{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T23:40:16Z","timestamp":1778283616670,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871002"],"award-info":[{"award-number":["81871002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["2015jcyA10046"],"award-info":[{"award-number":["2015jcyA10046"]}],"id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["cstc2017jcjAX0211"],"award-info":[{"award-number":["cstc2017jcjAX0211"]}],"id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.yexcr.2019.05.036","type":"journal-article","created":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T10:21:56Z","timestamp":1559384516000},"page":"111455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of PPARs\/20-HETE on the renal impairment under diabetic conditions"],"prefix":"10.1016","volume":"382","author":[{"given":"Shumei","family":"Ding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oumei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingsong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2019.05.036_bib1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","article-title":"IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for 2045","volume":"138","author":"Cho","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.yexcr.2019.05.036_bib2","first-page":"1875870","article-title":"Oxidative stress, apoptosis, and mitochondrial function in diabetic nephropathy","volume":"2018","author":"Sifuentes-Franco","year":"2018","journal-title":"Internet J. Endocrinol."},{"key":"10.1016\/j.yexcr.2019.05.036_bib3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ki.2014.128","article-title":"Diabetic kidney disease: a clinical update from kidney disease: improving global outcomes","volume":"87","author":"Molitch","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.yexcr.2019.05.036_bib4","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/ki.2010.530","article-title":"Fenofibrate, a PPARalpha agonist, has renoprotective effects in mice by enhancing renal lipolysis","volume":"79","author":"Tanaka","year":"2011","journal-title":"Kidney. Int."},{"key":"10.1016\/j.yexcr.2019.05.036_bib5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00011-006-6190-z","article-title":"Improvement of inflammatory responses associated with NF-kappa B pathway in kidneys from diabetic rats","volume":"57","author":"Chen","year":"2008","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.yexcr.2019.05.036_bib6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.vph.2006.01.004","article-title":"Renoprotective effects of fenofibrate in diabetic rats are achieved by suppressing kidney plasminogen activator inhibitor-1","volume":"44","author":"Chen","year":"2006","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.yexcr.2019.05.036_bib7","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11010-009-0132-3","article-title":"Do resident renal mast cells play a role in the pathogenesis of diabetic nephropathy?","volume":"330","author":"Balakumar","year":"2009","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.yexcr.2019.05.036_bib8","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1093\/ndt\/gfs358","article-title":"Peroxisome proliferator-activated receptor-delta activation ameliorates albuminuria by preventing nephrin loss and restoring podocyte integrity in type 2 diabetes","volume":"27","author":"Lee","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.yexcr.2019.05.036_bib9","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/dmrr.1100","article-title":"Advanced glycation end products-induced apoptosis attenuated by PPARdelta activation and epigallocatechin gallate through NF-kappa B pathway in human embryonic kidney cells and human mesangial cells","volume":"26","author":"Liang","year":"2010","journal-title":"Diabetes. Metab. Res. Rev."},{"key":"10.1016\/j.yexcr.2019.05.036_bib10","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.bbrc.2010.06.093","article-title":"Nifedipine inhibits advanced glycation end products (AGEs) and their receptor (RAGE) interaction-mediated proximal tubular cell injury via peroxisome proliferator-activated receptor-gamma activation","volume":"398","author":"Matsui","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexcr.2019.05.036_bib11","doi-asserted-by":"crossref","first-page":"F1072","DOI":"10.1152\/ajprenal.00020.2007","article-title":"Antioxidants attenuate high glucose-induced hypertrophic growth in renal tubular epithelial cells","volume":"293","author":"Huang","year":"2007","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.yexcr.2019.05.036_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/pharmaceutics9010009","article-title":"Clinical implications of 20-Hydroxyeicosatetraenoic acid in the kidney, liver, lung and brain: an emerging therapeutic target","volume":"9","author":"Elshenawy","year":"2017","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexcr.2019.05.036_bib13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.prostaglandins.2016.05.007","article-title":"The role of 20-HETE in cardiovascular diseases and its risk factors","volume":"125","author":"Waldman","year":"2016","journal-title":"Prostag. Other Lipid Mediat."},{"key":"10.1016\/j.yexcr.2019.05.036_bib14","doi-asserted-by":"crossref","first-page":"F556","DOI":"10.1152\/ajprenal.90613.2008","article-title":"Glomerular 20-HETE, EETs, and TGF-beta1 in diabetic nephropathy","volume":"296","author":"Luo","year":"2009","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.yexcr.2019.05.036_bib15","doi-asserted-by":"crossref","first-page":"502631","DOI":"10.1155\/2011\/502631","article-title":"Peroxisome proliferator-activated receptor-alpha activation decreases mean arterial pressure, plasma interleukin-6, and COX-2 while increasing renal CYP4A expression in an acute model of DOCA-salt hypertension","volume":"2011","author":"Lee","year":"2011","journal-title":"PPAR Res."},{"key":"10.1016\/j.yexcr.2019.05.036_bib16","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1124\/dmd.106.013839","article-title":"Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha","volume":"35","author":"Ng","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.yexcr.2019.05.036_bib17","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00011-016-0922-5","article-title":"Contribution of PPARalpha\/beta\/gamma, AP-1, importin-alpha3, and RXRalpha to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock","volume":"65","author":"Senol","year":"2016","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.yexcr.2019.05.036_bib18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.intimp.2018.07.027","article-title":"Protective effect of ginsenoside metabolite compound K against diabetic nephropathy by inhibiting NLRP3 inflammasome activation and NF-kappaB\/p38 signaling pathway in high-fat diet\/streptozotocin-induced diabetic mice","volume":"63","author":"Song","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.yexcr.2019.05.036_bib19","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrneph.2017.142","article-title":"Modelling diabetic nephropathy in mice","volume":"14","author":"Azushima","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.yexcr.2019.05.036_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.diabres.2017.04.019","article-title":"Involvement of glucose-regulated protein 78 and spliced X-box binding protein 1 in the protective effect of gliclazide in diabetic nephropathy","volume":"146","author":"Zhang","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.yexcr.2019.05.036_bib21","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1097\/01.ASN.0000089829.45296.7C","article-title":"Evaluation of a thick and thin section method for estimation of podocyte number, glomerular volume, and glomerular volume per podocyte in rat kidney with Wilms' tumor-1 protein used as a podocyte nuclear marker","volume":"14","author":"Sanden","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexcr.2019.05.036_bib22","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ejphar.2017.06.024","article-title":"Dencichine ameliorates kidney injury in induced type II diabetic nephropathy via the TGF-beta\/Smad signalling pathway","volume":"812","author":"Jie","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.yexcr.2019.05.036_bib23","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1517\/13543784.11.9.1205","article-title":"Advanced glycation end products and diabetic complications","volume":"11","author":"Stitt","year":"2002","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.yexcr.2019.05.036_bib24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11892-015-0611-8","article-title":"The evolving understanding of the contribution of lipid metabolism to diabetic kidney disease","volume":"15","author":"Stadler","year":"2015","journal-title":"Curr. Diabetes Rep."},{"key":"10.1016\/j.yexcr.2019.05.036_bib25","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/ndt\/gfw320","article-title":"Peroxisome proliferator activating receptor-gamma and the podocyte","volume":"32","author":"Platt","year":"2017","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.yexcr.2019.05.036_bib26","first-page":"693","article-title":"Involvement of renal cytochromes P450 and arachidonic acid metabolites in diabetic nephropathy","volume":"27","author":"Eid","year":"2013","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.yexcr.2019.05.036_bib27","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/01.HYP.0000085650.29823.F2","article-title":"Role of COX-2 in the enhanced vasoconstrictor effect of arachidonic acid in the diabetic rat kidney","volume":"42","author":"Quilley","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.yexcr.2019.05.036_bib28","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1523-1755.2005.00065.x","article-title":"Protective effect of 20-hydroxyeicosatetraenoic acid (20-HETE) on glomerular protein permeability barrier","volume":"67","author":"McCarthy","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.yexcr.2019.05.036_bib29","doi-asserted-by":"crossref","first-page":"F501","DOI":"10.1152\/ajprenal.00131.2007","article-title":"Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier","volume":"293","author":"Williams","year":"2007","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.yexcr.2019.05.036_bib30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jff.2017.07.015","article-title":"Polydatin exhibits the hepatoprotective effects through PPAR-\u03b1\/-\u03b2 signaling pathway in streptozocin-induced diabetic mice","volume":"36","author":"Xue","year":"2017","journal-title":"J. Funct. Foods"}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482719302873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482719302873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:16:36Z","timestamp":1762146996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482719302873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0014482719302873"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2019.05.036","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of PPARs\/20-HETE on the renal impairment under diabetic conditions","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2019.05.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111455"}}