{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:26:32Z","timestamp":1790270792970,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471576"],"award-info":[{"award-number":["81471576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701577"],"award-info":[{"award-number":["81701577"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.yexcr.2017.09.040","type":"journal-article","created":{"date-parts":[[2017,10,2]],"date-time":"2017-10-02T19:01:20Z","timestamp":1506970880000},"page":"46-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Treponema pallidum flagellins stimulate MMP-9 and MMP-13 expression via TLR5 and MAPK\/NF-\u03baB signaling pathways in human epidermal keratinocytes"],"prefix":"10.1016","volume":"361","author":[{"given":"Chuanhao","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manyi","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafeng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feijun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimou","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2017.09.040_bib1","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1172\/JCI57173","article-title":"Syphilis: using modern approaches to understand an old disease","volume":"121","author":"Ho","year":"2011","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.yexcr.2017.09.040_bib2","doi-asserted-by":"crossref","first-page":"e0143304","DOI":"10.1371\/journal.pone.0143304","article-title":"Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting","volume":"10","author":"Newman","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.yexcr.2017.09.040_bib3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1128\/CMR.19.1.29-49.2006","article-title":"Biological basis for syphilis","volume":"19","author":"Lafond","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.yexcr.2017.09.040_bib4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/0956462415590710","article-title":"Neurosyphilis: from infection to autoinflammation?","volume":"27","author":"Drago","year":"2016","journal-title":"Int. J. STD AIDS"},{"key":"10.1016\/j.yexcr.2017.09.040_bib5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nri3646","article-title":"Mechanisms regulating skin immunity and inflammation","volume":"14","author":"Pasparakis","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.yexcr.2017.09.040_bib6","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.jaad.2008.11.901","article-title":"Reflectance confocal microscopy for the in vivo detection of Treponema pallidum in skin lesions of secondary syphilis","volume":"60","author":"Venturini","year":"2009","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.yexcr.2017.09.040_bib7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3109\/01913123.2011.584498","article-title":"Cell and tissue interactions of Treponema pallidum in primary and secondary syphilitic skin lesions: an ultrastructural study of serial sections","volume":"37","author":"Juanpere-Rodero","year":"2013","journal-title":"Ultrastruct. Pathol."},{"key":"10.1016\/j.yexcr.2017.09.040_bib8","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri2622","article-title":"Skin immune sentinels in health and disease","volume":"9","author":"Nestle","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.yexcr.2017.09.040_bib9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/sj.jid.5700530","article-title":"Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9","volume":"127","author":"Lebre","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.yexcr.2017.09.040_bib10","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1111\/j.1600-0625.2009.00963.x","article-title":"Activation of toll-like receptors 2, 3 or 5 induces matrix metalloproteinase-1 and -9 expression with the involvement of MAPKs and NF-kappaB in human epidermal keratinocytes","volume":"19","author":"Lee","year":"2010","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.yexcr.2017.09.040_bib11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/mi.2009.9","article-title":"Flagellin: key target of mucosal innate immunity","volume":"2","author":"Vijay-Kumar","year":"2009","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.yexcr.2017.09.040_bib12","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nature10510","article-title":"The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus","volume":"477","author":"Zhao","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2017.09.040_bib13","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/35074106","article-title":"The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5","volume":"410","author":"Hayashi","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2017.09.040_bib14","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.tim.2004.09.002","article-title":"Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa","volume":"12","author":"Ramos","year":"2004","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.yexcr.2017.09.040_bib15","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.jmb.2010.09.020","article-title":"Cellular architecture of Treponema pallidum: novel flagellum, periplasmic cone, and cell envelope as revealed by cryo electron tomography","volume":"403","author":"Liu","year":"2010","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.yexcr.2017.09.040_bib16","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1128\/IAI.00173-10","article-title":"Characterization and serologic analysis of the Treponema pallidum proteome","volume":"78","author":"McGill","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.yexcr.2017.09.040_bib17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.diagmicrobio.2015.10.005","article-title":"Evaluation of FlaB1, FlaB2, FlaB3, and Tp0463 of Treponema pallidum for serodiagnosis of syphilis","volume":"84","author":"Jiang","year":"2016","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.yexcr.2017.09.040_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2017.01.002","article-title":"Treponema pallidum flagellins elicit proinflammatory cytokines from human monocytes via TLR5 signaling pathway","author":"Xu","year":"2017","journal-title":"Immunobiology"},{"key":"10.1016\/j.yexcr.2017.09.040_bib19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.molimm.2016.11.005","article-title":"Treponema pallidum flagellin FlaA2 induces IL-6 secretion in THP-1 cells via the Toll-like receptor 2 signaling pathway","volume":"81","author":"Xie","year":"2017","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.yexcr.2017.09.040_bib20","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1016\/j.bbagen.2014.03.007","article-title":"Matrix metalloproteinases in inflammation","volume":"1840","author":"Nissinen","year":"2014","journal-title":"Biochim. Et. Biophys. Acta"},{"key":"10.1016\/j.yexcr.2017.09.040_bib21","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nri3499","article-title":"Metalloproteinases and their natural inhibitors in inflammation and immunity","volume":"13","author":"Khokha","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.yexcr.2017.09.040_bib22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/cmi.12211","article-title":"Porphyromonas gingivalis promotes invasion of oral squamous cell carcinoma through induction of proMMP9 and its activation","volume":"16","author":"Inaba","year":"2014","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.yexcr.2017.09.040_bib23","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1111\/j.1462-5822.2007.00997.x","article-title":"Mycobacterium avium-induced matrix metalloproteinase-9 expression occurs in a cyclooxygenase-2-dependent manner and involves phosphorylation- and acetylation-dependent chromatin modification","volume":"9","author":"Basu","year":"2007","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.yexcr.2017.09.040_bib24","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1128\/IAI.00887-15","article-title":"Vigilant keratinocytes trigger pathogen-associated molecular pattern signaling in response to streptococcal M1 protein","volume":"83","author":"Persson","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.yexcr.2017.09.040_bib25","doi-asserted-by":"crossref","first-page":"6492","DOI":"10.4049\/jimmunol.0903811","article-title":"Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and activator Protein-1-dependent monocyte networks","volume":"184","author":"Green","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexcr.2017.09.040_bib26","doi-asserted-by":"crossref","first-page":"e0137979","DOI":"10.1371\/journal.pone.0137979","article-title":"Mycobacterium tuberculosis upregulates TNF-alpha expression via TLR2\/ERK signaling and induces MMP-1 and MMP-9 production in human pleural mesothelial cells","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.yexcr.2017.09.040_bib27","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/cei.12725","article-title":"Matrix metalloproteinases contribute to the regulation of chemokine expression and pulmonary inflammation in Cryptococcus infection","volume":"183","author":"Supasorn","year":"2016","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.yexcr.2017.09.040_bib28","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1128\/IAI.01600-07","article-title":"Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction","volume":"76","author":"Shin","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.yexcr.2017.09.040_bib29","doi-asserted-by":"crossref","first-page":"e1000444","DOI":"10.1371\/journal.ppat.1000444","article-title":"Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta","volume":"5","author":"Salazar","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.yexcr.2017.09.040_bib30","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1128\/IAI.01078-08","article-title":"Live Borrelia burgdorferi spirochetes elicit inflammatory mediators from human monocytes via the Toll-like receptor signaling pathway","volume":"77","author":"Dennis","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.yexcr.2017.09.040_bib31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12974-015-0274-z","article-title":"Inflammatory mediator release from primary rhesus microglia in response to Borrelia burgdorferi results from the activation of several receptors and pathways","volume":"12","author":"Parthasarathy","year":"2015","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.yexcr.2017.09.040_bib32","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1423-0127-21-12","article-title":"TNF-alpha induces matrix metalloproteinase-9-dependent soluble intercellular adhesion molecule-1 release via TRAF2-mediated MAPKs and NF-kappaB activation in osteoblast-like MC3T3-E1 cells","volume":"21","author":"Tsai","year":"2014","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.yexcr.2017.09.040_bib33","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/jcp.20992","article-title":"Interleukin-1beta induces MMP-9 expression via p42\/p44 MAPK, p38 MAPK, JNK, and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells","volume":"211","author":"Liang","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.yexcr.2017.09.040_bib34","doi-asserted-by":"crossref","first-page":"e0161875","DOI":"10.1371\/journal.pone.0161875","article-title":"Hyaluronan oligosaccharides induce MMP-1 and -3 via transcriptional activation of NF-kappab and p38 MAPK in rheumatoid synovial fibroblasts","volume":"11","author":"Hanabayashi","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.yexcr.2017.09.040_bib35","doi-asserted-by":"crossref","first-page":"e0116393","DOI":"10.1371\/journal.pone.0116393","article-title":"High mobility group box 1 induced human lung myofibroblasts differentiation and enhanced migration by activation of MMP-9","volume":"10","author":"Lee","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.yexcr.2017.09.040_bib36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cyto.2011.02.007","article-title":"Expression of matrix metalloproteinases and their tissue inhibitors in the serum and cerebrospinal fluid of patients with HIV-1 infection and syphilis or neurosyphilis","volume":"54","author":"Tsai","year":"2011","journal-title":"Cytokine"}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482717305281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482717305281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:15:07Z","timestamp":1762146907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482717305281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0014482717305281"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2017.09.040","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treponema pallidum flagellins stimulate MMP-9 and MMP-13 expression via TLR5 and MAPK\/NF-\u03baB signaling pathways in human epidermal keratinocytes","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2017.09.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}