{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:55:36Z","timestamp":1778612136423,"version":"3.51.4"},"reference-count":91,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006143","name":"Department of Science and Technology, Government of Kerala","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.yexcr.2007.03.019","type":"journal-article","created":{"date-parts":[[2007,3,31]],"date-time":"2007-03-31T11:19:02Z","timestamp":1175339942000},"page":"2476-2492","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["C3G is required for c-Abl-induced filopodia and its overexpression promotes filopodia formation"],"prefix":"10.1016","volume":"313","author":[{"given":"Vegesna","family":"Radha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajumeera","family":"Rajanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aninda","family":"Mitra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandini","family":"Rangaraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghanshyam","family":"Swarup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2007.03.019_bib1","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1073\/pnas.91.8.3443","article-title":"C3G, a guanine nucleotide-releasing protein expressed ubiquitously binds to the SH3 domains of Crk and Grb2\/ASH proteins","volume":"91","author":"Tanaka","year":"1994","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.yexcr.2007.03.019_bib2","doi-asserted-by":"crossref","first-page":"32781","DOI":"10.1016\/S0021-9258(20)30059-4","article-title":"Four proline rich sequences of the GNEF, C3G bind with unique specificity to the first SH3 domain of Crk","volume":"269","author":"Knudsen","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib3","doi-asserted-by":"crossref","first-page":"6746","DOI":"10.1128\/MCB.15.12.6746","article-title":"Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide releasing factor C3G","volume":"15","author":"Gotoh","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib4","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1073\/pnas.94.6.2356","article-title":"Downstream of Crk adaptor signaling pathway: activation of Jun kinase by V-Crk through the guanine nucleotide exchange protein, C3G","volume":"94","author":"Tanaka","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.yexcr.2007.03.019_bib5","doi-asserted-by":"crossref","first-page":"37525","DOI":"10.1074\/jbc.274.53.37525","article-title":"The adapter protein Crk L links Cbl to C3G after integrin ligation and enhances cell migration","volume":"274","author":"Uemura","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib6","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1182\/blood.V93.11.3713","article-title":"Crk L activates integrin-mediated hematopoietic cell adhesion through the guanine nucleotide exchange factor, C3G","volume":"93","author":"Arai","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2007.03.019_bib7","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/35073608","article-title":"Insulin-stimulated GLUT 4 translocation requires the CAP-dependent activation of TC-10","volume":"410","author":"Chiang","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2007.03.019_bib8","doi-asserted-by":"crossref","first-page":"27301","DOI":"10.1074\/jbc.M302516200","article-title":"Src-Crk II-C3G-dependent activation of Rap1 switches growth hormone-stimulated p44\/42 MAP kinase and JNK SAPK activities","volume":"278","author":"Ling","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib9","doi-asserted-by":"crossref","first-page":"13118","DOI":"10.1074\/jbc.275.17.13118","article-title":"The association of Crk II with C3G can be regulated by integrins and defines a novel means to regulate the MAP kinases","volume":"275","author":"Buensuceso","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib10","doi-asserted-by":"crossref","first-page":"52188","DOI":"10.1074\/jbc.M310656200","article-title":"Physical and functional interaction between Hck tyrosine kinase and GNEF, C3G results in apoptosis, which is independent of C3G catalytic domain","volume":"278","author":"Shivakrupa","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/emboj\/18.1.145","article-title":"Activation of the Drosophila C3G leads to cell face changes and overproliferation during development, mediated by Ras-MAPK pathway and Rap 1","volume":"18","author":"Ishimaru","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.yexcr.2007.03.019_bib12","doi-asserted-by":"crossref","first-page":"12667","DOI":"10.1074\/jbc.275.17.12667","article-title":"Crk activation of JNK via C3G and R-Ras","volume":"275","author":"Mochizuki","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1097-2765(01)00432-4","article-title":"PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap-1","volume":"9","author":"Schmitt","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.yexcr.2007.03.019_bib14","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1038\/sj.onc.1207622","article-title":"C3G-mediated suppression of oncogene induced focus formation in fibroblasts involves inhibition of ERK activation, cyclin A expression and alterations of anchorage-independent growth","volume":"23","author":"Guerrero","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2007.03.019_bib15","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1038\/sj.emboj.7601234","article-title":"C3G regulates size of the cerebral cortex neural precursor population","volume":"25","author":"Voss","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.yexcr.2007.03.019_bib16","doi-asserted-by":"crossref","first-page":"25673","DOI":"10.1074\/jbc.273.40.25673","article-title":"Direct binding of p130cas to the guanine nucleotide exchange factor, C3G","volume":"273","author":"Kirsch","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib17","doi-asserted-by":"crossref","first-page":"6690","DOI":"10.1128\/MCB.24.15.6690-6700.2004","article-title":"Rap1 regulates the formation of E-cadherin based cell\u2013cell contacts","volume":"24","author":"Hogan","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib18","doi-asserted-by":"crossref","first-page":"14376","DOI":"10.1074\/jbc.274.20.14376","article-title":"Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of Tyr 504","volume":"274","author":"Ichiba","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2121-5-31","article-title":"Phosphorylated GNEF, C3G induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton","volume":"5","author":"Radha","year":"2004","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib20","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/sj.onc.1201569","article-title":"Transformation suppressor activity of C3G is independent of its cdc25 homology domain","volume":"16","author":"Guerrero","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2007.03.019_bib21","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1093\/emboj\/20.13.3333","article-title":"Requirement of C3G-dependent Rap1 activation for cell adhesion and embryogenesis","volume":"20","author":"Ohba","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.yexcr.2007.03.019_bib22","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1242\/dev.00217","article-title":"The GNEF, C3G is necessary for the formation of focal adhesions and vascular maturation","volume":"130","author":"Voss","year":"2003","journal-title":"Develop"},{"key":"10.1016\/j.yexcr.2007.03.019_bib23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0092-8674(95)90370-4","article-title":"Rho, rac and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia and filopodia","volume":"81","author":"Nobes","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2007.03.019_bib24","doi-asserted-by":"crossref","first-page":"26448","DOI":"10.1074\/jbc.M103856200","article-title":"Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-Wasp-Asp 2\/3 pathway","volume":"276","author":"Rohatgi","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib25","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.tcb.2004.04.007","article-title":"Regulation of actin dynamics by Wasp and Wave family proteins","volume":"14","author":"Stradal","year":"2004","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ceb.2005.02.009","article-title":"Linking Rap1 to cell adhesion","volume":"17","author":"Bos","year":"2005","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib27","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1242\/jcs.00238","article-title":"Cellular functions of Rap1 GTP-binding protein: a pattern emerges","volume":"116","author":"Caron","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2007.03.019_bib28","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1074\/jbc.M510070200","article-title":"Regulation of assembly and adhesion activity of E. cadherin by nectin and afadin for the formation of adherens junctions in MDCK cells","volume":"281","author":"Sato","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib29","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1242\/jcs.00208","article-title":"Small GTPase TC10 and its homologue Rho T induce N-Wasp mediated long process formation and neurite outgrowth","volume":"116","author":"Abe","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2007.03.019_bib30","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0962-8924(03)00130-2","article-title":"Function and regulation of Ena\/Vasp proteins","volume":"13","author":"Kwiatkowski","year":"2003","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib31","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev.cellbio.19.050103.103356","article-title":"Ena\/VASP proteins: regulators of the actin cytoskeleton and cell migration","volume":"19","author":"Krause","year":"2003","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ceb.2003.10.019","article-title":"Formin induced nucleation of actin filaments","volume":"16","author":"Zigmond","year":"2004","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib33","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1042\/BST0331256","article-title":"Formins and Vasps may cooperate in the formation of filopodia","volume":"33","author":"Schirenbeck","year":"2005","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.yexcr.2007.03.019_bib34","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cell.2005.11.038","article-title":"Control of the assembly of ATP and ADP-actin by formins and profilin","volume":"124","author":"Kovar","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2007.03.019_bib35","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/excr.1999.4723","article-title":"The role of the filopodia in motility and morphogenesis","volume":"253","author":"Mc Clay","year":"1999","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2007.03.019_bib36","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0092-8674(03)00120-X","article-title":"Cellular motility driven by assembly and disassembly of actin filaments","volume":"112","author":"Pollard","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2007.03.019_bib37","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1016\/S0960-9822(00)00039-7","article-title":"Epithelial morphogenesis: filopodia at work","volume":"11","author":"Martin-Blanco","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib38","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S1357-2725(01)00172-8","article-title":"Structures in focus: filopodia","volume":"34","author":"Wood","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib39","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.cellbio.18.040202.112133","article-title":"Cellular control of actin nucleation","volume":"18","author":"Welsh","year":"2002","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib40","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1042\/BST0321115","article-title":"What is in a filopodium? Starfish vs hedgehog","volume":"32","author":"Passay","year":"2004","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.yexcr.2007.03.019_bib41","first-page":"1","article-title":"The making of filopodia","volume":"17","author":"Faix","year":"2005","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib42","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0896-6273(00)80646-7","article-title":"Essential roles for Abl and Arg tyrosine kinases in neurulation","volume":"21","author":"Koleske","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.yexcr.2007.03.019_bib43","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0962-8924(99)01549-4","article-title":"Cycling, stressed-out and nervous: cellular functions of c-Abl","volume":"9","author":"Van Etten","year":"1999","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib44","doi-asserted-by":"crossref","first-page":"16185","DOI":"10.1074\/jbc.M100095200","article-title":"Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-Cas complexes","volume":"276","author":"Kain","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib45","doi-asserted-by":"crossref","first-page":"E74","DOI":"10.1038\/ncb0402-e74","article-title":"Ready and Abl","volume":"4","author":"Greaves","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib46","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1242\/jcs.00622","article-title":"Regulation of F-actin dependent processes by the Abl family of tyrosine kinases","volume":"116","author":"Woodring","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2007.03.019_bib47","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.tcb.2003.11.003","article-title":"How do Abl family kinases regulate cell shape and movement?","volume":"14","author":"Hernandez","year":"2004","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib48","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1074\/jbc.M508454200","article-title":"Deregulation of proteasome function induces Abl mediated cell death by uncoupling p130Cas and c-CRK-II","volume":"281","author":"Holcomb","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib49","doi-asserted-by":"crossref","first-page":"6516","DOI":"10.1093\/emboj\/17.22.6516","article-title":"The essential role of profilin in the assembly of actin for microspike formation","volume":"17","author":"Suetsugu","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.yexcr.2007.03.019_bib50","doi-asserted-by":"crossref","first-page":"6047","DOI":"10.1073\/pnas.092143499","article-title":"RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells","volume":"99","author":"Yu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2007.03.019_bib51","doi-asserted-by":"crossref","first-page":"36664","DOI":"10.1074\/jbc.M413261200","article-title":"Role of p73 in regulating human caspase-1 gene transcription induced by IFN-\u03b3 and cisplatin","volume":"280","author":"Jain","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib52","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1083\/jcb.200110014","article-title":"Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension","volume":"156","author":"Woodring","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib53","doi-asserted-by":"crossref","first-page":"21007","DOI":"10.1074\/jbc.M201212200","article-title":"p59 Hck isoform induces F-actin reorganization to form protrusions of the cell membrane in a Cdc42 and Rac dependent manner","volume":"277","author":"Carreno","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib54","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.279.5350.509","article-title":"Rho GTPases and the actin cytoskeleton","volume":"279","author":"Hall","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2007.03.019_bib55","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1091\/mbc.e06-05-0466","article-title":"Gene targeting of cdc42 and cdc42 GAP affirms the critical involvement of cdc42 in filopodia induction, directed migration and proliferation in primary mouse embryonic fibroblasts","volume":"17","author":"Yang","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yexcr.2007.03.019_bib56","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/34208","article-title":"Induction of filopodium formation by WASP-related actin depolymerizing protein, N-WASP","volume":"391","author":"Miki","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2007.03.019_bib57","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ncb1001-897","article-title":"N-wasp deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility","volume":"3","author":"Snapper","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib58","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1074\/jbc.M306382200","article-title":"Spatio-temporal regulation of Rac 1 and cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cells","volume":"279","author":"Aoki","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib59","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/35017080","article-title":"A complex of N-Wasp and Wip integrates signaling cascades that lead to actin polymerization","volume":"2","author":"Moreau","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib60","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/jb\/mvg146","article-title":"Regulation of actin dynamics by Wasp family proteins","volume":"134","author":"Miki","year":"2003","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1016\/j.yexcr.2007.03.019_bib61","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nsmb796","article-title":"Chemical inhibition of N-Wasp by stabilization of a native autoinhibited conformation","volume":"11","author":"Peterson","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib62","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0076-6879(06)06021-6","article-title":"Biochemical properties and inhibitors of N-Wasp","volume":"406","author":"Leung","year":"2006","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib63","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tcb.2004.07.003","article-title":"The role of profilin complexes in cell motility and other cellular processes","volume":"14","author":"Witke","year":"2004","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib64","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0167-4889(97)00100-6","article-title":"Profilins as regulators of actin dynamics","volume":"27","author":"Schluter","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexcr.2007.03.019_bib65","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0962-8924(93)90087-H","article-title":"Profilin as a mediator of membrane cytoskeleton communication","volume":"3","author":"Machesky","year":"1993","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib66","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/cm.970220106","article-title":"Distribution of profilin in fibroblasts correlates with the presence of highly dynamic actin filaments","volume":"22","author":"Buss","year":"1992","journal-title":"Cell Motil. Cytoskelet."},{"key":"10.1016\/j.yexcr.2007.03.019_bib67","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0962-8924(00)01876-6","article-title":"Cell motility: proline-rich proteins promote protrusions","volume":"11","author":"Holt","year":"2001","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib68","doi-asserted-by":"crossref","first-page":"9274","DOI":"10.1021\/bi9803675","article-title":"The role of profilin in actin polymerization and nucleotide exchange","volume":"37","author":"Korenbaum","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.yexcr.2007.03.019_bib69","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1091\/mbc.e03-12-0873","article-title":"Tumor suppressor activity of profilin requires a functional actin binding site","volume":"15","author":"Wittenmayer","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yexcr.2007.03.019_bib70","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0014-5793(99)01086-8","article-title":"Distinct roles of profilin in cell morphological changes: microspikes, membrane ruffles, stress fibers and cytokinesis","volume":"457","author":"Suetsugu","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yexcr.2007.03.019_bib71","first-page":"139","article-title":"Abl protein tyrosine kinase inhibitor STI 571 inhibits in vitro signal transduction mediated by c-kit and PGDF receptors","volume":"295","author":"Buchdunger","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.yexcr.2007.03.019_bib72","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/sj.onc.1209007","article-title":"FMS receptor for M-CSF is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance","volume":"25","author":"Taylor","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2007.03.019_bib73","doi-asserted-by":"crossref","first-page":"15174","DOI":"10.1073\/pnas.93.26.15174","article-title":"Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic nuclear transport","volume":"93","author":"Lewis","year":"1996","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.yexcr.2007.03.019_bib74","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1146\/annurev.cellbio.18.031802.150501","article-title":"Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity","volume":"18","author":"Luo","year":"2002","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib75","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cub.2003.12.033","article-title":"Inducible clustering of membrane-targeted SH3 domain of the adaptor protein Nck triggers localized actin polymerization","volume":"14","author":"Rivera","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib76","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cub.2005.01.011","article-title":"The Rho family GTPase Rif induces filopodia through m Dia2","volume":"15","author":"Pellegrin","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib77","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1091\/mbc.e05-01-0061","article-title":"Cdc42 is not essential for filopodium formation, directed migration, cell polarization and mitosis in fibroblastoid cells","volume":"16","author":"Czuchra","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yexcr.2007.03.019_bib78","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.tcb.2006.08.006","article-title":"Rho GTPases and other dynamics in membrane protrusions and vesicle trafficking","volume":"16","author":"Ridley","year":"2006","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20041103","article-title":"Regulation of actin cytoskeleton by mDab1 through N-Wasp and ubiquitination of mDab1","volume":"384","author":"Suetsugu","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.yexcr.2007.03.019_bib80","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.200312171","article-title":"c-Abl phosphorylates Dok1 to promote filopodia during cell spreading","volume":"165","author":"Woodring","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib81","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1083\/jcb.146.5.1097","article-title":"Regulated actin cytoskeleton assembly at filopodium tips controls their extension and retraction","volume":"146","author":"Mallavarapu","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib82","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0960-9822(01)00239-1","article-title":"The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia","volume":"11","author":"Stradal","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib83","doi-asserted-by":"crossref","first-page":"22893","DOI":"10.1074\/jbc.M309693200","article-title":"Temporal dissection of \u03b21 integrin signaling indicates a role for p130 Cas-Crk in filopodium formation","volume":"279","author":"Gustavsson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib84","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1074\/jbc.M411099200","article-title":"Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin induced activation of cdc42 and formation of adherens junctions","volume":"280","author":"Fukuyama","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib85","doi-asserted-by":"crossref","first-page":"44490","DOI":"10.1074\/jbc.M405144200","article-title":"Activation of Rac1 by paxittin-Crk-Dock 180 signaling complex is antagonized by Rap1 in migrating NBT-II cells","volume":"279","author":"Vall\u00e9s","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2007.03.019_bib86","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/sj.onc.1209010","article-title":"Activation of Rac by cadherin through c-Src-Rap1-P13K-Vav2 pathway","volume":"25","author":"Fukuyama","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2007.03.019_bib87","first-page":"131","article-title":"Abl: mechanisms of regulation and activation","volume":"7","author":"Smith","year":"2002","journal-title":"Front. Biosci."},{"key":"10.1016\/j.yexcr.2007.03.019_bib88","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.cub.2005.03.049","article-title":"Rin1 is an Abl tyrosine kinase activator and a regulator of epithelial cell adhesion and migration","volume":"15","author":"Hu","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2007.03.019_bib89","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1046\/j.1365-2443.2001.00431.x","article-title":"Crk family adaptor proteins transactivate c-Abl kinase","volume":"6","author":"Shishido","year":"2001","journal-title":"Genes Cells"},{"key":"10.1016\/j.yexcr.2007.03.019_bib90","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.bbrc.2005.06.030","article-title":"Interaction of Bcr\/Abl with C3G, an exchange factor for the small GTPase Rap 1, through the adapter protein CrkL","volume":"333","author":"Cho","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexcr.2007.03.019_bib91","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.yexcr.2005.12.007","article-title":"Characterization of p87 C3G, a novel truncated C3G isoform that is overexpressed in CML and interacts with Bcr-Abl","volume":"312","author":"Gutierrez-Berzal","year":"2006","journal-title":"Exp. Cell Res."}],"updated-by":[{"DOI":"10.1016\/j.yexcr.2007.06.017","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T00:00:00Z","timestamp":1189382400000}}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482707001395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482707001395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T19:40:56Z","timestamp":1709667656000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482707001395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":91,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0014482707001395"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2007.03.019","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.yexcr.2007.06.017","asserted-by":"object"}]},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"C3G is required for c-Abl-induced filopodia and its overexpression promotes filopodia formation","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2007.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}