{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T12:41:37Z","timestamp":1768740097196,"version":"3.49.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.yexcr.2011.12.013","type":"journal-article","created":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T16:36:52Z","timestamp":1324485412000},"page":"311-325","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Kr\u00fcppel-like factor 4 regulates membranous and endochondral ossification"],"prefix":"10.1016","volume":"318","author":[{"given":"Ikumi","family":"Michikami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiya","family":"Fukushi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Egusa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ooshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Wakisaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2011.12.013_bb0005","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2007.05.047","article-title":"Endocrine regulation of energy metabolism by the skeleton","volume":"130","author":"Lee","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2011.12.013_bb0010","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.1073\/pnas.0711119105","article-title":"Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice","volume":"105","author":"Ferron","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0015","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1753-4887.2008.00027.x","article-title":"Energy regulation by the skeleton","volume":"66","author":"Wolf","year":"2008","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0020","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1677\/JOE-08-0294","article-title":"A possible role of osteocalcin in the regulation of insulin secretion: human in vivo evidence?","volume":"199","author":"Kassi","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0025","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.tem.2009.02.001","article-title":"Bone as an endocrine organ","volume":"20","author":"Fukumoto","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0030","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1172\/JCI39366","article-title":"The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts","volume":"119","author":"Yoshizawa","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0035","first-page":"357-68","article-title":"FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice","volume":"120","author":"Rached","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0040","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/0092-8674(86)90817-2","article-title":"A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Kruppel, a Drosophila segmentation gene","volume":"47","author":"Schuh","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2011.12.013_bb0045","doi-asserted-by":"crossref","first-page":"31384","DOI":"10.1074\/jbc.271.49.31384","article-title":"A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells","volume":"271","author":"Garrett-Sinha","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0050","doi-asserted-by":"crossref","first-page":"20009","DOI":"10.1074\/jbc.271.33.20009","article-title":"Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest","volume":"271","author":"Shields","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0055","doi-asserted-by":"crossref","first-page":"18504","DOI":"10.1074\/jbc.272.29.18504","article-title":"Two potent nuclear localization signals in the gut-enriched Kruppel-like factor define a subfamily of closely related Kruppel proteins","volume":"272","author":"Shields","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0060","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/nar\/26.3.796","article-title":"Identification of the DNA sequence that interacts with the gut-enriched Kruppel-like factor","volume":"26","author":"Shields","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0065","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/bies.20581","article-title":"The diverse functions of Kruppel-like factors 4 and 5 in epithelial biology and pathobiology","volume":"29","author":"McConnell","year":"2007","journal-title":"Bioessays"},{"key":"10.1016\/j.yexcr.2011.12.013_bb0070","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/sj.cr.7290271","article-title":"Kruppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation","volume":"15","author":"Ghaleb","year":"2005","journal-title":"Cell Res."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0075","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.archoralbio.2009.02.003","article-title":"Spatial and temporal expression of KLF4 and KLF5 during murine tooth development","volume":"54","author":"Chen","year":"2009","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0080","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/(SICI)1097-0177(200004)217:4<421::AID-DVDY9>3.0.CO;2-1","article-title":"Developmental expression of the mouse gene coding for the Kruppel-like transcription factor KLF5","volume":"217","author":"Ohnishi","year":"2000","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0085","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/11926","article-title":"Klf4 is a transcription factor required for establishing the barrier function of the skin","volume":"22","author":"Segre","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0090","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1242\/dev.129.11.2619","article-title":"The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon","volume":"129","author":"Katz","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2011.12.013_bb0095","doi-asserted-by":"crossref","first-page":"7147","DOI":"10.1158\/0008-5472.CAN-07-1302","article-title":"Haploinsufficiency of Kruppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis","volume":"67","author":"Ghaleb","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0100","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1128\/MCB.26.6.2055-2064.2006","article-title":"Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression","volume":"26","author":"Zhang","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0105","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1158\/1541-7786.MCR-08-0224","article-title":"Notch inhibits expression of the Kruppel-like factor 4 tumor suppressor in the intestinal epithelium","volume":"6","author":"Ghaleb","year":"2008","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0110","first-page":"3","article-title":"Signals that determine the fate of osteoblastic cells","volume":"28","author":"Canalis","year":"2005","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0115","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/dvdy.10100","article-title":"Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast","volume":"224","author":"Dacquin","year":"2002","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0120","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.bone.2009.11.022","article-title":"Hand2 regulates chondrogenesis in vitro and in vivo","volume":"46","author":"Abe","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.yexcr.2011.12.013_bb0125","doi-asserted-by":"crossref","first-page":"20029","DOI":"10.1074\/jbc.M010601200","article-title":"AP-1 and Cbfa\/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2\/AP-1 composite element","volume":"276","author":"Hess","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0130","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1073\/pnas.97.8.4076","article-title":"Action of the Caenorhabditis elegans GATA factor END-1 in Xenopus suggests that similar mechanisms initiate endoderm development in ecdysozoa and vertebrates","volume":"97","author":"Shoichet","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0135","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1128\/MCB.15.4.1858","article-title":"Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene","volume":"15","author":"Ducy","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0140","first-page":"324","article-title":"Applications of retrovirus-mediated expression cloning","volume":"24","author":"Onishi","year":"1996","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0145","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1038\/nprot.2007.418","article-title":"Induction of pluripotent stem cells from fibroblast cultures","volume":"2","author":"Takahashi","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0150","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1749-6632.2003.tb03214.x","article-title":"How proteases regulate bone morphogenesis","volume":"995","author":"Ortega","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0155","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0092-8674(00)81169-1","article-title":"MMP-9\/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes","volume":"93","author":"Vu","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2011.12.013_bb0160","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/9467","article-title":"VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation","volume":"5","author":"Gerber","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0165","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/03008200590935547","article-title":"Angiogenesis inhibitors localized in hypovascular mesenchymal tissues: chondromodulin-I and tenomodulin","volume":"46","author":"Hiraki","year":"2005","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0170","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0925-4773(01)00601-3","article-title":"Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188","volume":"111","author":"Maes","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0175","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1242\/dev.01461","article-title":"Altered endochondral bone development in matrix metalloproteinase 13-deficient mice","volume":"131","author":"Stickens","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2011.12.013_bb0180","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1196\/annals.1346.013","article-title":"Regulation of osteoclast differentiation","volume":"1068","author":"Roodman","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0185","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF02555901","article-title":"Normal bone particles are preferentially resorbed in the presence of osteocalcin-deficient bone particles in vivo","volume":"49","author":"DeFranco","year":"1991","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0190","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/jcb.240450312","article-title":"A role for osteocalcin in osteoclast differentiation","volume":"45","author":"Glowacki","year":"1991","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0195","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0045-6039(87)90479-9","article-title":"Impaired recruitment and differentiation of osteoclast progenitors by osteocalcin-deplete bone implants","volume":"21","author":"Glowacki","year":"1987","journal-title":"Cell Differ."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0200","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF02405025","article-title":"Chemotactic activity of the gamma-carboxyglutamic acid containing protein in bone","volume":"35","author":"Mundy","year":"1983","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0205","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1083\/jcb.92.1.227","article-title":"Recruitment of osteoclast precursors by purified bone matrix constituents","volume":"92","author":"Malone","year":"1982","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0210","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1083\/jcb.127.4.1149","article-title":"Osteocalcin induces chemotaxis, secretion of matrix proteins, and calcium-mediated intracellular signaling in human osteoclast-like cells","volume":"127","author":"Chenu","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0215","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/382448a0","article-title":"Increased bone formation in osteocalcin-deficient mice","volume":"382","author":"Ducy","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2011.12.013_bb0220","doi-asserted-by":"crossref","first-page":"30973","DOI":"10.1074\/jbc.270.52.30973","article-title":"A PEBP2 alpha\/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element","volume":"270","author":"Geoffroy","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11154-006-9001-5","article-title":"Networks and hubs for the transcriptional control of osteoblastogenesis","volume":"7","author":"Lian","year":"2006","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0230","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1093\/nar\/28.5.1106","article-title":"Transactivation and growth suppression by the gut-enriched Kruppel-like factor (Kruppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction","volume":"28","author":"Geiman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0235","doi-asserted-by":"crossref","first-page":"30509","DOI":"10.1074\/jbc.273.46.30509","article-title":"Functional hierarchy between two OSE2 elements in the control of osteocalcin gene expression in vivo","volume":"273","author":"Frendo","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0240","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2011.12.013_bb0245","first-page":"1343","article-title":"The role of Kruppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells","volume":"24","author":"Nandan","year":"2009","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0250","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/386078a0","article-title":"Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein","volume":"386","author":"Luo","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2011.12.013_bb0255","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3109\/03008208909049995","article-title":"Gla-containing proteins of bone","volume":"21","author":"Price","year":"1989","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbspin.2011.03.020","article-title":"Animal models with pathological mineralization phenotypes","author":"Kornak","year":"2011","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.yexcr.2011.12.013_bb0265","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1074\/jbc.M109683200","article-title":"Matrix Gla protein, a regulatory protein for bone morphogenetic protein-2","volume":"277","author":"Zebboudj","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0270","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1083\/jcb.151.4.879","article-title":"Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones","volume":"151","author":"Engsig","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0275","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1182\/blood-2009-08-237628","article-title":"Osteoclasts are important for bone angiogenesis","volume":"115","author":"Cackowski","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2011.12.013_bb0280","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ydbio.2009.05.552","article-title":"Differential actions of VEGF-A isoforms on perichondrial angiogenesis during endochondral bone formation","volume":"332","author":"Takimoto","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0285","doi-asserted-by":"crossref","first-page":"38247","DOI":"10.1074\/jbc.M509378200","article-title":"Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages","volume":"280","author":"Feinberg","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0290","doi-asserted-by":"crossref","first-page":"28097","DOI":"10.1074\/jbc.M111.236950","article-title":"Down-regulation of Kruppel-like Factor-4 (KLF4) by MicroRNA-143\/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-b and bone morphogenetic protein 4","volume":"286","author":"Davis-Dusenbery","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0295","doi-asserted-by":"crossref","first-page":"6890","DOI":"10.1074\/jbc.M110.179952","article-title":"Regulation of Kruppel-like Factor 4 by anaphase promoting complex pathway is involved in TGF-b signaling","volume":"286","author":"Hu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0300","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/10454411980090020401","article-title":"Is all bone the same? Distinctive distributions and properties of non-collagenous matrix proteins in lamellar vs. woven bone imply the existence of different underlying osteogenic mechanisms","volume":"9","author":"Gorski","year":"1998","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0305","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1002\/dvdy.21187","article-title":"Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency","volume":"236","author":"Maruyama","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0310","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S1534-5807(04)00058-9","article-title":"A twist code determines the onset of osteoblast differentiation","volume":"6","author":"Bialek","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.yexcr.2011.12.013_bb0315","doi-asserted-by":"crossref","first-page":"6137","DOI":"10.1093\/nar\/gkm656","article-title":"Tip60 functions as a potential corepressor of KLF4 in regulation of HDC promoter activity","volume":"35","author":"Ai","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yexcr.2011.12.013_bb0320","doi-asserted-by":"crossref","first-page":"33994","DOI":"10.1074\/jbc.M701847200","article-title":"Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation","volume":"282","author":"Evans","year":"2007","journal-title":"J. Biol. Chem."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482711004848?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482711004848?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:12:40Z","timestamp":1757995960000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482711004848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0014482711004848"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2011.12.013","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kr\u00fcppel-like factor 4 regulates membranous and endochondral ossification","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2011.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}