{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:47:24Z","timestamp":1788871644762,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.yexcr.2009.12.009","type":"journal-article","created":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T04:08:13Z","timestamp":1261454893000},"page":"775-788","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor"],"prefix":"10.1016","volume":"316","author":[{"given":"Shigenori","family":"Miura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Mitsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Heishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisa","family":"Shukunami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotoshi","family":"Sekiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasufumi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Hiraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2009.12.009_bib1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nm0195-27","article-title":"Angiogenesis in cancer, vascular, rheumatoid and other disease","volume":"1","author":"Folkman","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexcr.2009.12.009_bib2","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/nrc1094","article-title":"Basement membranes: structure, assembly and role in tumour angiogenesis","volume":"3","author":"Kalluri","year":"2003","journal-title":"Nat. Rev., Cancer"},{"key":"10.1016\/j.yexcr.2009.12.009_bib3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0092-8674(00)81848-6","article-title":"Endostatin: an endogenous inhibitor of angiogenesis and tumor growth","volume":"88","author":"O'Reilly","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2009.12.009_bib4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mvr.2007.05.005","article-title":"Type IV collagen-derived angiogenesis inhibitors","volume":"74","author":"Mundel","year":"2007","journal-title":"Microvasc. Res"},{"key":"10.1016\/j.yexcr.2009.12.009_bib5","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0006-291X(91)91660-5","article-title":"Molecular cloning of a new class of cartilage-specific matrix, chondromodulin-I, which stimulates growth of cultured chondrocytes","volume":"175","author":"Hiraki","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexcr.2009.12.009_bib6","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.2174\/138161207781039751","article-title":"Chondromodulin-I and tenomodulin: the negative control of angiogenesis in connective tissue","volume":"13","author":"Shukunami","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.yexcr.2009.12.009_bib7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0014-5793(97)01151-4","article-title":"Inhibition of DNA synthesis and tube morphogenesis of cultured vascular endothelial cells by chondromodulin-I","volume":"415","author":"Hiraki","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yexcr.2009.12.009_bib8","doi-asserted-by":"crossref","first-page":"32419","DOI":"10.1074\/jbc.272.51.32419","article-title":"Identification of chondromodulin I as a novel endothelial cell growth inhibitor. Purification and its localization in the avascular zone of epiphyseal cartilage","volume":"272","author":"Hiraki","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2009.12.009_bib9","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1046\/j.1432-1327.1999.00227.x","article-title":"Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells","volume":"260","author":"Hiraki","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.yexcr.2009.12.009_bib10","first-page":"39","article-title":"Spatiotemporal pattern of the mouse chondromodulin-I gene expression and its regulatory role in vascular invasion into cartilage during endochondral bone formation","volume":"43","author":"Shukunami","year":"1999","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.yexcr.2009.12.009_bib11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/(SICI)1097-0177(199911)216:3<233::AID-DVDY2>3.0.CO;2-G","article-title":"Spatio-temporal distribution of chondromodulin-I mRNA in the chicken embryo: expression during cartilage development and formation of the heart and eye","volume":"216","author":"Dietz","year":"1999","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.yexcr.2009.12.009_bib12","first-page":"1193","article-title":"Expression and localization of angiogenic inhibitory factor, chondromodulin-I, in adult rat eye","volume":"42","author":"Funaki","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.yexcr.2009.12.009_bib13","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/nm1476","article-title":"Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis","volume":"12","author":"Yoshioka","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexcr.2009.12.009_bib14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00441-007-0570-8","article-title":"Chondromodulin-I and tenomodulin are differentially expressed in the avascular mesenchyme during mouse and chick development","volume":"332","author":"Shukunami","year":"2008","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.yexcr.2009.12.009_bib15","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1128\/MCB.23.2.636-644.2003","article-title":"is a bone remodeling factor","volume":"23","author":"Nakamichi","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yexcr.2009.12.009_bib16","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/386671a0","article-title":"Mechanisms of angiogenesis","volume":"386","author":"Risau","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2009.12.009_bib17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0378-1119(91)90434-D","article-title":"Efficient selection for high-expression transfectants with a novel eukaryotic vector","volume":"108","author":"Niwa","year":"1991","journal-title":"Gene"},{"key":"10.1016\/j.yexcr.2009.12.009_bib18","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1242\/jcs.01112","article-title":"Anti-angiogenic action of the C-terminal domain of tenomodulin that shares homology with chondromodulin-I","volume":"117","author":"Oshima","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2009.12.009_bib19","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1172\/JCI200421152","article-title":"Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis","volume":"114","author":"Watanabe","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexcr.2009.12.009_bib20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1247\/csf.16.87","article-title":"Endothelial cells create a hematopoietic inductive microenvironment preferential to erythropoiesis in the mouse spleen","volume":"16","author":"Yanai","year":"1991","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.yexcr.2009.12.009_bib21","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/sj.onc.1203257","article-title":"Indispensable role of the transcription factor PEBP2\/CBF in angiogenic activity of a murine endothelial cell MSS31","volume":"19","author":"Namba","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2009.12.009_bib22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1083\/jcb.133.2.457","article-title":"Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)\/PTH-related peptide receptor","volume":"133","author":"Shukunami","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2009.12.009_bib23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.yexcr.2009.12.009_bib24","doi-asserted-by":"crossref","first-page":"20178","DOI":"10.1074\/jbc.M312921200","article-title":"An endostatin-derived peptide interacts with integrins and regulates actin cytoskeleton and migration of endothelial cells","volume":"279","author":"Wickstrom","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2009.12.009_bib25","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1158\/0008-5472.CAN-04-2427","article-title":"Endogenous inhibitors of angiogenesis","volume":"65","author":"Nyberg","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.yexcr.2009.12.009_bib26","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1093\/emboj\/18.16.4414","article-title":"Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding","volume":"18","author":"Yamaguchi","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.yexcr.2009.12.009_bib27","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0092-8674(85)90104-7","article-title":"Tumor-promoting phorbol esters induce angiogenesis in vitro","volume":"42","author":"Montesano","year":"1985","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2009.12.009_bib28","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1096\/fj.00-0134com","article-title":"Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis","volume":"14","author":"English","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.yexcr.2009.12.009_bib29","doi-asserted-by":"crossref","first-page":"35343","DOI":"10.1074\/jbc.274.50.35343","article-title":"Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis","volume":"274","author":"Wang","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2009.12.009_bib30","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1359-6101(00)00014-9","article-title":"FGF signals for cell proliferation and migration through different pathways","volume":"11","author":"Boilly","year":"2000","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.yexcr.2009.12.009_bib31","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1128\/MCB.15.2.954","article-title":"Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases","volume":"15","author":"Calalb","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yexcr.2009.12.009_bib32","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1092053","article-title":"Cell migration: integrating signals from front to back","volume":"302","author":"Ridley","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2009.12.009_bib33","doi-asserted-by":"crossref","first-page":"15442","DOI":"10.1074\/jbc.272.24.15442","article-title":"Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells","volume":"272","author":"Abedi","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2009.12.009_bib34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/excr.2001.5295","article-title":"Rho family GTPases regulate VEGF-stimulated endothelial cell motility","volume":"269","author":"Soga","year":"2001","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2009.12.009_bib35","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1016\/j.yexcr.2007.05.027","article-title":"VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2","volume":"313","author":"Garrett","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2009.12.009_bib36","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1096\/fasebj.12.15.1731","article-title":"Characterization of kringle domains of angiostatin as antagonists of endothelial cell migration, an important process in angiogenesis","volume":"12","author":"Ji","year":"1998","journal-title":"FASEB J"},{"key":"10.1016\/j.yexcr.2009.12.009_bib37","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1083\/jcb.200407060","article-title":"Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins","volume":"168","author":"Short","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2009.12.009_bib38","first-page":"1944","article-title":"Endostatin regulates endothelial cell adhesion and cytoskeletal organization","volume":"62","author":"Dixelius","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexcr.2009.12.009_bib39","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1073\/pnas.0730882100","article-title":"Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins","volume":"100","author":"Sudhakar","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2009.12.009_bib40","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1083\/jcb.200401150","article-title":"Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin","volume":"166","author":"Bix","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2009.12.009_bib41","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1172\/JCI24813","article-title":"Human alpha1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by alpha1beta1 integrin","volume":"115","author":"Sudhakar","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexcr.2009.12.009_bib42","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1242\/jcs.023333","article-title":"The regulation of cell motility and chemotaxis by phospholipid signaling","volume":"121","author":"Kolsch","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2009.12.009_bib43","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1242\/jcs.018564","article-title":"Integrins in cell migration\u2014the actin connection","volume":"122","author":"Vicente-Manzanares","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2009.12.009_bib44","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1101\/gad.432007","article-title":"Angiomotin regulates endothelial cell migration during embryonic angiogenesis","volume":"21","author":"Aase","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.yexcr.2009.12.009_bib45","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1242\/jcs.114.15.2713","article-title":"Rho GTPases and cell migration","volume":"114","author":"Ridley","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2009.12.009_bib46","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1242\/jcs.02662","article-title":"Cell migration at a glance","volume":"118","author":"Vicente-Manzanares","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2009.12.009_bib47","first-page":"6405","article-title":"Angiogenesis inhibitors target the endothelial cell cytoskeleton through altered regulation of heat shock protein 27 and cofilin","volume":"63","author":"Keezer","year":"2003","journal-title":"Cancer Res"}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482709005412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482709005412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:09:14Z","timestamp":1757995754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482709005412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0014482709005412"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2009.12.009","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2009.12.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}