{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:08:10Z","timestamp":1789409290680,"version":"build-2803163510"},"reference-count":76,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC102-2320-B-030-009"],"award-info":[{"award-number":["NSC102-2320-B-030-009"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Science and Technology","award":["MOST 103-2320-B-030-006"],"award-info":[{"award-number":["MOST 103-2320-B-030-006"]}]},{"DOI":"10.13039\/501100013784","name":"Fu Jen Catholic University","doi-asserted-by":"crossref","award":["A0203104"],"award-info":[{"award-number":["A0203104"]}],"id":[{"id":"10.13039\/501100013784","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Terry Whole Brain & Potential Development Center","award":["103-11-01"],"award-info":[{"award-number":["103-11-01"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.yexcr.2015.09.005","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T19:19:44Z","timestamp":1441739984000},"page":"183-193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Rosiglitazone activation of PPAR\u03b3-dependent signaling is neuroprotective in mutant huntingtin expressing cells"],"prefix":"10.1016","volume":"338","author":[{"given":"Ming-Chang","family":"Chiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Nicol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Hung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Hui","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiang-Jiuun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Nan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2015.09.005_bib1","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2015.09.005_bib2","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1056\/NEJM198611133152006","article-title":"Huntington's disease. Pathogenesis and management","volume":"315","author":"Martin","year":"1986","journal-title":"N Engl. J. Med."},{"key":"10.1016\/j.yexcr.2015.09.005_bib3","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington's disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.yexcr.2015.09.005_bib4","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1091\/mbc.12.5.1393","article-title":"Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation","volume":"12","author":"Waelter","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yexcr.2015.09.005_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0166-2236(99)01415-0","article-title":"Recent advances in understanding the pathogenesis of Huntington's disease","volume":"22","author":"Reddy","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.yexcr.2015.09.005_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2011.12.013","article-title":"Protein aggregates in Huntington's disease","volume":"238","author":"Arrasate","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.yexcr.2015.09.005_bib7","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1093\/hmg\/9.13.2009","article-title":"Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity","volume":"9","author":"Jana","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2015.09.005_bib8","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1083\/jcb.153.2.283","article-title":"Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression","volume":"153","author":"Suhr","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2015.09.005_bib9","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1172\/JCI27607","article-title":"Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase","volume":"116","author":"Borrell-Pages","year":"2006","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.yexcr.2015.09.005_bib10","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1093\/hmg\/ddp230","article-title":"The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system","volume":"18","author":"Chiang","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2015.09.005_bib11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1083\/jcb.201110093","article-title":"Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease","volume":"196","author":"Hipp","year":"2012","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2015.09.005_bib12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mcn.2012.11.011","article-title":"Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases","volume":"55","author":"Chaturvedi","year":"2013","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.yexcr.2015.09.005_bib13","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1093\/hmg\/11.13.1505","article-title":"Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation","volume":"11","author":"Kouroku","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2015.09.005_bib14","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1101\/gad.992302","article-title":"ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats","volume":"16","author":"Nishitoh","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.yexcr.2015.09.005_bib15","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0092-8674(01)00240-9","article-title":"Obesity and the regulation of energy balance","volume":"104","author":"Spiegelman","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2015.09.005_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.biochi.2004.10.021","article-title":"PPAR gamma, 10 years later","volume":"87","author":"Lazar","year":"2005","journal-title":"Biochimie"},{"key":"10.1016\/j.yexcr.2015.09.005_bib17","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.cell.2005.11.026","article-title":"The many faces of PPARgamma","volume":"123","author":"Lehrke","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2015.09.005_bib18","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1042\/BST0341341","article-title":"PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases","volume":"34","author":"Bordet","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.yexcr.2015.09.005_bib19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuint.2006.03.020","article-title":"PPARgamma as a therapeutic target in central nervous system diseases","volume":"49","author":"Sundararajan","year":"2006","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.yexcr.2015.09.005_bib20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.expneurol.2006.04.006","article-title":"PPARgamma agonists as new therapeutic agents for the treatment of Alzheimer's disease","volume":"199","author":"Landreth","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.yexcr.2015.09.005_bib21","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.expneurol.2012.02.017","article-title":"Pharmacological manipulation of peroxisome proliferator-activated receptor gamma (PPARgamma) reveals a role for anti-oxidant protection in a model of Parkinson's disease","volume":"235","author":"Martin","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.yexcr.2015.09.005_bib22","doi-asserted-by":"crossref","first-page":"25628","DOI":"10.1074\/jbc.M804291200","article-title":"Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin-expressing cells: possible role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in the pathogenesis of Huntington disease","volume":"283","author":"Quintanilla","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2015.09.005_bib23","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1093\/hmg\/ddq322","article-title":"Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma","volume":"19","author":"Chiang","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2015.09.005_bib24","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.bbadis.2011.05.006","article-title":"The dysfunction of hepatic transcriptional factors in mice with Huntington's Disease","volume":"1812","author":"Chiang","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexcr.2015.09.005_bib25","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.nbd.2011.08.016","article-title":"PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease","volume":"45","author":"Chiang","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.yexcr.2015.09.005_bib26","doi-asserted-by":"crossref","first-page":"14331","DOI":"10.1074\/jbc.M413279200","article-title":"cAMP-response element-binding protein contributes to suppression of the A2A adenosine receptor promoter by mutant Huntingtin with expanded polyglutamine residues","volume":"280","author":"Chiang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2015.09.005_bib27","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jneumeth.2012.04.005","article-title":"Beta-adrenoceptor pathway enhances mitochondrial function in human neural stem cells via rotary cell culture system","volume":"207","author":"Chiang","year":"2012","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.yexcr.2015.09.005_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mito.2013.12.003","article-title":"Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway","volume":"14","author":"Chiang","year":"2014","journal-title":"Mitochondrion"},{"key":"10.1016\/j.yexcr.2015.09.005_bib29","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/hmg\/ddl481","article-title":"Dysregulation of C\/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease","volume":"16","author":"Chiang","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2015.09.005_bib30","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1074\/mcp.M600356-MCP200","article-title":"Systematic uncovering of multiple pathways underlying the pathology of Huntington disease by an acid-cleavable isotope-coded affinity tag approach","volume":"6","author":"Chiang","year":"2007","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.yexcr.2015.09.005_bib31","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neuroscience.2012.11.003","article-title":"PPARgamma regulates the mitochondrial dysfunction in human neural stem cells with tumor necrosis factor alpha","volume":"229","author":"Chiang","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.yexcr.2015.09.005_bib32","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.bbadis.2015.01.006","article-title":"The neuroprotective role of metformin in advanced glycation end product treated human neural stem cells is AMPK-dependent","volume":"1852","author":"Chung","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexcr.2015.09.005_bib33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2006.09.015","article-title":"Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration","volume":"127","author":"Cui","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2015.09.005_bib34","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1210\/er.2002-0012","article-title":"Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator","volume":"24","author":"Puigserver","year":"2003","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.yexcr.2015.09.005_bib35","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1242\/jcs.087510","article-title":"Changes in BiP availability reveal hypersensitivity to acute endoplasmic reticulum stress in cells expressing mutant huntingtin","volume":"124","author":"Lajoie","year":"2011","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2015.09.005_bib36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1517\/14740338.2013.741585","article-title":"Examining the safety of PPAR agonists-current trends and future prospects","volume":"12","author":"Bortolini","year":"2013","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.yexcr.2015.09.005_bib37","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1523\/JNEUROSCI.20-02-00558.2000","article-title":"Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists","volume":"20","author":"Combs","year":"2000","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yexcr.2015.09.005_bib38","doi-asserted-by":"crossref","first-page":"418765","DOI":"10.1155\/2008\/418765","article-title":"Peroxisome proliferator-activated receptor-gamma in amyotrophic lateral sclerosis and Huntington's disease","volume":"2008","author":"Kiaei","year":"2008","journal-title":"PPAR Res."},{"key":"10.1016\/j.yexcr.2015.09.005_bib39","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1007\/s00018-007-6516-1","article-title":"Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases","volume":"64","author":"Lleo","year":"2007","journal-title":"Cell. Mol. Life Sci.: CMLS"},{"key":"10.1016\/j.yexcr.2015.09.005_bib40","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s00221-005-2357-z","article-title":"Atypical diabetes associated with inclusion formation in the R6\/2 mouse model of Huntington's disease is not improved by treatment with hypoglycaemic agents","volume":"166","author":"Hunt","year":"2005","journal-title":"Exp. Brain Res.: Experimentelle Hirnforschung"},{"key":"10.1016\/j.yexcr.2015.09.005_bib41","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pbb.2010.04.018","article-title":"Pioglitazone ameliorates behavioral, biochemical and cellular alterations in quinolinic acid induced neurotoxicity: possible role of peroxisome proliferator activated receptor-Upsilon (PPARUpsilon) in Huntington's disease","volume":"96","author":"Kalonia","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.yexcr.2015.09.005_bib42","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.brainresbull.2011.03.011","article-title":"Protective effect of pioglitazone, a PPARgamma ligand, in a 3 nitropropionic acid model of Huntington's disease","volume":"85","author":"Napolitano","year":"2011","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.yexcr.2015.09.005_bib43","doi-asserted-by":"crossref","first-page":"e30406","DOI":"10.1371\/journal.pone.0030406","article-title":"Metabolic state determines sensitivity to cellular stress in Huntington disease: normalization by activation of PPARgamma","volume":"7","author":"Jin","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.yexcr.2015.09.005_bib44","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10863-010-9286-7","article-title":"The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease","volume":"42","author":"Jin","year":"2010","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.yexcr.2015.09.005_bib45","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.pneurobio.2011.10.004","article-title":"PGC-1alpha at the intersection of bioenergetics regulation and neuron function: from Huntington's disease to Parkinson's disease and beyond","volume":"97","author":"Tsunemi","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.yexcr.2015.09.005_bib46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0896-6273(01)00177-5","article-title":"Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases","volume":"29","author":"Sherman","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.yexcr.2015.09.005_bib47","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.cell.2007.05.007","article-title":"Proteasomes: machines for all reasons","volume":"129","author":"Demartino","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2015.09.005_bib48","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbamcr.2013.03.012","article-title":"Proteostasis and neurodegeneration: the roles of proteasomal degradation and autophagy","volume":"1843","author":"Tanaka","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexcr.2015.09.005_bib49","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.yexcr.2010.02.003","article-title":"Illuminating the ubiquitin\/proteasome system","volume":"316","author":"Salomons","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2015.09.005_bib50","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1126\/science.292.5521.1552","article-title":"Impairment of the ubiquitin-proteasome system by protein aggregation","volume":"292","author":"Bence","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2015.09.005_bib51","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.tins.2007.08.005","article-title":"The ubiquitin-proteasome pathway in health and disease of the nervous system","volume":"30","author":"Hegde","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.yexcr.2015.09.005_bib52","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bbamcr.2013.08.012","article-title":"Regulation of proteasome activity in health and disease","volume":"1843","author":"Schmidt","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexcr.2015.09.005_bib53","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nature06022","article-title":"Global changes to the ubiquitin system in Huntington's disease","volume":"448","author":"Bennett","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2015.09.005_bib54","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1083\/jcb.200709080","article-title":"Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice","volume":"180","author":"Wang","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2015.09.005_bib55","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1007\/s00018-007-7222-8","article-title":"Is the ubiquitin-proteasome system impaired in Huntington's disease?","volume":"64","author":"Ortega","year":"2007","journal-title":"Cell. Mol. Life Sci.: CMLS"},{"key":"10.1016\/j.yexcr.2015.09.005_bib56","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.yexcr.2006.10.031","article-title":"Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin","volume":"313","author":"Yang","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2015.09.005_bib57","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1152\/physiolgenomics.00027.2004","article-title":"Gene expression profiling of potential PPAR{gamma} target genes in mouse aorta","volume":"18","author":"Keen","year":"2004","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.yexcr.2015.09.005_bib58","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s00018-004-4464-6","article-title":"Hsp70 chaperones: cellular functions and molecular mechanism","volume":"62","author":"Mayer","year":"2005","journal-title":"Cell. Mol. Life Sci.: CMLS"},{"key":"10.1016\/j.yexcr.2015.09.005_bib59","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1007\/s00018-007-7188-6","article-title":"To be, or not to be\u2014molecular chaperones in protein degradation","volume":"64","author":"Arndt","year":"2007","journal-title":"Cell. Mol. Life Sci.: CMLS"},{"key":"10.1016\/j.yexcr.2015.09.005_bib60","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1093\/hmg\/ddh144","article-title":"Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach","volume":"13","author":"Hay","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2015.09.005_bib61","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1016\/j.yexcr.2007.07.034","article-title":"Modulation of polyglutamine inclusion formation by the Hsp70 chaperone machine","volume":"313","author":"Rujano","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2015.09.005_bib62","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1073\/pnas.97.6.2898","article-title":"Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease","volume":"97","author":"Wyttenbach","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yexcr.2015.09.005_bib63","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/mt.sj.6300141","article-title":"Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease","volume":"15","author":"Perrin","year":"2007","journal-title":"Mol. Ther.: J. Am. Soc. Gene Ther."},{"key":"10.1016\/j.yexcr.2015.09.005_bib64","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/nsmb860","article-title":"Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer","volume":"11","author":"Wacker","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.yexcr.2015.09.005_bib65","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.bbamcr.2014.01.004","article-title":"Roles of Hsp104 and trehalose in solubilisation of mutant huntingtin in heat shocked Saccharomyces cerevisiae cells","volume":"1843","author":"Saleh","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexcr.2015.09.005_bib66","doi-asserted-by":"crossref","first-page":"34908","DOI":"10.1074\/jbc.M506288200","article-title":"Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models","volume":"280","author":"Fujimoto","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2015.09.005_bib67","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1124\/jpet.106.113472","article-title":"Thiazolidinedione class of peroxisome proliferator-activated receptor {gamma} agonists prevents neuronal damage, motor dysfunction, myelin loss, neuropathic pain, and inflammation after spinal cord injury in adult rats","volume":"320","author":"Park","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.yexcr.2015.09.005_bib68","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/sj.cdd.4401778","article-title":"ER stress and neurodegenerative diseases","volume":"13","author":"Lindholm","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.yexcr.2015.09.005_bib69","doi-asserted-by":"crossref","first-page":"18167","DOI":"10.1074\/jbc.M109.018325","article-title":"Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease","volume":"284","author":"Carnemolla","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2015.09.005_bib70","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.yexcr.2007.12.025","article-title":"Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins","volume":"314","author":"Reijonen","year":"2008","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2015.09.005_bib71","doi-asserted-by":"crossref","first-page":"21836","DOI":"10.1074\/jbc.M202726200","article-title":"Coupling endoplasmic reticulum stress to the cell death program","volume":"277","author":"Rao","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2015.09.005_bib72","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/hmg\/ddh162","article-title":"Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release","volume":"13","author":"Choo","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2015.09.005_bib73","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1093\/hmg\/9.19.2859","article-title":"Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis","volume":"9","author":"Li","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2015.09.005_bib74","doi-asserted-by":"crossref","first-page":"14525","DOI":"10.1073\/pnas.0704482104","article-title":"Inhibitors of metabolism rescue cell death in Huntington's disease models","volume":"104","author":"Varma","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yexcr.2015.09.005_bib75","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1523\/JNEUROSCI.23-06-02193.2003","article-title":"Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease","volume":"23","author":"Yu","year":"2003","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yexcr.2015.09.005_bib76","doi-asserted-by":"crossref","first-page":"37006","DOI":"10.1074\/jbc.M700447200","article-title":"Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis","volume":"282","author":"Fuenzalida","year":"2007","journal-title":"J. Biol. Chem."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482715300884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482715300884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T20:45:18Z","timestamp":1589575518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482715300884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":76,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0014482715300884"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2015.09.005","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rosiglitazone activation of PPAR\u03b3-dependent signaling is neuroprotective in mutant huntingtin expressing cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2015.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}