{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:09:47Z","timestamp":1761235787459},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81000299","39071364"],"award-info":[{"award-number":["81000299","39071364"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of CQ CSTC","doi-asserted-by":"crossref","award":["2010BB5385"],"award-info":[{"award-number":["2010BB5385"]}],"id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Applied Basic Research Programs of the Public Health Bureau Foundation of Chongqing Province","award":["2010-2-126"],"award-info":[{"award-number":["2010-2-126"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.yexcr.2014.07.001","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T20:03:18Z","timestamp":1406923398000},"page":"287-296","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Augmenter of liver regeneration inhibits TGF-\u03b21-induced renal tubular epithelial-to-mesenchymal transition via suppressing T\u03b2R II expression in vitro"],"prefix":"10.1016","volume":"327","author":[{"given":"Xiao-hui","family":"Liao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-tao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru-yu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2014.07.001_bib1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1053\/j.ackd.2005.07.011","article-title":"Progression in chronic kidney disease","volume":"12","author":"Eddy","year":"2005","journal-title":"Adv. Chronic Kidney Dis."},{"key":"10.1016\/j.yexcr.2014.07.001_bib2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/01.ASN.0000102479.92582.43","article-title":"A cytokine released by activated mononuclear cells, induces epithelial cell-myofibroblast transdifferentiation via Jak\/Stat pathway activation","volume":"15","author":"Nightingale","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexcr.2014.07.001_bib3","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI200320530","article-title":"Epithelial-mesenchymal transition and its implications for fibrosis","volume":"112","author":"Kalluri","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexcr.2014.07.001_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ASN.0000106015.29070.E7","article-title":"Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention","volume":"15","author":"Liu","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexcr.2014.07.001_bib5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ncpneph0093","article-title":"Mechanisms of disease: fibroblasts-a new look at an old problem","volume":"2","author":"Neilson","year":"2006","journal-title":"Nat. Clin. Pract. Nephrol."},{"key":"10.1016\/j.yexcr.2014.07.001_bib6","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/ki.2008.425","article-title":"EMT and proteinuria as progression factors","volume":"75","author":"Strutz","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.yexcr.2014.07.001_bib7","first-page":"403","article-title":"BMP-7 counteracts TGF-beta1 epithelial to mesenchymal transiton in human renal proximal tubular epithelial cells","volume":"22","author":"Xu","year":"2009","journal-title":"J. Nephrol."},{"key":"10.1016\/j.yexcr.2014.07.001_bib8","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1681\/ASN.2003090795","article-title":"Mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition","volume":"16","author":"Yang","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexcr.2014.07.001_bib9","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1681\/ASN.2005080866","article-title":"Erythropoietin decreases renal fibrosis in mice with ureteral obstruction:role of inhibiting TGF-beta-induced epithelial-to-mesenchymal transition","volume":"18","author":"Park","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexcr.2014.07.001_bib10","doi-asserted-by":"crossref","first-page":"12068","DOI":"10.1073\/pnas.210397997","article-title":"A viral member of the ERV1\/ALR protein family participates in a cytoplasmic pathway of disulfide bond formation","volume":"97","author":"Senkevich","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yexcr.2014.07.001_bib11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2119\/molmed.2010.00117","article-title":"Liver regeneration associated protein (ALR) exhibits antimetastatic potential in hepatocellular carcinoma","volume":"17","author":"Dayoub","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.yexcr.2014.07.001_bib12","doi-asserted-by":"crossref","first-page":"8142","DOI":"10.1073\/pnas.91.17.8142","article-title":"Cloning and sequence analysis of the rat augmenter of liver regeneration (ALR) gene: expression of biologically active recombinant ALR and demonstration of tissue distribution","volume":"91","author":"Hagiya","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yexcr.2014.07.001_bib13","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1093\/ndt\/gfq151","article-title":"Augmenter of liver regeneration protects kidneys from ischaemia\/reperfusion injury in rats","volume":"25","author":"Liao","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.yexcr.2014.07.001_bib14","doi-asserted-by":"crossref","first-page":"946","DOI":"10.3109\/08860220903216154","article-title":"Expression of augmenter of liver regeneration in rats with gentamicin-induced acute renal failure and its protective effect on kidney","volume":"31","author":"Liao","year":"2009","journal-title":"Ren. Fail."},{"key":"10.1016\/j.yexcr.2014.07.001_bib15","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3109\/0886022X.2012.664470","article-title":"Augmenter of liver regeneration attenuates tubular cell apoptosis in acute kidney injury in rats: the possible mechanisms","volume":"34","author":"Liao","year":"2012","journal-title":"Ren. Fail."},{"key":"10.1016\/j.yexcr.2014.07.001_bib16","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.3748\/wjg.v11.i16.2438","article-title":"Effects of augmentation of liver regeneration recombinant plasmid on rat hepatic fibrosis","volume":"11","author":"Li","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.yexcr.2014.07.001_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1365-2559.2005.02172.x","article-title":"Expression of augmenter of liver regeneration(ALR) in human liver cirrhosis and carcinoma","volume":"47","author":"Thasler","year":"2005","journal-title":"Histopathology"},{"key":"10.1016\/j.yexcr.2014.07.001_bib18","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1440-1797.2005.00334.x","article-title":"Transforming growth factor-\u03b2 and Smad signalling in kidney diseases","volume":"10","author":"Wang","year":"2005","journal-title":"Nephrology"},{"key":"10.1016\/j.yexcr.2014.07.001_bib19","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1242\/jeb.205.14.1979","article-title":"Accumulation of the mitochondrialform of the sulphydryl oxidase Erv1p\/Alrp during the early stages of spermatogenesis","volume":"205","author":"Klissenbauer","year":"2002","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.yexcr.2014.07.001_bib20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.brainres.2005.04.050","article-title":"Expression of the sulfhydryl oxidase ALR (Augmenter of Liver Regeneration) in adult rat brain","volume":"1048","author":"Tury","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.yexcr.2014.07.001_bib21","unstructured":"M. Song, X.Yi, W. Chen, et al. Augmenter of liver regeneration (ALR) gene therapy attenuates CCl4-induced liver injury and fibrosis in rats. Biochem. Bophys. Res. Commun. 415 (2011) 152-156. 10.1016\/j.bbrc.2011.10.039.PMID:22033404"},{"key":"10.1016\/j.yexcr.2014.07.001_bib22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/08923973.2013.764502","article-title":"Augmenter of liver regeneration inhibits apoptosis of activated human peripheral blood lymphocytes in vitro","volume":"35","author":"Wang","year":"2013","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.yexcr.2014.07.001_bib23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.intimp.2013.01.002","article-title":"Augmenter of liver regeneration improves therapeutic effect of hepatocyte homotransplantation in acute liver failure rats","volume":"15","author":"Wang","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.yexcr.2014.07.001_bib24","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s00595-010-4282-4","article-title":"The augmenter of liver regeneration protects the kidneys after orthotopic liver transplantation possibly by upregulating HIF-1\u03b1and O2-sensitive K+ channels","volume":"41","author":"Chen","year":"2011","journal-title":"Surg. Today"},{"key":"10.1016\/j.yexcr.2014.07.001_bib25","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1681\/ASN.V7122495","article-title":"Molecular insights into interstitial fibrosis","volume":"7","author":"Eddy","year":"1996","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexcr.2014.07.001_bib26","first-page":"108","article-title":"Renal tubulointerstitial fibrosis.new thoughts on its development and progression","author":"O\u2019Donnell","year":"2000","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.yexcr.2014.07.001_bib27","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.2337\/diabetes.54.6.1626","article-title":"From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy","volume":"54","author":"Wolf","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.yexcr.2014.07.001_bib28","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1097\/01.ASN.0000093460.24823.5B","article-title":"Mediators of diabetic renal disease: the case for tgf Beta as the major mediator","volume":"15","author":"Ziyadeh","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexcr.2014.07.001_bib29","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1097\/01.ASN.0000033611.79556.AE","article-title":"TGF-beta signaling in renal disease","volume":"13","author":"B\u00f6ttinger","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexcr.2014.07.001_bib30","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.semnephrol.2007.02.009","article-title":"TGF-beta in renal injury and disease","volume":"27","author":"B\u00f6ttinger","year":"2007","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.yexcr.2014.07.001_bib31","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and smad-independent pathways in TGF-beta family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482714002705?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482714002705?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T12:17:04Z","timestamp":1649852224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482714002705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0014482714002705"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2014.07.001","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Augmenter of liver regeneration inhibits TGF-\u03b21-induced renal tubular epithelial-to-mesenchymal transition via suppressing T\u03b2R II expression in vitro","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2014.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}