Kondziella","year":"2007","journal-title":"J Neurochem"},{"issue":"SUPPL. 10","key":"10.1016\/j.yebeh.2026.111214_b0140","first-page":"s21","article-title":"Depression in epilepsy: etiology, phenomenology, and treatment","volume":"40","author":"Lambert","year":"1999","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.yebeh.2026.111214_b0145","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/j.1528-1167.2008.01883.x","article-title":"Temporal lobe epilepsy, depression, and hippocampal volume","volume":"50","author":"Shamim","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2026.111214_b0150","doi-asserted-by":"crossref","unstructured":"B\u0142aszczyk B, Czuczwar SJ. Epilepsy coexisting with depression. In Pharmacological Reports. 2016, (Vol. 68, Number 5, pp. 1084\u20131092). Elsevier B.V. doi: 10.1016\/j.pharep.2016.06.011.","DOI":"10.1016\/j.pharep.2016.06.011"},{"key":"10.1016\/j.yebeh.2026.111214_b0155","doi-asserted-by":"crossref","unstructured":"Qin SK, Yang ZX, Guan ZW, Zhang JH, Ping X, Lu Y, et al. Exploring the association between epilepsy and depression: a systematic review and meta-analysis. In PLoS ONE. 2022. (Vol. 17, Number 12 December). Public Library of Science. doi: 10.1371\/journal.pone.0278907.","DOI":"10.1371\/journal.pone.0278907"},{"issue":"8","key":"10.1016\/j.yebeh.2026.111214_b0160","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.seizure.2010.07.004","article-title":"Psychiatric disorders in temporal lobe epilepsy: an overview from a tertiary service in Brazil","volume":"19","author":"De Oliveira","year":"2010","journal-title":"Seizure"},{"issue":"5","key":"10.1016\/j.yebeh.2026.111214_b0165","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1006\/ebeh.2001.0247","article-title":"Depression and anxiety in patients with epilepsy","volume":"2","author":"Piazzini","year":"2001","journal-title":"Epilepsy Behav: E&B"},{"key":"10.1016\/j.yebeh.2026.111214_b0170","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.seizure.2020.07.031","article-title":"Neuropsychological findings related to the presence of pre-surgical comorbid depression in Latin-American patients with mesial temporal lobe epilepsy and hippocampal sclerosis","volume":"81","author":"de Figueiredo","year":"2020","journal-title":"Seizure"},{"issue":"18","key":"10.1016\/j.yebeh.2026.111214_b0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810414","article-title":"Elevated serum cortisol levels in patients with focal epilepsy, depression, and comorbid epilepsy and depression","volume":"23","author":"Druzhkova","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.yebeh.2026.111214_b0180","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.nbd.2009.02.018","article-title":"Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy","volume":"34","author":"Mazarati","year":"2009","journal-title":"Neurobiol Dis"},{"issue":"8","key":"10.1016\/j.yebeh.2026.111214_b0185","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1176\/ajp.138.8.1098","article-title":"CSF GABA in normal subjects and patients with depression, schizophrenia, mania, and anorexia nervosa","volume":"138","author":"Gerner","year":"1981","journal-title":"Am J Psychiatry"},{"issue":"4","key":"10.1016\/j.yebeh.2026.111214_b0190","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/mp.2010.120","article-title":"The GABAergic deficit hypothesis of major depressive disorder","volume":"16","author":"Luscher","year":"2011","journal-title":"Mol Psych"},{"key":"10.1016\/j.yebeh.2026.111214_b0195","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1046\/j.1528-1157.2001.042suppl.3008.x","article-title":"GABAergic mechanisms in epilepsy","volume":"42","author":"Treiman","year":"2001","journal-title":"Epilepsia"},{"issue":"9","key":"10.1016\/j.yebeh.2026.111214_b0200","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.jpsychires.2013.04.007","article-title":"Glutamate transporters: a key piece in the glutamate puzzle of major depressive disorder","volume":"47","author":"Medina","year":"2013","journal-title":"J Psychiatr Res"},{"issue":"8","key":"10.1016\/j.yebeh.2026.111214_b0205","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1093\/brain\/awn117","article-title":"Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine","volume":"131","author":"Mazarati","year":"2008","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.yebeh.2026.111214_b0210","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.yebeh.2010.08.012","article-title":"Neuroimaging changes in mesial temporal lobe epilepsy are magnified in the presence of depression","volume":"19","author":"Salgado","year":"2010","journal-title":"Epilepsy Behav"},{"issue":"11","key":"10.1016\/j.yebeh.2026.111214_b0215","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.2174\/13894501113149990156","article-title":"Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue","volume":"14","author":"Rajkowska","year":"2013","journal-title":"Curr Drug Targets"},{"issue":"3","key":"10.1016\/j.yebeh.2026.111214_b0220","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1590\/S0004-282X2013000300011","article-title":"Depression and temporal lobe epilepsy represent an epiphenomenon sharing similar neural networks: clinical and brain structural evidences","volume":"71","author":"Valente","year":"2013","journal-title":"Arq Neuropsiquiatr"},{"key":"10.1016\/j.yebeh.2026.111214_b0240","doi-asserted-by":"crossref","DOI":"10.3389\/fnint.2021.747237","article-title":"Do hippocampal neurons really count for comorbid depression in patients with mesial temporal lobe epilepsy and hippocampal sclerosis? A histopathological study","volume":"15","author":"Vison\u00e1 de Figueiredo","year":"2021","journal-title":"Front Integr Neurosci"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505026003355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505026003355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:26:19Z","timestamp":1789010779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505026003355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":45,"alternative-id":["S1525505026003355"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2026.111214","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Temporal lobe epilepsy and depression: a dysfunctional lobe overshadows a sclerotic hippocampus","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2026.111214","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111214"}}