{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:23:19Z","timestamp":1783977799603,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.yexcr.2017.07.030","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T08:03:04Z","timestamp":1500969784000},"page":"185-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Long non-coding RNA CCAT1 promotes metastasis and poor prognosis in epithelial ovarian cancer"],"prefix":"10.1016","volume":"359","author":[{"given":"Yuan","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huirong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruitao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2017.07.030_bib1","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA: Cancer J. Clin."},{"key":"10.1016\/j.yexcr.2017.07.030_bib2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nrc2946","article-title":"The genesis and evolution of high-grade serous ovarian cancer","volume":"10","author":"Bowtell","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.yexcr.2017.07.030_bib3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.lfs.2016.12.007","article-title":"MiR-376a promotion of proliferation and metastases in ovarian cancer: potential role as a biomarker","volume":"173","author":"Yang","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.yexcr.2017.07.030_bib4","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(10)61268-8","article-title":"Early versus delayed treatment of relapsed ovarian cancer (MRC OV05\/EORTC 55955): a randomised trial","volume":"376","author":"Rustin","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.yexcr.2017.07.030_bib5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ccr.2009.01.023","article-title":"Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells","volume":"15","author":"Kudo-Saito","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.yexcr.2017.07.030_bib6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s10555-009-9194-7","article-title":"Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer","volume":"28","author":"McConkey","year":"2009","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.yexcr.2017.07.030_bib7","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.yexcr.2012.07.019","article-title":"Epigenetic control of epithelial-to-mesenchymal transition and cancer metastasis","volume":"319","author":"Wang","year":"2013","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2017.07.030_bib8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.yexcr.2017.01.022","article-title":"miR-598 inhibits metastasis in colorectal cancer by suppressing JAG1\/Notch2 pathway stimulating EMT","volume":"352","author":"Chen","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2017.07.030_bib9","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1016\/j.yexcr.2013.05.014","article-title":"Small interfering RNA targeting ILK inhibits metastasis in human tongue cancer cells through repression of epithelial-to-mesenchymal transition","volume":"319","author":"Xing","year":"2013","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2017.07.030_bib10","doi-asserted-by":"crossref","first-page":"496","DOI":"10.4161\/rna.8.3.14800","article-title":"LSINCT5 is over expressed in breast and ovarian cancer and affects cellular proliferation","volume":"8","author":"Silva","year":"2011","journal-title":"RNA Biol."},{"key":"10.1016\/j.yexcr.2017.07.030_bib11","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/hmg\/ddu502","article-title":"LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b","volume":"24","author":"Gao","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2017.07.030_bib12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ygyno.2014.03.556","article-title":"Overexpression of long non-coding RNA HOTAIR predicts poor patient prognosis and promotes tumor metastasis in epithelial ovarian cancer","volume":"134","author":"Qiu","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.yexcr.2017.07.030_bib13","doi-asserted-by":"crossref","first-page":"25381","DOI":"10.18632\/oncotarget.4541","article-title":"A long noncoding RNA AB073614 promotes tumorigenesis and predicts poor prognosis in ovarian cancer","volume":"6","author":"Cheng","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.yexcr.2017.07.030_bib14","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.3892\/ijo.2015.2943","article-title":"Long non-coding RNA ANRIL predicts poor prognosis and promotes invasion\/metastasis in serous ovarian cancer","volume":"46","author":"Qiu","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.yexcr.2017.07.030_bib15","doi-asserted-by":"crossref","first-page":"e1583","DOI":"10.1038\/cddis.2014.541","article-title":"Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p","volume":"6","author":"Ma","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.yexcr.2017.07.030_bib16","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13046-015-0136-7","article-title":"Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge","volume":"34","author":"Deng","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.yexcr.2017.07.030_bib17","first-page":"5427","article-title":"CCAT1 promotes hepatocellular carcinoma cell proliferation and invasion","volume":"8","author":"Zhu","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.yexcr.2017.07.030_bib18","first-page":"4338","article-title":"CCAT1 promotes laryngeal squamous cell carcinoma cell proliferation and invasion","volume":"8","author":"Zhuang","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.yexcr.2017.07.030_bib19","doi-asserted-by":"crossref","first-page":"12181","DOI":"10.1007\/s13277-014-2526-4","article-title":"C-Myc-activated long noncoding RNA CCAT1 promotes colon cancer cell proliferation and invasion","volume":"35","author":"He","year":"2014","journal-title":"Tumor Biol."},{"key":"10.1016\/j.yexcr.2017.07.030_bib20","first-page":"9440","article-title":"Overexpression of long non-coding RNA CCAT1 is a novel biomarker of poor prognosis in patients with breast cancer","volume":"8","author":"Zhang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.yexcr.2017.07.030_bib21","first-page":"1242","article-title":"LncRNA CCAT1 as the unfavorable prognostic biomarker for cholangiocarcinoma","volume":"21","author":"Jiang","year":"2017","journal-title":"Eur. Rev. Med. Pharmcol."},{"key":"10.1016\/j.yexcr.2017.07.030_bib22","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3892\/br.2017.876","article-title":"Long non-coding RNA CCAT1 is overexpressed in oral squamous cell carcinomas and predicts poor prognosis","volume":"6","author":"Arunkumar","year":"1899","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.yexcr.2017.07.030_bib23","first-page":"138","article-title":"Identification of differentially expressed long non-coding RNAs in human ovarian cancer cells with different metastatic potentials","volume":"10","author":"Liu","year":"2013","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.yexcr.2017.07.030_bib24","first-page":"1271","article-title":"Claudin-4: a potential therapeutic target in chemotherapy-resistant ovarian cancer","volume":"31","author":"Yoshida","year":"2011","journal-title":"Anticancer. Res."},{"key":"10.1016\/j.yexcr.2017.07.030_bib25","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1111\/febs.12902","article-title":"lncRNA H19\/miR\u2010675 axis represses prostate cancer metastasis by targeting TGFBI","volume":"281","author":"Zhu","year":"2014","journal-title":"FEBS J."},{"key":"10.1016\/j.yexcr.2017.07.030_bib26","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1158\/0008-5472.CAN-14-2931","article-title":"Long noncoding RNA MALAT1 promotes aggressive renal cell carcinoma through Ezh2 and interacts with miR-205","volume":"75","author":"Hirata","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexcr.2017.07.030_bib27","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.canlet.2012.10.026","article-title":"MiR-15b and miR-152 reduce glioma cell invasion and angiogenesis via NRP-2 and MMP-3","volume":"329","author":"Zheng","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.yexcr.2017.07.030_bib28","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1038\/emm.2014.51","article-title":"MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2","volume":"46","author":"Cheng","year":"2014","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.yexcr.2017.07.030_bib29","doi-asserted-by":"crossref","first-page":"11367","DOI":"10.1007\/s13277-014-2471-2","article-title":"miR-152 suppresses gastric cancer cell proliferation and motility by targeting CD151","volume":"35","author":"Zhai","year":"2014","journal-title":"Tumor Biol."},{"key":"10.1016\/j.yexcr.2017.07.030_bib30","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1002\/mc.22204","article-title":"MiR\u2010130b suppresses prostate cancer metastasis through down\u2010regulation of MMP2","volume":"54","author":"Chen","year":"2015","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.yexcr.2017.07.030_bib31","doi-asserted-by":"crossref","first-page":"e73803","DOI":"10.1371\/journal.pone.0073803","article-title":"MiR-130b is a prognostic marker and inhibits cell proliferation and invasion in pancreatic cancer through targeting STAT3","volume":"8","author":"Zhao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.yexcr.2017.07.030_bib32","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1476-4598-11-58","article-title":"Regulation of colony stimulating factor-1 expression and ovarian cancer cell behavior in vitro by miR-128 and miR-152","volume":"11","author":"Woo","year":"2012","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.yexcr.2017.07.030_bib33","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ygyno.2011.10.013","article-title":"Epigenetic silencing of miR-130b in ovarian cancer promotes the development of multidrug resistance by targeting colony-stimulating factor 1","volume":"124","author":"Yang","year":"2012","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.yexcr.2017.07.030_bib34","doi-asserted-by":"crossref","first-page":"32421","DOI":"10.18632\/oncotarget.8718","article-title":"miR-1207-5p suppresses lung cancer growth and metastasis by targeting CSF1","volume":"7","author":"Dang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.yexcr.2017.07.030_bib35","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.3892\/mmr.2014.2029","article-title":"ADAM17 silencing suppresses the migration and invasion of non-small cell lung cancer","volume":"9","author":"Lv","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.yexcr.2017.07.030_bib36","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1038\/onc.2010.591","article-title":"Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion","volume":"30","author":"Yu","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2017.07.030_bib37","doi-asserted-by":"crossref","first-page":"12465","DOI":"10.1038\/srep12465","article-title":"Blockade of Wnt\/\u03b2-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype","volume":"5","author":"Jang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexcr.2017.07.030_bib38","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/sj.onc.1206122","article-title":"Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis","volume":"22","author":"Wei","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2017.07.030_bib39","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.canlet.2015.01.003","article-title":"IFN-\u03b3-mediated IRF1\/miR-29b feedback loop suppresses colorectal cancer cell growth and metastasis by repressing IGF1","volume":"359","author":"Yuan","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.yexcr.2017.07.030_bib40","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/ncb1998","article-title":"The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs","volume":"11","author":"Wellner","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2017.07.030_bib41","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/ncb1722","article-title":"The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1","volume":"10","author":"Gregory","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2017.07.030_bib42","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1038\/onc.2011.96","article-title":"Zeb1 is required for TrkB-induced epithelial-mesenchymal transition, anoikis resistance and metastasis","volume":"30","author":"Smit","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2017.07.030_bib43","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/ijc.23465","article-title":"Heregulin\u2010induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells","volume":"123","author":"Ueno","year":"2008","journal-title":"Int. J. Cancer"}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482717304020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482717304020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:21:31Z","timestamp":1757996491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482717304020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0014482717304020"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2017.07.030","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long non-coding RNA CCAT1 promotes metastasis and poor prognosis in epithelial ovarian cancer","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2017.07.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}