{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:29:14Z","timestamp":1789770554338,"version":"4.0.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.yexcr.2013.10.004","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T12:02:26Z","timestamp":1381838546000},"page":"17-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Non-canonical functions of the peripheral nerve"],"prefix":"10.1016","volume":"321","author":[{"given":"Mark\u00e9ta","family":"Kauck\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Adameyko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2013.10.004_bib1","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1007\/s00018-010-0390-y","article-title":"Glial versus melanocyte cell fate choice: Schwann cell precursors as a cellular origin of melanocytes","volume":"67","author":"Adameyko","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.yexcr.2013.10.004_bib2","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cell.2009.07.049","article-title":"Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin","volume":"139","author":"Adameyko","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2013.10.004_bib3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1242\/dev.065581","article-title":"Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest","volume":"139","author":"Adameyko","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2013.10.004_bib4","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuron.2012.06.021","article-title":"c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration","volume":"75","author":"Arthur-Farraj","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.yexcr.2013.10.004_bib5","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.stem.2009.10.019","article-title":"SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cells","volume":"5","author":"Biernaskie","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.yexcr.2013.10.004_bib6","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1002\/glia.20753","article-title":"Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation","volume":"56","author":"Birchmeier","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.yexcr.2013.10.004_bib7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1469-7580.2010.01313.x","article-title":"Peripheral nerve regeneration in the MRL\/MpJ ear wound model","volume":"218","author":"Buckley","year":"2011","journal-title":"J. Anat."},{"key":"10.1016\/j.yexcr.2013.10.004_bib8","doi-asserted-by":"crossref","first-page":"e1002044","DOI":"10.1371\/journal.pgen.1002044","article-title":"Post-embryonic nerve-associated precursors to adult pigment cells: genetic requirements and dynamics of morphogenesis and differentiation","volume":"7","author":"Budi","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.yexcr.2013.10.004_bib9","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1002\/glia.20776","article-title":"How does the Schwann cell lineage form tumors in NF1?","volume":"56","author":"Carroll","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.yexcr.2013.10.004_bib10","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1242\/dev.087007","article-title":"On the embryonic origin of adult melanophores: the role of ErbB and Kit signalling in establishing melanophore stem cells in zebrafish","volume":"140","author":"Dooley","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2013.10.004_bib11","doi-asserted-by":"crossref","first-page":"5229","DOI":"10.1073\/pnas.0831229100","article-title":"Reversal of developmental restrictions in neural crest lineages: transition from Schwann cells to glial-melanocytic precursors in vitro","volume":"100","author":"Dupin","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.yexcr.2013.10.004_bib12","doi-asserted-by":"crossref","first-page":"6503","DOI":"10.1073\/pnas.1015449108","article-title":"Dual origin of mesenchymal stem cells contributing to organ growth and repair","volume":"108","author":"Feng","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.yexcr.2013.10.004_bib13","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/ncb1181","article-title":"A dermal niche for multipotent adult skin-derived precursor cells","volume":"6","author":"Fernandes","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2013.10.004_bib14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1098\/rstb.2006.2020","article-title":"Multipotent skin-derived precursors: adult neural crest-related precursors with therapeutic potential","volume":"363","author":"Fernandes","year":"2008","journal-title":"Philos. Trans. R. Soc. Lond. B: Biol. Sci."},{"key":"10.1016\/j.yexcr.2013.10.004_bib15","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1056\/NEJM199604253341707","article-title":"Mechanisms of disease \u2013 the enteric nervous system","volume":"334","author":"Goyal","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yexcr.2013.10.004_bib16","first-page":"535","article-title":"[Role of the nervous system during the regeneration of an arm in a starfish: Asterina gibbosa Penn. (Echinodermata, Asteriidae)]","volume":"33","author":"Huet","year":"1975","journal-title":"J. Embryol. Exp. Morphol."},{"key":"10.1016\/j.yexcr.2013.10.004_bib17","doi-asserted-by":"crossref","first-page":"e1000544","DOI":"10.1371\/journal.pgen.1000544","article-title":"Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes","volume":"5","author":"Hultman","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.yexcr.2013.10.004_bib18","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ydbio.2009.11.019","article-title":"Differential contribution of direct-developing and stem cell-derived melanocytes to the zebrafish larval pigment pattern","volume":"337","author":"Hultman","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.yexcr.2013.10.004_bib19","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrn1746","article-title":"The origin and development of glial cells in peripheral nerves","volume":"6","author":"Jessen","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.yexcr.2013.10.004_bib20","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1002\/glia.20761","article-title":"Negative regulation of myelination: relevance for development, injury, and demyelinating disease","volume":"56","author":"Jessen","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.yexcr.2013.10.004_bib21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.stemcr.2013.04.004","article-title":"Sox2-mediated regulation of adult neural crest precursors and skin repair","volume":"1","author":"Johnston","year":"2013","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.yexcr.2013.10.004_bib22","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1242\/dev.01429","article-title":"Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells","volume":"131","author":"Joseph","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2013.10.004_bib23","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/CMR.0b013e32831270d7","article-title":"Melanocytic schwannoma of the cutaneous and subcutaneous tissues: three cases and a review of the literature","volume":"18","author":"Kaehler","year":"2008","journal-title":"Melanoma Res."},{"key":"10.1016\/j.yexcr.2013.10.004_bib24","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/dbio.2002.0568","article-title":"Developmental changes in Notch1 and numb expression mediated by local cell\u2013cell interactions underlie progressively increasing delta sensitivity in neural crest stem cells","volume":"244","author":"Kubu","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.yexcr.2013.10.004_bib25","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.tins.2012.08.003","article-title":"Nerve dependence in tissue, organ, and appendage regeneration","volume":"35","author":"Kumar","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.yexcr.2013.10.004_bib26","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1126\/science.1147710","article-title":"Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate","volume":"318","author":"Kumar","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2013.10.004_bib27","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/(SICI)1096-9861(19970811)384:4<483::AID-CNE1>3.0.CO;2-Z","article-title":"Peripheral development of cranial nerves in a cyclostome, Lampetra japonica: morphological distribution of nerve branches and the vertebrate body plan","volume":"384","author":"Kuratani","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.yexcr.2013.10.004_bib28","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1113\/jphysiol.1975.sp011017","article-title":"The development of functional innervation in the hind limb of the chick embryo","volume":"249","author":"Landmesser","year":"1975","journal-title":"J. Physiol."},{"key":"10.1016\/j.yexcr.2013.10.004_bib29","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1126\/science.3952494","article-title":"Cell line segregation during peripheral nervous system ontogeny","volume":"231","author":"Le Douarin","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2013.10.004_bib30","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1242\/dev.01350","article-title":"Neural crest cell plasticity and its limits","volume":"131","author":"Le Douarin","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2013.10.004_bib31","first-page":"323","article-title":"Tissue patterning in the developing mouse limb","volume":"34","author":"Martin","year":"1990","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.yexcr.2013.10.004_bib32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cell.2012.12.014","article-title":"Reprogramming adult Schwann cells to stem cell-like cells by leprosy bacilli promotes dissemination of infection","volume":"152","author":"Masaki","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2013.10.004_bib33","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1180616","article-title":"The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer","volume":"327","author":"Murchison","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2013.10.004_bib34","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1306287110","article-title":"Neural crest and Schwann cell progenitor-derived melanocytes are two spatially segregated populations similarly regulated by Foxd3","author":"Nitzan","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.yexcr.2013.10.004_bib35","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1002\/stem.751","article-title":"Concise review: transmissible animal tumors as models of the cancer stem-cell process","volume":"29","author":"O'Neill","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.yexcr.2013.10.004_bib36","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1440-0960.2009.00562.x","article-title":"Cutaneous malignant melanoma arising in an acquired naevus of Ota","volume":"50","author":"Patterson","year":"2009","journal-title":"Australas. J. Dermatol."},{"key":"10.1016\/j.yexcr.2013.10.004_bib37","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/39593","article-title":"Severe neuropathies in mice with targeted mutations in the ErbB3 receptor","volume":"389","author":"Riethmacher","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2013.10.004_bib38","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1242\/dev.118.4.1313","article-title":"Basic fibroblast growth factor (bFGF) acts intracellularly to cause the transdifferentiation of avian neural crest-derived Schwann cell precursors into melanocytes","volume":"118","author":"Sherman","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2013.10.004_bib39","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1006\/dbio.1993.1286","article-title":"Genetic analysis of developmental mechanisms in hydra. XXI. Enhancement of regeneration in a regeneration-deficient mutant strain by the elimination of the interstitial cell lineage","volume":"160","author":"Sugiyama","year":"1993","journal-title":"Dev. Biol."},{"key":"10.1016\/j.yexcr.2013.10.004_bib40","first-page":"84","article-title":"On the process of reproduction of the members of the aquatic salamander","volume":"16","author":"Todd","year":"1823","journal-title":"Q. J. Sci. Lit. Arts"},{"key":"10.1016\/j.yexcr.2013.10.004_bib41","doi-asserted-by":"crossref","first-page":"e21010","DOI":"10.1371\/journal.pone.0021010","article-title":"Lineage relationship of direct-developing melanocytes and melanocyte stem cells in the zebrafish","volume":"6","author":"Tryon","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.yexcr.2013.10.004_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.1994.1228","article-title":"Evidence for a neural influence on tooth germ generation in a polyphyodont species","volume":"165","author":"Tuisku","year":"1994","journal-title":"Dev. Biol."},{"key":"10.1016\/j.yexcr.2013.10.004_bib43","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1016\/j.athoracsur.2009.07.030","article-title":"Skin depigmentation: could it be a complication caused by thoracic sympathectomy","volume":"88","author":"Westphal","year":"2009","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.yexcr.2013.10.004_bib44","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cell.2011.09.053","article-title":"Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche","volume":"147","author":"Yamazaki","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2013.10.004_bib45","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1242\/dev.02533","article-title":"Small molecule-induced ablation and subsequent regeneration of larval zebrafish melanocytes","volume":"133","author":"Yang","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2013.10.004_bib46","doi-asserted-by":"crossref","first-page":"22329","DOI":"10.1073\/pnas.0907464106","article-title":"Planarian Hedgehog\/patched establishes anterior-posterior polarity by regulating Wnt signaling","volume":"106","author":"Yazawa","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.yexcr.2013.10.004_bib47","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/BF02254984","article-title":"Melanocyte destruction and repigmentation in vitiligo: a model for nerve cell damage and regrowth","volume":"9","author":"Yu","year":"2002","journal-title":"J. Biomed. Sci."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482713004217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482713004217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:16:20Z","timestamp":1757996180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482713004217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0014482713004217"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2013.10.004","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-canonical functions of the peripheral nerve","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2013.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}