{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:15:02Z","timestamp":1790792102036,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2013CB531203"],"award-info":[{"award-number":["2013CB531203"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2014CB542206"],"award-info":[{"award-number":["2014CB542206"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271148"],"award-info":[{"award-number":["81271148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371350"],"award-info":[{"award-number":["31371350"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.yexcr.2016.08.007","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T21:12:06Z","timestamp":1470777126000},"page":"212-221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Mitochondrial reactive oxygen species mediate the lipopolysaccharide-induced pro-inflammatory response in human gingival fibroblasts"],"prefix":"10.1016","volume":"347","author":[{"given":"Xue","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing Xian","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.yexcr.2016.08.007_bib1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrmicro2337","article-title":"Periodontitis: a polymicrobial disruption of host homeostasis","volume":"8","author":"Darveau","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"issue":"8","key":"10.1016\/j.yexcr.2016.08.007_bib2","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1902\/jop.1998.69.8.899","article-title":"Increased presence of interleukin-6 (IL-6) and IL-8 secreting fibroblast subpopulations in adult periodontitis","volume":"69","author":"Dongari-Bagtzoglou","year":"1998","journal-title":"J. Periodontol."},{"issue":"2","key":"10.1016\/j.yexcr.2016.08.007_bib3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1128\/mr.60.2.316-341.1996","article-title":"Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis","volume":"60","author":"Henderson","year":"1996","journal-title":"Microbiol. Rev."},{"issue":"2","key":"10.1016\/j.yexcr.2016.08.007_bib4","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s10753-013-9766-0","article-title":"Beyond toll-like receptors: porphyromonas gingivalis induces IL-6, IL-8, and VCAM-1 expression through NOD-mediated NF-kappaB and ERK signaling pathways in periodontal fibroblasts","volume":"37","author":"Liu","year":"2014","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.yexcr.2016.08.007_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/10454411980090030101","article-title":"Cytokine expression in periodontal health and disease","volume":"9","author":"Okada","year":"1998","journal-title":"Crit. Rev. Oral Biol. Med."},{"issue":"1","key":"10.1016\/j.yexcr.2016.08.007_bib6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1902\/jop.2003.74.1.103","article-title":"Perspective of cytokine regulation for periodontal treatment: fibroblast biology","volume":"74","author":"Takashiba","year":"2003","journal-title":"J. Periodontol."},{"issue":"3","key":"10.1016\/j.yexcr.2016.08.007_bib7","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3164\/jcbn.14-129","article-title":"Biological impacts of resveratrol, quercetin, and N-acetylcysteine on oxidative stress in human gingival fibroblasts","volume":"56","author":"Orihuela-Campos","year":"2015","journal-title":"J. Clin. Biochem. Nutr."},{"issue":"10","key":"10.1016\/j.yexcr.2016.08.007_bib8","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/BF02980269","article-title":"N-acetylcysteine prevents LPS-induced pro-inflammatory cytokines and MMP2 production in gingival fibroblasts","volume":"30","author":"Kim do","year":"2007","journal-title":"Arch. Pharm. Res."},{"issue":"4","key":"10.1016\/j.yexcr.2016.08.007_bib9","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/jnr.20180","article-title":"Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma","volume":"77","author":"Pawate","year":"2004","journal-title":"J. Neurosci. Res."},{"issue":"6","key":"10.1016\/j.yexcr.2016.08.007_bib10","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.freeradbiomed.2008.06.019","article-title":"The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase\/PTEN\/Akt and NF-kappaB-inducing kinase pathways: role of H(2)O(2) in NF-kappaB activation","volume":"45","author":"Kim","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yexcr.2016.08.007_bib11","doi-asserted-by":"crossref","first-page":"d369","DOI":"10.2741\/999","article-title":"Mitogen-activated protein kinase pathways in redox signaling","volume":"8","author":"Torres","year":"2003","journal-title":"Front Biosci."},{"issue":"3","key":"10.1016\/j.yexcr.2016.08.007_bib12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1084\/jem.20110367","article-title":"Mitochondrial reactive oxygen species drive proinflammatory cytokine production","volume":"208","author":"Naik","year":"2011","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.yexcr.2016.08.007_bib13","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.freeradbiomed.2012.05.036","article-title":"Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially targeted antioxidants","volume":"53","author":"Mukhopadhyay","year":"2012","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.yexcr.2016.08.007_bib14","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1084\/jem.20102049","article-title":"Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)","volume":"208","author":"Bulua","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.yexcr.2016.08.007_bib15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neulet.2014.10.016","article-title":"Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-kappaB pathways","volume":"584","author":"Park","year":"2015","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.yexcr.2016.08.007_bib16","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.tiv.2008.12.021","article-title":"Prunella vulgaris extract and rosmarinic acid suppress lipopolysaccharide-induced alteration in human gingival fibroblasts","volume":"23","author":"Zdarilova","year":"2009","journal-title":"Toxicol. Vitr."},{"issue":"3","key":"10.1016\/j.yexcr.2016.08.007_bib17","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2249.2008.03634.x","article-title":"Redox signalling and the inflammatory response in rheumatoid arthritis","volume":"152","author":"Filippin","year":"2008","journal-title":"Clin. Exp. Immunol."},{"issue":"3","key":"10.1016\/j.yexcr.2016.08.007_bib18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00415-004-0348-9","article-title":"The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy","volume":"251","author":"Gilgun-Sherki","year":"2004","journal-title":"J. Neurol."},{"issue":"7","key":"10.1016\/j.yexcr.2016.08.007_bib19","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.autrev.2008.04.006","article-title":"Autoimmune thyroiditis and ROS","volume":"7","author":"Burek","year":"2008","journal-title":"Autoimmun. Rev."},{"issue":"3","key":"10.1016\/j.yexcr.2016.08.007_bib20","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1152\/physrev.1979.59.3.527","article-title":"Hydroperoxide metabolism in mammalian organs","volume":"59","author":"Chance","year":"1979","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.yexcr.2016.08.007_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchemneu.2015.12.013","article-title":"Mitochondrial regulation of reactive oxygen species (ROS) production-Unexpected observations in early postnatal cerebral vasculature","volume":"74","author":"Wolf","year":"2015","journal-title":"J. Chem. Neuroanat."},{"issue":"7344","key":"10.1016\/j.yexcr.2016.08.007_bib22","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature09973","article-title":"TLR signalling augments macrophage bactericidal activity through mitochondrial ROS","volume":"472","author":"West","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2016.08.007_bib23","article-title":"Electron transport chain inhibitors induce microglia activation through enhancing mitochondrial reactive oxygen species production","author":"Ye","year":"2015","journal-title":"Exp. Cell Res."},{"issue":"8","key":"10.1016\/j.yexcr.2016.08.007_bib24","first-page":"562","article-title":"Effect of vitamin E on alcohol-induced changes in oxidative stress and expression of transcription factors NFkappaB and AP-1 in mice brain cerebral hemispheres","volume":"46","author":"Kaur","year":"2008","journal-title":"Indian J. Exp. Biol."},{"issue":"7329","key":"10.1016\/j.yexcr.2016.08.007_bib25","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.yexcr.2016.08.007_bib26","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.yexcr.2016.08.007_bib27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00005-009-0026-9","article-title":"Increased salivary level of 8-hydroxydeoxyguanosine is a marker of premature oxidative mitochondrial DNA damage in gingival tissue of patients with periodontitis","volume":"57","author":"Canakci","year":"2009","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"},{"issue":"3","key":"10.1016\/j.yexcr.2016.08.007_bib28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1155\/2012\/215430","article-title":"Increased salivary levels of 8-hydroxydeoxyguanosine may be a marker for disease activity for periodontitis","volume":"32","author":"Sezer","year":"2012","journal-title":"Dis. Markers"},{"issue":"3","key":"10.1016\/j.yexcr.2016.08.007_bib29","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.mito.2011.01.009","article-title":"Mitochondrial dysfunction and genetic heterogeneity in chronic periodontitis","volume":"11","author":"Govindaraj","year":"2011","journal-title":"Mitochondrion"}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482716302361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482716302361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:20:40Z","timestamp":1757996440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482716302361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0014482716302361"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2016.08.007","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial reactive oxygen species mediate the lipopolysaccharide-induced pro-inflammatory response in human gingival fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2016.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}