{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:29:22Z","timestamp":1768973362758,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2010\/51051\u20136"],"award-info":[{"award-number":["2010\/51051\u20136"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.yexcr.2020.111938","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T20:22:10Z","timestamp":1586463730000},"page":"111938","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Identification of very small cancer stem cells expressing hallmarks of pluripotency in B16F10 melanoma cells and their reoccurrence in B16F10-derived clones"],"prefix":"10.1016","volume":"391","author":[{"given":"Diana Aparecida","family":"Dias C\u00e2mara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Luiz de S\u00e1 Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Alexandre de Azevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Rog\u00e9rio","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Pinheiro","family":"Araldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dener","family":"Madeiro de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Kerkis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2013","key":"10.1016\/j.yexcr.2020.111938_bib1","first-page":"11","volume":"63","author":"Siegel R","year":"2013","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.yexcr.2020.111938_bib2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/labinvest.2011.50","article-title":"Melanoma stem cells: not rare, but well done","volume":"91","author":"Girouard","year":"2011","journal-title":"Lab. Invest."},{"key":"10.1016\/j.yexcr.2020.111938_bib3","doi-asserted-by":"crossref","first-page":"9339","DOI":"10.1158\/0008-5472.CAN-06-3126","article-title":"Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells","volume":"66","author":"Clarke","year":"2006","journal-title":"Canc. Res."},{"key":"10.1016\/j.yexcr.2020.111938_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrc3184","article-title":"Cancer stem cells: an evolving concept","volume":"12","author":"V Nguyen","year":"2012","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.yexcr.2020.111938_bib5","doi-asserted-by":"crossref","DOI":"10.1089\/scd.2018.0129","article-title":"Cancer stem cells or tumor survival cells?","volume":"27","author":"Teng","year":"2018","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.yexcr.2020.111938_bib6","doi-asserted-by":"crossref","first-page":"9328","DOI":"10.1158\/0008-5472.CAN-05-1343","article-title":"A tumorigenic subpopulation with stem cell properties in melanomas","volume":"65","author":"Fang","year":"2005","journal-title":"Canc. Res."},{"key":"10.1016\/j.yexcr.2020.111938_bib7","first-page":"1779","article-title":"BANCR: a cancer-related long non-coding RNA","volume":"7","author":"Yu","year":"2017","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.yexcr.2020.111938_bib8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.canlet.2012.10.009","article-title":"Testing the cancer stem cell hypothesis in melanoma: the clinics will tell","volume":"338","author":"Shakhova","year":"2013","journal-title":"Canc. Lett."},{"key":"10.1016\/j.yexcr.2020.111938_bib9","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/sj.jid.5700017","article-title":"Melanoma, a tumor based on a mutant stem cell?","volume":"126","author":"Grichnik","year":"2006","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.yexcr.2020.111938_bib10","article-title":"Stemness in Cancer\u00a0: stem cells , cancer stem cells , and their microenvironment","volume":"2017","author":"Aponte","year":"2017","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.yexcr.2020.111938_bib11","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1038\/onc.2014.71","article-title":"SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells","volume":"33","author":"Santini","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2020.111938_bib12","doi-asserted-by":"crossref","first-page":"44917","DOI":"10.18632\/oncotarget.16570","article-title":"The dark side of SOX2: cancer - a comprehensive overview","volume":"8","author":"Wuebben","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.yexcr.2020.111938_bib13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12964-018-0297-z","article-title":"SOX2 as a novel contributor of oxidative metabolism in melanoma cells","volume":"16","author":"Andreucci","year":"2018","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.yexcr.2020.111938_bib14","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.00212.2015","article-title":"The emerging roles of Oct4 in tumor-initiating cells. A review in the theme: cell and molecular processes in cancer metastasis","author":"Wang","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.yexcr.2020.111938_bib15","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00432-012-1186-2","article-title":"Nanog and Oct4 overexpression increases motility and transmigration of melanoma cells","volume":"138","author":"Borrull","year":"2012","journal-title":"J. Canc. Res. Clin. Oncol."},{"key":"10.1016\/j.yexcr.2020.111938_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/stem.1193","article-title":"ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets","volume":"30","author":"Luo","year":"2012","journal-title":"Stem Cell."},{"key":"10.1016\/j.yexcr.2020.111938_bib17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10585-015-9755-9","article-title":"Aldehyde dehydrogenase as a marker and functional mediator of metastasis in solid tumors","volume":"33","author":"Rodriguez-Torres","year":"2016","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.yexcr.2020.111938_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cpr.12352","article-title":"Murine melanoma cells incomplete reprogramming using non-viral vector","volume":"50","author":"C\u00e2mara","year":"2017","journal-title":"Cell Prolif"},{"key":"10.1016\/j.yexcr.2020.111938_bib19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.biochi.2013.12.008","article-title":"Cytotoxic effects of dillapiole on MDA-MB-231 cells involve the induction of apoptosis through the mitochondrial pathway by inducing an oxidative stress while altering the cytoskeleton network","volume":"99","author":"Ferreira","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.yexcr.2020.111938_bib20","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.canlet.2009.02.041","article-title":"Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells","volume":"281","author":"Xavier","year":"2009","journal-title":"Canc. Lett."},{"key":"10.1016\/j.yexcr.2020.111938_bib21","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/sj.bjc.6605821","article-title":"Understanding the cancer stem cell","volume":"103","author":"Bomken","year":"2010","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.yexcr.2020.111938_bib22","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/ncb2717","article-title":"Cancer stem cells: the challenges ahead","volume":"15","author":"Medema","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2020.111938_bib23","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.cell.2010.04.020","article-title":"A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth","volume":"141","author":"Roesch","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2020.111938_bib24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.5483\/BMBRep.2017.50.3.222","article-title":"Cancer stem cell heterogeneity: origin and new perspectives on CSC targeting","volume":"50","author":"Eun","year":"2017","journal-title":"BMB Rep"},{"key":"10.1016\/j.yexcr.2020.111938_bib25","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.stem.2017.09.001","article-title":"Melanocyte stem cell activation and translocation initiate cutaneous melanoma in response to UV exposure","volume":"21","author":"Moon","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.yexcr.2020.111938_bib26","doi-asserted-by":"crossref","first-page":"7833","DOI":"10.1158\/0008-5472.CAN-06-0731","article-title":"Influence of the microenvironment on melanoma cell fate determination and phenotype","volume":"66","author":"Postovit","year":"2006","journal-title":"Canc. Res."},{"key":"10.1016\/j.yexcr.2020.111938_bib27","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1089\/107632704322791754","article-title":"Multiplication of human chondrocytes with low seeding densities accelerates cell yield without losing redifferentiation capacity","volume":"10","author":"Mandl","year":"2004","journal-title":"Tissue Eng."},{"key":"10.1016\/j.yexcr.2020.111938_bib28","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.4161\/cc.6.19.4914","article-title":"Breast tumor heterogeneity","volume":"6","author":"Campbell","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.yexcr.2020.111938_bib29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/scd.2014.0442","article-title":"Cancer stem cell division: when the rules of asymmetry are broken","volume":"24","author":"Mukherjee","year":"2015","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.yexcr.2020.111938_bib30","series-title":"Molecular Programs Underlying Asymmetric Stem Cell Division and Their Disruption in Malignancy","author":"Mukherjee S","year":"2017"},{"key":"10.1016\/j.yexcr.2020.111938_bib31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2217\/mmt.15.4","article-title":"Understanding melanoma stem cells","volume":"2","author":"Nguyen","year":"2015","journal-title":"Melanoma Manag"},{"key":"10.1016\/j.yexcr.2020.111938_bib32","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1038\/jid.2010.69","article-title":"Heterogeneous phenotype of human melanoma cells with in vitro and in vivo features of tumor-initiating cells","volume":"130","author":"Perego","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.yexcr.2020.111938_bib33","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/CMR.0b013e3283531317","article-title":"Sphere formation and self-renewal capacity of melanoma cells is affected by the microenvironment","volume":"22","author":"Sztiller-Sikorska","year":"2012","journal-title":"Melanoma Res."},{"key":"10.1016\/j.yexcr.2020.111938_bib34","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1002\/stem.2413","article-title":"Immunomodulatory factors control the fate of melanoma tumor initiating cells","volume":"34","author":"Tuccitto","year":"2016","journal-title":"Stem Cell."},{"key":"10.1016\/j.yexcr.2020.111938_bib35","series-title":"New Insights into Vinculin Function and Regulation","author":"Peng","year":"2011"},{"key":"10.1016\/j.yexcr.2020.111938_bib36","first-page":"625","article-title":"Differential expression of vinculin between weakly and highly metastatic B16-melanoma cell lines","volume":"83","author":"IM","year":"1992","journal-title":"Jpn. J. Canc. Res."},{"key":"10.1016\/j.yexcr.2020.111938_bib37","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/ncb1037","article-title":"Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells","volume":"5","author":"Beil","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2020.111938_bib38","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/excr.1996.3451","article-title":"Vinculin promotes cell spreading by mechanically coupling integrins to the cytoskeleton","volume":"231","author":"Ezzell","year":"1997","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2020.111938_bib39","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/nm.4409","article-title":"Cancer stem cells revisited","volume":"23","author":"Batlle","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexcr.2020.111938_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/nature07567","article-title":"Efficient tumour formation by single human melanoma cells","volume":"456","author":"Quintana","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2020.111938_bib41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4252\/wjsc.v7.i1.27","article-title":"Cancer stem cell plasticity and tumor hierarchy","volume":"7","author":"Cabrera","year":"2015","journal-title":"World J. Stem Cell."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482720301439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482720301439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:30:17Z","timestamp":1757997017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482720301439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0014482720301439"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2020.111938","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of very small cancer stem cells expressing hallmarks of pluripotency in B16F10 melanoma cells and their reoccurrence in B16F10-derived clones","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2020.111938","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111938"}}