{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:44:08Z","timestamp":1770957848849,"version":"3.50.1"},"reference-count":81,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK081431"],"award-info":[{"award-number":["DK081431"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.yexcr.2017.04.001","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T17:53:41Z","timestamp":1491242021000},"page":"142-152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Ouabain promotes partial epithelial to mesenchymal transition (EMT) changes in human autosomal dominant polycystic kidney disease (ADPKD) cells"],"prefix":"10.1016","volume":"355","author":[{"given":"Jessica","family":"Venugopal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"McDermott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladis","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhulika","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail A.","family":"Reif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren P.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.yexcr.2017.04.001_bib1","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0272-6386(83)80044-4","article-title":"Epidemiology of adult polycystic kidney disease, Olmsted County, Minnesota: 1935\u20131980","volume":"2","author":"Iglesias","year":"1983","journal-title":"Am. J. Kidney Dis."},{"issue":"6815","key":"10.1016\/j.yexcr.2017.04.001_bib2","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/35050128","article-title":"Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents","volume":"408","author":"Hanaoka","year":"2000","journal-title":"Nature"},{"issue":"14","key":"10.1016\/j.yexcr.2017.04.001_bib3","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJM198810063191405","article-title":"Linkage heterogeneity of autosomal dominant polycystic kidney disease","volume":"319","author":"Kimberling","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yexcr.2017.04.001_bib4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000421651","article-title":"Genetic heterogeneity of polycystic kidney disease in Europe","volume":"97","author":"Peters","year":"1992","journal-title":"Contrib. Nephrol."},{"issue":"11","key":"10.1016\/j.yexcr.2017.04.001_bib5","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1681\/ASN.2006080835","article-title":"Cyst number but not the rate of cystic growth is associated with the mutated gene in autosomal dominant polycystic kidney disease","volume":"17","author":"Harris","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"issue":"9147","key":"10.1016\/j.yexcr.2017.04.001_bib6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0140-6736(98)03495-3","article-title":"Comparison of phenotypes of polycystic kidney disease types 1 and 2. European PKD1-PKD2 study group","volume":"353","author":"Hateboer","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.yexcr.2017.04.001_bib7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.med.60.101707.125712","article-title":"Polycystic kidney disease","volume":"60","author":"Harris","year":"2009","journal-title":"Annu Rev. Med."},{"issue":"1\u20133","key":"10.1016\/j.yexcr.2017.04.001_bib8","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000101323","article-title":"The role of tubular epithelial-mesenchymal transition in progressive kidney disease","volume":"185","author":"Burns","year":"2007","journal-title":"Cells Tissues Organs"},{"issue":"5","key":"10.1016\/j.yexcr.2017.04.001_bib9","doi-asserted-by":"crossref","first-page":"F1238","DOI":"10.1152\/ajprenal.00326.2007","article-title":"Mesenchymal transition in kidney collecting duct epithelial cells","volume":"294","author":"Ivanova","year":"2008","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"issue":"1","key":"10.1016\/j.yexcr.2017.04.001_bib10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1523-1755.2002.00430.x","article-title":"Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies","volume":"62","author":"Rastaldi","year":"2002","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.yexcr.2017.04.001_bib11","doi-asserted-by":"crossref","first-page":"p139","DOI":"10.1159\/000092453","article-title":"Recapitulation of embryological programmes in renal fibrosis--the importance of epithelial cell plasticity and developmental genes","volume":"103","author":"Roxburgh","year":"2006","journal-title":"Nephron Physiol."},{"issue":"1","key":"10.1016\/j.yexcr.2017.04.001_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/path.2734","article-title":"Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease","volume":"222","author":"Hassane","year":"2010","journal-title":"J. Pathol."},{"issue":"1","key":"10.1016\/j.yexcr.2017.04.001_bib13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3349\/ymj.2009.50.1.105","article-title":"TGF-beta mediated epithelial-mesenchymal transition in autosomal dominant polycystic kidney disease","volume":"50","author":"Chea","year":"2009","journal-title":"Yonsei Med. J."},{"issue":"7","key":"10.1016\/j.yexcr.2017.04.001_bib14","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1093\/ndt\/gfl071","article-title":"Gene profiling of polycystic kidneys","volume":"21","author":"Schieren","year":"2006","journal-title":"Nephrol. Dial. Transplant."},{"issue":"5","key":"10.1016\/j.yexcr.2017.04.001_bib15","doi-asserted-by":"crossref","first-page":"F1423","DOI":"10.1152\/ajprenal.00275.2007","article-title":"Polycystic kidney disease and renal injury repair: common pathways, fluid flow, and the function of polycystin-1","volume":"293","author":"Weimbs","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.yexcr.2017.04.001_bib16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.mehy.2013.03.020","article-title":"Epithelial-mesenchymal transition of renal tubules: divergent processes of repairing in acute or chronic injury?","volume":"81","author":"Jiang","year":"2013","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.yexcr.2017.04.001_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm5010006","article-title":"Emerging transcriptional mechanisms in the regulation of epithelial to mesenchymal transition and cellular plasticity in the kidney","volume":"5","author":"De Chiara","year":"2016","journal-title":"J. Clin. Med."},{"issue":"11","key":"10.1016\/j.yexcr.2017.04.001_bib18","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1093\/hmg\/9.11.1641","article-title":"Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1","volume":"9","author":"Ibraghimov-Beskrovnaya","year":"2000","journal-title":"Hum. Mol. Genet."},{"issue":"12","key":"10.1016\/j.yexcr.2017.04.001_bib19","doi-asserted-by":"crossref","first-page":"6397","DOI":"10.1073\/pnas.94.12.6397","article-title":"Polycystin: in vitro synthesis, in vivo tissue expression, and subcellular localization identifies a large membrane-associated protein","volume":"94","author":"Ibraghimov-Beskrovnaya","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.yexcr.2017.04.001_bib20","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.bbadis.2011.03.003","article-title":"Polycystins, focal adhesions and extracellular matrix interactions","volume":"1812","author":"Drummond","year":"2011","journal-title":"Biochim Biophys. Acta"},{"issue":"10","key":"10.1016\/j.yexcr.2017.04.001_bib21","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1091\/mbc.e07-02-0142","article-title":"Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell mechanical adhesion","volume":"18","author":"Boca","year":"2007","journal-title":"Mol. Biol. Cell"},{"issue":"2","key":"10.1016\/j.yexcr.2017.04.001_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0272-6386(97)90039-1","article-title":"Gender and the effect of gonadal hormones on the progression of inherited polycystic kidney disease in rats","volume":"29","author":"Cowley","year":"1997","journal-title":"Am. J. Kidney Dis."},{"issue":"6","key":"10.1016\/j.yexcr.2017.04.001_bib23","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0092-8674(00)81793-6","article-title":"The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I","volume":"87","author":"Qian","year":"1996","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.yexcr.2017.04.001_bib24","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1055\/s-2000-8140","article-title":"Ouabain, a new steroid hormone of adrenal gland and hypothalamus","volume":"108","author":"Schoner","year":"2000","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"issue":"10","key":"10.1016\/j.yexcr.2017.04.001_bib25","doi-asserted-by":"crossref","first-page":"101505","DOI":"10.1117\/1.JBO.17.10.101505","article-title":"Effect of ouabain on metabolic oxidative state in living cardiomyocytes evaluated by time-resolved spectroscopy of endogenous NAD(P)H fluorescence","volume":"17","author":"Chorvatova","year":"2012","journal-title":"J. Biomed. Opt."},{"issue":"7","key":"10.1016\/j.yexcr.2017.04.001_bib26","doi-asserted-by":"crossref","first-page":"F982","DOI":"10.1152\/ajprenal.00677.2011","article-title":"Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways","volume":"303","author":"Jansson","year":"2012","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.yexcr.2017.04.001_bib27","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1681\/ASN.2006010086","article-title":"Ouabain binds with high affinity to the Na,K-ATPase in human polycystic kidney cells and induces extracellular signal-regulated kinase activation and cell proliferation","volume":"18","author":"Nguyen","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"issue":"29","key":"10.1016\/j.yexcr.2017.04.001_bib28","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.1073\/pnas.0604496103","article-title":"Contacts and cooperation between cells depend on the hormone ouabain","volume":"103","author":"Larre","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.yexcr.2017.04.001_bib29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1124\/pr.108.000711","article-title":"Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets","volume":"61","author":"Bagrov","year":"2009","journal-title":"Pharmacol. Rev."},{"issue":"7","key":"10.1016\/j.yexcr.2017.04.001_bib30","doi-asserted-by":"crossref","first-page":"C491","DOI":"10.1152\/ajpcell.00359.2015","article-title":"Na+-K+-ATPase, a new class of plasma membrane receptors","volume":"310","author":"Aperia","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"10","key":"10.1016\/j.yexcr.2017.04.001_bib31","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1046\/j.1432-1033.2002.02910.x","article-title":"Na(+)\/K(+)-ATPase as a signal transducer","volume":"269","author":"Xie","year":"2002","journal-title":"Eur. J. Biochem."},{"issue":"12","key":"10.1016\/j.yexcr.2017.04.001_bib32","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/iub.1229","article-title":"Regulation of renal function and structure by the signaling Na\/K-ATPase","volume":"65","author":"Xie","year":"2013","journal-title":"IUBMB Life"},{"issue":"3","key":"10.1016\/j.yexcr.2017.04.001_bib33","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1385\/CBB:46:3:303","article-title":"The Na,K-ATPase receptor complex: its organization and membership","volume":"46","author":"Pierre","year":"2006","journal-title":"Cell Biochem. Biophys."},{"issue":"6","key":"10.1016\/j.yexcr.2017.04.001_bib34","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00232-015-9832-7","article-title":"Ouabain regulates CFTR-mediated anion secretion and Na,K-ATPase transport in ADPKD Cells","volume":"248","author":"Jansson","year":"2015","journal-title":"J. Membr. Biol."},{"issue":"4","key":"10.1016\/j.yexcr.2017.04.001_bib35","doi-asserted-by":"crossref","first-page":"F897","DOI":"10.1152\/ajprenal.00095.2011","article-title":"Ouabain activates the Na-K-ATPase signalosome to induce autosomal dominant polycystic kidney disease cell proliferation","volume":"301","author":"Nguyen","year":"2011","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"3","key":"10.1016\/j.yexcr.2017.04.001_bib36","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1124\/mol.104.007302","article-title":"Digitalis-induced signaling by Na+\/K+-ATPase in human breast cancer cells","volume":"67","author":"Kometiani","year":"2005","journal-title":"Mol. Pharmacol."},{"issue":"37","key":"10.1016\/j.yexcr.2017.04.001_bib37","doi-asserted-by":"crossref","first-page":"32394","DOI":"10.1074\/jbc.M110.207597","article-title":"Na\/K-ATPase mimetic pNaKtide peptide inhibits the growth of human cancer cells","volume":"286","author":"Li","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.yexcr.2017.04.001_bib38","doi-asserted-by":"crossref","first-page":"C1489","DOI":"10.1152\/ajpcell.00158.2007","article-title":"Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes","volume":"293","author":"Liu","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"7","key":"10.1016\/j.yexcr.2017.04.001_bib39","doi-asserted-by":"crossref","first-page":"F982","DOI":"10.1152\/ajprenal.00677.2011","article-title":"Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways","volume":"303","author":"Jansson","year":"2012","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"issue":"22","key":"10.1016\/j.yexcr.2017.04.001_bib40","doi-asserted-by":"crossref","first-page":"14921","DOI":"10.1074\/jbc.M808355200","article-title":"Changes in sodium pump expression dictate the effects of ouabain on cell growth","volume":"284","author":"Tian","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.yexcr.2017.04.001_bib41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00232-013-9607-y","article-title":"Ouabain-induced alterations of the apical junctional complex involve alpha1 and beta1 Na,K-ATPase downregulation and ERK1\/2 activation independent of caveolae in colorectal cancer cells","volume":"247","author":"de Souza","year":"2014","journal-title":"J. Membr. Biol."},{"issue":"3","key":"10.1016\/j.yexcr.2017.04.001_bib42","doi-asserted-by":"crossref","first-page":"F388","DOI":"10.1152\/ajprenal.00439.2002","article-title":"Role of Na-K-ATPase in the assembly of tight junctions","volume":"285","author":"Rajasekaran","year":"2003","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"25","key":"10.1016\/j.yexcr.2017.04.001_bib43","doi-asserted-by":"crossref","first-page":"11387","DOI":"10.1073\/pnas.1000500107","article-title":"Ouabain modulates epithelial cell tight junction","volume":"107","author":"Larre","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.yexcr.2017.04.001_bib44","doi-asserted-by":"crossref","first-page":"F922","DOI":"10.1152\/ajprenal.90605.2008","article-title":"The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition","volume":"296","author":"Fedorova","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.yexcr.2017.04.001_bib45","doi-asserted-by":"crossref","first-page":"c19","DOI":"10.1159\/000320887","article-title":"Practical genetics for autosomal dominant polycystic kidney disease","volume":"118","author":"Pei","year":"2011","journal-title":"Nephron Clin. Pract."},{"issue":"5","key":"10.1016\/j.yexcr.2017.04.001_bib46","doi-asserted-by":"crossref","first-page":"F1005","DOI":"10.1152\/ajprenal.00243.2011","article-title":"Tolvaptan inhibits ERK-dependent cell proliferation, Cl(-) secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin","volume":"301","author":"Reif","year":"2011","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"6","key":"10.1016\/j.yexcr.2017.04.001_bib47","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1046\/j.1523-1755.2003.00023.x","article-title":"Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys","volume":"63","author":"Yamaguchi","year":"2003","journal-title":"Kidney Int"},{"issue":"13","key":"10.1016\/j.yexcr.2017.04.001_bib48","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1093\/hmg\/ddp165","article-title":"Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks","volume":"18","author":"Song","year":"2009","journal-title":"Hum. Mol. Genet"},{"issue":"3","key":"10.1016\/j.yexcr.2017.04.001_bib49","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.yexcr.2017.04.001_bib50","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Invest"},{"issue":"2","key":"10.1016\/j.yexcr.2017.04.001_bib51","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a002584","article-title":"Physiology and function of the tight junction","volume":"1","author":"Anderson","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"3","key":"10.1016\/j.yexcr.2017.04.001_bib52","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.tcb.2009.12.002","article-title":"Dynamics and functions of tight junctions","volume":"20","author":"Steed","year":"2010","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.yexcr.2017.04.001_bib53","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.149.1.111","article-title":"Compromised cytoarchitechture and polarized trafficking in autosomal dominant polycystic kidney disease cells","volume":"149","author":"Charron","year":"2000","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.yexcr.2017.04.001_bib54","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/path.2392","article-title":"Tight junction composition is altered in the epithelium of polycystic kidneys","volume":"216","author":"Yu","year":"2008","journal-title":"J. Pathol."},{"issue":"344","key":"10.1016\/j.yexcr.2017.04.001_bib55","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2005189","article-title":"Signaling mechanisms of the epithelial-mesenchymal transition","volume":"7","author":"Gonzalez","year":"2014","journal-title":"Sci. Signal"},{"key":"10.1016\/j.yexcr.2017.04.001_bib56","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/2001-1326-3-23","article-title":"Biomechanics of TGFbeta-induced epithelial-mesenchymal transition: implications for fibrosis and cancer","volume":"3","author":"O'Connor","year":"2014","journal-title":"Clin. Transl. Med"},{"issue":"7","key":"10.1016\/j.yexcr.2017.04.001_bib57","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1681\/ASN.V371378","article-title":"Growth factor gene expression in kidney of murine polycystic kidney disease","volume":"3","author":"Nakamura","year":"1993","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.yexcr.2017.04.001_bib58","doi-asserted-by":"crossref","first-page":"638","DOI":"10.4161\/cc.6.6.4022","article-title":"Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis?","volume":"6","author":"Boutet","year":"2007","journal-title":"Cell Cycle"},{"issue":"23","key":"10.1016\/j.yexcr.2017.04.001_bib59","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1038\/sj.emboj.7601421","article-title":"Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney","volume":"25","author":"Boutet","year":"2006","journal-title":"EMBO J."},{"issue":"6","key":"10.1016\/j.yexcr.2017.04.001_bib60","doi-asserted-by":"crossref","first-page":"F797","DOI":"10.1152\/ajprenal.00248.2013","article-title":"Novel role of ouabain as a cystogenic factor in autosomal dominant polycystic kidney disease","volume":"305","author":"Blanco","year":"2013","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"25","key":"10.1016\/j.yexcr.2017.04.001_bib61","doi-asserted-by":"crossref","first-page":"11387","DOI":"10.1073\/pnas.1000500107","article-title":"Ouabain modulates epithelial cell tight junction","volume":"107","author":"Larre","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.yexcr.2017.04.001_bib62","doi-asserted-by":"crossref","first-page":"F922","DOI":"10.1152\/ajprenal.90605.2008","article-title":"The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition","volume":"296","author":"Fedorova","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"17","key":"10.1016\/j.yexcr.2017.04.001_bib63","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.4161\/cc.10.17.17188","article-title":"Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer","volume":"10","author":"Jordan","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.yexcr.2017.04.001_bib64","first-page":"371","article-title":"P-Cadherin linking breast cancer stem cells and invasion: a promising marker to identify an \"Intermediate\/Metastable\" EMT state","volume":"4","author":"Ribeiro","year":"2014","journal-title":"Front Oncol."},{"key":"10.1016\/j.yexcr.2017.04.001_bib65","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/bs.ctdb.2014.11.021","article-title":"Epithelial-mesenchymal transitions: from cell plasticity to concept elasticity","volume":"112","author":"Savagner","year":"2015","journal-title":"Curr. Top. Dev. Biol."},{"issue":"1","key":"10.1016\/j.yexcr.2017.04.001_bib66","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1523-1755.2002.00430.x","article-title":"Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies","volume":"62","author":"Rastaldi","year":"2002","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.yexcr.2017.04.001_bib67","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.molmed.2015.11.009","article-title":"Epithelial plasticity versus EMT in kidney fibrosis","volume":"22","author":"Huang","year":"2016","journal-title":"Trends Mol. Med."},{"issue":"9","key":"10.1016\/j.yexcr.2017.04.001_bib68","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nm.3938","article-title":"A new twist in kidney fibrosis","volume":"21","author":"Ovadya","year":"2015","journal-title":"Nat. Med"},{"issue":"2","key":"10.1016\/j.yexcr.2017.04.001_bib69","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1172\/JCI44595","article-title":"Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?","volume":"121","author":"Kriz","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.yexcr.2017.04.001_bib70","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.bbadis.2011.06.012","article-title":"Fibrosis and progression of autosomal dominant polycystic kidney disease (ADPKD)","volume":"1812","author":"Norman","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.yexcr.2017.04.001_bib71","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1172\/JCI5111","article-title":"Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins","volume":"104","author":"Huan","year":"1999","journal-title":"J. Clin. Invest"},{"issue":"1","key":"10.1016\/j.yexcr.2017.04.001_bib72","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0925-4439(00)00079-X","article-title":"Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation","volume":"1535","author":"Geng","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexcr.2017.04.001_bib73","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1091\/mbc.e03-05-0296","article-title":"A polycystin-1 multiprotein complex Is disrupted in polycystic kidney disease cells","volume":"15","author":"Roitbak","year":"2004","journal-title":"Mol. Biol. Cell"},{"issue":"Pt 9","key":"10.1016\/j.yexcr.2017.04.001_bib74","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1242\/jcs.045021","article-title":"Homophilic and heterophilic polycystin 1 interactions regulate E-cadherin recruitment and junction assembly in MDCK cells","volume":"122","author":"Streets","year":"2009","journal-title":"J. Cell Sci."},{"issue":"Pt 19","key":"10.1016\/j.yexcr.2017.04.001_bib75","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1242\/jcs.113.19.3387","article-title":"Inducible expression of claudin-1-myc but not occludin-VSV-G results in aberrant tight junction strand formation in MDCK cells","volume":"113","author":"McCarthy","year":"2000","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.yexcr.2017.04.001_bib76","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1083\/jcb.134.4.1031","article-title":"Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein","volume":"134","author":"Balda","year":"1996","journal-title":"J. Cell Biol."},{"issue":"Pt 23","key":"10.1016\/j.yexcr.2017.04.001_bib77","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1242\/jcs.112.23.4223","article-title":"Relationship between Na(+),K(+)-ATPase and cell attachment","volume":"112","author":"Contreras","year":"1999","journal-title":"J. Cell Sci."},{"issue":"51","key":"10.1016\/j.yexcr.2017.04.001_bib78","doi-asserted-by":"crossref","first-page":"39573","DOI":"10.1074\/jbc.M606507200","article-title":"The role of the beta1 subunit of the Na,K-ATPase and its glycosylation in cell-cell adhesion","volume":"281","author":"Vagin","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.yexcr.2017.04.001_bib79","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1158\/1535-7163.MCT-09-0832","article-title":"Na,K-ATPase subunits as markers for epithelial-mesenchymal transition in cancer and fibrosis","volume":"9","author":"Rajasekaran","year":"2010","journal-title":"Mol. Cancer Ther."},{"issue":"5","key":"10.1016\/j.yexcr.2017.04.001_bib80","doi-asserted-by":"crossref","first-page":"F1463","DOI":"10.1152\/ajprenal.90266.2008","article-title":"Periostin induces proliferation of human autosomal dominant polycystic kidney cells through alphaV-integrin receptor","volume":"295","author":"Wallace","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"10","key":"10.1016\/j.yexcr.2017.04.001_bib81","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm3434","article-title":"TGFbeta signalling in context","volume":"13","author":"Massague","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482717302008?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482717302008?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T04:55:46Z","timestamp":1658897746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482717302008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":81,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0014482717302008"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2017.04.001","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ouabain promotes partial epithelial to mesenchymal transition (EMT) changes in human autosomal dominant polycystic kidney disease (ADPKD) cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2017.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}