{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:15:19Z","timestamp":1778642119152,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.yexcr.2016.06.010","type":"journal-article","created":{"date-parts":[[2016,6,18]],"date-time":"2016-06-18T05:42:02Z","timestamp":1466228522000},"page":"111-118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Upregulation of CBS\/H2S system contributes to asymmetric dimethylarginine-triggered protection against the neurotoxicity of glutamate to PC12 cells by inhibiting NOS\/NO pathway"],"prefix":"10.1016","volume":"346","author":[{"given":"Xiang-Yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2016.06.010_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1523\/JNEUROSCI.08-01-00185.1988","article-title":"Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists","volume":"8","author":"Choi","year":"1988","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yexcr.2016.06.010_bib2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/aps.2009.24","article-title":"Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases","volume":"30","author":"Dong","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.yexcr.2016.06.010_bib3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrn2803","article-title":"Do astrocytes really exocytose neurotransmitters?","volume":"11","author":"Hamilton","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.yexcr.2016.06.010_bib4","doi-asserted-by":"crossref","first-page":"338","DOI":"10.5604\/17322693.946637","article-title":"Glutamate NMDA receptors in pathophysiology and pharmacotherapy of selected nervous system diseases","volume":"65","author":"Dobrek","year":"2011","journal-title":"Postepy Hig. Med. Dosw."},{"key":"10.1016\/j.yexcr.2016.06.010_bib5","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJM199403033300907","article-title":"Excitatory amino acids as a final common pathway for neurologic disorders","volume":"330","author":"Lipton","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yexcr.2016.06.010_bib6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.brainresrev.2004.04.001","article-title":"Neuroprotection and peptide toxins","volume":"45","author":"Rajendra","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.yexcr.2016.06.010_bib7","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/0896-6273(95)90186-8","article-title":"Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function","volume":"15","author":"Ankarcrona","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.yexcr.2016.06.010_bib8","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/sj.cdd.4402138","article-title":"S-Nitrosylation and uncompetitive\/fast off-rate (UFO) drug therapy in neurodegenerative disorders of protein misfolding","volume":"14","author":"Nakamura","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.yexcr.2016.06.010_bib9","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/0140-6736(92)90865-Z","article-title":"Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure","volume":"339","author":"Vallance","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.yexcr.2016.06.010_bib10","first-page":"159","article-title":"Asymmetric dimethylarginine (ADMA) as a target for pharmacotherapy","volume":"58","author":"Beltowski","year":"2006","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.yexcr.2016.06.010_bib11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s12031-012-9897-z","article-title":"Asymmetrical dimethylarginine antagonizes glutamate-induced apoptosis in PC12 cells","volume":"49","author":"Wang","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.yexcr.2016.06.010_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1385\/MN:26:1:013","article-title":"Hydrogen sulfide as a neuromodulator","volume":"26","author":"Kimura","year":"2002","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.yexcr.2016.06.010_bib13","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two\u2019s company, three\u2019s a crowd: can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.yexcr.2016.06.010_bib14","first-page":"4","article-title":"Hydrogen sulfide (H2S) - the third gas of interest for pharmacologists","volume":"59","author":"Lowicka","year":"2007","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.yexcr.2016.06.010_bib15","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6","author":"Szabo","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.yexcr.2016.06.010_bib16","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1007\/s11064-009-0006-9","article-title":"Hydrogen sulfide attenuates neuronal injury induced by vascular dementia via inhibiting apoptosis in rats","volume":"34","author":"Zhang","year":"2009","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.yexcr.2016.06.010_bib17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neuint.2009.08.008","article-title":"Hydrogen sulfide: a novel signaling molecule in the central nervous system","volume":"56","author":"Tan","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.yexcr.2016.06.010_bib18","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuint.2007.05.016","article-title":"Hydrogen sulfide: neurochemistry and neurobiology","volume":"52","author":"Qu","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.yexcr.2016.06.010_bib19","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1096\/fj.04-1815fje","article-title":"Hydrogen sulfide protects neurons from oxidative stress","volume":"18","author":"Kimura","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.yexcr.2016.06.010_bib20","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1471-4159.2004.02617.x","article-title":"The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite'scavenger\u2019?","volume":"90","author":"Whiteman","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.yexcr.2016.06.010_bib21","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbrc.2004.11.110","article-title":"Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?","volume":"326","author":"Whiteman","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexcr.2016.06.010_bib22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.lfs.2009.05.023","article-title":"Hydrogen sulfide inhibits MPP(+)-induced apoptosis in PC12 cells","volume":"85","author":"Yin","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.yexcr.2016.06.010_bib23","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1440-1681.2007.04799.x","article-title":"Effect of hydrogen sulphide on beta-amyloid-induced damage in PC12 cells","volume":"35","author":"Tang","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.yexcr.2016.06.010_bib24","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neures.2010.07.2039","article-title":"Hydrogen sulfide antagonizes homocysteine-induced neurotoxicity in PC12 cells","volume":"68","author":"Tang","year":"2010","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.yexcr.2016.06.010_bib25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1474-9726.2009.00543.x","article-title":"Neuroprotective effects of hydrogen sulfide on Parkinson\u2019s disease rat models","volume":"9","author":"Hu","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.yexcr.2016.06.010_bib26","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1440-1681.2010.05462.x","article-title":"Heat shock protein 90 mediates cytoprotection by HS against chemical hypoxia-induced injury in PC12 cells","volume":"38","author":"Meng","year":"2011","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.yexcr.2016.06.010_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(01)02437-1","article-title":"Glutamate neurotoxicity, oxidative stress and mitochondria","volume":"497","author":"Atlante","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yexcr.2016.06.010_bib28","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.2174\/0929867033456404","article-title":"Neurotransmission and neurotoxicity by nitric oxide, catecholamines, and glutamate: unifying themes of reactive oxygen species and electron transfer","volume":"10","author":"Jacintho","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.yexcr.2016.06.010_bib29","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/glycob\/8.6.597","article-title":"Nerve growth factor-induced neurite formation in PC12 cells is independent of endogenous cellular gangliosides","volume":"8","author":"Li","year":"1998","journal-title":"Glycobiology"},{"key":"10.1016\/j.yexcr.2016.06.010_bib30","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1002\/jnr.21999","article-title":"All-trans retinoic acid inhibits cobalt chloride-induced apoptosis in PC12 cells: role of the dimethylarginine dimethylaminohydrolase\/asymmetric dimethylarginine pathway","volume":"87","author":"Wang","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.yexcr.2016.06.010_bib31","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1742-7843.2008.00314.x","article-title":"Rho kinase inhibitor Y-27632 down-regulates norepinephrine synthesis and release in PC12 cells","volume":"104","author":"Duan","year":"2009","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.yexcr.2016.06.010_bib32","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s12640-010-9180-4","article-title":"Inhibition of hydrogen sulfide generation contributes to 1-methy-4-phenylpyridinium ion-induced neurotoxicity","volume":"19","author":"Tang","year":"2011","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.yexcr.2016.06.010_bib33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0003-2697(83)90270-1","article-title":"Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay","volume":"134","author":"Cathcart","year":"1983","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.yexcr.2016.06.010_bib34","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/jnr.490320108","article-title":"Synaptosomal plasma membrane transport of excitatory sulphur amino acid transmitter candidates: kinetic characterisation and analysis of carrier specificity","volume":"32","author":"Grieve","year":"1992","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.yexcr.2016.06.010_bib35","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nrn1788","article-title":"Axon degeneration mechanisms: commonality amid diversity","volume":"6","author":"Coleman","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.yexcr.2016.06.010_bib36","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00424-010-0809-1","article-title":"Glutamate receptors, neurotoxicity and neurodegeneration","volume":"460","author":"Lau","year":"2010","journal-title":"Pflug. Arch."},{"key":"10.1016\/j.yexcr.2016.06.010_bib37","doi-asserted-by":"crossref","first-page":"e37080","DOI":"10.1371\/journal.pone.0037080","article-title":"Water extract from the leaves of Withania somnifera protect RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity","volume":"7","author":"Kataria","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.yexcr.2016.06.010_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3164\/jcbn.08-193R","article-title":"Therapeutic antioxidant medical gas","volume":"44","author":"Nakao","year":"2009","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.yexcr.2016.06.010_bib39","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1007\/s11064-011-0542-y","article-title":"Endogenous hydrogen sulfide is involved in asymmetric dimethylarginine-induced protection against neurotoxicity of 1-methyl-4-phenyl-pyridinium ion","volume":"36","author":"Tang","year":"2011","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.yexcr.2016.06.010_bib40","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.neuint.2012.01.015","article-title":"Glutamate oxidative injury to RGC-5 cells in culture is necrostatin sensitive and blunted by a hydrogen sulfide (H2S)-releasing derivative of aspirin (ACS14)","volume":"60","author":"Osborne","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.yexcr.2016.06.010_bib41","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0162-0134(01)00335-X","article-title":"Characterization of NO binding to human cystathionine beta-synthase: possible implications of the effects of CO and NO binding to the human enzyme","volume":"87","author":"Taoka","year":"2001","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.yexcr.2016.06.010_bib42","doi-asserted-by":"crossref","first-page":"F912","DOI":"10.1152\/ajprenal.00040.2008","article-title":"Inhibition of cystathionine-beta-synthase activity during renal ischemia-reperfusion: role of pH and nitric oxide","volume":"295","author":"Prathapasinghe","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482716301598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482716301598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T18:45:42Z","timestamp":1718649942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482716301598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0014482716301598"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2016.06.010","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Upregulation of CBS\/H2S system contributes to asymmetric dimethylarginine-triggered protection against the neurotoxicity of glutamate to PC12 cells by inhibiting NOS\/NO pathway","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2016.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}