{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:27:38Z","timestamp":1782552458929,"version":"3.54.5"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.yexcr.2019.05.030","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T22:33:29Z","timestamp":1559255609000},"page":"111449","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Sox9 regulates the luminal stem\/progenitor cell properties of salivary glands"],"prefix":"10.1016","volume":"382","author":[{"given":"Junichi","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo","family":"Mabuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Hata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Yasuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koki","family":"Takamatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Kujiraoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Yukimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Takakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Sumimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Fukada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Azuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riko","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikazu","family":"Shimane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Mishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2019.05.030_bib1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature13851","article-title":"Identification of multipotent mammary stem cells by protein C receptor expression","volume":"517","author":"Wang","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2019.05.030_bib2","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/ncb3025","article-title":"Mammary stem cells have myoepithelial cell properties","volume":"16","author":"Prater","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2019.05.030_bib3","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/ncb3309","article-title":"Stem cells versus plasticity in liver and pancreas regeneration","volume":"18","author":"Kopp","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2019.05.030_bib4","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1126\/science.1192046","article-title":"Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis","volume":"329","author":"Knox","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2019.05.030_bib5","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.stem.2011.09.001","article-title":"Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice","volume":"9","author":"Arnold","year":"2011","journal-title":"Cell stem cell"},{"key":"10.1016\/j.yexcr.2019.05.030_bib6","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.stemcr.2013.10.013","article-title":"Combined KIT and FGFR2b signaling regulates epithelial progenitor expansion during organogenesis","volume":"1","author":"Lombaert","year":"2013","journal-title":"Stem cell reports"},{"key":"10.1016\/j.yexcr.2019.05.030_bib7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1053\/jhep.2003.50259","article-title":"Salivary gland progenitor cells induced by duct ligation differentiate into hepatic and pancreatic lineages","volume":"38","author":"Okumura","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2019.05.030_bib8","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/hep.20063","article-title":"Flow cytometric isolation of endodermal progenitors from mouse salivary gland differentiate into hepatic and pancreatic lineages","volume":"39","author":"Hisatomi","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2019.05.030_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002063","article-title":"Rescue of salivary gland function after stem cell transplantation in irradiated glands","volume":"3","author":"Lombaert","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.yexcr.2019.05.030_bib10","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1172\/JCI74096","article-title":"Neurotrophic factor GDNF promotes survival of salivary stem cells","volume":"124","author":"Xiao","year":"2014","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.yexcr.2019.05.030_bib11","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.stemcr.2014.09.015","article-title":"Purification and ex vivo expansion of fully functional salivary gland stem cells","volume":"3","author":"Nanduri","year":"2014","journal-title":"Stem cell reports"},{"key":"10.1016\/j.yexcr.2019.05.030_bib12","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.stemcr.2015.11.009","article-title":"Long-term in vitro expansion of salivary gland stem cells driven by Wnt signals","volume":"6","author":"Maimets","year":"2016","journal-title":"Stem cell reports"},{"key":"10.1016\/j.yexcr.2019.05.030_bib13","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1002\/stem.1715","article-title":"Defining the localization and molecular characteristic of minor salivary gland label-retaining cells","volume":"32","author":"Zhang","year":"2014","journal-title":"Stem Cell."},{"key":"10.1016\/j.yexcr.2019.05.030_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107893","article-title":"Label-retaining cells in the adult murine salivary glands possess characteristics of adult progenitor cells","volume":"9","author":"Chibly","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.yexcr.2019.05.030_bib15","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/ar.1098","article-title":"Contributions of intercalated duct cells to the normal parenchyma of submandibular glands of adult rats","volume":"263","author":"Man","year":"2001","journal-title":"Anat. Rec."},{"key":"10.1016\/j.yexcr.2019.05.030_bib16","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1177\/0022034515599770","article-title":"Salivary glands: stem cells, self-duplication, or both?","volume":"94","author":"Aure","year":"2015","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.yexcr.2019.05.030_bib17","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1002\/stem.1173","article-title":"Transplantation of side population cells restores the function of damaged exocrine glands through clusterin","volume":"30","author":"Mishima","year":"2012","journal-title":"Stem Cell."},{"key":"10.1016\/j.yexcr.2019.05.030_bib18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.radonc.2011.05.085","article-title":"Regeneration of irradiated salivary glands with stem cell marker expressing cells, Radiotherapy and oncology","volume":"99","author":"Nanduri","year":"2011","journal-title":"J. Eur. Soc. Ther. Radiol. Oncol."},{"key":"10.1016\/j.yexcr.2019.05.030_bib19","series-title":"Reduced Salivary Gland Size and Increased Presence of Epithelial Progenitor Cells in DLK1-Deficient Mice, Cell and Tissue Research","author":"Garcia-Gallastegui","year":"2015"},{"key":"10.1016\/j.yexcr.2019.05.030_bib20","first-page":"132349","article-title":"Expressions of ABCG2, CD133, and podoplanin in salivary adenoid cystic carcinoma","author":"Li","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.yexcr.2019.05.030_bib21","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.radonc.2013.05.020","article-title":"Salisphere derived c-Kit+ cell transplantation restores tissue homeostasis in irradiated salivary gland, Radiotherapy and oncology","volume":"108","author":"Nanduri","year":"2013","journal-title":"J. Eur. Soc. Ther. Radiol. Oncol."},{"key":"10.1016\/j.yexcr.2019.05.030_bib22","series-title":"Induction and Differentiation of Adipose-Derived Stem Cells from Human Buccal Fat Pads into Salivary Gland Cells, Human Cell","author":"Kawakami","year":"2016"},{"key":"10.1016\/j.yexcr.2019.05.030_bib23","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.3892\/etm.2015.2700","article-title":"Establishment of immortalized mesenchymal stem cells derived from the submandibular glands of tdTomato transgenic mice","volume":"10","author":"Furukawa","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.yexcr.2019.05.030_bib24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/path.2283","article-title":"CD133: molecule of the moment","volume":"214","author":"Mizrak","year":"2008","journal-title":"J. Pathol."},{"key":"10.1016\/j.yexcr.2019.05.030_bib25","doi-asserted-by":"crossref","DOI":"10.1177\/0022034516634664","article-title":"Identification of stem cells in the secretory complex of salivary glands","author":"Kwak","year":"2016","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.yexcr.2019.05.030_bib26","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/0092-8674(94)90041-8","article-title":"Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9","volume":"79","author":"Wagner","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2019.05.030_bib27","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.cub.2005.06.064","article-title":"Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment","volume":"15","author":"Vidal","year":"2005","journal-title":"Curr. Biol. : CB"},{"key":"10.1016\/j.yexcr.2019.05.030_bib28","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1053\/j.gastro.2009.02.051","article-title":"Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9","volume":"136","author":"Antoniou","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yexcr.2019.05.030_bib29","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/j.biocel.2007.05.019","article-title":"Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors","volume":"39","author":"Lefebvre","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.yexcr.2019.05.030_bib30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/cne.21746","article-title":"Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in Muller glial cell development","volume":"510","author":"Poche","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.yexcr.2019.05.030_bib31","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0925-4773(02)00249-6","article-title":"Expression of Sox8, Sox9 and Sox10 in the developing valves and autonomic nerves of the embryonic heart","volume":"118","author":"Montero","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1016\/j.yexcr.2019.05.030_bib32","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3109\/s10165-008-0048-x","article-title":"Control of chondrogenesis by the transcription factor Sox9","volume":"18","author":"Akiyama","year":"2008","journal-title":"Mod. Rheumatol.\/Japan Rheumatism Assoc."},{"key":"10.1016\/j.yexcr.2019.05.030_bib33","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1073\/pnas.0609217104","article-title":"SOX9 is required for maintenance of the pancreatic progenitor cell pool","volume":"104","author":"Seymour","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.yexcr.2019.05.030_bib34","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1242\/dev.108944","article-title":"FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands","volume":"141","author":"Chen","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2019.05.030_bib35","first-page":"2294","article-title":"Fgf10 and Sox9 are essential for the establishment of distal progenitor cells during mouse salivary gland development","volume":"144","author":"Chatzeli","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2019.05.030_bib36","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1038\/s41467-018-06469-7","article-title":"Generation of orthotopically functional salivary gland from embryonic stem cells","volume":"9","author":"Tanaka","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yexcr.2019.05.030_bib37","first-page":"24","article-title":"Immortalization of normal human salivary gland cells with duct-, myoepithelial-, acinar-, or squamous phenotype by transfection with SV40 ori- mutant deoxyribonucleic acid, Laboratory investigation","volume":"69","author":"Azuma","year":"1993","journal-title":"J. Tech. Methods Pathol."},{"key":"10.1016\/j.yexcr.2019.05.030_bib38","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0014-5793(97)00313-X","article-title":"Green mice' as a source of ubiquitous green cells","volume":"407","author":"Okabe","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yexcr.2019.05.030_bib39","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/dvg.20667","article-title":"Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons","volume":"48","author":"Soeda","year":"2010","journal-title":"Genesis"},{"key":"10.1016\/j.yexcr.2019.05.030_bib40","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yexcr.2019.05.030_bib41","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-1-60761-533-0_13","article-title":"The RNA silencing technology applied by lentiviral vectors in oncology","volume":"614","author":"Sumimoto","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.yexcr.2019.05.030_bib42","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1172\/JCI31373","article-title":"Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice","volume":"118","author":"Hata","year":"2008","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.yexcr.2019.05.030_bib43","doi-asserted-by":"crossref","first-page":"36303","DOI":"10.1038\/srep36303","article-title":"Single cell clones purified from human parotid glands display features of multipotent epitheliomesenchymal stem cells","volume":"6","author":"Yi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexcr.2019.05.030_bib44","article-title":"Restoring the secretory function of irradiation-damaged salivary gland by administrating deferoxamine in mice","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.yexcr.2019.05.030_bib45","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.stem.2012.05.023","article-title":"Developmental stage and time dictate the fate of Wnt\/beta-catenin-responsive stem cells in the mammary gland","volume":"11","author":"van Amerongen","year":"2012","journal-title":"Cell stem cell"},{"key":"10.1016\/j.yexcr.2019.05.030_bib46","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nature10573","article-title":"Distinct stem cells contribute to mammary gland development and maintenance","volume":"479","author":"Van Keymeulen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2019.05.030_bib47","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1369\/jhc.7A7269.2007","article-title":"Label-retaining cells in the rat submandibular gland","volume":"56","author":"Kimoto","year":"2008","journal-title":"J. Histochem. Cytochem. : Off. J. Histochem. Soc."},{"key":"10.1016\/j.yexcr.2019.05.030_bib48","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.devcel.2015.02.013","article-title":"Salivary gland homeostasis is maintained through acinar cell self-duplication","volume":"33","author":"Aure","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.yexcr.2019.05.030_bib49","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1006\/bbrc.2000.3721","article-title":"FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development","volume":"277","author":"Ohuchi","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexcr.2019.05.030_bib50","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1242\/dev.127.3.483","article-title":"An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis","volume":"127","author":"De Moerlooze","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2019.05.030_bib51","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/ncb1240","article-title":"Wnt signalling induces maturation of Paneth cells in intestinal crypts","volume":"7","author":"van Es","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2019.05.030_bib52","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1083\/jcb.200704152","article-title":"Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium","volume":"178","author":"Bastide","year":"2007","journal-title":"J. Cell Biol."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482719302812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482719302812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:16:07Z","timestamp":1762146967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482719302812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0014482719302812"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2019.05.030","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sox9 regulates the luminal stem\/progenitor cell properties of salivary glands","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2019.05.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111449"}}