{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:33:21Z","timestamp":1791178401716,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["121457"],"award-info":[{"award-number":["121457"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004155","name":"Magnus Ehrnroothin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001658","name":"Minerva Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["202272"],"award-info":[{"award-number":["202272"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005633","name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30971104"],"award-info":[{"award-number":["30971104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.yexcr.2010.06.008","type":"journal-article","created":{"date-parts":[[2010,6,17]],"date-time":"2010-06-17T04:36:38Z","timestamp":1276749398000},"page":"3304-3316","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi\u2013late endosome interface"],"prefix":"10.1016","volume":"316","author":[{"given":"You","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko I.","family":"M\u00e4yr\u00e4np\u00e4\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"B\u00e4ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoguang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesa M.","family":"Olkkonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2010.06.008_bib1","doi-asserted-by":"crossref","first-page":"12382","DOI":"10.1016\/S0021-9258(18)90757-X","article-title":"Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme A reductase","volume":"259","author":"Taylor","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2010.06.008_bib2","doi-asserted-by":"crossref","first-page":"16798","DOI":"10.1016\/S0021-9258(19)84776-2","article-title":"cDNA cloning and expression of oxysterol-binding protein, an oligomer with a potential leucine zipper","volume":"264","author":"Dawson","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2010.06.008_bib3","doi-asserted-by":"crossref","first-page":"9046","DOI":"10.1016\/S0021-9258(18)81900-7","article-title":"Purification of oxysterol binding protein from hamster liver cytosol","volume":"264","author":"Dawson","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2010.06.008_bib4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1083\/jcb.116.2.307","article-title":"Translocation of oxysterol binding protein to golgi apparatus triggered by ligand binding","volume":"116","author":"Ridgway","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.06.008_bib5","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1091\/mbc.e06-01-0060","article-title":"Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein","volume":"17","author":"Perry","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yexcr.2010.06.008_bib6","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1091\/mbc.e08-05-0498","article-title":"Coordinated lipid transfer between the endoplasmic reticulum and the golgi complex requires the VAP proteins and is essential for golgi-mediated transport","volume":"19","author":"Peretti","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yexcr.2010.06.008_bib7","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1126\/science.1107710","article-title":"OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1\/2 activation","volume":"307","author":"Wang","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2010.06.008_bib8","doi-asserted-by":"crossref","first-page":"8034","DOI":"10.1074\/jbc.M707631200","article-title":"The N terminus controls sterol binding while the C terminus regulates the scaffolding function of OSBP","volume":"283","author":"Wang","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2010.06.008_bib9","doi-asserted-by":"crossref","first-page":"9595","DOI":"10.1074\/jbc.M710092200","article-title":"Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1","volume":"283","author":"Romeo","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2010.06.008_bib10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1750-1326-3-5","article-title":"Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein","volume":"3","author":"Zerbinatti","year":"2008","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.yexcr.2010.06.008_bib11","doi-asserted-by":"crossref","first-page":"18210","DOI":"10.1074\/jbc.M800918200","article-title":"OSBP negatively regulates ABCA1 protein stability","volume":"283","author":"Bowden","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2010.06.008_bib12","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1161\/ATVBAHA.106.138545","article-title":"Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis","volume":"27","author":"Yan","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yexcr.2010.06.008_bib13","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00018-007-7325-2","article-title":"Emerging roles of the oxysterol-binding protein family in metabolism, transport, and signaling","volume":"65","author":"Fairn","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.yexcr.2010.06.008_bib14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0074-7696(07)65007-4","article-title":"Characteristics of oxysterol binding proteins","volume":"265","author":"Yan","year":"2008","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.yexcr.2010.06.008_bib15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/geno.2001.6663","article-title":"A family of 12 human genes containing oxysterol-binding domains","volume":"78","author":"Jaworski","year":"2001","journal-title":"Genomics."},{"key":"10.1016\/j.yexcr.2010.06.008_bib16","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0022-2275(20)31570-4","article-title":"The OSBP-related protein family in humans","volume":"42","author":"Lehto","year":"2001","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.yexcr.2010.06.008_bib17","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1089\/104454902320308942","article-title":"An oxysterol-binding protein family identified in the mouse","volume":"21","author":"Anniss","year":"2002","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.yexcr.2010.06.008_bib18","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1093\/genetics\/157.3.1117","article-title":"Overlapping functions of the yeast oxysterol-binding protein homologues","volume":"157","author":"Beh","year":"2001","journal-title":"Genetics"},{"key":"10.1016\/j.yexcr.2010.06.008_bib19","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1091\/mbc.e02-08-0459","article-title":"The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct","volume":"14","author":"Johansson","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yexcr.2010.06.008_bib20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00441-003-0817-y","article-title":"Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7","volume":"315","author":"Lehto","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.yexcr.2010.06.008_bib21","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0960-9822(98)70296-9","article-title":"The pleckstrin homology domain of oxysterol-binding protein recognises a determinant specific to golgi membranes","volume":"8","author":"Levine","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2010.06.008_bib22","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.yexcr.2004.03.052","article-title":"VAMP-associated protein-A regulates partitioning of oxysterol-binding protein-related protein-9 between the endoplasmic reticulum and golgi apparatus","volume":"297","author":"Wyles","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2010.06.008_bib23","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0960-9822(02)00779-0","article-title":"Targeting of golgi-specific pleckstrin homology domains involves both PtdIns 4-kinase-dependent and -independent components","volume":"12","author":"Levine","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2010.06.008_bib24","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.yexcr.2005.08.003","article-title":"Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants","volume":"310","author":"Lehto","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2010.06.008_bib25","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.1091\/mbc.e05-03-0189","article-title":"The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments","volume":"16","author":"Johansson","year":"2005","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.yexcr.2010.06.008_bib26","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1093\/emboj\/cdg201","article-title":"A conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAP","volume":"22","author":"Loewen","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.yexcr.2010.06.008_bib27","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1038\/oby.2009.71","article-title":"Association of OSBPL11 gene polymorphisms with cardiovascular disease risk factors in obesity","volume":"17","author":"Bouchard","year":"2009","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.yexcr.2010.06.008_bib28","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/ncb1920","article-title":"Golgi-derived CLASP-dependent microtubules control golgi organization and polarized trafficking in motile cells","volume":"11","author":"Miller","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.06.008_bib29","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1091\/mbc.e08-09-0905","article-title":"Oxysterol binding protein-related protein 9 (ORP9) is a cholesterol transfer protein that regulates golgi structure and function","volume":"20","author":"Ngo","year":"2009","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.yexcr.2010.06.008_bib30","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.yexcr.2007.01.018","article-title":"Characterization of the sterol-binding domain of oxysterol-binding protein (OSBP)-related protein 4 reveals a novel role in vimentin organization","volume":"313","author":"Wyles","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2010.06.008_bib31","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/j.1460-2075.1993.tb05701.x","article-title":"Rab9 functions in transport between late endosomes and the trans golgi network","volume":"12","author":"Lombardi","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/j.yexcr.2010.06.008_bib32","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1083\/jcb.200510010","article-title":"TIP47 is a key effector for Rab9 localization","volume":"173","author":"Aivazian","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.06.008_bib33","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1091\/mbc.11.2.467","article-title":"Rab7: a key to lysosome biogenesis","volume":"11","author":"Bucci","year":"2000","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.yexcr.2010.06.008_bib34","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1083\/jcb.200804048","article-title":"Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7","volume":"183","author":"Rojas","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.06.008_bib35","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1242\/jcs.048686","article-title":"Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the rab-GAP TBC1D5","volume":"122","author":"Seaman","year":"2009","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.yexcr.2010.06.008_bib36","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1139\/o03-088","article-title":"Oxysterol binding proteins: in more than one place at one time?","volume":"82","author":"Olkkonen","year":"2004","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.06.008_bib37","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1083\/jcb.200811005","article-title":"Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 glued and late endosome positioning","volume":"185","author":"Rocha","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.06.008_bib38","doi-asserted-by":"crossref","first-page":"15352","DOI":"10.1073\/pnas.0705571104","article-title":"The oxysterol binding protein Kes1p regulates golgi apparatus phosphatidylinositol-4-phosphate function","volume":"104","author":"Fairn","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2010.06.008_bib39","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1091\/mbc.e08-10-1036","article-title":"Control of protein and sterol trafficking by antagonistic activities of a type IV P-type ATPase and oxysterol binding protein homologue","volume":"20","author":"Muthusamy","year":"2009","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.yexcr.2010.06.008_bib40","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ceb.2006.06.011","article-title":"Inter-organelle membrane contact sites: through a glass, darkly","volume":"18","author":"Levine","year":"2006","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.06.008_bib41","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/28879","article-title":"EEA1 links PI(3)K function to Rab5 regulation of endosome fusion","volume":"394","author":"Simonsen","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2010.06.008_bib42","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.bbalip.2008.12.007","article-title":"Endolysosomal phospholipidosis and cytosolic lipid droplet storage and release in macrophages","volume":"1791","author":"Schmitz","year":"2009","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.yexcr.2010.06.008_bib43","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1016\/j.febslet.2006.08.061","article-title":"Drug-induced phospholipidosis","volume":"580","author":"Anderson","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yexcr.2010.06.008_bib44","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3945\/ajcn.2009.28085","article-title":"Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction","volume":"91","author":"Bouchard","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.yexcr.2010.06.008_bib45","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s00109-009-0490-z","article-title":"OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism","volume":"87","author":"Perttil\u00e4","year":"2009","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.yexcr.2010.06.008_bib46","first-page":"1","article-title":"Variation in OSBPL10 is associated with dyslipidemia","author":"Koriyama","year":"2010","journal-title":"Hypertens. Res."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482710003174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482710003174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:09:15Z","timestamp":1757995755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482710003174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":46,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0014482710003174"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2010.06.008","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi\u2013late endosome interface","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2010.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}