{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:08:50Z","timestamp":1762146530417,"version":"build-2065373602"},"reference-count":60,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.yexcr.2004.10.023","type":"journal-article","created":{"date-parts":[[2004,12,16]],"date-time":"2004-12-16T11:51:11Z","timestamp":1103197871000},"page":"391-406","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["The cytoplasmic C-terminus of polycystin-1 increases cell proliferation in kidney epithelial cells through serum-activated and Ca2+-dependent pathway(s)"],"prefix":"10.1016","volume":"304","author":[{"given":"Elisa","family":"Manzati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Aguiari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Banzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Manzati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Selvatici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Falzarano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iva","family":"Maestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Pinton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Rizzuto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"del Senno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2004.10.023_bib1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0272-6386(12)80051-5","article-title":"Autosomal dominant polycystic kidney disease: more than a renal disease","volume":"16","author":"Gabow","year":"1990","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.yexcr.2004.10.023_bib2","first-page":"S93","article-title":"Mechanisms of progression in autosomal dominant polycystic kidney disease","volume":"630","author":"Grantham","year":"1997","journal-title":"Kidney Int., Suppl."},{"key":"10.1016\/j.yexcr.2004.10.023_bib3","first-page":"219","article-title":"Polycystic kidney disease in SBM transgenic mice: role of c-myc in disease induction and progression","volume":"152","author":"Trudel","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexcr.2004.10.023_bib4","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1681\/ASN.V96937","article-title":"Increased epithelial cell proliferation and abnormal extracellular matrix in rat polycystic kidney disease","volume":"9","author":"Ramasubbu","year":"1998","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexcr.2004.10.023_bib5","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1093\/hmg\/8.10.1861","article-title":"Autosomal dominant polycystic kidney disease: clues to pathogenesis","volume":"8","author":"Harris","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2004.10.023_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1067\/mlc.2003.13","article-title":"Autosomal dominant polycystic kidney disease: molecular genetics and pathophysiology","volume":"141","author":"Sutters","year":"2003","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.yexcr.2004.10.023_bib7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/ng0695-151","article-title":"The polycystic kidney disease 1 -(PKD1) gene encodes a novel protein with multiple cell recognition domains","volume":"10","author":"Hughes","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yexcr.2004.10.023_bib8","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0960-9822(99)80379-0","article-title":"A latrophilin\/CL-1-like GPS domain in polycystin-1","volume":"9","author":"Ponting","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2004.10.023_bib9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0014-5793(03)00130-3","article-title":"Structure-function relationships of the extracellular domain of the autosomal dominant polycystic kidney disease-associated protein, polycystin-1","volume":"558","author":"Weston","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yexcr.2004.10.023_bib10","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1073\/pnas.94.13.6965","article-title":"Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2","volume":"94","author":"Tsiokas","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2004.10.023_bib11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ng0697-179","article-title":"PKD1 interacts with PKD2 through a probable coiled-coil domain","volume":"16","author":"Qian","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yexcr.2004.10.023_bib12","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1126\/science.272.5266.1339","article-title":"PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein","volume":"272","author":"Mochizuki","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2004.10.023_bib13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1006\/bbrc.2001.4554","article-title":"Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease","volume":"282","author":"Vassilev","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexcr.2004.10.023_bib14","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ncb754","article-title":"Polycystin-2 is an intracellular calcium release channel","volume":"4","author":"Koulen","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2004.10.023_bib15","doi-asserted-by":"crossref","first-page":"20763","DOI":"10.1074\/jbc.M107788200","article-title":"Identification, characterization, and localization of a novel kidney polycystin-1\u2013polycystin-2 complex","volume":"277","author":"Newby","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2004.10.023_bib16","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1159\/000066648","article-title":"Molecular complexes formed with polycystins","volume":"93","author":"Lakkis","year":"2003","journal-title":"Nephron Exp. Nephrol."},{"key":"10.1016\/j.yexcr.2004.10.023_bib17","doi-asserted-by":"crossref","first-page":"R356","DOI":"10.1016\/S0960-9822(01)00193-2","article-title":"Human disease: calcium signalling in polycystic kidney disease","volume":"11","author":"Somlo","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2004.10.023_bib18","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0165-6147(00)01832-0","article-title":"Polycystin channels and kidney disease","volume":"22","author":"Stayner","year":"2001","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.yexcr.2004.10.023_bib19","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/35050128","article-title":"Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents","volume":"408","author":"Hanaoka","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2004.10.023_bib20","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1074\/jbc.M209996200","article-title":"Polycystin-1 activates and stabilizes the polycystin-2 channel","volume":"278","author":"Xu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2004.10.023_bib21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ng1076","article-title":"Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells","volume":"33","author":"Nauli","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yexcr.2004.10.023_bib22","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.1074\/jbc.273.11.6013","article-title":"The polycystic kidney disease 1 gene product mediates protein kinase C alpha-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1","volume":"273","author":"Arnould","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2004.10.023_bib23","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1074\/jbc.274.8.4947","article-title":"The polycystic kidney disease 1 gene product modulates Wnt signaling","volume":"274","author":"Kim","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2004.10.023_bib24","doi-asserted-by":"crossref","first-page":"11276","DOI":"10.1074\/jbc.M110483200","article-title":"Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2","volume":"277","author":"Delmas","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2004.10.023_bib25","doi-asserted-by":"crossref","first-page":"19566","DOI":"10.1074\/jbc.M201875200","article-title":"Polycystin-1 activation of c-Jun-N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins","volume":"277","author":"Parnell","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2004.10.023_bib26","first-page":"6371","article-title":"Interaction between RGS7 and polycystin","volume":"2596","author":"Arnould","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2004.10.023_bib27","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1006\/bbrc.1999.0810","article-title":"Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins","volume":"259","author":"Parnell","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexcr.2004.10.023_bib28","first-page":"1311","article-title":"The PKD1 gene product, polycystin-1, is a tyrosine-phosphorylated protein that colocalizes with alpha2beta1-integrin in focal clusters in adherent renal epithelia","volume":"79","author":"Wilson","year":"1999","journal-title":"Lab. Invest."},{"key":"10.1016\/j.yexcr.2004.10.023_bib29","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1046\/j.1523-1755.2001.060002484.x","article-title":"Polycystin-1 transforms the cAMP growth-responsive phenotype of M-1 cells","volume":"60","author":"Sutters","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.yexcr.2004.10.023_bib30","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1093\/hmg\/9.18.2617","article-title":"A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype","volume":"9","author":"Pritchard","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2004.10.023_bib31","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S1097-2765(00)00123-4","article-title":"Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells","volume":"6","author":"Boletta","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.yexcr.2004.10.023_bib32","first-page":"657","article-title":"Expression of polycystin-1 C-terminal fragment enhances the ATP-induced Ca2+ release in human kidney cells","volume":"301","author":"Aguiari","year":"2003","journal-title":"BBRC"},{"key":"10.1016\/j.yexcr.2004.10.023_bib33","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1096\/fj.03-0687fje","article-title":"Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells","volume":"18","author":"Aguiari","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.yexcr.2004.10.023_bib34","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/bbrc.1998.8086","article-title":"The role of calcium in the cell cycle: facts and hypotheses","volume":"244","author":"Santella","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexcr.2004.10.023_bib35","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/27094","article-title":"Calcium\u2014A life and death signal","volume":"395","author":"Berridge","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2004.10.023_bib36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/hmg\/11.1.59","article-title":"Distinct subcellular expression of endogenous polycystin-2 in the plasma membrane and Golgi apparatus of MDCK-cells","volume":"11","author":"Scheffers","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2004.10.023_bib37","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/excr.1998.4198","article-title":"K562 erythroid and HL60 macrophage differentiation downregulates polycystin, a large membrane-associated protein","volume":"244","author":"Aguiari","year":"1998","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2004.10.023_bib38","doi-asserted-by":"crossref","first-page":"9896","DOI":"10.1074\/jbc.270.17.9896","article-title":"Transfected aequorin in the measurement of cytosolic Ca2+ concentration ([Ca2+]c). A critical evaluation","volume":"270","author":"Brini","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2004.10.023_bib39","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2004.10.023_bib40","doi-asserted-by":"crossref","first-page":"34709","DOI":"10.1074\/jbc.M302016200","article-title":"Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes","volume":"278","author":"Soh","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2004.10.023_bib41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0378-1119(02)01055-7","article-title":"Linking cyclins to transcriptional control","volume":"299","author":"Coqueret","year":"2002","journal-title":"Gene"},{"key":"10.1016\/j.yexcr.2004.10.023_bib42","doi-asserted-by":"crossref","first-page":"23589","DOI":"10.1074\/jbc.270.40.23589","article-title":"Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions","volume":"270","author":"Albanese","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2004.10.023_bib43","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1073\/pnas.96.10.5522","article-title":"The cyclin D1 gene is a target of the beta-catenin\/LEF-1 pathway","volume":"96","author":"Shtutman","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2004.10.023_bib44","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0960-9822(00)00358-4","article-title":"PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition","volume":"10","author":"Balciunaite","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2004.10.023_bib45","doi-asserted-by":"crossref","first-page":"D406","DOI":"10.2741\/Black","article-title":"Protein kinase C-mediated regulation of the cell cycle","volume":"5","author":"Black","year":"2000","journal-title":"Front. Biosci."},{"key":"10.1016\/j.yexcr.2004.10.023_bib46","doi-asserted-by":"crossref","first-page":"29054","DOI":"10.1074\/jbc.M201130200","article-title":"Interplay between calcium, diacylglycerol, and phosphorylation in the spatial and temporal regulation of PKC-GFP*","volume":"277","author":"Tanimura","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2004.10.023_bib47","doi-asserted-by":"crossref","first-page":"37702","DOI":"10.1074\/jbc.M204478200","article-title":"Dynamics of glucose-induced membrane recruitment of protein kinase C beta II in living pancreatic islet beta-cells","volume":"277","author":"Pinton","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2004.10.023_bib48","first-page":"F593","article-title":"MAPK signalling and the kidney","volume":"279","author":"Tian","year":"2000","journal-title":"Am. J. Physiol.: Renal., Physiol."},{"key":"10.1016\/j.yexcr.2004.10.023_bib49","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1046\/j.1523-1755.2003.00023.x","article-title":"Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys","volume":"63","author":"Yamaguchi","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.yexcr.2004.10.023_bib50","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/oxfordjournals.jbchem.a003272","article-title":"Protein kinase C\u03b1\u00a0(PKC\u03b1): regulation and biological function","volume":"132","author":"Nakashima","year":"2002","journal-title":"J. Biochem."},{"key":"10.1016\/j.yexcr.2004.10.023_bib51","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1172\/JCI0212867","article-title":"The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells","volume":"109","author":"Nickel","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexcr.2004.10.023_bib52","first-page":"125","article-title":"Down-regulation of nerve growth factor in poorly differentiated and advanced human esophageal cancer","volume":"20","author":"Zhu","year":"2000","journal-title":"Anticancer Res."},{"key":"10.1016\/j.yexcr.2004.10.023_bib53","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1091\/mbc.4.3.293","article-title":"Intracellular free Ca2+ in the cell cycle in human fibroblasts: transition between G1 and G0 and progression into S phase","volume":"4","author":"Wahl","year":"1993","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yexcr.2004.10.023_bib54","doi-asserted-by":"crossref","first-page":"39713","DOI":"10.1074\/jbc.M200464200","article-title":"Spontaneous calcium oscillations control c-fos transcription via the serum response element in neuroendocrine cells","volume":"18","author":"Maturana","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2004.10.023_bib55","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1073\/pnas.96.7.3934","article-title":"Specific association of the gene product of PKD2 with the TRPC1 channel","volume":"96","author":"Tsiokas","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2004.10.023_bib56","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1128\/MCB.23.7.2600-2607.2003","article-title":"Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia","volume":"23","author":"Luo","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yexcr.2004.10.023_bib57","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0092-8674(02)00716-X","article-title":"PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2","volume":"109","author":"Bhunia","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2004.10.023_bib58","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.ejhg.5201136","article-title":"Depletion of PKD1 by antisense oligodeoxynucleotide induces premature G1\/S-phase transition","volume":"12","author":"Kim","year":"2004","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.yexcr.2004.10.023_bib59","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1046\/j.1523-1755.2000.00991.x","article-title":"Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys","volume":"57","author":"Yamaguchi","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.yexcr.2004.10.023_bib60","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1681\/ASN.V1171179","article-title":"cAMP regulates cell proliferation and cyst formation in autosomal polycystic kidney disease cells","volume":"11","author":"Hanaoka","year":"2000","journal-title":"J. Am. Soc. Nephrol."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482704006275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482704006275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:04:12Z","timestamp":1762146252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482704006275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0014482704006275"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2004.10.023","relation":{},"ISSN":["0014-4827"],"issn-type":[{"type":"print","value":"0014-4827"}],"subject":[],"published":{"date-parts":[[2005,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The cytoplasmic C-terminus of polycystin-1 increases cell proliferation in kidney epithelial cells through serum-activated and Ca2+-dependent pathway(s)","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2004.10.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}