{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:53:16Z","timestamp":1789383196392,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.yexcr.2006.05.007","type":"journal-article","created":{"date-parts":[[2006,5,20]],"date-time":"2006-05-20T07:22:17Z","timestamp":1148109737000},"page":"2826-2836","source":"Crossref","is-referenced-by-count":22,"title":["Characterization of two distinct liver progenitor cell subpopulations of hematopoietic and hepatic origins"],"prefix":"10.1016","volume":"312","author":[{"given":"V.","family":"Corcelle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Stieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gjinovci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.B.","family":"Wollheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.R.","family":"Gauthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2006.05.007_bib1","first-page":"375","article-title":"Regenerative changes in the liver after acute yellow atrophy","volume":"10","author":"MacCallum","year":"1902","journal-title":"Johns Hopkins Hosp., Rep."},{"key":"10.1016\/j.yexcr.2006.05.007_bib2","first-page":"142","article-title":"Similarities in the sequence of early histological changes induced in the liver of rat by ethionine, 2-acetylaminofluorene, and 3\u2032-methyl-4-dimethylaminoazobenzene","volume":"16","author":"Farber","year":"1956","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexcr.2006.05.007_bib3","first-page":"3811","article-title":"Is there a liver stem cell?","volume":"50","author":"Sell","year":"1990","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexcr.2006.05.007_bib4","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1093\/carcin\/8.11.1737","article-title":"A precursor\u2013product relationship exists between oval cells and hepatocytes in rat liver","volume":"8","author":"Evarts","year":"1987","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.yexcr.2006.05.007_bib5","first-page":"1541","article-title":"In vivo differentiation of rat liver oval cells into hepatocytes","author":"Evarts","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexcr.2006.05.007_bib6","first-page":"1243","article-title":"Oval cell differentiation into hepatocytes in the acetylaminofluorene-treated regenerating rat liver","volume":"22","author":"Golding","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2006.05.007_bib7","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2184.1996.tb00982.x","article-title":"Pluripotential liver stem cells: facultative stem cells located in the biliary tree","volume":"29","author":"Alison","year":"1996","journal-title":"Cell Proliferation"},{"key":"10.1016\/j.yexcr.2006.05.007_bib8","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0002-9440(10)64082-5","article-title":"Origin and structural evolution of the early proliferating oval cells in rat liver","author":"Paku","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexcr.2006.05.007_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF00750732","article-title":"Keratin immunohistochemistry in normal human liver. Cytokeratin pattern of hepatocytes, bile ducts and acinar gradient","volume":"412","author":"van Eyken","year":"1987","journal-title":"Virchows Arch. A. Pathol. Anat. Histopathol."},{"key":"10.1016\/j.yexcr.2006.05.007_bib10","first-page":"4887","article-title":"Production of monoclonal antibodies to preneoplastic liver cell populations induced by chemical carcinogens in rats and to transplantable Morris hepatomas","volume":"49","author":"Dunsford","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexcr.2006.05.007_bib11","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0168-8278(97)80467-9","article-title":"Heterogeneity of the \u201coval-cell\u201d response in the hamster liver during cholangiocarcinogenesis following Clonorchis sinensis infection and dimethylnitrosamine treatment","volume":"26","author":"Lee","year":"1997","journal-title":"J. Hepatol."},{"key":"10.1016\/j.yexcr.2006.05.007_bib12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S1357-2725(02)00182-6","article-title":"The hepatocyte: heterogeneity and plasticity of liver cells","volume":"35","author":"Sell","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.yexcr.2006.05.007_bib13","first-page":"511","article-title":"Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat","volume":"70","author":"Fujio","year":"1994","journal-title":"Lab. Invest."},{"key":"10.1016\/j.yexcr.2006.05.007_bib14","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/hep.510270218","article-title":"Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat","volume":"27","author":"Petersen","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2006.05.007_bib15","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/hep.510260325","article-title":"Partial cloning of rat CD34 cDNA and expression during stem cell-dependent liver regeneration in the adult rat","volume":"26","author":"Omori","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2006.05.007_bib16","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1126\/science.284.5417.1168","article-title":"Bone marrow as a potential source of hepatic oval cells","volume":"284","author":"Petersen","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2006.05.007_bib17","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0092-8674(01)00328-2","article-title":"Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell","volume":"105","author":"Krause","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2006.05.007_bib18","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1006\/bbrc.2000.3985","article-title":"Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro","volume":"279","author":"Oh","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexcr.2006.05.007_bib19","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/81326","article-title":"Purified hematopoietic stem cells can differentiate into hepatocytes in vivo","volume":"6","author":"Lagasse","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexcr.2006.05.007_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1053\/jhep.2000.9124","article-title":"Liver from bone marrow in humans","volume":"32","author":"Theise","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2006.05.007_bib21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/hep.510310135","article-title":"Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation","volume":"31","author":"Theise","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2006.05.007_bib22","first-page":"368","article-title":"Cells of the hepatic side population contribute to liver regeneration and can be replenished with bone marrow stem cells","volume":"88","author":"Wulf","year":"2003","journal-title":"Haematologica"},{"key":"10.1016\/j.yexcr.2006.05.007_bib23","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/ncb1132","article-title":"Hematopoietic stem cells convert into liver cells within days without fusion","volume":"6","author":"Jang","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2006.05.007_bib24","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S0959-437X(03)00110-2","article-title":"Cell fusion: an alternative to stem cell plasticity and its therapeutic implications","volume":"13","author":"Vassilopoulos","year":"2003","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.yexcr.2006.05.007_bib25","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/nature01531","article-title":"Cell fusion is the principal source of bone-marrow-derived hepatocytes","volume":"422","author":"Wang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2006.05.007_bib26","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1634\/stemcells.22-6-1049","article-title":"Bone marrow progenitors are not the source of expanding oval cells in injured liver","volume":"22","author":"Menthena","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.yexcr.2006.05.007_bib27","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s00418-005-0021-0","article-title":"Identification of genes specific to \u201coval cells\u201d in the rat 2-acetylaminofluorene\/partial hepatectomy model","volume":"124","author":"Batusic","year":"2005","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.yexcr.2006.05.007_bib28","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1006\/excr.1993.1025","article-title":"Isolation, biochemical characterization, long-term culture, and phenotype modulation of oval cells from carcinogen-fed rats","volume":"204","author":"Pack","year":"1993","journal-title":"Exp.Cell Res."},{"key":"10.1016\/j.yexcr.2006.05.007_bib29","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1053\/gast.2001.21175","article-title":"Human hepatic stem-like cells isolated using c-kit or CD34 can differentiate into biliary epithelium","volume":"120","author":"Crosby","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yexcr.2006.05.007_bib30","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2184.2004.00293.x","article-title":"Activation, isolation, identification and in vitro proliferation of oval cells from adult rat livers","volume":"37","author":"He","year":"2004","journal-title":"Cell Proliferation"},{"key":"10.1016\/j.yexcr.2006.05.007_bib31","doi-asserted-by":"crossref","first-page":"8078","DOI":"10.1073\/pnas.122210699","article-title":"In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells","volume":"99","author":"Yang","year":"2002","journal-title":"Proc. Natl. Acad. Sci U. S. A."},{"key":"10.1016\/j.yexcr.2006.05.007_bib32","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1053\/jhep.2001.21900","article-title":"Heterogeneity and plasticity of hepatocyte lineage cells","volume":"33","author":"Sell","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2006.05.007_bib33","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/hep.510270419","article-title":"Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats","volume":"27","author":"Petersen","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2006.05.007_bib34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0091-679X(08)61797-5","article-title":"Preparation of isolated rat liver cells","volume":"13","author":"Seglen","year":"1976","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.yexcr.2006.05.007_bib35","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1083\/jcb.200405148","article-title":"The diabetes-linked transcription factor Pax4 promotes beta-cell proliferation and survival in rat and human islets","volume":"167","author":"Brun","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2006.05.007_bib36","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0021-9150(98)00245-7","article-title":"Cholesteryl ester transfer protein gene expression during differentiation of human preadipocytes to adipocytes in primary culture","volume":"142","author":"Gauthier","year":"1999","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.yexcr.2006.05.007_bib37","first-page":"805","article-title":"Mobilization of peripheral blood hematopoietic stem cells following liver resection surgery","volume":"51","author":"De Silvestro","year":"2004","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.yexcr.2006.05.007_bib38","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1172\/JCI15956","article-title":"Spontaneous circulation of myeloid-lymphoid-initiating cells and SCID-repopulating cells in sickle cell crisis","volume":"111","author":"Lamming","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexcr.2006.05.007_bib39","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1096\/fj.04-2604rev","article-title":"Hematopoietic stem cell trafficking in liver injury","volume":"19","author":"Dalakas","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.yexcr.2006.05.007_bib40","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/292154a0","article-title":"Establishment in culture of pluripotential cells from mouse embryos","volume":"292","author":"Evans","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2006.05.007_bib41","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1053\/j.gastro.2005.03.081","article-title":"Role of connective tissue growth factor in oval cell response during liver regeneration after 2-AAF\/PHx in rats","volume":"128","author":"Pi","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yexcr.2006.05.007_bib42","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1084952102001271","article-title":"Hepatic oval \u2018stem\u2019 cell in liver regeneration","volume":"13","author":"Oh","year":"2002","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.yexcr.2006.05.007_bib43","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/hep.20178","article-title":"2-acetylaminofluorene dose-dependent differentiation of rat oval cells into hepatocytes: confocal and electron microscopic studies","volume":"39","author":"Paku","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2006.05.007_bib44","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/hep.510290304","article-title":"Role of c-kit receptor tyrosine kinase in development of oval cells in the rat 2-acetylaminofluorene\/partial hepatectomy model","volume":"29","author":"Matsusaka","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2006.05.007_bib45","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.cellbio.17.1.387","article-title":"Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations","volume":"17","author":"Weissman","year":"2001","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.yexcr.2006.05.007_bib46","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1053\/jhep.2002.31355","article-title":"Derivation, characterization, and phenotypic variation of hepatic progenitor cell lines isolated from adult rats","volume":"35","author":"Yin","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2006.05.007_bib47","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1002\/hep.20130","article-title":"Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers","volume":"39","author":"Roskams","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2006.05.007_bib48","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1182\/blood-2003-04-1249","article-title":"Identification of in vitro growth conditions for c-Kit-negative hematopoietic stem cells","volume":"102","author":"Klarmann","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2006.05.007_bib49","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cellbi.2004.11.016","article-title":"Characterization of the interactions between stromal and haematopoietic progenitor cells in expansion cell culture models","volume":"29","author":"Bilko","year":"2005","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.yexcr.2006.05.007_bib50","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/0470091452.ch3","article-title":"Bone marrow-derived hepatocytes","volume":"265","author":"Grompe","year":"2005","journal-title":"Novartis Found Symp."},{"key":"10.1016\/j.yexcr.2006.05.007_bib51","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0092-8674(04)00255-7","article-title":"Socializing with the neighbors: stem cells and their niche","volume":"116","author":"Fuchs","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2006.05.007_bib52","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1101\/gad.313104","article-title":"c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation","volume":"18","author":"Wilson","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.yexcr.2006.05.007_bib53","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1172\/JCI23486","article-title":"TWEAK induces liver progenitor cell proliferation","volume":"115","author":"Jakubowski","year":"2005","journal-title":"J. Clin. Invest."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482706001893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482706001893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T06:55:39Z","timestamp":1547621739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482706001893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":53,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0014482706001893"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2006.05.007","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}