{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:33:42Z","timestamp":1780529622148,"version":"3.54.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1016\/j.yexcr.2003.09.009","type":"journal-article","created":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:32:49Z","timestamp":1067646769000},"page":"332-341","source":"Crossref","is-referenced-by-count":11,"title":["Characterization of the antigenicity of the formiminotransferase-cyclodeaminase in type 2 autoimmune hepatitis"],"prefix":"10.1016","volume":"292","author":[{"given":"Reginald","family":"Renous","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Lapierre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idriss","family":"Djilali-Saiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Vitozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2003.09.009_BIB1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis","volume":"31","author":"Alvarez","year":"1999","journal-title":"J. Hepatol."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/hep.1840030320","article-title":"Seroimmunologic classification of chronic hepatitis in 57 children","volume":"3","author":"Odievre","year":"1983","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB3","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1002\/hep.1840080632","article-title":"Antibody to liver cytosol (anti-LC1) in patients with autoimmune chronic active hepatitis type 2","volume":"8","author":"Martini","year":"1988","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB4","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/hep.1840160407","article-title":"Characterization of the liver cytosol antigen type 1 reacting with autoantibodies in chronic active hepatitis","volume":"16","author":"Abuaf","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0016-5085(99)70186-1","article-title":"Formiminotransferase cyclodeaminase is an organ-specific autoantigen recognized by sera of patients with autoimmune hepatitis","volume":"116","author":"Lapierre","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0005-2795(76)90259-2","article-title":"Formiminotransferase cyclodeaminase from porcine liver. An octomeric enzyme containing bifunctional polypeptides","volume":"453","author":"Beaudet","year":"1976","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB7","doi-asserted-by":"crossref","first-page":"19612","DOI":"10.1074\/jbc.273.31.19612","article-title":"58 K, a microtubule-binding Golgi protein, is a formiminotransferase cyclodeaminase","volume":"273","author":"Bashour","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0005-2744(80)90054-6","article-title":"Tetrahydropterolypolyglutamate derivatives as substrates of two multifunctional proteins with folate-dependent enzyme activities","volume":"611","author":"Mackenzie","year":"1980","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB9","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1021\/bi00409a042","article-title":"Renaturation of formiminotransferase-cyclodeaminase from guanidine hydrochloride. Quaternary structure requirements for the activities and polyglutamate specificity","volume":"27","author":"Findlay","year":"1988","journal-title":"Biochemistry"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB10","doi-asserted-by":"crossref","first-page":"16083","DOI":"10.1016\/S0021-9258(18)71590-1","article-title":"A novel 58-kDa protein associates with the Golgi apparatus and microtubules","volume":"264","author":"Bloom","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB11","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1083\/jcb.152.5.877","article-title":"A novel interaction of the Golgi complex with the vimentin intermediate filament cytoskeleton","volume":"152","author":"Gao","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB12","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1136\/gut.42.5.721","article-title":"Liver\/kidney microsomal antibody type 1 and liver cytosol antibody type 1 concentrations in type 2 autoimmune hepatitis","volume":"42","author":"Muratori","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB13","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/hep.1840180435","article-title":"Meeting report: International Autoimmune Hepatitis Group","volume":"18","author":"Johnson","year":"1993","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB14","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1083\/jcb.62.3.717","article-title":"Analytical study of microsomes and isolated subcellular membranes from rat liver. IV. Biochemical, physical, and morphological modifications of microsomal components induced by digitonin, EDTA, and pyrophosphate","volume":"62","author":"Amar-Costesec","year":"1974","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0022-1759(02)00016-9","article-title":"Autoantibody detection in type 2 autoimmune hepatitis using a chimera recombinant protein","volume":"262","author":"Vitozzi","year":"2002","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB16","doi-asserted-by":"crossref","first-page":"31655","DOI":"10.1074\/jbc.M004935200","article-title":"Characterization of a cDNA encoding a novel human Golgi alpha 1, 2-mannosidase (IC) involved in N-glycan biosynthesis","volume":"275","author":"Tremblay","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB17","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1083\/jcb.61.1.213","article-title":"Analytical study of microsomes and isolated subcellular membranes from rat liver. 3. Subfractionation of the microsomal fraction by isopycnic and differential centrifugation in density gradients","volume":"61","author":"Beaufay","year":"1974","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/00327487208061453","article-title":"A simplified procedure for isolation of Golgi apparatus from rat liver","volume":"2","author":"Morre","year":"1972","journal-title":"Prep. Biochem."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB20","unstructured":"D.L. Spector, R.D. Goldman, L.A. Leinwand, Cells a laboratory manual 72(1998) 1\u201372.4."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB21","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB22","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/0022-2836(74)90048-5","article-title":"Turbidimetric studies of the in vitro assembly and disassembly of porcine neurotubules","volume":"89","author":"Gaskin","year":"1974","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB23","first-page":"G757","article-title":"Ethanol-induced alterations of the microtubule cytoskeleton in hepatocytes","volume":"274","author":"Yoon","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB24","series-title":"Studying Intermediate Filaments in the Cytoskeleton: A Practical Approach","first-page":"223","author":"Domingo","year":"1991"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB25","doi-asserted-by":"crossref","first-page":"469","DOI":"10.4049\/jimmunol.141.2.469","article-title":"Epitope mapping with a recombinant human 68-kDa (U1) ribonucleoprotein antigen reveals heterogeneous autoantibody profiles in human autoimmune sera","volume":"141","author":"Guldner","year":"1988","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB26","first-page":"354","article-title":"A new antigen recognized by anti-liver-kidney-microsome antibody (LKMA)","volume":"75","author":"Codoner-Franch","year":"1989","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB27","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/clin.1996.0121","article-title":"Detection on immunoblot of new proteins from the microsomal fraction recognized by anti-liver-kidney microsome antibodies type 1","volume":"80","author":"Ballot","year":"1996","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB28","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1084\/jem.161.5.1231","article-title":"Anti-liver-kidney microsome antibody recognizes a 50,000 molecular weight protein of the endoplasmic reticulum","volume":"161","author":"Alvarez","year":"1985","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB29","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/gut.36.5.749","article-title":"Liver cytosolic 1 antigen-antibody system in type 2 autoimmune hepatitis and hepatitis C virus infection","volume":"36","author":"Lenzi","year":"1995","journal-title":"Gut"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB30","doi-asserted-by":"crossref","first-page":"19602","DOI":"10.1074\/jbc.273.31.19602","article-title":"A formiminotransferase cyclodeaminase isoform is localized to the Golgi complex and can mediate interaction of trans-Golgi network-derived vesicles with microtubules","volume":"273","author":"Hennig","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB31","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/0092-8674(90)90464-P","article-title":"Epitopes on protein antigens: misconceptions and realities","volume":"61","author":"Laver","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB32","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1006\/jmbi.1999.2655","article-title":"High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase","volume":"287","author":"Schwartz","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB33","doi-asserted-by":"crossref","first-page":"14487","DOI":"10.1073\/pnas.96.25.14487","article-title":"Key residues revealed in a major conformational epitope of the U1-70K protein","volume":"96","author":"Welin Henriksson","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB34","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/art.1780380610","article-title":"Autoimmune response to the spliceosome. An immunologic link between rheumatoid arthritis, mixed connective tissue disease, and systemic lupus erythematosus","volume":"38","author":"Hassfeld","year":"1995","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB35","doi-asserted-by":"crossref","first-page":"6655","DOI":"10.4049\/jimmunol.164.12.6655","article-title":"Ro60 peptides induce antibodies to similar epitopes shared among lupus-related autoantigens","volume":"164","author":"Deshmukh","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB36","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1034\/j.1600-0528.2002.017410.x","article-title":"The peculiar autoimmunity of primary biliary cirrhosis","volume":"174","author":"Mackay","year":"2000","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB37","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1053\/jhep.2001.27179","article-title":"Distinct epitopes on formiminotransferase cyclodeaminase induce autoimmune liver cytosol antibody type 1","volume":"34","author":"Muratori","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB38","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/0016-5085(95)90076-4","article-title":"Conformational epitopes on CYP2D6 are recognized by liver\/kidney microsomal antibodies","volume":"108","author":"Duclos-Vallee","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB39","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4049\/jimmunol.169.1.277","article-title":"Key residues of a major cytochrome P4502D6 epitope are located on the surface of the molecule","volume":"169","author":"Ma","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB40","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(91)90356-4","article-title":"Autoantibodies in pathology and cell biology","volume":"67","author":"Tan","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB41","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s004310051278","article-title":"Auto-antibodies to the asialoglycoprotein receptor in sera of children with auto-immune hepatitis","volume":"159","author":"Hajoui","year":"2000","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB42","first-page":"347","article-title":"Identification of the hepatic asialo-glycoprotein receptor (hepatic lectin) as a component of liver specific membrane lipoprotein (LSP)","volume":"55","author":"McFarlane","year":"1984","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB43","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1006\/jaut.1998.0216","article-title":"Penetration of anti-DNA antibodies into immature live cells","volume":"11","author":"Ruiz-Arguelles","year":"1998","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB44","first-page":"121","article-title":"Penetration of autoantibodies into living cells 2000","volume":"3","author":"Ruiz-Arguelles","year":"2001","journal-title":"Isr. Med. Assoc. J."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB45","unstructured":"A. Ruiz-Arguelles, D. Alarcon-Segovia, Penetration of autoantibodies into living cells, in: K. Conrad, R.L. Humbel, M. Meurer, T. Shoenfeld, E.M. Tan (Eds.), Pathogenic and Diagnostic Relevance of Autoantibodies, Update Clin Immunol."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB46","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1053\/jhep.2002.31165","article-title":"Keratins: guardians of the liver","volume":"35","author":"Omary","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB47","series-title":"Autoanticorps: marqueurs des maladies auto-immunes","author":"Meyer","year":"1999"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB48","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/cm.970150202","article-title":"Role of microtubules in the organisation of the Golgi apparatus","volume":"15","author":"Kreis","year":"1990","journal-title":"Cell Motil. Cytoskelet."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB49","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1091\/mbc.7.4.631","article-title":"Golgi dispersal during microtubule disruption: regeneration of Golgi stacks at peripheral endoplasmic reticulum exit sites","volume":"7","author":"Cole","year":"1996","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB50","doi-asserted-by":"crossref","first-page":"18824","DOI":"10.1074\/jbc.M000024200","article-title":"Activated ADP-ribosylation factor assembles distinct pools of actin on Golgi membranes","volume":"275","author":"Fucini","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB51","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000015483","article-title":"Cloning and characterization of human FTCD on 21q22.3, a candidate gene for glutamate formiminotransferase deficiency","volume":"88","author":"Solans","year":"2000","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB52","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0022-2836(84)90149-9","article-title":"Heterotypic tetramer (A2D2) complexes of non-epidermal keratins isolated from cytoskeletons of rat hepatocytes and hepatoma cells","volume":"178","author":"Quinlan","year":"1984","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB53","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1432-0436.1982.tb01266.x","article-title":"Formation of cytoskeletal elements during mouse embryogenesis. III. Primary mesenchymal cells and the first appearance of vimentin filaments","volume":"23","author":"Franke","year":"1982","journal-title":"Differentiation"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB54","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0014-4827(79)90418-X","article-title":"Widespread occurrence of intermediate-sized filaments of the vimentin-type in cultured cells from diverse vertebrates","volume":"123","author":"Franke","year":"1979","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB55","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1083\/jcb.200102130","article-title":"Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation","volume":"154","author":"Gilbert","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB56","doi-asserted-by":"crossref","first-page":"27075","DOI":"10.1016\/S0021-9258(19)61482-1","article-title":"Mapping and regulation of the tumor-associated epitope recognized by monoclonal antibody RS-11","volume":"275","author":"Eto","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2003.09.009_BIB57","first-page":"58","article-title":"Anti-liver cytosolic antigen type 1 (LC1) antibodies in childhood autoimmune liver disease","volume":"21","author":"Han","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2003.09.009_BIB58","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1365-2249.2001.01568.x","article-title":"Anti-cytokeratin antibodies in sera of the patients with autoimmune hepatitis","volume":"125","author":"Murota","year":"2001","journal-title":"Clin. Exp. Immunol."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448270300497X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448270300497X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T11:02:20Z","timestamp":1682593340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448270300497X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S001448270300497X"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2003.09.009","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}