{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:39:17Z","timestamp":1792543157549,"version":"4.5.0"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.yebeh.2026.111340","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:03:35Z","timestamp":1792530215000},"page":"111340","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Physical exercise as an adjunct to the pharmacological treatment of epilepsy: a priority for future research"],"prefix":"10.1016","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1981-1092","authenticated-orcid":false,"given":"Rodrigo Luiz","family":"Vancini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5749-6877","authenticated-orcid":false,"given":"Claudio Andre","family":"Barbosa de Lira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7004-4565","authenticated-orcid":false,"given":"Marilia Santos","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-9103","authenticated-orcid":false,"given":"Beat","family":"Knechtle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7771-6133","authenticated-orcid":false,"given":"Ricardo Mario","family":"Arida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2026.111340_b0005","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000503831","article-title":"The Epidemiology of Epilepsy","volume":"54","author":"Beghi","year":"2020","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.yebeh.2026.111340_b0010","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S1474-4422(23)00151-5","article-title":"Drug resistance in epilepsy","volume":"22","author":"Perucca","year":"2023","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2026.111340_b0015","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S1474-4422(20)30035-1","article-title":"30 years of second-generation antiseizure medications: impact and future perspectives","volume":"19","author":"Perucca","year":"2020","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2026.111340_b0020","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2165\/00003088-198207010-00004","article-title":"Pharmacokinetic Interactions with Antiepileptic Drugs","volume":"7","author":"Perucca","year":"1982","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.yebeh.2026.111340_b0025","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/ane.12703","article-title":"A review of medication adherence in people with epilepsy","volume":"135","author":"Malek","year":"2017","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.yebeh.2026.111340_b0030","article-title":"Impact of Physical Activity and Medication Adherence on the Seizure Frequency and Quality of Life of Epileptic Patients: A Population Study in West Texas","author":"Lee","year":"2022","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.yebeh.2026.111340_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/sms.12581","article-title":"Exercise as medicine \u2013 evidence for prescribing exercise as therapy in 26 different chronic diseases","volume":"25","author":"Pedersen","year":"2015","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.yebeh.2026.111340_b0040","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/HCO.0000000000000437","article-title":"Health benefits of physical activity","volume":"32","author":"Warburton","year":"2017","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.yebeh.2026.111340_b0045","doi-asserted-by":"crossref","first-page":"6720","DOI":"10.2174\/1381612811319380004","article-title":"Role of Physical Exercise as Complementary Treatment for Epilepsy and other Brain Disorders","volume":"19","author":"Arida","year":"2013","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.yebeh.2026.111340_b0050","article-title":"Physical exercise and seizure activity","volume":"121","author":"Arida","year":"2021","journal-title":"Biochim Biophys Acta - Mol Basis Dis"},{"key":"10.1016\/j.yebeh.2026.111340_b0055","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/epi.13261","article-title":"Epilepsy, seizures, physical exercise, and sports: A report from the ILAE Task Force on Sports and Epilepsy","volume":"57","author":"Capovilla","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2026.111340_b0060","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1528-1157.1990.tb05365.x","article-title":"Effect of Physical Training on Aerobic Capacity, Seizure Occurrence, and Serum Level of Antiepileptic Drugs in Adults with Epilepsy","volume":"31","author":"Nakken","year":"1990","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2026.111340_b0065","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/sms.12708","article-title":"Exercise as medicine for people with epilepsy","volume":"26","author":"Vancini","year":"2016","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.yebeh.2026.111340_b0070","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3109\/07853899109148062","article-title":"Effect of Exercise on Pharmacokinetics","volume":"23","author":"Ylitalo","year":"1991","journal-title":"Ann Med"},{"key":"10.1016\/j.yebeh.2026.111340_b0075","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2165\/00003088-199019010-00003","article-title":"Influence of Exercise on the Pharmacokinetics of Drugs","volume":"19","author":"van Baak","year":"1990","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.yebeh.2026.111340_b0080","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/ddr.430200302","article-title":"Effect of exercise on disposition and pharmacokinetics of drugs","volume":"20","author":"Somani","year":"1990","journal-title":"Drug Dev Res"},{"key":"10.1016\/j.yebeh.2026.111340_b0085","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1177\/1359105320967421","article-title":"Exercise and antiretroviral adherence in adults living with HIV: A systematic review","volume":"27","author":"SantaBarbara","year":"2022","journal-title":"J Health Psychol"},{"key":"10.1016\/j.yebeh.2026.111340_b0090","doi-asserted-by":"crossref","first-page":"504","DOI":"10.5414\/CPP41504","article-title":"A review of the effects of chronic exercise and physical fitness level on resting pharmacokinetics","volume":"41","author":"Persky","year":"2003","journal-title":"Int J Clin Pharmacol Ther"},{"key":"10.1016\/j.yebeh.2026.111340_b0095","doi-asserted-by":"crossref","first-page":"583","DOI":"10.14740\/jocmr3894","article-title":"Adherence to Medication, Physical Activity and Diet in Older Adults With Diabetes: Its Association With Cognition, Anxiety and Depression","volume":"11","author":"Mendes","year":"2019","journal-title":"J Clin Med Res"},{"key":"10.1016\/j.yebeh.2026.111340_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2022.107052","article-title":"Exercise, medication adherence, and the menstrual cycle: How much do these change seizure risk?","volume":"188","author":"Eccleston","year":"2022","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2026.111340_b0105","first-page":"292","article-title":"The effects of exercise on the pharmacokinetics of drugs","volume":"3","author":"Khazaeinia","year":"2000","journal-title":"J Pharm Pharm Sci"},{"key":"10.1016\/j.yebeh.2026.111340_b0110","doi-asserted-by":"crossref","first-page":"7692","DOI":"10.3390\/ijms22147692","article-title":"The Impact of Diet and Exercise on Drug Responses","volume":"22","author":"Niederberger","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.yebeh.2026.111340_b0115","doi-asserted-by":"crossref","unstructured":"Chaudri NA. Adherence to Long-term Therapies Evidence for ActionWorld Health Organization (WHO). 2003, 216 pages [English]. ISBN 92 4 154599 2. Ann Saudi Med 2004;24:221\u20132. https:\/\/doi.org\/10.5144\/0256-4947.2004.221.","DOI":"10.5144\/0256-4947.2004.221"},{"key":"10.1016\/j.yebeh.2026.111340_b0120","doi-asserted-by":"crossref","first-page":"98","DOI":"10.11622\/smedj.2016022","article-title":"An evaluation of factors affecting adherence to antiepileptic drugs in patients with epilepsy: a cross-sectional study","volume":"58","author":"Gurumurthy","year":"2017","journal-title":"Singapore Med J"},{"key":"10.1016\/j.yebeh.2026.111340_b0125","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.seizure.2016.12.006","article-title":"Identifying the barriers to antiepileptic drug adherence among adults with epilepsy","volume":"45","author":"O\u2019 Rourke G, O\u2019 Brien JJ.","year":"2017","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2026.111340_b0130","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.eplepsyres.2018.03.018","article-title":"The prevalence rates of medication adherence and factors influencing adherence to antiepileptic drugs in children with epilepsy: A systematic review and meta analysis","volume":"142","author":"Yang","year":"2018","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2026.111340_b0135","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/ane.12668","article-title":"Increasing adherence to treatment in epilepsy: what do the strongest trials show?","volume":"135","author":"da Mota","year":"2017","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.yebeh.2026.111340_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2026.111051","article-title":"A randomized feasibility pilot trial of a remotely delivered physical activity intervention for adults with epilepsy","volume":"180","author":"Alexander","year":"2026","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2026.111340_b0145","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.jdiacomp.2015.07.005","article-title":"Adherence to diabetes guidelines for screening, physical activity and medication and onset of complications and death","volume":"29","author":"Chen","year":"2015","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.yebeh.2026.111340_b0150","unstructured":"Vancini RL; Arida RM; Nouailhetas VLA; de Lira CAB. Epilepsia. In: Vagner Raso; Julia Maria D Greve, editor. Pollock - Fisiol. Cl\u00ednica do Exerc. 2 ed, S\u00e3o Paulo: Atheneu; 2021."},{"key":"10.1016\/j.yebeh.2026.111340_b0155","unstructured":"Bloomquist LEC. Epilepsy. In: Durstine; LJ and GEM, editor. ACSM\u2019s Exerc. Manag. Pers. with Chronic Dis. Disabil., ACSM; 2002, p. 384."},{"key":"10.1016\/j.yebeh.2026.111340_b0160","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.71550","article-title":"Factors Associated With Antiseizure Medication Adherence in Patients With Epilepsy: A Systematic Review","volume":"16","author":"Turan","year":"2026","journal-title":"Brain Behav"},{"key":"10.1016\/j.yebeh.2026.111340_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/2806341","article-title":"Medication Belief and Adherence among Patients with Epilepsy","volume":"2019","author":"Niriayo","year":"2019","journal-title":"Behav Neurol"},{"key":"10.1016\/j.yebeh.2026.111340_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2022.109029","article-title":"Determinants of medication adherence in people with epilepsy: A multicenter, cross-sectional survey","volume":"138","author":"Narducci","year":"2023","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2026.111340_b0175","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.seizure.2025.06.016","article-title":"Barriers and enablers to antiseizure medication adherence in children with Epilepsy: A systematic review using meta-ethnography","volume":"130","author":"Kyeremaa","year":"2025","journal-title":"Seizure Eur J Epilepsy"},{"key":"10.1016\/j.yebeh.2026.111340_b0180","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1249\/MSS.0000000000001936","article-title":"Physical Activity, Cognition, and Brain Outcomes: A Review of the 2018 Physical Activity Guidelines","volume":"51","author":"Erickson","year":"2019","journal-title":"Med Sci Sport Exerc"},{"key":"10.1016\/j.yebeh.2026.111340_b0185","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nrn2298","article-title":"Be smart, exercise your heart: exercise effects on brain and cognition","volume":"9","author":"Hillman","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.yebeh.2026.111340_b0190","article-title":"Strategies for improving adherence to antiepileptic drug treatment in people with epilepsy","author":"Al-aqeel","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.yebeh.2026.111340_b0195","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3961\/jpmph.23.592","article-title":"The Role of Pharmacists\u2019 Interventions in Increasing Medication Adherence of Patients With Epilepsy: A Scoping Review","volume":"57","author":"Ernawati","year":"2024","journal-title":"J Prev Med Public Heal"},{"key":"10.1016\/j.yebeh.2026.111340_b0200","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1002\/epi4.70110","article-title":"Facilitators and barriers of antiseizure medication adherence from Australian healthcare providers\u2019 perspectives: A qualitative study","volume":"10","author":"Conquest","year":"2025","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.yebeh.2026.111340_b0205","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/s12883-025-04433-9","article-title":"Barriers and facilitators of antiseizure medication adherence: a qualitative study among persons with epilepsy in Pakistan","volume":"25","author":"Zahra","year":"2025","journal-title":"BMC Neurol"},{"key":"10.1016\/j.yebeh.2026.111340_b0210","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12906-021-03224-2","article-title":"Impact of complementary and alternative medicines on antiepileptic medication adherence among epilepsy patients","volume":"21","author":"Farrukh","year":"2021","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.yebeh.2026.111340_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2024.109761","article-title":"The relationship between medication adherence and complementary medicine use in epilepsy patients","volume":"154","author":"G\u00fcnd\u00fcz Oru\u00e7","year":"2024","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2026.111340_b0220","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.yebeh.2017.03.004","article-title":"How do you exercise with epilepsy? Insights into the barriers and adaptations to successfully exercise with epilepsy","volume":"70","author":"Collard","year":"2017","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2026.111340_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2023.109491","article-title":"A single-center survey on physical activity barriers, behaviors and preferences in adults with epilepsy","volume":"149","author":"Alexander","year":"2023","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2026.111340_b0230","article-title":"Exercise in patients with epilepsy and neurostimulation devices - physical activity levels, barriers, and beliefs","volume":"27","author":"Mauney","year":"2024","journal-title":"Epilepsy Behav Reports"},{"key":"10.1016\/j.yebeh.2026.111340_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2024.109772","article-title":"\u201cOne size does not fit all\u201d \u2013 Barriers to and facilitators of physical activity in adolescents with epilepsy","volume":"156","author":"Idowu","year":"2024","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2026.111340_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2026.111091","article-title":"What is known about the barriers and facilitators to physical activity participation among females with epilepsy: A scoping review","volume":"181","author":"Williams","year":"2026","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2026.111340_b0245","article-title":"Do people with epilepsy want to participate in an exercise intervention randomized controlled trial? \u2013 Results of a brief survey and its preliminary application","volume":"24","author":"Mitchell","year":"2023","journal-title":"Epilepsy Behav Reports"},{"key":"10.1016\/j.yebeh.2026.111340_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2022.108705","article-title":"Neurologists\u2019 knowledge of and attitudes toward physical exercise for people with epilepsy in Latin America","volume":"131","author":"Arida","year":"2022","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2026.111340_b0255","doi-asserted-by":"crossref","DOI":"10.1136\/bmjpo-2026-004519","article-title":"Barriers and enablers to antiseizure medication adherence in children with epilepsy: a systematic review using the theoretical domains framework (TDF)","volume":"10","author":"Abrefa Kyeremaa","year":"2026","journal-title":"BMJ Paediatr Open"},{"key":"10.1016\/j.yebeh.2026.111340_b0260","doi-asserted-by":"crossref","first-page":"31","DOI":"10.33588\/rn.7101.2020028","article-title":"El ejercicio como estrategia terap\u00e9utica en la epilepsia: revisi\u00f3n bibliogr\u00e1fica","volume":"71","author":"Cartagena Agudelo","year":"2020","journal-title":"Rev Neurol"},{"key":"10.1016\/j.yebeh.2026.111340_b0265","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0891-8422(23)00515-3","article-title":"Basic pharmacology and pharmacokinetics","volume":"9","author":"Rasymas","year":"1992","journal-title":"Clin Podiatr Med Surg"},{"key":"10.1016\/j.yebeh.2026.111340_b0270","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1517\/17425255.2011.553190","article-title":"The effects of high physical activity on pharmacokinetic drug interactions","volume":"7","author":"Lenz","year":"2011","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.yebeh.2026.111340_b0275","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1046\/j.1365-2125.1998.00711.x","article-title":"Assessment of hepatic blood flow using continuous infusion of high clearance drugs","volume":"45","author":"Schoemaker","year":"1998","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.yebeh.2026.111340_b0280","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1113\/jphysiol.2003.039743","article-title":"Effects of short\u2010term training on plasma acid\u2010base balance during incremental exercise in man","volume":"550","author":"Putman","year":"2003","journal-title":"J Physiol"},{"key":"10.1016\/j.yebeh.2026.111340_b0285","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ijpharm.2008.03.032","article-title":"The effect of heat on skin permeability","volume":"359","author":"Park","year":"2008","journal-title":"Int J Pharm"},{"key":"10.1016\/j.yebeh.2026.111340_b0290","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1249\/00005768-199408000-00008","article-title":"Exercise training does not alter cytochrome P-450 content and microsomal metabolism","volume":"26","author":"Michaud","year":"1994","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.yebeh.2026.111340_b0295","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1039\/C2CS35348B","article-title":"The significance of acid\/base properties in drug discovery","volume":"42","author":"Manallack","year":"2013","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.yebeh.2026.111340_b0300","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1124\/dmd.124.001809","article-title":"Quantitatively Predicting Effects of Exercise on Pharmacokinetics of Drugs Using a Physiologically Based Pharmacokinetic Model","volume":"52","author":"Guo","year":"2024","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.yebeh.2026.111340_b0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2021.108079","article-title":"Exercise-linked consequences on epilepsy","volume":"121","author":"Cavalcante","year":"2021","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2026.111340_b0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165979","article-title":"Physical exercise and seizure activity","volume":"1867","author":"Arida","year":"2021","journal-title":"Biochim Biophys Acta - Mol Basis Dis"},{"key":"10.1016\/j.yebeh.2026.111340_b0315","article-title":"Physical exercise-mediated neuroprotective mechanisms in Parkinson\u2019s disease, Alzheimer\u2019s disease, and epilepsy. Brazilian J Med","volume":"57","author":"Pinho","year":"2024","journal-title":"Biol Res"},{"key":"10.1016\/j.yebeh.2026.111340_b0320","article-title":"Physical activity and sedentary levels among people living with epilepsy: A systematic review and meta-analysis","volume":"99","author":"Vancampfort","year":"2019","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2026.111340_b0325","first-page":"607","volume":"38","author":"Arida","year":"2008","journal-title":"Physical Activity and Epilepsy. Sport Med"},{"key":"10.1016\/j.yebeh.2026.111340_b0330","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.seizure.2014.09.015","article-title":"Epilepsy and physical exercise","volume":"25","author":"Pimentel","year":"2015","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2026.111340_b0335","article-title":"Safety and feasibility of exhaustive exercise testing for people with epilepsy","volume":"30","author":"van den Bongard","year":"2025","journal-title":"Epilepsy Behav Reports"},{"key":"10.1016\/j.yebeh.2026.111340_b0340","article-title":"Self-reported exercise engagement and seizure control \u2013 A preliminary survey of people with epilepsy at a safety-net hospital","volume":"28","author":"Farb","year":"2024","journal-title":"Epilepsy Behav Reports"},{"key":"10.1016\/j.yebeh.2026.111340_b0345","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1177\/1359105317729560","article-title":"\u2018I\u2019d rather you didn\u2019t come\u2019: The impact of stigma on exercising with epilepsy","volume":"24","author":"Collard","year":"2019","journal-title":"J Health Psychol"},{"key":"10.1016\/j.yebeh.2026.111340_b0350","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.yebeh.2017.07.039","article-title":"Physical activity, stigma, and quality of life in patients with epilepsy","volume":"77","author":"Tedrus","year":"2017","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2026.111340_b0355","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1017\/cjn.2018.340","article-title":"Epilepsy, Physical Activity and Sports: A Narrative Review","volume":"45","author":"Carrizosa-Moog","year":"2018","journal-title":"Can J Neurol Sci \/ J Can Des Sci Neurol"},{"key":"10.1016\/j.yebeh.2026.111340_b0360","article-title":"Socio economic factors and adherence to home based exercise in people with epilepsy","volume":"27","author":"Vooturi","year":"2024","journal-title":"Epilepsy Behav Reports"},{"key":"10.1016\/j.yebeh.2026.111340_b0365","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.944605","article-title":"Innovative Approaches to Enhance and Measure Medication Adherence in Chronic Disease Management: A Review","volume":"30","author":"Gackowski","year":"2024","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.yebeh.2026.111340_b0370","doi-asserted-by":"crossref","DOI":"10.2196\/24190","article-title":"Mobile Apps to Improve Medication Adherence in Cardiovascular Disease: Systematic Review and Meta-analysis","volume":"23","author":"Al-Arkee","year":"2021","journal-title":"J Med Internet Res"},{"key":"10.1016\/j.yebeh.2026.111340_b0375","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","article-title":"The global epidemiology of hypertension","volume":"16","author":"Mills","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.yebeh.2026.111340_b0380","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dyz148","article-title":"Physical activity of UK adults with chronic disease: cross-sectional analysis of accelerometer-measured physical activity in 96 706 UK Biobank participants","author":"Barker","year":"2019","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.yebeh.2026.111340_b0385","year":"2025","journal-title":"Work"},{"key":"10.1016\/j.yebeh.2026.111340_b0390","first-page":"2022","author":"Organization","year":"2022","journal-title":"Global status report on physical activity"},{"key":"10.1016\/j.yebeh.2026.111340_b0395","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1590\/S0102-311X2005000400037","article-title":"Adherence to long term therapies: evidence for action","volume":"21","author":"Dal-Fabbro","year":"2005","journal-title":"Cad Saude Publica"},{"key":"10.1016\/j.yebeh.2026.111340_b0400","doi-asserted-by":"crossref","first-page":"e5641","DOI":"10.1097\/MD.0000000000005641","article-title":"Nonadherence to antihypertensive drugs","volume":"96","author":"Abegaz","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.yebeh.2026.111340_b0405","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1528-1167.2009.02477.x","article-title":"Health status and health\u2010related behaviors in epilepsy compared to other chronic conditions\u2014A national population\u2010based study","volume":"51","author":"Hinnell","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2026.111340_b0410","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/dme.12651","article-title":"Adherence to diabetes medication: a systematic review","volume":"32","author":"Krass","year":"2015","journal-title":"Diabet Med"},{"key":"10.1016\/j.yebeh.2026.111340_b0415","first-page":"22","article-title":"Adherence to oral antineoplastic agents by cancer patients: definition and literature review","volume":"23","author":"Bassan","year":"2014","journal-title":"Eur J Cancer Care (Engl)"},{"key":"10.1016\/j.yebeh.2026.111340_b0425","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1093\/eurheartj\/eht295","article-title":"Adherence to cardiovascular therapy: a meta-analysis of prevalence and clinical consequences","volume":"34","author":"Chowdhury","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.yebeh.2026.111340_b0430","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.3390\/jcm12051981","article-title":"Adherence to Oral Antidiabetic Drugs in Patients with Type 2 Diabetes: Systematic Review and Meta-Analysis","volume":"12","author":"Piragine","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.yebeh.2026.111340_b0435","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/CIRCULATIONAHA.108.830299","article-title":"Adherence to antihypertensive medications and cardiovascular morbidity among newly diagnosed hypertensive patients","volume":"120","author":"Mazzaglia","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.yebeh.2026.111340_b0440","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1634\/theoncologist.2015-0405","article-title":"A Systematic Review of Adherence to Oral Antineoplastic Therapies","volume":"21","author":"Greer","year":"2016","journal-title":"Oncologist"},{"key":"10.1016\/j.yebeh.2026.111340_b0445","series-title":"Adherence to long-term therapies: evidence for action","author":"World Health Organization","year":"2003"},{"key":"10.1016\/j.yebeh.2026.111340_b0450","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-014435","article-title":"Factors predicting self-reported medication low adherence in a large sample of adults in the US general population: a cross-sectional study","volume":"7","author":"Feehan","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.yebeh.2026.111340_b0455","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.amjcard.2007.10.015","article-title":"Are United States Adults With Coronary Heart Disease Meeting Physical Activity Recommendations?\u2020\u2020The findings and conclusions in this report are those of the investigators and do not necessarily represent the views of the Centers for Disease Control and P","volume":"101","author":"Zhao","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.yebeh.2026.111340_b0460","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.037357","article-title":"Antihypertensive Medication Adherence and Medical Costs, Health Care Use, and Labor Productivity Among People With Hypertension","volume":"13","author":"Lee","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.yebeh.2026.111340_b0465","unstructured":"National Cancer Institute. Cancer Survivors and Physical Activity 2022. https:\/\/progressreport.cancer.gov\/after\/physical_activity (accessed September 13, 2026)."},{"key":"10.1016\/j.yebeh.2026.111340_b0470","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2519\/josptopen.2024.1130","article-title":"Are US Adults With Chronic Health Conditions Meeting Public Health Recommendations for Physical Activity?","volume":"2","author":"Alqahtani","year":"2024","journal-title":"JOSPT Open"},{"key":"10.1016\/j.yebeh.2026.111340_b0475","doi-asserted-by":"crossref","first-page":"85","DOI":"10.15585\/mmwr.mm7204a1","article-title":"Prevalence of Meeting Aerobic, Muscle-Strengthening, and Combined Physical Activity Guidelines During Leisure Time Among Adults, by Rural-Urban Classification and Region \u2014 United States, 2020","volume":"72","author":"Abildso","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.yebeh.2026.111340_b0420","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nri3041","article-title":"The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease","volume":"11","author":"Gleeson","year":"2011","journal-title":"Nat Rev Immunol"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505026004610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505026004610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:11:45Z","timestamp":1792541505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505026004610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":95,"alternative-id":["S1525505026004610"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2026.111340","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physical exercise as an adjunct to the pharmacological treatment of epilepsy: a priority for future research","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2026.111340","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111340"}}