{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:37:32Z","timestamp":1787499452901,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.yexcr.2013.05.014","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T19:17:00Z","timestamp":1369336620000},"page":"2058-2072","source":"Crossref","is-referenced-by-count":33,"title":["Small interfering RNA targeting ILK inhibits metastasis in human tongue cancer cells through repression of epithelial-to-mesenchymal transition"],"prefix":"10.1016","volume":"319","author":[{"given":"Yu","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixiong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2013.05.014_bib1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.oraloncology.2010.02.015","article-title":"Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival","volume":"46","author":"Warnakulasuriya","year":"2010","journal-title":"Oral. Oncol."},{"key":"10.1016\/j.yexcr.2013.05.014_bib2","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.oraloncology.2010.06.008","article-title":"Prognostic evaluation of oral tongue cancer: means, markers and perspectives (II)","volume":"46","author":"Bello","year":"2010","journal-title":"Oral. Oncol."},{"key":"10.1016\/j.yexcr.2013.05.014_bib3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/emboj.2009.376","article-title":"The ILK\/PINCH\/parvin complex: the kinase is dead, long live the pseudokinase!","volume":"29","author":"Wickstrom","year":"2010","journal-title":"EMBO. J."},{"key":"10.1016\/j.yexcr.2013.05.014_bib4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.ceb.2012.06.003","article-title":"ILK: a pseudokinase in the center stage of cell\u2013matrix adhesion and signaling","volume":"24","author":"Qin","year":"2012","journal-title":"Curr. Opin. Cell. Biol."},{"key":"10.1016\/j.yexcr.2013.05.014_bib5","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1242\/jcs.081422","article-title":"A central multifunctional role of integrin-linked kinase at muscle attachment sites","volume":"124","author":"Zervas","year":"2011","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.yexcr.2013.05.014_bib6","doi-asserted-by":"crossref","first-page":"e24115","DOI":"10.1371\/journal.pone.0024115","article-title":"The impairment of ILK related angiogenesis involved in cardiac maladaptation after infarction","volume":"6","author":"Xie","year":"2011","journal-title":"PloS one"},{"key":"10.1016\/j.yexcr.2013.05.014_bib7","doi-asserted-by":"crossref","first-page":"e16984","DOI":"10.1371\/journal.pone.0016984","article-title":"Integrin-linked kinase overexpression and its oncogenic role in promoting tumorigenicity of hepatocellular carcinoma","volume":"6","author":"Chan","year":"2011","journal-title":"PloS one"},{"key":"10.1016\/j.yexcr.2013.05.014_bib8","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1365-2559.2010.03556.x","article-title":"ILK expression in human basal cell carcinoma correlates with epithelial\u2013mesenchymal transition markers and tumour invasion","volume":"56","author":"Papanikolaou","year":"2010","journal-title":"Histopathology"},{"key":"10.1016\/j.yexcr.2013.05.014_bib9","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jtcvs.2011.04.034","article-title":"Detection of integrin-linked kinase in the serum of patients with malignant pleural mesothelioma","volume":"142","author":"Watzka","year":"2011","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.yexcr.2013.05.014_bib10","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/bcr2252","volume":"11","author":"Kalra","year":"2009","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.yexcr.2013.05.014_bib11","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1016\/j.febslet.2012.05.050","article-title":"Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK","volume":"586","author":"Wang","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yexcr.2013.05.014_bib12","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.ctrv.2011.11.001","article-title":"Epithelial\u2013mesenchymal transition and breast cancer: role, molecular mechanisms and clinical impact","volume":"38","author":"Foroni","year":"2012","journal-title":"Cancer. Treat. Rev."},{"key":"10.1016\/j.yexcr.2013.05.014_bib13","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.semcancer.2012.02.013","article-title":"EMT as the ultimate survival mechanism of cancer cells","volume":"22","author":"Tiwari","year":"2012","journal-title":"Semin. Cancer. Biol."},{"key":"10.1016\/j.yexcr.2013.05.014_bib14","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexcr.2013.05.014_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2012.05.011","article-title":"Epithelial to mesenchymal transition (EMT) biomarkers \u2013 E-cadherin, beta-catenin, APC and Vimentin \u2013 in oral squamous cell carcinogenesis and transformation","author":"Chaw","year":"2012","journal-title":"Oral. Oncol."},{"key":"10.1016\/j.yexcr.2013.05.014_bib16","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1245\/s10434-011-2052-1","article-title":"Overexpression of SIP1 and downregulation of E-cadherin predict delayed neck metastasis in stage I\/II oral tongue squamous cell carcinoma after partial glossectomy","volume":"19","author":"Sakamoto","year":"2012","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.yexcr.2013.05.014_bib17","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/onc.2011.263","article-title":"MiR-200b and miR-15b regulate chemotherapy-induced epithelial\u2013mesenchymal transition in human tongue cancer cells by targeting BMI1","volume":"31","author":"Sun","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2013.05.014_bib18","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.biocel.2011.05.003","article-title":"Small interfering RNA targeting integrin-linked kinase inhibited the growth and induced apoptosis in human bladder cancer cells","volume":"43","author":"Gao","year":"2011","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"10.1016\/j.yexcr.2013.05.014_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1001\/archotol.133.1.15","article-title":"Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck","volume":"133","author":"Younes","year":"2007","journal-title":"Arch. Otolaryngol. Head. Neck. Surg."},{"key":"10.1016\/j.yexcr.2013.05.014_bib20","first-page":"97","article-title":"The establishment and some biological characteristics of a squamous cell cancer cell line of the human tongue (TCA 8113)","volume":"3","author":"He","year":"1983","journal-title":"Tumor"},{"key":"10.1016\/j.yexcr.2013.05.014_bib21","first-page":"152","article-title":"Establishement of a metastatic cell line from brain metastasis induced by injection of tongue cancer Tca8113 cells in nude mouse","volume":"6","author":"Wu","year":"1999","journal-title":"J. Pract. Stomatol."},{"key":"10.1016\/j.yexcr.2013.05.014_bib22","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1007\/s10495-012-0769-3","article-title":"Balance between apoptosis or survival induced by changes in extracellular-matrix composition in human mesangial cells: a key role for ILK-NFkappaB pathway","volume":"17","author":"Del Nogal","year":"2012","journal-title":"Apoptosis: Int. J. Program. Cell Death"},{"key":"10.1016\/j.yexcr.2013.05.014_bib23","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1016\/j.ejca.2008.07.021","article-title":"Expression of integrin-linked kinase and its binding partners in chondrosarcoma: association with prognostic significance","volume":"44","author":"Papachristou","year":"2008","journal-title":"Eur. J. Cancer."},{"key":"10.1016\/j.yexcr.2013.05.014_bib24","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1242\/jcs.017996","article-title":"Integrin-linked kinase--essential roles in physiology and cancer biology","volume":"121","author":"McDonald","year":"2008","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.yexcr.2013.05.014_bib25","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1083\/jcb.200710074","article-title":"Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization","volume":"180","author":"Fielding","year":"2008","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.yexcr.2013.05.014_bib26","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1101\/gad.255603","article-title":"Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation","volume":"17","author":"Sakai","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.yexcr.2013.05.014_bib27","first-page":"75","article-title":"Epithelial\u2013mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic","volume":"1796","author":"Voulgari","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexcr.2013.05.014_bib28","doi-asserted-by":"crossref","first-page":"6715","DOI":"10.1158\/0008-5472.CAN-10-1377","article-title":"Functional roles of multiple feedback loops in extracellular signal-regulated kinase and Wnt signaling pathways that regulate epithelial-mesenchymal transition","volume":"70","author":"Shin","year":"2010","journal-title":"Cancer. Res."},{"key":"10.1016\/j.yexcr.2013.05.014_bib29","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/embor.2008.30","article-title":"The physiology and pathology of the EMT. Meeting on the epithelial\u2013mesenchymal transition","volume":"9","author":"Acloque","year":"2008","journal-title":"EMBO. Rep."},{"key":"10.1016\/j.yexcr.2013.05.014_bib30","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1038\/bjc.2011.452","article-title":"E\/N-cadherin switch mediates cancer progression via TGF-beta-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma","volume":"105","author":"Araki","year":"2011","journal-title":"Br. J. Cancer."},{"key":"10.1016\/j.yexcr.2013.05.014_bib31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrc2620","article-title":"Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits","volume":"9","author":"Polyak","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.yexcr.2013.05.014_bib32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1083\/jcb.201001073","article-title":"Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2\/ASF proto-oncogene","volume":"191","author":"Valacca","year":"2010","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.yexcr.2013.05.014_bib33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrc2131","article-title":"Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?","volume":"7","author":"Peinado","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.yexcr.2013.05.014_bib34","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1038\/onc.2008.118","article-title":"Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines","volume":"27","author":"Olmeda","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2013.05.014_bib35","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1242\/bio.20121867","article-title":"Adhesion rings surround invadopodia and promote maturation","volume":"1","author":"Branch","year":"2012","journal-title":"Biol. Open"},{"key":"10.1016\/j.yexcr.2013.05.014_bib36","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1158\/0008-5472.CAN-07-5869","article-title":"Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival","volume":"68","author":"McDonald","year":"2008","journal-title":"Cancer. Res."},{"key":"10.1016\/j.yexcr.2013.05.014_bib37","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1158\/1535-7163.MCT-05-0258","article-title":"Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma","volume":"4","author":"Koul","year":"2005","journal-title":"Mol. Cancer. Ther."},{"key":"10.1016\/j.yexcr.2013.05.014_bib38","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000101306","article-title":"Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions","volume":"185","author":"Doble","year":"2007","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.yexcr.2013.05.014_bib39","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/dvdy.21685","article-title":"Integrin-linked kinase regulates E-cadherin expression through PARP-1","volume":"237","author":"McPhee","year":"2008","journal-title":"Dev. Dynam.: Off. Pub. Am. Assoc. Anatomists"},{"key":"10.1016\/j.yexcr.2013.05.014_bib40","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/bjc.2012.24","article-title":"Acquisition of EMT phenotype in the gefitinib-resistant cells of a head and neck squamous cell carcinoma cell line through Akt\/GSK-3beta\/snail signalling pathway","volume":"106","author":"Maseki","year":"2012","journal-title":"Br. J. Cancer."},{"key":"10.1016\/j.yexcr.2013.05.014_bib41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2407-11-49","article-title":"Activation of beta-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters","volume":"11","author":"Li","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.yexcr.2013.05.014_bib42","doi-asserted-by":"crossref","first-page":"6343","DOI":"10.1038\/onc.2010.366","article-title":"Suppression of Her2\/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1","volume":"29","author":"Kalra","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2013.05.014_bib43","article-title":"Role of the integrin-linked kinase (ILK)\/Rictor complex in TGFbeta-1-induced epithelial-mesenchymal transition (EMT)","author":"Serrano","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2013.05.014_bib44","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/jb\/mvr044","article-title":"Cancer early dissemination: cancerous epithelial-mesenchymal transdifferentiation and transforming growth factor beta signalling","volume":"149","author":"Sabe","year":"2011","journal-title":"J. Biochem."},{"key":"10.1016\/j.yexcr.2013.05.014_bib45","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10911-010-9178-9","article-title":"Epithelial\u2013mesenchymal transition in cancer: parallels between normal development and tumor progression","volume":"15","author":"Micalizzi","year":"2010","journal-title":"J. Mammary. Gland. Biol. Neoplasia"},{"key":"10.1016\/j.yexcr.2013.05.014_bib46","doi-asserted-by":"crossref","first-page":"8211","DOI":"10.1158\/0008-5472.CAN-10-0202","article-title":"Vascular endothelial growth factor receptor-1 signaling promotes mobilization of macrophage lineage cells from bone marrow and stimulates solid tumor growth","volume":"70","author":"Muramatsu","year":"2010","journal-title":"Cancer. Res."}],"updated-by":[{"DOI":"10.1016\/j.yexcr.2022.113391","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000}}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482713002206?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482713002206?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T20:09:55Z","timestamp":1588795795000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482713002206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":46,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0014482713002206"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2013.05.014","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]}}}