{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:59:42Z","timestamp":1790067582523,"version":"4.0.1"},"reference-count":69,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.yexcr.2012.12.028","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T23:47:08Z","timestamp":1358293628000},"page":"623-632","source":"Crossref","is-referenced-by-count":50,"title":["IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways"],"prefix":"10.1016","volume":"319","author":[{"given":"Changdong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2012.12.028_bib1","doi-asserted-by":"crossref","first-page":"R526","DOI":"10.1016\/j.cub.2009.05.025","article-title":"The primary cilium as a complex signaling center","volume":"19","author":"Berbari","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nrm3085","article-title":"Ciliogenesis: building the cell\u2019s antenna","volume":"12","author":"Ishikawa","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev.physiol.69.040705.141236","article-title":"Overview of structure and function of mammalian cilia","volume":"69","author":"Satir","year":"2007","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib4","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.diff.2011.11.002","article-title":"Structure and function of vertebrate cilia, towards a new taxonomy","volume":"83","author":"Takeda","year":"2012","journal-title":"Differentiation"},{"key":"10.1016\/j.yexcr.2012.12.028_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0070-2153(08)00802-8","article-title":"Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling","volume":"85","author":"Pedersen","year":"2008","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib6","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1083\/jcb.151.3.709","article-title":"Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella","volume":"151","author":"Pazour","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ydbio.2008.09.019","article-title":"Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain","volume":"325","author":"Gorivodsky","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib8","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1126\/science.8191288","article-title":"Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice","volume":"264","author":"Moyer","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2012.12.028_bib9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature02061","article-title":"Hedgehog signalling in the mouse requires intraflagellar transport proteins","volume":"426","author":"Huangfu","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2012.12.028_bib10","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0022-3476(87)80244-5","article-title":"Polycystic kidney disease in the first year of life","volume":"111","author":"Cole","year":"1987","journal-title":"J. Pediatr."},{"key":"10.1016\/j.yexcr.2012.12.028_bib11","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.devcel.2012.04.009","article-title":"IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport","volume":"22","author":"Keady","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.yexcr.2012.12.028_bib12","doi-asserted-by":"crossref","first-page":"e5384","DOI":"10.1371\/journal.pone.0005384","article-title":"Intraflagellar transport (IFT) protein IFT25 is a phosphoprotein component of IFT complex B and physically interacts with IFT27 in Chlamydomonas","volume":"4","author":"Wang","year":"2009","journal-title":"PloS One"},{"key":"10.1016\/j.yexcr.2012.12.028_bib13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cub.2006.12.040","article-title":"Intraflagellar transport protein 27 is a small G protein involved in cell-cycle control","volume":"17","author":"Qin","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib14","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0022-5320(78)90036-9","article-title":"Cilia of adult canine articular chondrocytes","volume":"64","author":"Wilsman","year":"1978","journal-title":"J. Ultrastruct. Res."},{"key":"10.1016\/j.yexcr.2012.12.028_bib15","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0022-5320(67)80080-7","article-title":"Single cilia in chondrocytes","volume":"19","author":"Scherft","year":"1967","journal-title":"J. Ultrastruct. Res."},{"key":"10.1016\/j.yexcr.2012.12.028_bib16","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1006\/cbir.1997.0177","article-title":"Confocal analysis of primary cilia structure and colocalization with the Golgi apparatus in chondrocytes and aortic smooth muscle cells","volume":"21","author":"Poole","year":"1997","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.yexcr.2012.12.028_bib17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cellbi.2003.11.007","article-title":"Ultrastructural, tomographic and confocal imaging of the chondrocyte primary cilium in situ","volume":"28","author":"Jensen","year":"2004","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.yexcr.2012.12.028_bib18","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1096\/fj.11-193649","article-title":"Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes","volume":"26","author":"Wann","year":"2012","journal-title":"FASEB J.: Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib19","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1042\/CBI20090094","article-title":"Mechanical loading modulates chondrocyte primary cilia incidence and length","volume":"34","author":"McGlashan","year":"2010","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.yexcr.2012.12.028_bib20","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ydbio.2007.02.003","article-title":"Development of the post-natal growth plate requires intraflagellar transport proteins","volume":"305","author":"Song","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib21","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1007\/s00018-011-0911-3","article-title":"The primary cilium as a dual sensor of mechanochemical signals in chondrocytes","volume":"69","author":"Muhammad","year":"2012","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.yexcr.2012.12.028_bib22","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1002\/art.23985","article-title":"Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone-related protein in mice","volume":"58","author":"Chen","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.yexcr.2012.12.028_bib23","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1002\/dvdy.21501","article-title":"Primary cilia in osteoarthritic chondrocytes: from chondrons to clusters","volume":"237","author":"McGlashan","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.yexcr.2012.12.028_bib24","doi-asserted-by":"crossref","unstructured":"A.K. Wann, M.M. Knight, Primary Cilia Elongation in Response to Interleukin-1 Mediates the Inflammatory Response, Cellular and Molecular Life Sciences: CMLS (2012).","DOI":"10.1007\/s00018-012-0980-y"},{"key":"10.1016\/j.yexcr.2012.12.028_bib25","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.ajhg.2009.03.015","article-title":"Ciliary abnormalities due to defects in the retrograde transport protein DYNC2H1 in short-rib polydactyly syndrome","volume":"84","author":"Merrill","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.yexcr.2012.12.028_bib26","first-page":"384","article-title":"Postnatal growth and development of a cerebral arteriovenous malformation on serial magnetic resonance imaging in a child with hemangiomatosis. Case report","volume":"106","author":"Song","year":"2007","journal-title":"J Neurosurg."},{"key":"10.1016\/j.yexcr.2012.12.028_bib27","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1177\/0022034511409407","article-title":"TMJ development and growth require primary cilia function","volume":"90","author":"Kinumatsu","year":"2011","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.yexcr.2012.12.028_bib28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bone.2011.08.033","article-title":"Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes","volume":"50","author":"Shao","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.yexcr.2012.12.028_bib29","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.joca.2011.11.009","article-title":"Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis Osteoarthritis and cartilage\/OARS","volume":"20","author":"Chang","year":"2012","journal-title":"Osteoarthritis Res. Soc."},{"key":"10.1016\/j.yexcr.2012.12.028_bib30","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.cellbio.23.090506.123249","article-title":"Cilia and developmental signaling","volume":"23","author":"Eggenschwiler","year":"2007","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib31","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1002\/dvdy.21551","article-title":"Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts","volume":"237","author":"Ocbina","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.yexcr.2012.12.028_bib32","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1242\/dev.001586","article-title":"Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis","volume":"134","author":"Koyama","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2012.12.028_bib33","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1101\/gad.13.16.2072","article-title":"Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation","volume":"13","author":"St-Jacques","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.yexcr.2012.12.028_bib34","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev-cellbio-092910-154048","article-title":"Gli proteins in development and disease","volume":"27","author":"Hui","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib35","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1126\/science.1124534","article-title":"The primary cilium as the cell\u2019s antenna: signaling at a sensory organelle","volume":"313","author":"Singla","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2012.12.028_bib36","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.devcel.2008.11.010","article-title":"Hedgehog signaling in development and cancer","volume":"15","author":"Jiang","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.yexcr.2012.12.028_bib37","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1101\/gad.1693608","article-title":"Hedgehog: functions and mechanisms","volume":"22","author":"Varjosalo","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.yexcr.2012.12.028_bib38","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1101\/gad.11.24.3286","article-title":"Wnt signaling: a common theme in animal development","volume":"11","author":"Cadigan","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.yexcr.2012.12.028_bib39","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1146\/annurev.cellbio.14.1.59","article-title":"Mechanisms of Wnt signaling in development","volume":"14","author":"Wodarz","year":"1998","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib40","doi-asserted-by":"crossref","first-page":"19185","DOI":"10.1074\/jbc.M414275200","article-title":"Developmental regulation of Wnt\/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification","volume":"280","author":"Tamamura","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2012.12.028_bib41","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.2353\/ajpath.2009.081173","article-title":"Transient activation of Wnt\/{beta}-catenin signaling induces abnormal growth plate closure and articular cartilage thickening in postnatal mice","volume":"175","author":"Yuasa","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib42","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/ncb1670","article-title":"Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms","volume":"10","author":"Corbit","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/ncb0108-11","article-title":"Cilia put a brake on Wnt signalling","volume":"10","author":"He","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib44","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/ng2038","article-title":"IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy","volume":"39","author":"Beales","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yexcr.2012.12.028_bib45","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1167\/iovs.09-4312","article-title":"The intraflagellar transport protein ift80 is essential for photoreceptor survival in a zebrafish model of jeune asphyxiating thoracic dystrophy","volume":"51","author":"Hudak","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.yexcr.2012.12.028_bib46","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/jmg.2009.069468","article-title":"Mutation in IFT80 in a fetus with the phenotype of Verma-Naumoff provides molecular evidence for Jeune-Verma-Naumoff dysplasia spectrum","volume":"48","author":"Cavalcanti","year":"2011","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.yexcr.2012.12.028_bib47","article-title":"Integration of a novel injectable nano calcium sulfate\/alginate scaffold and BMP2 gene-modified mesenchymal stem cells for bone regeneration","author":"He","year":"2012","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.yexcr.2012.12.028_bib48","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1261\/rna.2192803","article-title":"Lentivirus-delivered stable gene silencing by RNAi in primary cells","volume":"9","author":"Stewart","year":"2003","journal-title":"RNA"},{"key":"10.1016\/j.yexcr.2012.12.028_bib49","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1101\/gad.1544107","article-title":"RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulation","volume":"21","author":"Yang","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.yexcr.2012.12.028_bib50","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1359\/jbmr.061007","article-title":"RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro","volume":"22","author":"Yang","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.yexcr.2012.12.028_bib51","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.7150\/ijbs.5136","article-title":"Collagen XXIV (Col24alpha1) promotes osteoblastic differentiation and mineralization through TGF-beta\/Smads signaling pathway","volume":"8","author":"Wang","year":"2012","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.yexcr.2012.12.028_bib52","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1038\/onc.2010.235","article-title":"GLI3-dependent repression of DR4 mediates hedgehog antagonism of TRAIL-induced apoptosis","volume":"29","author":"Kurita","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2012.12.028_bib53","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1242\/jcs.095893","article-title":"Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia","volume":"125","author":"Qiu","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2012.12.028_bib54","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1007\/BF01974689","article-title":"Teratogenicity of arotinoids (retinoids) in vivo and in vitro","volume":"64","author":"Kistler","year":"1990","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib55","doi-asserted-by":"crossref","first-page":"21666","DOI":"10.1073\/pnas.0912180106","article-title":"Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus","volume":"106","author":"Kim","year":"2009","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"10.1016\/j.yexcr.2012.12.028_bib56","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1534\/g3.111.000919","article-title":"Whole-genome sequencing to identify mutants and polymorphisms in Chlamydomonas reinhardtii","volume":"2","author":"Dutcher","year":"2012","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.yexcr.2012.12.028_bib57","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1093\/hmg\/ddr013","article-title":"An Ift80 mouse model of short rib polydactyly syndromes shows defects in hedgehog signalling without loss or malformation of cilia","volume":"20","author":"Rix","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2012.12.028_bib58","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.bone.2012.06.021","article-title":"The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesis","volume":"51","author":"Yang","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.yexcr.2012.12.028_bib59","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.cell.2011.05.030","article-title":"A role for the primary cilium in Notch signaling and epidermal differentiation during skin development","volume":"145","author":"Ezratty","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2012.12.028_bib60","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2174\/138920211795860134","article-title":"Keeping the balance between proliferation and differentiation: the primary cilium","volume":"12","author":"Irigoin","year":"2011","journal-title":"Curr. Genomics"},{"key":"10.1016\/j.yexcr.2012.12.028_bib61","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s12195-010-0127-x","article-title":"The role of primary cilia in mesenchymal stem cell differentiation: a pivotal switch in guiding lineage commitment","volume":"3","author":"Tummala","year":"2010","journal-title":"Cell. Mol. Bioeng."},{"key":"10.1016\/j.yexcr.2012.12.028_bib62","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1093\/hmg\/ddr613","article-title":"Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies","volume":"21","author":"Ashe","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2012.12.028_bib63","article-title":"Roles of Wnt signals in bone resorption during physiological and pathological states","author":"Maeda","year":"2012","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.yexcr.2012.12.028_bib64","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cell.2006.10.018","article-title":"Wnt\/beta-catenin signaling in development and disease","volume":"127","author":"Clevers","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2012.12.028_bib65","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1242\/dev.02546","article-title":"Wnt\/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation","volume":"133","author":"Mak","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2012.12.028_bib66","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1242\/jcs.00152","article-title":"Wnt regulation of chondrocyte differentiation","volume":"115","author":"Church","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2012.12.028_bib67","article-title":"Ift88 regulates hedgehog signaling, Sfrp5 expression, and beta-catenin activity in post-natal growth plate","author":"Chang","year":"2012","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.yexcr.2012.12.028_bib68","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrm2654","article-title":"Beta-catenin hits chromatin: regulation of Wnt target gene activation","volume":"10","author":"Mosimann","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yexcr.2012.12.028_bib69","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.2860","article-title":"Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model","volume":"18","author":"McIntyre","year":"2012","journal-title":"Nat. Med."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482713000165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482713000165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T06:14:33Z","timestamp":1562566473000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482713000165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":69,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0014482713000165"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2012.12.028","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}