{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:46:22Z","timestamp":1790801182910,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Israel Cancer Association, the Israel Science Foundation","award":["1287\/08"],"award-info":[{"award-number":["1287\/08"]}]},{"name":"Chief Scientist, Israel Ministry of Health","award":["39938"],"award-info":[{"award-number":["39938"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.yexcr.2018.01.024","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T18:46:48Z","timestamp":1517424408000},"page":"42-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["O -GlcNAcylation affects \u03b2-catenin and E-cadherin expression, cell motility and tumorigenicity of colorectal cancer"],"prefix":"10.1016","volume":"364","author":[{"given":"Shani Ben","family":"Harosh-Davidovich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isam","family":"Khalaila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2018.01.024_bib1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.R114.609776","article-title":"Nutrient regulation of cellular metabolism & physiology by O-GlcNAcylation","author":"Hart","year":"2014","journal-title":"J. Biol.Chem."},{"key":"10.1016\/j.yexcr.2018.01.024_bib2","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nature05815","article-title":"Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins","volume":"446","author":"Hart","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2018.01.024_bib3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.tibs.2010.04.005","article-title":"O-GlcNAc signaling: a metabolic link between diabetes and cancer?","volume":"35","author":"Slawson","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.yexcr.2018.01.024_bib4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1242\/jcs.053678","article-title":"The intersections between O-GlcNAcylation and phosphorylation: implications for multiple signaling pathways","volume":"123","author":"Zeidan","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2018.01.024_bib5","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.yexcr.2016.11.023","article-title":"The effect of O-GlcNAcylation on hnRNP A1 translocation and interaction with transportin1","volume":"350","author":"Roth","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2018.01.024_bib6","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.R114.577718","article-title":"Cancer metabolism and elevated O-GlcNAc in oncogenic signaling","author":"Ma","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2018.01.024_bib7","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2018.01.024_bib8","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1038\/onc.2010.41","article-title":"Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1","volume":"29","author":"Caldwell","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2018.01.024_bib9","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1074\/jbc.M111.302547","article-title":"Critical role of O-linked beta-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis","volume":"287","author":"Lynch","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2018.01.024_bib10","doi-asserted-by":"crossref","first-page":"6344","DOI":"10.1158\/0008-5472.CAN-09-1887","article-title":"GlcNAcylation plays an essential role in breast cancer metastasis","volume":"70","author":"Gu","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexcr.2018.01.024_bib11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/onc.2016.228","article-title":"O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway","volume":"36","author":"Ferrer","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2018.01.024_bib12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10911-010-9178-9","article-title":"Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression","volume":"15","author":"Micalizzi","year":"2010","journal-title":"J. Mammary Gland Biol. neoplasia"},{"key":"10.1016\/j.yexcr.2018.01.024_bib13","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/jcb.21215","article-title":"Mechanisms of metastasis: epithelial-to-mesenchymal transition and contribution of tumor microenvironment","volume":"101","author":"Tse","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.yexcr.2018.01.024_bib14","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.mito.2012.08.002","article-title":"Redox regulation of cancer cell migration and invasion","volume":"13","author":"Tochhawng","year":"2013","journal-title":"Mitochondrion"},{"key":"10.1016\/j.yexcr.2018.01.024_bib15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fendo.2013.00099","article-title":"O-GlcNAcylation: a new cancer hallmark?","volume":"4","author":"Fardini","year":"2013","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.yexcr.2018.01.024_bib16","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.yexcr.2013.03.013","article-title":"A correlation between altered O-GlcNAcylation, migration and with changes in E-cadherin levels in ovarian cancer cells","volume":"319","author":"Jin","year":"2013","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2018.01.024_bib17","doi-asserted-by":"crossref","first-page":"28755","DOI":"10.1074\/jbc.M112.345546","article-title":"O-linked beta-N-acetylglucosaminylation (O-GlcNAcylation) in primary and metastatic colorectal cancer clones and effect of N-acetyl-beta-D-glucosaminidase silencing on cell phenotype and transcriptome","volume":"287","author":"Yehezkel","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2018.01.024_bib18","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1096\/fj.13-243535","article-title":"O-GlcNAcylation stabilizes beta-catenin through direct competition with phosphorylation at threonine 41","volume":"28","author":"Olivier-Van Stichelen","year":"2014","journal-title":"FASEB J.: Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.yexcr.2018.01.024_bib19","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.1093\/emboj\/20.21.5999","article-title":"Cytoplasmic O-glycosylation prevents cell surface transport of E-cadherin during apoptosis","volume":"20","author":"Zhu","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.yexcr.2018.01.024_bib20","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1016\/j.yexcr.2008.05.017","article-title":"O-GlcNAc-glycosylation of beta-catenin regulates its nuclear localization and transcriptional activity","volume":"314","author":"Sayat","year":"2008","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2018.01.024_bib21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.yexcr.2013.11.021","article-title":"beta-catenin is O-GlcNAc glycosylated at Serine 23: implications for beta-catenin's subcellular localization and transactivator function","volume":"321","author":"Ha","year":"2014","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2018.01.024_bib22","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1074\/jbc.M111.299099","article-title":"Specific armadillo repeat sequences facilitate beta-catenin nuclear transport in live cells via direct binding to nucleoporins Nup62, Nup153, and RanBP2\/Nup358","volume":"287","author":"Sharma","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2018.01.024_bib23","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1101\/gad.1385806","article-title":"The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes","volume":"20","author":"Sierra","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.yexcr.2018.01.024_bib24","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nprot.2007.30","article-title":"In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro","volume":"2","author":"Liang","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.yexcr.2018.01.024_bib25","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1038\/emboj.2012.150","article-title":"The many faces and functions of beta-catenin","volume":"31","author":"Valenta","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.yexcr.2018.01.024_bib26","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1038\/emboj.2010.254","article-title":"Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition","volume":"29","author":"Park","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.yexcr.2018.01.024_bib27","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.bbadis.2011.01.009","article-title":"O-GlcNAcylation is a novel regulator of lung and colon cancer malignancy","volume":"1812","author":"Mi","year":"2011","journal-title":"Biochim. Et. Biophys. Acta"},{"key":"10.1016\/j.yexcr.2018.01.024_bib28","doi-asserted-by":"crossref","first-page":"15280","DOI":"10.1038\/ncomms15280","article-title":"The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis","volume":"8","author":"Zhang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yexcr.2018.01.024_bib29","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.molcel.2014.04.026","article-title":"O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway","volume":"54","author":"Ferrer","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.yexcr.2018.01.024_bib30","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3892\/mmr.2014.2269","article-title":"O-GlcNAcylation is increased in prostate cancer tissues and enhances malignancy of prostate cancer cells","volume":"10","author":"Gu","year":"2014","journal-title":"Mol. Med. Rep."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482718300351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482718300351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T14:28:33Z","timestamp":1535120913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482718300351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S0014482718300351"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2018.01.024","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"O-GlcNAcylation affects \u03b2-catenin and E-cadherin expression, cell motility and tumorigenicity of colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2018.01.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}