{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:26:43Z","timestamp":1785281203844,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Science and Technological Development of the Republic of Serbia","award":["173053"],"award-info":[{"award-number":["173053"]}]},{"name":"Ministry of Science and Technological Development of the Republic of Serbia","award":["41025"],"award-info":[{"award-number":["41025"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.yexcr.2014.05.021","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T13:09:31Z","timestamp":1401973771000},"page":"90-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Idarubicin induces mTOR-dependent cytotoxic autophagy in leukemic cells"],"prefix":"10.1016","volume":"326","author":[{"given":"Biljana","family":"Ristic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihajlo","family":"Bosnjak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Arsikin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Mircic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Suzin-Zivkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrija","family":"Bogdanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Perovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Martinovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Kravic-Stevovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Bumbasirevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Trajkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljubica","family":"Harhaji-Trajkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2014.05.021_bib1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.yexcr.2014.05.021_bib2","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2014.05.021_bib3","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/cdd.2009.47","article-title":"Toward the understanding of autophagy regulation and its interplay with cell death pathways","volume":"16","author":"Fimia","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.yexcr.2014.05.021_bib4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0070-2153(06)78006-1","article-title":"Autophagy and cell death","volume":"78","author":"Gozuacik","year":"2007","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.yexcr.2014.05.021_bib5","doi-asserted-by":"crossref","first-page":"399","DOI":"10.4161\/auto.5907","article-title":"Autophagic cell death unraveled: pharmacological inhibition of apoptosis and autophagy enables necrosis","volume":"4","author":"White","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.yexcr.2014.05.021_bib6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00005-012-0205-y","article-title":"Autophagy, apoptosis, mitoptosis and necrosis: interdependence between those pathways and effects on cancer","volume":"61","author":"Chaabane","year":"2013","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"},{"key":"10.1016\/j.yexcr.2014.05.021_bib7","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1046\/j.1365-2141.1997.2623081.x","article-title":"Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells","volume":"98","author":"Jia","year":"1997","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.yexcr.2014.05.021_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1365-2141.2008.07555.x","article-title":"Involvement of macroautophagy in the caspase-independent killing of Burkitt lymphoma cell lines by rituximab","volume":"145","author":"Turzanski","year":"2009","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.yexcr.2014.05.021_bib9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2165\/00002512-199711010-00006","article-title":"Oral idarubicin. A review of its pharmacological properties and clinical efficacy in the treatment of haematological malignancies and advanced breast cancer","volume":"11","author":"Buckley","year":"1997","journal-title":"Drugs Aging"},{"key":"10.1016\/j.yexcr.2014.05.021_bib10","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1124\/pr.56.2.6","article-title":"Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity","volume":"56","author":"Minotti","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.yexcr.2014.05.021_bib11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0005-2736(97)00241-1","article-title":"Comparison of the interaction of doxorubicin, daunorubicin, idarubicin and idarubicinol with large unilamellar vesicles. Circular dichroism study","volume":"1370","author":"Gallois","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexcr.2014.05.021_bib12","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/CAD.0b013e32832f4e6f","article-title":"Alterations of cellular organelles in human liver-derived hepatoma G2 cells induced by adriamycin","volume":"20","author":"Qian","year":"2009","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.yexcr.2014.05.021_bib13","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.bcp.2008.12.016","article-title":"Apoptosis, autophagy, accelerated senescence and reactive oxygen in the response of human breast tumor cells to adriamycin","volume":"77","author":"Di","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.yexcr.2014.05.021_bib14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ijcard.2008.01.043","article-title":"Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure","volume":"134","author":"Lu","year":"2009","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.yexcr.2014.05.021_bib15","doi-asserted-by":"crossref","first-page":"e28491","DOI":"10.1371\/journal.pone.0028491","article-title":"Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells","volume":"6","author":"Han","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.yexcr.2014.05.021_bib16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1258\/ebm.2011.011106","article-title":"Daunorubicin therapy is associated with upregulation of E3 ubiquitin ligases in the heart","volume":"237","author":"Sishi","year":"2012","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.yexcr.2014.05.021_bib17","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.4161\/auto.7.9.16521","article-title":"Autophagy protects breast cancer cells from epirubicin-induced apoptosis and facilitates epirubicin-resistance development","volume":"7","author":"Sun","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.yexcr.2014.05.021_bib18","first-page":"937","article-title":"The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes","volume":"114","author":"Vardiman","year":"2009"},{"key":"10.1016\/j.yexcr.2014.05.021_bib19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1006\/abio.1996.0383","article-title":"An acid phosphatase assay for quantifying the growth of adherent and nonadherent cells","volume":"241","author":"Yang","year":"1996","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.yexcr.2014.05.021_bib20","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/ijc.21080","article-title":"Novel platinum(IV) complexes induce rapid tumor cell death in vitro","volume":"116","author":"Kaludjerovic","year":"2005","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.yexcr.2014.05.021_bib21","first-page":"657","article-title":"Stathmo-apoptosis: arresting apoptosis by fluorochrome-labeled inhibitor of caspases","volume":"19","author":"Smolewski","year":"2001","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.yexcr.2014.05.021_bib22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2014.05.021_bib23","first-page":"19","article-title":"Caspases\u2014their role in apoptosis and other physiological processes as revealed by knock-out studies","volume":"50","author":"Sadowski-Debbing","year":"2002","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"},{"key":"10.1016\/j.yexcr.2014.05.021_bib24","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1046\/j.1432-1327.1998.2540439.x","article-title":"Apoptosis signaling by death receptors","volume":"254","author":"Schulze-Osthoff","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.yexcr.2014.05.021_bib25","doi-asserted-by":"crossref","first-page":"585","DOI":"10.4161\/auto.5.5.8823","article-title":"In search of an \u201cautophagomometer\u201d","volume":"5","author":"Rubinsztein","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.yexcr.2014.05.021_bib26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrm3249","article-title":"Canonical and non-canonical autophagy: variations on a common theme of self-eating?","volume":"13","author":"Codogno","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yexcr.2014.05.021_bib27","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1432-1033.1997.0240a.x","article-title":"The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes","volume":"243","author":"Blommaart","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.yexcr.2014.05.021_bib28","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1083\/jcb.63.2.430","article-title":"Protein degradation in cultured cells. II. The uptake of chloroquine by rat fibroblasts and the inhibition of cellular protein degradation and cathepsin B1","volume":"63","author":"Wibo","year":"1974","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2014.05.021_bib29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1247\/csf.23.33","article-title":"Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells","volume":"23","author":"Yamamoto","year":"1998","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.yexcr.2014.05.021_bib30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0014-4827(78)90289-6","article-title":"Specific inhibition by NH4Cl of autophagy-associated proteloysis in cultured fibroblasts","volume":"115","author":"Amenta","year":"1978","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2014.05.021_bib31","doi-asserted-by":"crossref","first-page":"6561","DOI":"10.1073\/pnas.1204429109","article-title":"Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death","volume":"109","author":"Gammoh","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yexcr.2014.05.021_bib32","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/1479-5876-9-161","article-title":"c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells","volume":"9","author":"Sun","year":"2011","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.yexcr.2014.05.021_bib33","doi-asserted-by":"crossref","first-page":"691","DOI":"10.4161\/cbt.12.8.15978","article-title":"Atorvastatin induces autophagy in prostate cancer PC3 cells through activation of LC3 transcription","volume":"12","author":"Toepfer","year":"2011","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.yexcr.2014.05.021_bib34","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1038\/cdd.2010.53","article-title":"Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN\/SkiL expression in ovarian carcinoma cells","volume":"17","author":"Smith","year":"2010","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.yexcr.2014.05.021_bib35","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.4161\/auto.6.8.13336","article-title":"Beclin 1-independent autophagy induced by a Bcl-XL\/Bcl-2 targeting compound, Z18","volume":"6","author":"Tian","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.yexcr.2014.05.021_bib36","doi-asserted-by":"crossref","first-page":"6319","DOI":"10.1128\/JVI.02627-10","article-title":"Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment","volume":"85","author":"Li","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.yexcr.2014.05.021_bib37","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3324\/haematol.2009.013797","article-title":"Role of the PI3K\/AKT and mTOR signaling pathways in acute myeloid leukemia","volume":"95","author":"Park","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.yexcr.2014.05.021_bib38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/CIRCULATIONAHA.108.799700","article-title":"Acute doxorubicin cardiotoxicity is associated with p53-induced inhibition of the mammalian target of rapamycin pathway","volume":"119","author":"Zhu","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.yexcr.2014.05.021_bib39","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12013-011-9153-0","article-title":"Activation of AMP-activated protein kinase contributes to doxorubicin-induced cell death and apoptosis in cultured myocardial H9c2 cells","volume":"60","author":"Chen","year":"2011","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.yexcr.2014.05.021_bib40","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3892\/ijo.2012.1680","article-title":"N-acetylcysteine potentiates doxorubicin-induced ATM and p53 activation in ovarian cancer cells","volume":"42","author":"Brum","year":"2013","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.yexcr.2014.05.021_bib41","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/10623320490904124","article-title":"Differential toxicity of anthracyclines on cultured endothelial cells","volume":"11","author":"Kaushal","year":"2004","journal-title":"Endothelium"},{"key":"10.1016\/j.yexcr.2014.05.021_bib42","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/j.febslet.2009.05.054","article-title":"Ubiquitin ligase Cbl-b sensitizes leukemia and gastric cancer cells to anthracyclines by activating the mitochondrial pathway and modulating Akt and ERK survival signals","volume":"583","author":"Qu","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yexcr.2014.05.021_bib43","first-page":"958","article-title":"Interplay between PI3K\/Akt and MAPK signaling pathways in DNA-damaging drug-induced apoptosis","volume":"2006","author":"Lee","year":"1763","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexcr.2014.05.021_bib44","first-page":"1123","article-title":"Activation of caspases-3\/7 is dispensable for idarubicin-induced apoptotic DNA fragmentation in human leukemia cells","volume":"22","author":"Qi","year":"2003","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.yexcr.2014.05.021_bib45","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1073\/pnas.0511288103","article-title":"Autophagic programmed cell death by selective catalase degradation","volume":"103","author":"Yu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yexcr.2014.05.021_bib46","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3109\/10428194.2013.811579","volume":"55","author":"Wu","year":"2013","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.yexcr.2014.05.021_bib47","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/hon.1013","article-title":"Antileukaemia effect of rapamycin alone or in combination with daunorubicin on Ph+ acute lymphoblastic leukaemia cell line","volume":"30","author":"Yang","year":"2012","journal-title":"Hematol. Oncol."},{"key":"10.1016\/j.yexcr.2014.05.021_bib48","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1158\/1078-0432.CCR-10-0890","article-title":"Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-damaging chemotherapy","volume":"17","author":"Pan","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.yexcr.2014.05.021_bib49","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1111\/j.1742-4658.2011.08271.x","article-title":"Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib\u2014the role of extracellular signal-regulated kinase counteraction","volume":"278","author":"Manov","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.yexcr.2014.05.021_bib50","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bcp.2012.10.005","article-title":"Autophagy upregulation promotes survival and attenuates doxorubicin-induced cardiotoxicity","volume":"85","author":"Sishi","year":"2013","journal-title":"Biochem. Pharmacol."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482714002298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482714002298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T04:51:26Z","timestamp":1565499086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482714002298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0014482714002298"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2014.05.021","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Idarubicin induces mTOR-dependent cytotoxic autophagy in leukemic cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2014.05.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}