{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:32:00Z","timestamp":1788283920560,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004324","name":"Astellas Pharma Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004324","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.yexcr.2015.05.019","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T02:31:58Z","timestamp":1432693918000},"page":"62-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner"],"prefix":"10.1016","volume":"335","author":[{"given":"Mikio","family":"Takeuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2015.05.019_bib1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tibs.2006.11.006","article-title":"NAD+ metabolism in health and disease","volume":"32","author":"Belenky","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.yexcr.2015.05.019_bib2","first-page":"1057","article-title":"WK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia cells","volume":"62","author":"Wosikowski","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexcr.2015.05.019_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1248\/bpb.b13-00495","article-title":"Discovery of a novel nicotinamide phosphoribosyl transferase (NAMPT) inhibitor via in silico screening","volume":"37","author":"Takeuchi","year":"2014","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.yexcr.2015.05.019_bib4","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.ejca.2004.12.023","article-title":"Phase I study and pharmacokinetic of CHS-828, a guanidino-containing compound, administered orally as a single dose every 3 weeks in solid tumours: an ECSG\/EORTC study","volume":"41","author":"Ravaud","year":"2005","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.yexcr.2015.05.019_bib5","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.bmcl.2013.11.006","article-title":"Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors","volume":"24","author":"Zheng","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.yexcr.2015.05.019_bib6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0014-2999(01)00925-6","article-title":"Cell death with atypical features induced by the novel antitumoral drug CHS 828, in human U-937 GTB cells","volume":"417","author":"Martinsson","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.yexcr.2015.05.019_bib7","doi-asserted-by":"crossref","first-page":"e7897","DOI":"10.1371\/journal.pone.0007897","article-title":"Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE","volume":"4","author":"Bruzzone","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.yexcr.2015.05.019_bib8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.bbrc.2012.06.075","article-title":"Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells","volume":"424","author":"Thakur","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexcr.2015.05.019_bib9","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/ijc.27726","article-title":"Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells","volume":"132","author":"Thakur","year":"2013","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.yexcr.2015.05.019_bib10","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1074\/jbc.M112.394510","article-title":"Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications","volume":"288","author":"Tan","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2015.05.019_bib11","doi-asserted-by":"crossref","first-page":"21067","DOI":"10.1074\/jbc.M111.324269","article-title":"NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes","volume":"287","author":"Magnone","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2015.05.019_bib12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12033-011-9425-3","article-title":"Selection of suitable reference genes for quantitative real-time PCR in apoptosis-induced MCF-7 breast cancer cells","volume":"50","author":"Ferreira","year":"2012","journal-title":"Mol. Biotechnol."},{"issue":"7","key":"10.1016\/j.yexcr.2015.05.019_bib13","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.yexcr.2015.05.019_bib14","doi-asserted-by":"crossref","first-page":"23813","DOI":"10.1074\/jbc.M402796200","article-title":"Calcium\/calmodulin-dependent protein kinase II phosphorylation drives synapse-associated protein 97 into spines","volume":"279","author":"Mauceri","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2015.05.019_bib15","first-page":"1063","article-title":"G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+\/CaM kinase)","volume":"6","author":"Tombes","year":"1995","journal-title":"Cell Growth Differ."},{"key":"10.1016\/j.yexcr.2015.05.019_bib16","first-page":"7436","article-title":"FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis","volume":"63","author":"Hasmann","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexcr.2015.05.019_bib17","doi-asserted-by":"crossref","first-page":"a008714","DOI":"10.1101\/cshperspect.a008714","article-title":"Mechanisms of action of Bcl-2 family proteins","volume":"5","author":"Shamas-Din","year":"2013","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.yexcr.2015.05.019_bib18","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.cell.2007.04.027","article-title":"ER stress triggers apoptosis by activating BH3-only protein Bim","volume":"129","author":"Puthalakath","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2015.05.019_bib19","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.bbrc.2006.05.066","article-title":"CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of l-type calcium channels","volume":"345","author":"Gao","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexcr.2015.05.019_bib20","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.1523\/JNEUROSCI.21-16-05944.2001","article-title":"Neuronal Ca(V)1.3alpha(1) l-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines","volume":"21","author":"Xu","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yexcr.2015.05.019_bib21","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrm1150","article-title":"Regulation of cell death: the calcium-apoptosis link","volume":"4","author":"Orrenius","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yexcr.2015.05.019_bib22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.18388\/abp.2011_2238","article-title":"Conventional calpains and programmed cell death","volume":"58","author":"Lopatniuk","year":"2011","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.yexcr.2015.05.019_bib23","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1083\/jcb.150.4.887","article-title":"Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis","volume":"150","author":"Nakagawa","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2015.05.019_bib24","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1046\/j.1471-4159.2001.00368.x","article-title":"Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: protective role of Bcl-2","volume":"77","author":"Choi","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.yexcr.2015.05.019_bib25","doi-asserted-by":"crossref","first-page":"385","DOI":"10.4161\/auto.5635","article-title":"NAD depletion by FK866 induces autophagy","volume":"4","author":"Billington","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.yexcr.2015.05.019_bib26","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1182\/blood-2012-03-416776","article-title":"Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1\/2) inhibition","volume":"120","author":"Cea","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2015.05.019_bib27","doi-asserted-by":"crossref","first-page":"35182","DOI":"10.1074\/jbc.M114.580159","article-title":"Depletion of the central metabolite NAD leads to oncosis-mediated cell death","volume":"289","author":"Del Nagro","year":"2014","journal-title":"J. Biol. Chem."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482715300033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482715300033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T07:46:37Z","timestamp":1589528797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482715300033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0014482715300033"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2015.05.019","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2015.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}