{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:34:47Z","timestamp":1793835287253,"version":"4.6.1"},"reference-count":115,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.yexcr.2010.12.007","type":"journal-article","created":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T15:48:19Z","timestamp":1299512899000},"page":"632-641","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"title":["Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers"],"prefix":"10.1016","volume":"317","author":[{"given":"Ronen","family":"Alon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziv","family":"Shulman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2010.12.007_bb0005","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/ni1275","article-title":"Immune cell migration in inflammation: present and future therapeutic targets","volume":"6","author":"Luster","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0010","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nri2156","article-title":"Getting to the site of inflammation: the leukocyte adhesion cascade updated","volume":"7","author":"Ley","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0015","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/ni1194","article-title":"Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines","volume":"6","author":"Shamri","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0020","doi-asserted-by":"crossref","first-page":"6828","DOI":"10.4049\/jimmunol.178.11.6828","article-title":"Regulation of cell adhesion by affinity and conformational unbending of alpha4beta1 integrin","volume":"178","author":"Chigaev","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0025","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1146\/annurev.immunol.25.022106.141618","article-title":"Structural basis of integrin regulation and signaling","volume":"25","author":"Luo","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0030","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.immuni.2007.01.002","article-title":"Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells","volume":"26","author":"Alon","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0035","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1242\/jcs.042127","article-title":"The mechanical integrin cycle","volume":"122","author":"Puklin-Faucher","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0040","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.ceb.2009.05.003","article-title":"Mechanical modes of \u2018amoeboid\u2019 cell migration","volume":"21","author":"Lammermann","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0045","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0952-7915(00)00096-0","article-title":"Chemokines in tissue-specific and microenvironment-specific lymphocyte homing","volume":"12","author":"Campbell","year":"2000","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0050","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1146\/annurev.immunol.22.012703.104543","article-title":"Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells","volume":"22","author":"Rot","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0055","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1385\/IR:34:3:211","article-title":"Chemoattractant receptor signaling and the control of lymphocyte migration","volume":"34","author":"Kehrl","year":"2006","journal-title":"Immunol. Res."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0060","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nm.1921","article-title":"Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells","volume":"15","author":"Moser","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0065","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/ni.f.212","article-title":"Interstitial leukocyte migration and immune function","volume":"9","author":"Friedl","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0070","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/ni.f.207","article-title":"How chemokines invite leukocytes to dance","volume":"9","author":"Thelen","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0075","doi-asserted-by":"crossref","first-page":"14337","DOI":"10.1074\/jbc.M901178200","article-title":"Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation","volume":"284","author":"Chigaev","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0080","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0085","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.molcel.2008.11.018","article-title":"Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces","volume":"32","author":"Zhu","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0090","doi-asserted-by":"crossref","first-page":"15020","DOI":"10.1021\/bi061566o","article-title":"Importance of force linkage in mechanochemistry of adhesion receptors","volume":"45","author":"Astrof","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0095","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1083\/jcb.200602071","article-title":"How the headpiece hinge angle is opened: new insights into the dynamics of integrin activation","volume":"175","author":"Puklin-Faucher","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0100","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.1169414","article-title":"Cell biology. The force is with us","volume":"323","author":"Schwartz","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0105","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.immuni.2006.06.012","article-title":"Cytoskeletal regulation couples LFA-1 conformational changes to receptor lateral mobility and clustering","volume":"25","author":"Cairo","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0110","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1083\/jcb.200503155","article-title":"Integrin \u03b14\u03b21(VLA-4)-dependent T cell tethering and adhesion strengthening under shear stress requires paxillin binding to the \u03b14 cytoplasmic domain","volume":"171","author":"Alon","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0115","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1126\/science.1086652","article-title":"Talin binding to integrin beta tails: a final common step in integrin activation","volume":"302","author":"Tadokoro","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0120","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0968-0004(98)01237-7","article-title":"The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane","volume":"23","author":"Chishti","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0125","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1242\/jcs.018085","article-title":"Talin at a glance","volume":"121","author":"Critchley","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0130","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.biophys.050708.133744","article-title":"Biochemical and structural properties of the integrin-associated cytoskeletal protein talin","volume":"38","author":"Critchley","year":"2009","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0135","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1084\/jem.20071800","article-title":"Talin is required for integrin-mediated platelet function in hemostasis and thrombosis","volume":"204","author":"Petrich","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0140","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature06887","article-title":"Rapid leukocyte migration by integrin-independent flowing and squeezing","volume":"453","author":"Lammermann","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0145","doi-asserted-by":"crossref","first-page":"25338","DOI":"10.1074\/jbc.M700089200","article-title":"Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1","volume":"282","author":"Manevich","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0150","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.immuni.2009.09.021","article-title":"Chemokine-induced Zap70 kinase-mediated dissociation of the Vav1-talin complex activates alpha4beta1 integrin for T cell adhesion","volume":"31","author":"Garcia-Bernal","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0155","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jmb.2008.06.087","article-title":"Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain","volume":"382","author":"Wegener","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0160","doi-asserted-by":"crossref","first-page":"21217","DOI":"10.1074\/jbc.M102373200","article-title":"Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides","volume":"276","author":"Martel","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0165","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ceb.2003.11.007","article-title":"Talin: an emerging focal point of adhesion dynamics","volume":"16","author":"Nayal","year":"2004","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0170","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/embor.2008.202","article-title":"Kindlins: essential regulators of integrin signalling and cell-matrix adhesion","volume":"9","author":"Larjava","year":"2008","journal-title":"EMBO Rep."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0175","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1126\/science.1163865","article-title":"The tail of integrins, talin, and kindlins","volume":"324","author":"Moser","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0180","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nm.1917","article-title":"A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans","volume":"15","author":"Malinin","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0185","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nm.1931","article-title":"Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation","volume":"15","author":"Svensson","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0190","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/00130832-200412000-00003","article-title":"Leukocyte adhesion deficiency III: a group of integrin activation defects in hematopoietic lineage cells","volume":"4","author":"Etzioni","year":"2004","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0195","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/ni.1691","article-title":"Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module","volume":"10","author":"Bolomini-Vittori","year":"2009","journal-title":"Nat. Immunol."},{"issue":"Pt 21","key":"10.1016\/j.yexcr.2010.12.007_bb0200","first-page":"3685","article-title":"The actin cytoskeleton and plasma membrane connection: PtdIns(4, 5)P(2) influences cytoskeletal protein activity at the plasma membrane","volume":"113","author":"Sechi","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0205","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(00)81560-3","article-title":"Phosphatidylinositol 4, 5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion","volume":"100","author":"Raucher","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0210","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0955-0674(00)00241-6","article-title":"PI(4, 5)P(2) regulation of surface membrane traffic","volume":"13","author":"Martin","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0215","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1083\/jcb.200708123","article-title":"WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells","volume":"180","author":"Sarmiento","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0220","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.cub.2006.08.035","article-title":"Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3","volume":"16","author":"Han","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0225","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1189\/jlb.1206726","article-title":"Intracellular signaling required for CCL25-stimulated T cell adhesion mediated by the integrin alpha4beta1","volume":"82","author":"Parmo-Cabanas","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0230","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1083\/jcb.200301133","article-title":"Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow","volume":"161","author":"Shimonaka","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0235","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0065-2776(06)93005-3","article-title":"Integrin regulation of lymphocyte trafficking: lessons from structural and signaling studies","volume":"93","author":"Kinashi","year":"2007","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0240","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1182\/blood-2009-03-211979","article-title":"Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners","volume":"115","author":"Ebisuno","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0245","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.immuni.2008.12.020","article-title":"Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin","volume":"30","author":"Shulman","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0250","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/ni1499","article-title":"Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces","volume":"8","author":"Woolf","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0255","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1083\/jcb.200412032","article-title":"A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes","volume":"170","author":"Smith","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0260","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1092053","article-title":"Cell migration: integrating signals from front to back","volume":"302","author":"Ridley","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0265","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1084\/jem.20041850","article-title":"Importance of integrin LFA-1 deactivation for the generation of immune responses","volume":"201","author":"Semmrich","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0270","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1182\/blood-2007-03-077628","article-title":"Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion","volume":"110","author":"Ghandour","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0275","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.4049\/jimmunol.179.4.2223","article-title":"Phospholipase cbeta is critical for T cell chemotaxis","volume":"179","author":"Bach","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0280","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/ni1191","article-title":"T cell costimulation by chemokine receptors","volume":"6","author":"Molon","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0285","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1172\/JCI30575","article-title":"Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III","volume":"117","author":"Bergmeier","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0290","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S1074-7613(00)00074-1","article-title":"Chemokines trigger immediate \u03b22 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow","volume":"13","author":"Constantin","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0295","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1084\/jem.192.4.495","article-title":"Subsecond induction of \u03b14 integrin clustering by immobilized chemokines enhances leukocyte capture and rolling under flow prior to firm adhesion to endothelium","volume":"192","author":"Grabovsky","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0300","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1182\/blood-2006-01-029199","article-title":"Phospholipase C, calcium, and calmodulin are critical for alpha4beta1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants","volume":"109","author":"Hyduk","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0305","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1083\/jcb.140.3.699","article-title":"LFA-1-mediated adhesion is regulated by cytoskeletal restraint and by a Ca2+-dependent protease, calpain","volume":"140","author":"Stewart","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0310","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/ni950","article-title":"RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1","volume":"4","author":"Katagiri","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0315","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/ni1374","article-title":"Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion","volume":"7","author":"Katagiri","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0320","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1182\/blood-2009-08-237917","article-title":"Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes","volume":"115","author":"Park","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0325","doi-asserted-by":"crossref","first-page":"13991","DOI":"10.1073\/pnas.0605716103","article-title":"AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes","volume":"103","author":"Shimaoka","year":"2006","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0330","doi-asserted-by":"crossref","first-page":"33588","DOI":"10.1074\/jbc.273.50.33588","article-title":"Cytoskeletal interactions with the leukocyte integrin \u03b22 cytoplasmic tail. Activation-dependent regulation of associations with talin and \u03b1-actinin","volume":"273","author":"Sampath","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0335","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/sj.emboj.7601959","article-title":"Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell","volume":"27","author":"Stanley","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0340","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0167-5699(00)01649-2","article-title":"Lipids on the move: phosphoinositide 3-kinases in leukocyte function","volume":"21","author":"Wymann","year":"2000","journal-title":"Immunol. Today"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0345","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.4049\/jimmunol.179.9.5649","article-title":"Cutting edge: Atypical PKCs regulate T lymphocyte polarity and scanning behavior","volume":"179","author":"Real","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0350","doi-asserted-by":"crossref","first-page":"30306","DOI":"10.1074\/jbc.273.46.30306","article-title":"Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis","volume":"273","author":"Laudanna","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0355","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1074-7613(03)00350-9","article-title":"RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines. Critical role of LFA-1 affinity triggering in lymphocyte in vivo homing","volume":"20","author":"Giagulli","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0360","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1182\/blood-2005-06-2303","article-title":"Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium","volume":"107","author":"Green","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0365","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1182\/blood-2002-12-3807","article-title":"Chemokine stimulation of human peripheral blood T lymphocytes induces rapid dephosphorylation of ERM proteins, which facilitates loss of microvilli and polarization","volume":"102","author":"Brown","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0370","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1182\/blood-2006-04-017608","article-title":"DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration","volume":"108","author":"Shulman","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0375","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1084\/jem.20061780","article-title":"A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress","volume":"204","author":"Nombela-Arrieta","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0380","doi-asserted-by":"crossref","first-page":"6138","DOI":"10.1182\/blood-2008-07-167668","article-title":"The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration","volume":"113","author":"Gerard","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0385","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.immuni.2004.07.012","article-title":"Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing","volume":"21","author":"Nombela-Arrieta","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0390","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.4049\/jimmunol.177.8.5215","article-title":"DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin alpha4beta1","volume":"177","author":"Garcia-Bernal","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0395","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1091\/mbc.e04-12-1049","article-title":"Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin \u03b14\u03b21","volume":"16","author":"Garcia-Bernal","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0400","doi-asserted-by":"crossref","first-page":"7282","DOI":"10.4049\/jimmunol.173.12.7282","article-title":"Chemoattractant signals and \u03b22 integrin occupancy at apical endothelial contacts combine with shear stress signals to promote transendothelial neutrophil migration","volume":"173","author":"Cinamon","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0405","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1182\/blood-2006-07-032995","article-title":"Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm","volume":"109","author":"Schreiber","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0410","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.immuni.2007.04.015","article-title":"Transcellular diapedesis is initiated by invasive podosomes","volume":"26","author":"Carman","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0415","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1189\/jlb.0309214","article-title":"Dynamic alterations in chemokine gradients induce transendothelial shuttling of human T cells under physiologic shear conditions","volume":"86","author":"Lee","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0420","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/(SICI)1521-4141(199902)29:02<700::AID-IMMU700>3.0.CO;2-1","article-title":"Differential immobilization and hierarchical involvement of chemokines in monocyte arrest and transmigration on inflamed endothelium in shear flow","volume":"29","author":"Weber","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0425","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/aja.1001860202","article-title":"Endothelial attachment and plasmalemmal apposition in the transcellular movement of intravascular leukemic cells entering the myeloid parenchyma","volume":"186","author":"De Bruyn","year":"1989","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0430","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nrm2889","article-title":"Breaching multiple barriers: leukocyte motility through venular walls and the interstitium","volume":"11","author":"Nourshargh","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0435","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1083\/jcb.200805076","article-title":"Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms","volume":"183","author":"Barreiro","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0440","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1083\/jcb.200112126","article-title":"Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes","volume":"157","author":"Barreiro","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0445","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1083\/jcb.200404129","article-title":"A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them","volume":"167","author":"Carman","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0450","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1084\/jem.20040965","article-title":"Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration","volume":"200","author":"Shaw","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0455","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.immuni.2006.06.014","article-title":"Impaired integrin-dependent function in Wiskott\u2013Aldrich syndrome protein-deficient murine and human neutrophils","volume":"25","author":"Zhang","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0460","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3609::AID-IMMU3609>3.0.CO;2-S","article-title":"Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes","volume":"29","author":"del Pozo","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0465","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1128\/MCB.01008-08","article-title":"Integrating receptor signal inputs that influence small Rho GTPase activation dynamics at the immunological synapse","volume":"29","author":"Makrogianneli","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0470","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.febslet.2005.01.006","article-title":"Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes","volume":"579","author":"Nishikimi","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0475","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1083\/jcb.200103048","article-title":"RhoA is required for monocyte tail retraction during transendothelial migration","volume":"154","author":"Worthylake","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0480","doi-asserted-by":"crossref","first-page":"40518","DOI":"10.1074\/jbc.M102896200","article-title":"Rho and Rho-associated kinase modulate the tyrosine kinase PYK2 in T-cells through regulation of the activity of the integrin LFA-1","volume":"276","author":"Rodriguez-Fernandez","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0485","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1091\/mbc.e02-09-0615","article-title":"The critical cytoplasmic regions of the {alpha}L\/{beta}2 integrin in Rap1-induced adhesion and migration","volume":"14","author":"Tohyama","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0490","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0962-8924(03)00128-4","article-title":"Podosomes: adhesion hot-spots of invasive cells","volume":"13","author":"Linder","year":"2003","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0495","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.coi.2005.04.003","article-title":"Vav-family proteins in T-cell signalling","volume":"17","author":"Tybulewicz","year":"2005","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0500","doi-asserted-by":"crossref","first-page":"604","DOI":"10.4049\/jimmunol.177.1.604","volume":"177","author":"Giagulli","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0505","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1016\/j.yexcr.2009.08.010","article-title":"Vav GEFs regulate macrophage morphology and adhesion-induced Rac and Rho activation","volume":"315","author":"Bhavsar","year":"2009","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0510","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1002\/eji.200636327","article-title":"Coy decoy with a new ploy: interceptor controls the levels of homeostatic chemokines","volume":"36","author":"Haraldsen","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0515","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.biocel.2007.12.009","article-title":"Proteolytic processing of chemokines: implications in physiological and pathological conditions","volume":"40","author":"Wolf","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0520","doi-asserted-by":"crossref","first-page":"40027","DOI":"10.1074\/jbc.M206806200","article-title":"Chemokine-stimulation of lymphocyte \u03b14 integrin avidity but not of LFA-1 avidity to endothelial ligands under shear flow requires cholesterol membrane rafts","volume":"277","author":"Shamri","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0525","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1242\/jcs.115.5.963","article-title":"The involvement of lipid rafts in the regulation of integrin function","volume":"115","author":"Leitinger","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0530","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nri2193","article-title":"Tether and trap: regulation of membrane-raft dynamics by actin-binding proteins","volume":"7","author":"Viola","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0535","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1073\/pnas.032497699","article-title":"Structural diversity of heparan sulfate binding domains in chemokines","volume":"99","author":"Lortat-Jacob","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0540","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1042\/BST0340422","article-title":"The biological relevance of chemokine-proteoglycan interactions","volume":"34","author":"Proudfoot","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0545","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0092-8674(00)80422-5","article-title":"Transcytosis and surface presentation of IL-8 by venular endothelial cells","volume":"91","author":"Middleton","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0550","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.4049\/jimmunol.175.8.5358","article-title":"Characterization of a novel chemokine-containing storage granule in endothelial cells: evidence for preferential exocytosis mediated by protein kinase A and diacylglycerol","volume":"175","author":"Oynebraten","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0555","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1182\/blood-2008-10-183699","article-title":"{beta}-arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation","volume":"114","author":"Molteni","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2010.12.007_bb0560","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ncb1610","article-title":"Filamin-A regulates actin-dependent clustering of HIV receptors","volume":"9","author":"Jimenez-Baranda","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0565","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2172-9-26","article-title":"Galphas-coupled receptor signaling actively down-regulates alpha4beta1-integrin affinity: a possible mechanism for cell de-adhesion","volume":"9","author":"Chigaev","year":"2008","journal-title":"BMC Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0570","doi-asserted-by":"crossref","first-page":"7780","DOI":"10.4049\/jimmunol.172.12.7780","article-title":"Shear-dependent capping of L-selectin and P-selectin glycoprotein ligand 1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophils","volume":"172","author":"Green","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexcr.2010.12.007_bb0575","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1600-065X.2007.00531.x","article-title":"Convergence of immunoreceptor and integrin signaling","volume":"218","author":"Abram","year":"2007","journal-title":"Immunol. Rev."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482710005653?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482710005653?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:10:59Z","timestamp":1762146659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482710005653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":115,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0014482710005653"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2010.12.007","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2010.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}