{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:54:25Z","timestamp":1778680465058,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.yexcr.2019.111511","type":"journal-article","created":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T10:45:54Z","timestamp":1564224354000},"page":"111511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["MSC-triggered metabolomic alterations in liver-resident immune cells isolated from CCl4-induced mouse ALI model"],"prefix":"10.1016","volume":"383","author":[{"given":"Xiaowei","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minglei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2019.111511_bib1","first-page":"2525","volume":"369","author":"Bernal","year":"2013","journal-title":"Acute liver failure"},{"key":"10.1016\/j.yexcr.2019.111511_bib2","first-page":"217","article-title":"Artificial and bioartificial support systems for acute and acute-on-chronic liver failure","volume":"289","author":"Kjaergard","year":"2003","journal-title":"a systematic review"},{"key":"10.1016\/j.yexcr.2019.111511_bib3","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gut.2004.053850","article-title":"Apoptosis: a mechanism of acute and chronic liver injury","volume":"54","author":"Guicciardi","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.yexcr.2019.111511_bib4","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1478-3231.2010.02262.x","article-title":"Acute liver failure: mechanisms of immune-mediated liver injury","volume":"30","author":"Wu","year":"2010","journal-title":"Liver Int."},{"key":"10.1016\/j.yexcr.2019.111511_bib5","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1053\/j.gastro.2008.03.015","article-title":"Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells","volume":"134","author":"Kuo","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yexcr.2019.111511_bib6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nri3209","article-title":"Multipotent mesenchymal stromal cells and the innate immune system","volume":"12","author":"Le Blanc","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.yexcr.2019.111511_bib7","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.lfs.2009.08.003","article-title":"Mesenchymal stem cells facilitate recovery from chemically induced liver damage and decrease liver fibrosis","volume":"85","author":"Chang","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.yexcr.2019.111511_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/103643","article-title":"Adipose derived mesenchymal stem cells efficiently rescue carbon tetrachloride-induced acute liver failure in mouse","volume":"2014","author":"Deng","year":"2014","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.yexcr.2019.111511_bib9","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1002\/stem.214","article-title":"Mesenchymal stem cells attenuate renal fibrosis through immune modulation and remodeling properties in a rat remnant kidney model","volume":"27","author":"Semedo","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.yexcr.2019.111511_bib10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/msb.2012.43","article-title":"Novel biomarkers for pre-diabetes identified by metabolomics","volume":"8","author":"Wang-Sattler","year":"2012","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.yexcr.2019.111511_bib11","doi-asserted-by":"crossref","first-page":"22893","DOI":"10.1074\/jbc.R113.486464","article-title":"How metabolism generates signals during innate immunity and inflammation","volume":"288","author":"McGettrick","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2019.111511_bib12","volume":"vol. 89","author":"Zhao","year":"2017"},{"key":"10.1016\/j.yexcr.2019.111511_bib13","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nprot.2009.238","article-title":"A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone","volume":"5","author":"Zhu","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.yexcr.2019.111511_bib14","unstructured":"C.F.B. Matthew A. Lorenz, Robert T. Kennedy, Reducing Time and Increasing Sensitivity in Sample Preparation for Adherent Mammalian Cell Metabolomics. ."},{"key":"10.1016\/j.yexcr.2019.111511_bib15","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1021\/acs.jproteome.6b00070","article-title":"High-performance chemical isotope labeling liquid chromatography-mass spectrometry for profiling the metabolomic reprogramming elicited by ammonium limitation in yeast","volume":"15","author":"Luo","year":"2016","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.yexcr.2019.111511_bib16","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.1016\/j.bmc.2014.07.022","article-title":"Synthesis and antifungal activity of substituted salicylaldehyde hydrazones, hydrazides and sulfohydrazides","volume":"22","author":"Backes","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.yexcr.2019.111511_bib17","first-page":"3406","volume":"83","author":"Lorenz","year":"2011","journal-title":"J Analytical Chemistry, Reducing time and increasing sensitivity in sample preparation for adherent mammalian cell metabolomics"},{"key":"10.1016\/j.yexcr.2019.111511_bib18","first-page":"3919","article-title":"Differential 12C-\/13C-isotope dansylation labeling and fast liquid chromatography\/mass spectrometry for absolute and relative","volume":"81","author":"Kevin","year":"2009","journal-title":"quantification of the metabolome"},{"key":"10.1016\/j.yexcr.2019.111511_bib19","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1021\/ac5009089","article-title":"IsoMS: automated processing of LC-MS data generated by a chemical isotope labeling metabolomics platform","volume":"86","author":"Zhou","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.yexcr.2019.111511_bib20","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1021\/ac5039994","article-title":"Counting missing values in a metabolite-intensity data set for measuring the analytical performance of a metabolomics platform","volume":"87","author":"Huan","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.yexcr.2019.111511_bib21","doi-asserted-by":"crossref","first-page":"7011","DOI":"10.1021\/acs.analchem.5b01434","article-title":"Quantitative metabolome analysis based on chromatographic peak reconstruction in chemical isotope labeling liquid chromatography mass spectrometry","volume":"87","author":"Huan","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.yexcr.2019.111511_bib22","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1021\/ac400099b","article-title":"MyCompoundID: using an evidence-based metabolome library for metabolite identification","volume":"85","author":"Li","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.yexcr.2019.111511_bib23","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3727\/096368915X689622","article-title":"Clinical trials with mesenchymal stem cells: an update","volume":"25","author":"Squillaro","year":"2016","journal-title":"Cell Transplant."},{"key":"10.1016\/j.yexcr.2019.111511_bib24","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/ni1001-907","article-title":"Nitric oxide and the immune response","volume":"2","author":"Bogdan","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.yexcr.2019.111511_bib25","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.immunol.021908.132532","article-title":"Alternative activation of macrophages: an immunologic functional perspective","volume":"27","author":"Martinez","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.yexcr.2019.111511_bib26","doi-asserted-by":"crossref","DOI":"10.1017\/S000711450769936X","article-title":"Amino acids and immune function","volume":"98","author":"Li","year":"2007","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.yexcr.2019.111511_bib27","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2013.04.005","article-title":"Metabolic pathways in immune cell activation and quiescence","volume":"38","author":"Pearce","year":"2013","journal-title":"Immunity"}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482719303532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482719303532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:27:34Z","timestamp":1757996854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482719303532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S0014482719303532"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2019.111511","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MSC-triggered metabolomic alterations in liver-resident immune cells isolated from CCl4-induced mouse ALI model","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2019.111511","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111511"}}