{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:10:09Z","timestamp":1790745009531,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["055090\/A\/98\/Z"],"award-info":[{"award-number":["055090\/A\/98\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C26\/A1461"],"award-info":[{"award-number":["C26\/A1461"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C26\/A6694"],"award-info":[{"award-number":["C26\/A6694"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["J3-2274-0381"],"award-info":[{"award-number":["J3-2274-0381"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["J3-6132-0381"],"award-info":[{"award-number":["J3-6132-0381"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.yexcr.2009.07.013","type":"journal-article","created":{"date-parts":[[2009,7,18]],"date-time":"2009-07-18T05:00:30Z","timestamp":1247893230000},"page":"2995-3003","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Severe keratin 5 and 14 mutations induce down-regulation of junction proteins in keratinocytes"],"prefix":"10.1016","volume":"315","author":[{"given":"Mirjana","family":"Liovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariella","family":"D'Alessandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjana","family":"Tomic-Canic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viacheslav N.","family":"Bolshakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie E.","family":"Coats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Birgitte","family":"Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2009.07.013_bib1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/humu.20652","article-title":"The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases","volume":"29","author":"Szeverenyi","year":"2008","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.yexcr.2009.07.013_bib2","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1600-0625.2008.00820.x","article-title":"A novel mutation (p.Thr198Ser) in the 1A helix of keratin 5 causes the localized variant of Epidermolysis Bullosa Simplex","volume":"18","author":"Bowden","year":"2009","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.yexcr.2009.07.013_bib3","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/sj.jid.5701038","article-title":"Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita","volume":"128","author":"Chen","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.yexcr.2009.07.013_bib4","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1016\/j.yexcr.2007.05.019","article-title":"A mutation of keratin 18 within the coil 1A consensus motif causes widespread keratin aggregation but cell type-restricted lethality in mice","volume":"313","author":"Hesse","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2009.07.013_bib5","doi-asserted-by":"crossref","first-page":"882","DOI":"10.2353\/ajpath.2008.070830","article-title":"Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury","volume":"172","author":"Toivola","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexcr.2009.07.013_bib6","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1101\/gad.1387406","article-title":"Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion","volume":"20","author":"Tong","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.yexcr.2009.07.013_bib7","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s10495-008-0274-x","article-title":"Switch in Fas-activated death signaling pathway as result of keratin 8\/18-intermediate filament loss","volume":"13","author":"Gilbert","year":"2008","journal-title":"Apoptosis"},{"key":"10.1016\/j.yexcr.2009.07.013_bib8","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1016\/j.febslet.2008.04.064","article-title":"Providing cellular signposts \u2014 post-translational modifications of intermediate filaments","volume":"582","author":"Hydera","year":"2008","journal-title":"FEBS Letters"},{"key":"10.1016\/j.yexcr.2009.07.013_bib9","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/0092-8674(91)90051-Y","article-title":"Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses","volume":"66","author":"Coulombe","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2009.07.013_bib10","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1046\/j.1365-2133.2003.05493.x","article-title":"Generation and characterization of epidermolysis bullosa simplex cell lines: scratch assays show faster migration with disruptive keratin mutations","volume":"149","author":"Morley","year":"2003","journal-title":"Br. J. Dermatol."},{"issue":"Pt. 22","key":"10.1016\/j.yexcr.2009.07.013_bib11","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1242\/jcs.00120","article-title":"Keratin mutations of epidermolysis bullosa simplex alter the kinetics of stress response to osmotic shock","volume":"115","author":"D'Alessandro","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2009.07.013_bib12","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1016\/j.yexcr.2008.02.020","article-title":"Dual-specificity phosphatases in the hypo-osmotic stress response of keratin defective cell lines","volume":"314","author":"Liovic","year":"2008","journal-title":"Exp. Cell Res."},{"issue":"Pt. 22","key":"10.1016\/j.yexcr.2009.07.013_bib13","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1242\/jcs.01407","article-title":"Mechanical stress induces profound remodelling of keratin filaments and cell junctions in epidermolysis bullosa simplex keratinocytes","volume":"117","author":"Russell","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2009.07.013_bib14","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jaad.2008.02.004","article-title":"The classification of inherited epidermolysis bullosa (EB): report of the Third International Consensus Meeting on Diagnosis and Classification of EB","volume":"6","author":"Fine","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.yexcr.2009.07.013_bib15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1046\/j.1365-2133.2000.03304.x","article-title":"Laryngeal involvement in the Dowling\u2013Meara variant of epidermolysis bullosa simplex with keratin mutations of severely disruptive potential","volume":"142","author":"Shemanko","year":"2000","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.yexcr.2009.07.013_bib16","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/356244a0","article-title":"A mutation in the conserved helix termination peptide of keratin 5 in hereditary skin blistering","volume":"356","author":"Lane","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2009.07.013_bib17","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/ng1193-294","article-title":"Missing links: Weber\u2013Cockayne keratin mutations implicate the L12 linker domain in effective cytoskeleton function","volume":"5","author":"Rugg","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yexcr.2009.07.013_bib18","doi-asserted-by":"crossref","first-page":"8392","DOI":"10.1073\/pnas.90.18.8392","article-title":"Production of high-titer helper-free retroviruses by transient transfection","volume":"90","author":"Pear","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2009.07.013_bib19","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1089\/hum.1996.7.12-1405","article-title":"Episomal vectors rapidly and stably produce high-titer recombinant retrovirus","volume":"7","author":"Kinsella","year":"1996","journal-title":"Hum. Gene Ther."},{"issue":"Pt. 1","key":"10.1016\/j.yexcr.2009.07.013_bib20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1242\/jcs.97.1.39","article-title":"Antibody markers of basal cells in complex epithelia","volume":"97","author":"Purkis","year":"1990","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2009.07.013_bib21","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1006\/abbi.1993.1311","article-title":"Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction","volume":"303","author":"Berridge","year":"1993","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.yexcr.2009.07.013_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/path.1711530311","article-title":"Antidesmosomal monoclonal antibody in the diagnosis of intracranial tumours","volume":"153","author":"Parrish","year":"1987","journal-title":"J. Pathol."},{"key":"10.1016\/j.yexcr.2009.07.013_bib23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on bias and variance","volume":"19","author":"Bolstad","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.yexcr.2009.07.013_bib24","doi-asserted-by":"crossref","first-page":"374","DOI":"10.2144\/03342mt01","article-title":"TM4: a free, open-source system for microarray data management and analysis","volume":"34","author":"Saeed","year":"2003","journal-title":"Biotechniques"},{"key":"10.1016\/j.yexcr.2009.07.013_bib25","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2003-4-9-r60","article-title":"DAVID: Database for Annotation, Visualization, and Integrated Discovery","volume":"4","author":"Dennis","year":"2003","journal-title":"Genome Biol."},{"key":"10.1016\/j.yexcr.2009.07.013_bib26","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1016\/j.yexcr.2006.09.031","article-title":"Keratin 8 modulation of desmoplakin deposition at desmosomes in hepatocytes","volume":"312","author":"Loranger","year":"2006","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2009.07.013_bib27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.yexcr.2006.10.007","article-title":"Keratins modulate hepatic cell adhesion, size and G1\/S transition","volume":"313","author":"Galarneau","year":"2007","journal-title":"Exp. Cell Res."},{"issue":"Pt. 24","key":"10.1016\/j.yexcr.2009.07.013_bib28","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1242\/jcs.03304","article-title":"Periplakin-dependent re-organisation of keratin cytoskeleton and loss of collective migration in keratin-8-downregulated epithelial sheets","volume":"119","author":"Long","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2009.07.013_bib29","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.yexcr.2004.12.009","article-title":"Keratin-containing inclusions affect cell morphology and distribution of cytosolic cellular components","volume":"304","author":"Hanada","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2009.07.013_bib30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jdermsci.2006.10.006","article-title":"Discriminating roles of desmosomal cadherins: beyond desmosomal adhesion","volume":"45","author":"Dusek","year":"2007","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.yexcr.2009.07.013_bib31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbamcr.2006.04.009","article-title":"Plakophilins: multifunctional proteins or just regulators of desmosomal adhesion?","volume":"1773","author":"Hatzfeld","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexcr.2009.07.013_bib32","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/jcp.21394","article-title":"Transcriptional profiling defines the roles of ERK and p38 kinases in epidermal keratinocytes","volume":"215","author":"Gazel","year":"2008","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.yexcr.2009.07.013_bib33","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1365-2133.1992.tb11813.x","article-title":"Epidermolysis bullosa simplex (Dowling\u2013Meara). A clinicopathological review","volume":"126","author":"McGrath","year":"1992","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.yexcr.2009.07.013_bib34","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1111\/j.1349-7006.2007.00550.x","article-title":"Signaling networks guiding epithelial\u2013mesenchymal transitions during embryogenesis and cancer progression","volume":"98","author":"Moustakas","year":"2007","journal-title":"Cancer Sci."},{"key":"10.1016\/j.yexcr.2009.07.013_bib35","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1083\/jcb.200601018","article-title":"The epithelial\u2013mesenchymal transition: new insights in signaling, development, and disease","volume":"172","author":"Lee","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2009.07.013_bib36","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jaad.2008.09.035","article-title":"Epidermolysis bullosa and the risk of life-threatening cancers: the National EB Registry experience, 1986\u20132006","volume":"60","author":"Fine","year":"2009","journal-title":"J. Am. Acad. Dermatol."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482709003255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482709003255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:07:19Z","timestamp":1757995639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482709003255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":36,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0014482709003255"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2009.07.013","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Severe keratin 5 and 14 mutations induce down-regulation of junction proteins in keratinocytes","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2009.07.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}