{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:46:02Z","timestamp":1793763962094,"version":"4.6.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.yexcr.2010.02.043","type":"journal-article","created":{"date-parts":[[2010,3,9]],"date-time":"2010-03-09T09:46:57Z","timestamp":1268128017000},"page":"1390-1396","source":"Crossref","is-referenced-by-count":16,"title":["New clues to the molecular pathogenesis of myelodysplastic syndromes"],"prefix":"10.1016","volume":"316","author":[{"given":"Martin","family":"J\u00e4dersten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Hellstr\u00f6m-Lindberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2010.02.043_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1470-2045(09)70003-8","article-title":"Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study","volume":"10","author":"Fenaux","year":"2009","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.yexcr.2010.02.043_bib2","series-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow","year":"2008"},{"key":"10.1016\/j.yexcr.2010.02.043_bib3","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/251437a0","article-title":"Distinct haematological disorder with deletion of long arm of no. 5 chromosome","volume":"251","author":"Van den Berghe","year":"1974","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2010.02.043_bib4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/sj.leu.2403189","article-title":"Clinical, morphological, cytogenetic, and prognostic features of patients with myelodysplastic syndromes and del(5q) including band q31","volume":"18","author":"Giagounidis","year":"2004","journal-title":"Leukemia"},{"key":"10.1016\/j.yexcr.2010.02.043_bib5","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.1182\/blood.V99.12.4638","article-title":"Narrowing and genomic annotation of the commonly deleted region of the 5q- syndrome","volume":"99","author":"Boultwood","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.02.043_bib6","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1182\/blood.V96.6.2012","article-title":"Isolation and characterization of hematopoietic progenitor\/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level","volume":"96","author":"Nilsson","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.02.043_bib7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nature06494","article-title":"Identification of RPS14 as a 5q- syndrome gene by RNA interference screen","volume":"451","author":"Ebert","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2010.02.043_bib8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/5951","article-title":"The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia","volume":"21","author":"Draptchinskaia","year":"1999","journal-title":"Nat. Gen."},{"key":"10.1016\/j.yexcr.2010.02.043_bib9","doi-asserted-by":"crossref","first-page":"E139","DOI":"10.1371\/journal.pbio.0020139","article-title":"Many ribosomal protein genes are cancer genes in zebrafish","volume":"2","author":"Amsterdam","year":"2004","journal-title":"PLoS Biol."},{"key":"10.1016\/j.yexcr.2010.02.043_bib10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nm.2054","article-title":"Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype","volume":"16","author":"Starczynowski","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexcr.2010.02.043_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nm.2063","article-title":"A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome","volume":"16","author":"Barlow","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexcr.2010.02.043_bib12","doi-asserted-by":"crossref","first-page":"11406","DOI":"10.1073\/pnas.0610477104","article-title":"Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients","volume":"104","author":"Pellagatti","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2010.02.043_bib13","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/jcb.20091","article-title":"SPARC and tumor growth: where the seed meets the soil?","volume":"92","author":"Framson","year":"2004","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.yexcr.2010.02.043_bib14","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.3324\/haematol.2009.011528","article-title":"Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression","volume":"94","author":"Jadersten","year":"2009","journal-title":"Haematologica"},{"key":"10.1016\/j.yexcr.2010.02.043_bib15","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/leu.2009.53","article-title":"Deletion 5q in myelodysplastic syndrome: a paradigm for the study of hemizygous deletions in cancer","volume":"23","author":"Ebert","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.yexcr.2010.02.043_bib16","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1053\/j.seminhematol.2009.07.001","article-title":"Hereditary sideroblastic anemias: pathophysiology, diagnosis, and treatment","volume":"46","author":"Camaschella","year":"2009","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.yexcr.2010.02.043_bib17","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/ng.359","article-title":"Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia","volume":"41","author":"Guernsey","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yexcr.2010.02.043_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s100380050051","article-title":"Cloning and chromosomal mapping of a novel ABC transporter gene (hABC7), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia","volume":"43","author":"Shimada","year":"1998","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.yexcr.2010.02.043_bib19","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1182\/blood-2006-04-015768","article-title":"Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis","volume":"109","author":"Pondarre","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.02.043_bib20","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1182\/blood-2006-08-041632","article-title":"RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload","volume":"109","author":"Cavadini","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.02.043_bib21","doi-asserted-by":"crossref","first-page":"e1970","DOI":"10.1371\/journal.pone.0001970","article-title":"The role of the iron transporter ABCB7 in refractory anemia with ring sideroblasts","volume":"3","author":"Boultwood","year":"2008","journal-title":"PloS ONE"},{"key":"10.1016\/j.yexcr.2010.02.043_bib22","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.leukres.2006.06.005","article-title":"Candidate gene mutation analysis in idiopathic acquired sideroblastic anemia (refractory anemia with ringed sideroblasts)","volume":"31","author":"Steensma","year":"2007","journal-title":"Leuk. Res."},{"key":"10.1016\/j.yexcr.2010.02.043_bib23","unstructured":"M. Nikpour, A. Pellagatti, A. Liu, M. Karimi, L. Malcovati, V. Gogvadze, A. Forsblom, J.S. Wainscoat, M. Cazzola, B. Zhivotovsky, A. Grandien, J. Boultwood, E. Hellstrom-Lindberg, Gene expression profiling of erythroblasts from refractory anaemia with ring sideroblasts (RARS) and effects of G-CSF. Br. J. Haematology (in press)."},{"key":"10.1016\/j.yexcr.2010.02.043_bib24","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/nature03546","article-title":"A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera","volume":"434","author":"James","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2010.02.043_bib25","doi-asserted-by":"crossref","first-page":"e270","DOI":"10.1371\/journal.pmed.0030270","article-title":"MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia","volume":"3","author":"Pikman","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.yexcr.2010.02.043_bib26","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1056\/NEJMoa065202","article-title":"JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis","volume":"356","author":"Scott","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yexcr.2010.02.043_bib27","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1182\/blood-2006-02-005751","article-title":"Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation","volume":"108","author":"Szpurka","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.02.043_bib28","unstructured":"E. Hellstrom-Lindberg, Significance of JAK2 and TET2 mutations in myelodysplastic syndromes. Blood Rev. 115 (2010) 1779\u20131784."},{"key":"10.1016\/j.yexcr.2010.02.043_bib29","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s12185-008-0169-1","article-title":"Refractory anemia with ringed sideroblasts associated with thrombocytosis: comparative analysis of marked with non-marked thrombocytosis, and relationship with JAK2 V617F mutational status","volume":"88","author":"Raya","year":"2008","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.yexcr.2010.02.043_bib30","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/sj.leu.2404215","article-title":"The JAK2 V617F mutation identifies a subgroup of MDS patients with isolated deletion 5q and a proliferative bone marrow","volume":"20","author":"Ingram","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.yexcr.2010.02.043_bib31","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1182\/blood-2009-05-222331","article-title":"Molecular and clinical features of refractory anemia with ringed sideroblasts associated with marked thrombocytosis","volume":"114","author":"Malcovati","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.02.043_bib32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3324\/haematol.11581","article-title":"JAK2V617F mutation status identifies subtypes of refractory anemia with ringed sideroblasts associated with marked thrombocytosis","volume":"93","author":"Schmitt-Graeff","year":"2008","journal-title":"Haematologica"},{"key":"10.1016\/j.yexcr.2010.02.043_bib33","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1182\/blood-2009-03-210039","article-title":"Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies","volume":"114","author":"Abdel-Wahab","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.02.043_bib34","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1056\/NEJMoa0810069","article-title":"Mutation in TET2 in myeloid cancers","volume":"360","author":"Delhommeau","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yexcr.2010.02.043_bib35","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.1182\/blood-2009-02-205690","article-title":"Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic\/myeloproliferative neoplasms","volume":"113","author":"Jankowska","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.02.043_bib36","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ng.391","article-title":"Acquired mutations in TET2 are common in myelodysplastic syndromes","volume":"41","author":"Langemeijer","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yexcr.2010.02.043_bib37","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1200\/JCO.2009.22.6985","article-title":"Novel TET2 mutations associated with UPD4q24 in myelodysplastic syndrome","volume":"27","author":"Mohamedali","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.yexcr.2010.02.043_bib38","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.3324\/haematol.2009.011205","article-title":"TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia","volume":"94","author":"Kosmider","year":"2009","journal-title":"Haematologica"},{"key":"10.1016\/j.yexcr.2010.02.043_bib39","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1182\/blood-2009-04-215814","article-title":"TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes","volume":"114","author":"Kosmider","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.02.043_bib40","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1126\/science.1170116","article-title":"Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1","volume":"324","author":"Tahiliani","year":"2009","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.yexcr.2010.02.043_bib41","doi-asserted-by":"crossref","first-page":"10349","DOI":"10.1158\/0008-5472.CAN-08-2754","article-title":"250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies","volume":"68","author":"Dunbar","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexcr.2010.02.043_bib42","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.1200\/JCO.2009.23.7503","article-title":"Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies","volume":"27","author":"Makishima","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.yexcr.2010.02.043_bib43","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1158\/1078-0432.CCR-08-1325","article-title":"CBL exon 8\/9 mutants activate the FLT3 pathway and cluster in core binding factor\/11q deletion acute myeloid leukemia\/myelodysplastic syndrome subtypes","volume":"15","author":"Reindl","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.yexcr.2010.02.043_bib44","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/j.1365-2141.2009.07697.x","article-title":"Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia","volume":"145","author":"Gelsi-Boyer","year":"2009","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.yexcr.2010.02.043_bib45","unstructured":"J. Boultwood, J. Perry, A. Pellagatti, M. Fernandez-Mercado, C. Fernandez-Santamaria, M.J. Calasanz, M.J. Larrayoz, M. Garcia-Delgado, A. Giagounidis, L. Malcovati, M.G. della Porta, M. Jadersten, S. Killick, E. Hellstrom-Lindberg, M. Cazzola, J.S. Wainscoat, Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia. Leukemia [Feb 25, 2010 Electronic publication ahead of print]. PMID: 20182461."},{"key":"10.1016\/j.yexcr.2010.02.043_bib46","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1182\/blood-2009-07-230698","article-title":"Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia","volume":"115","author":"Fisher","year":"2010","journal-title":"Blood"}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482710001059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482710001059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T17:24:02Z","timestamp":1591118642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482710001059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0014482710001059"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2010.02.043","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}