{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:27:42Z","timestamp":1785536862573,"version":"3.56.0"},"reference-count":123,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T00:00:00Z","timestamp":1587686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002081","name":"Irish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.yexcr.2020.112005","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T02:12:37Z","timestamp":1587435157000},"page":"112005","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Alterations in osteocyte mediated osteoclastogenesis during estrogen deficiency and under ROCK-II inhibition: An in vitro study using a novel postmenopausal multicellular niche model"],"prefix":"10.1016","volume":"392","author":[{"given":"Irene","family":"Simfia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Schiavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laoise M.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.yexcr.2020.112005_bib1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1359\/jbmr.2005.20.5.886","article-title":"How many women have osteoporosis? JBMR anniversary classic. JBMR, volume 7, number 9, 1992","volume":"20","author":"Melton","year":"2005","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112005_bib2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1359\/jbmr.1998.13.5.763","article-title":"A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men","volume":"13","author":"Riggs","year":"1998","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112005_bib3","doi-asserted-by":"crossref","first-page":"S505","DOI":"10.1016\/8756-3282(95)00258-4","article-title":"The worldwide problem of osteoporosis: insights afforded by epidemiology","volume":"17","author":"Riggs","year":"1995","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.yexcr.2020.112005_bib4","first-page":"115","article-title":"Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis 1","volume":"21","author":"Manolagas","year":"2000","journal-title":"Endocr. Rev."},{"issue":"8","key":"10.1016\/j.yexcr.2020.112005_bib5","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/jbmr.5650110802","article-title":"Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis","volume":"11","author":"Pacifici","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.yexcr.2020.112005_bib6","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1016\/0378-5122(96)01016-X","article-title":"Hormone replacement therapy and osteoporosis","volume":"23","author":"Christiansen","year":"1996","journal-title":"Maturitas"},{"issue":"3","key":"10.1016\/j.yexcr.2020.112005_bib7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.maturitas.2004.02.005","article-title":"Compliance with drug therapies for the treatment and prevention of osteoporosis","volume":"48","author":"McCombs","year":"2004","journal-title":"Maturitas"},{"issue":"3","key":"10.1016\/j.yexcr.2020.112005_bib8","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1359\/jbmr.2002.17.3.528","article-title":"Does hormone-replacement therapy prevent fractures in early postmenopausal women?","volume":"17","author":"Randell","year":"2002","journal-title":"J. Bone Miner. Res."},{"issue":"44","key":"10.1016\/j.yexcr.2020.112005_bib9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1098\/rsif.2009.0282","article-title":"Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures","volume":"7","author":"McNamara","year":"2010","journal-title":"J. R. Soc. Interface"},{"issue":"10","key":"10.1016\/j.yexcr.2020.112005_bib10","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1359\/jbmr.090411","article-title":"Sclerostin mediates bone response to mechanical unloading through antagonizing wnt\/\u03b2\u2010catenin signaling","volume":"24","author":"Lin","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.yexcr.2020.112005_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jot.2015.08.004","article-title":"Sclerostin, an emerging therapeutic target for treating osteoporosis and osteoporotic fracture: a general review","volume":"4","author":"Suen","year":"2016","journal-title":"Journal of Orthopaedic Translation"},{"issue":"9","key":"10.1016\/j.yexcr.2020.112005_bib12","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1056\/NEJMra067395","article-title":"Mechanisms of anabolic therapies for osteoporosis","volume":"357","author":"Canalis","year":"2007","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.yexcr.2020.112005_bib13","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrendo.2011.108","article-title":"Parathyroid hormone analogues in the treatment of osteoporosis","volume":"7","author":"Kraenzlin","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"issue":"16","key":"10.1016\/j.yexcr.2020.112005_bib14","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa1607948","article-title":"Romosozumab treatment in postmenopausal women with osteoporosis","volume":"375","author":"Cosman","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.yexcr.2020.112005_bib15","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1359\/jbmr.081206","article-title":"Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis","volume":"24","author":"Li","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.yexcr.2020.112005_bib16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bone.2016.02.005","article-title":"Sclerostin antibody prevented progressive bone loss in combined ovariectomized and concurrent functional disuse","volume":"87","author":"Zhang","year":"2016","journal-title":"Bone"},{"issue":"12","key":"10.1016\/j.yexcr.2020.112005_bib17","doi-asserted-by":"crossref","first-page":"4785","DOI":"10.1210\/en.2013-1905","article-title":"Progressive increases in bone mass and bone strength in an ovariectomized rat model of osteoporosis after 26 Weeks of treatment with a sclerostin antibody","volume":"155","author":"Li","year":"2014","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.yexcr.2020.112005_bib18","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/jbmr.2351","article-title":"A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density","volume":"30","author":"Recker","year":"2015","journal-title":"J. Bone Miner. Res."},{"issue":"9","key":"10.1016\/j.yexcr.2020.112005_bib19","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1210\/en.2011-0252","article-title":"Increased bone formation and bone mass induced by sclerostin antibody is not affected by pretreatment or cotreatment with alendronate in osteopenic, ovariectomized rats","volume":"152","author":"Li","year":"2011","journal-title":"Endocrinology"},{"issue":"10","key":"10.1016\/j.yexcr.2020.112005_bib20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1177\/1759720X17726744","article-title":"Sclerostin antibodies in osteoporosis: latest evidence and therapeutic potential","volume":"9","author":"McClung","year":"2017","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"2","key":"10.1016\/j.yexcr.2020.112005_bib21","doi-asserted-by":"crossref","first-page":"R167","DOI":"10.1530\/JME-18-0176","article-title":"Novel actions of sclerostin on bone","volume":"62","author":"Holdsworth","year":"2019","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.yexcr.2020.112005_bib22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bone.2017.11.003","article-title":"Dampening of the bone formation response following repeat dosing with sclerostin antibody in mice is associated with up-regulation of Wnt antagonists","volume":"107","author":"Holdsworth","year":"2018","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.yexcr.2020.112005_bib23","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/jbmr.3036","article-title":"Romosozumab improves bone mass and strength while maintaining bone quality in ovariectomized cynomolgus monkeys","volume":"32","author":"Ominsky","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.yexcr.2020.112005_bib24","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bone.2016.10.019","article-title":"Effects of sclerostin antibodies in animal models of osteoporosis","volume":"96","author":"Ominsky","year":"2017","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.yexcr.2020.112005_bib25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/14728214.2017.1362389","article-title":"Emerging anabolic agents in the treatment of osteoporosis","volume":"22","author":"Lovato","year":"2017","journal-title":"Expet Opin. Emerg. Drugs"},{"key":"10.1016\/j.yexcr.2020.112005_bib26","article-title":"Effects of romosozumab in postmenopausal women with osteoporosis after 2 and 12 Months: bone histomorphometry substudy","volume":"32","author":"Chavassieux","year":"2017","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112005_bib27","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1056\/NEJMoa1305224","article-title":"Romosozumab in postmenopausal women with low bone mineral density","volume":"370","author":"McClung","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.yexcr.2020.112005_bib28","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1002\/jbmr.2482","article-title":"Transcriptional profiling of laser capture microdissected subpopulations of the osteoblast lineage provides insight into the early response to sclerostin antibody in rats","volume":"30","author":"Nioi","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.yexcr.2020.112005_bib29","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.bone.2015.08.007","article-title":"Differential temporal effects of sclerostin antibody and parathyroid hormone on cancellous and cortical bone and quantitative differences in effects on the osteoblast lineage in young intact rats","volume":"81","author":"Ominsky","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.yexcr.2020.112005_bib30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bone.2017.04.005","article-title":"Kinetic reconstruction reveals time-dependent effects of romosozumab on bone formation and osteoblast function in vertebral cancellous and cortical bone in cynomolgus monkeys","volume":"101","author":"Boyce","year":"2017","journal-title":"Bone"},{"issue":"2 Suppl 1","key":"10.1016\/j.yexcr.2020.112005_bib31","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.bone.2005.11.024","article-title":"Osteoporosis: a still increasing prevalence","volume":"38","author":"Reginster","year":"2006","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.yexcr.2020.112005_bib32","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s00198-004-1785-0","article-title":"Additive effects of estrogen and mechanical stress on nitric oxide and prostaglandin E2 production by bone cells from osteoporotic donors","volume":"16","author":"Bakker","year":"2005","journal-title":"Osteoporos. Int."},{"issue":"13","key":"10.1016\/j.yexcr.2020.112005_bib33","doi-asserted-by":"crossref","first-page":"9035","DOI":"10.1074\/jbc.M112.405456","article-title":"Estrogen receptor alpha mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor beta","volume":"288","author":"Galea","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112005_bib34","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1359\/jbmr.091008","article-title":"Estrogen augments shear stress-induced signaling and gene expression in osteoblast-like cells via estrogen receptor-mediated expression of beta1-integrin","volume":"25","author":"Yeh","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"8","key":"10.1016\/j.yexcr.2020.112005_bib35","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1074\/jbc.M412817200","article-title":"Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation","volume":"280","author":"Plotkin","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112005_bib36","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.bone.2012.12.004","article-title":"17beta estradiol regulation of connexin 43-based gap junction and mechanosensitivity through classical estrogen receptor pathway in osteocyte-like MLO-Y4 cells","volume":"53","author":"Ren","year":"2013","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.yexcr.2020.112005_bib37","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1074\/jbc.M111.294959","article-title":"Pro-survival effects of 17beta-estradiol on osteocytes are mediated by nitric oxide\/cGMP via differential actions of cGMP-dependent protein kinases I and II","volume":"287","author":"Marathe","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.yexcr.2020.112005_bib38","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.3892\/mmr.2017.6168","article-title":"Estrogen stimulates osteoprotegerin expression via the suppression of miR-145 expression in MG-63 cells","volume":"15","author":"Jia","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"8","key":"10.1016\/j.yexcr.2020.112005_bib39","doi-asserted-by":"crossref","first-page":"E937","DOI":"10.1152\/ajpendo.00458.2013","article-title":"Estrogen receptor-beta regulates mechanical signaling in primary osteoblasts","volume":"306","author":"Castillo","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112005_bib40","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S8756-3282(02)00953-5","article-title":"The effects of estrogen on osteoprotegerin, RANKL, and estrogen receptor expression in human osteoblasts","volume":"32","author":"Bord","year":"2003","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.yexcr.2020.112005_bib41","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1359\/jbmr.060504","article-title":"Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen","volume":"21","author":"Zaman","year":"2006","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112005_bib42","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jbiomech.2014.12.007","article-title":"Bone cell mechanosensitivity, estrogen deficiency, and osteoporosis","volume":"48","author":"Klein-Nulend","year":"2015","journal-title":"J. Biomech."},{"issue":"8","key":"10.1016\/j.yexcr.2020.112005_bib43","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1055\/s-0033-1363265","article-title":"Estrogen withdrawal from osteoblasts and osteocytes causes increased mineralization and apoptosis","volume":"46","author":"Brennan","year":"2014","journal-title":"Horm. Metab. Res."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112005_bib44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1055\/s-0031-1291358","article-title":"Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro","volume":"44","author":"Brennan","year":"2012","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.yexcr.2020.112005_bib45","series-title":"Orthopaedic Research Society","article-title":"The impact of shear stress during estrogen withdrawal on cell viability and mineral production of osteoblasts","author":"Brennan","year":"2012"},{"issue":"1","key":"10.1016\/j.yexcr.2020.112005_bib46","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1038\/s41598-019-41095-3","article-title":"Estrogen deficiency impairs integrin \u03b1v\u03b23-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling","volume":"9","author":"Geoghegan","year":"2019","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.yexcr.2020.112005_bib47","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1096\/fj.201601280R","article-title":"Estrogen deficiency attenuates fluid flow\u2013induced [Ca2+]i oscillations and mechanoresponsiveness of MLO-Y4 osteocytes","volume":"31","author":"Deepak","year":"2017","journal-title":"Faseb. J."},{"issue":"9","key":"10.1016\/j.yexcr.2020.112005_bib48","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1002\/ar.23173","article-title":"Differential beta3 and beta1 integrin expression in bone marrow and cortical bone of estrogen deficient rats","volume":"298","author":"Voisin","year":"2015","journal-title":"Anat. Rec."},{"issue":"11","key":"10.1016\/j.yexcr.2020.112005_bib49","doi-asserted-by":"crossref","first-page":"C1058","DOI":"10.1152\/ajpcell.00254.2013","article-title":"P2Y2 receptors regulate osteoblast mechanosensitivity during fluid flow","volume":"306","author":"Gardinier","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"4","key":"10.1016\/j.yexcr.2020.112005_bib50","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1242\/jcs.036293","article-title":"Mechanically induced osteogenic differentiation\u2013the role of RhoA, ROCKII and cytoskeletal dynamics","volume":"122","author":"Arnsdorf","year":"2009","journal-title":"J. Cell Sci."},{"issue":"Pt 4","key":"10.1016\/j.yexcr.2020.112005_bib51","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1242\/jcs.036293","article-title":"Mechanically induced osteogenic differentiation--the role of RhoA, ROCKII and cytoskeletal dynamics","volume":"122","author":"Arnsdorf","year":"2009","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112005_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/cells5020017","article-title":"The regulation of cellular responses to mechanical cues by Rho GTPases","volume":"5","author":"Hoon","year":"2016","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.yexcr.2020.112005_bib53","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1074\/jbc.M705092200","article-title":"Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost\/sclerostin","volume":"283","author":"Robling","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2020.112005_bib54","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bone.2016.10.007","article-title":"Role and mechanism of action of sclerostin in bone","volume":"96","author":"Delgado-Calle","year":"2017","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.yexcr.2020.112005_bib55","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: from human mutations to treatments","volume":"19","author":"Baron","year":"2013","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.yexcr.2020.112005_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025900","article-title":"Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway","volume":"6","author":"Wijenayaka","year":"2011","journal-title":"PloS One"},{"issue":"10","key":"10.1016\/j.yexcr.2020.112005_bib57","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1096\/fj.05-4221fje","article-title":"Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation","volume":"19","author":"Poole","year":"2005","journal-title":"Faseb. J."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112005_bib58","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bone.2011.10.025","article-title":"Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading","volume":"50","author":"Tu","year":"2012","journal-title":"Bone"},{"issue":"12","key":"10.1016\/j.yexcr.2020.112005_bib59","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1128\/MCB.01428-09","article-title":"Osteocyte wnt\/beta-catenin signaling is required for normal bone homeostasis","volume":"30","author":"Kramer","year":"2010","journal-title":"Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.yexcr.2020.112005_bib60","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nrrheum.2011.130","article-title":"New targets for intervention in the treatment of postmenopausal osteoporosis","volume":"7","author":"Lewiecki","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112005_bib61","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bone.2007.09.047","article-title":"Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading","volume":"42","author":"You","year":"2008","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.yexcr.2020.112005_bib62","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/1947603510383855","article-title":"Characterization of an ex vivo femoral head model assessed by markers of bone and cartilage turnover","volume":"2","author":"Madsen","year":"2011","journal-title":"Cartilage"},{"issue":"6937","key":"10.1016\/j.yexcr.2020.112005_bib63","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.yexcr.2020.112005_bib64","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/bbrc.1999.1632","article-title":"TGF-\u03b2 enhances osteoclast differentiation in hematopoietic cell cultures stimulated with RANKL and M-CSF","volume":"265","author":"Galvin","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112005_bib65","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","article-title":"Osteoprotegerin: a novel secreted protein involved in the regulation of bone density","volume":"89","author":"Simonet","year":"1997","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.yexcr.2020.112005_bib66","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"Lacey","year":"1998","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.yexcr.2020.112005_bib67","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1359\/jbmr.2002.17.11.2068","article-title":"MLO\u2010Y4 osteocyte\u2010like cells support osteoclast formation and activation","volume":"17","author":"Zhao","year":"2002","journal-title":"J. Bone Miner. Res."},{"issue":"10","key":"10.1016\/j.yexcr.2020.112005_bib68","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nm.2448","article-title":"Matrix-embedded cells control osteoclast formation","volume":"17","author":"Xiong","year":"2011","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112005_bib69","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.devcel.2005.02.013","article-title":"Canonical Wnt\/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes","volume":"8","author":"Hill","year":"2005","journal-title":"Dev. Cell"},{"issue":"1","key":"10.1016\/j.yexcr.2020.112005_bib70","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1242\/dev.01564","article-title":"Sequential roles of Hedgehog and Wnt signaling in osteoblast development","volume":"132","author":"Hu","year":"2005","journal-title":"Development"},{"issue":"5","key":"10.1016\/j.yexcr.2020.112005_bib71","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.devcel.2005.02.017","article-title":"Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation","volume":"8","author":"Glass","year":"2005","journal-title":"Dev. Cell"},{"issue":"5","key":"10.1016\/j.yexcr.2020.112005_bib72","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/BF02409482","article-title":"Morphological evidence of gap junctions between bone cells","volume":"33","author":"Doty","year":"1981","journal-title":"Calcif. Tissue Int."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112005_bib73","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1359\/jbmr.2001.16.2.249","article-title":"Expression of functional gap junctions and regulation by fluid flow in osteocyte-like MLO-Y4 cells","volume":"16","author":"Cheng","year":"2001","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112005_bib74","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S8756-3282(03)00167-4","article-title":"Oscillating fluid flow regulates gap junction communication in osteocytic MLO-Y4 cells by an ERK1\/2 MAP kinase-dependent mechanism","volume":"33","author":"Alford","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.yexcr.2020.112005_bib75","doi-asserted-by":"crossref","first-page":"13","DOI":"10.22203\/eCM.v023a02","article-title":"Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche","volume":"23","author":"Birmingham","year":"2012","journal-title":"Eur. Cell. Mater."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112005_bib76","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.abb.2008.03.027","article-title":"Osteoclast\u2013osteoblast communication","volume":"473","author":"Matsuo","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112005_bib77","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.bone.2006.05.017","article-title":"Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling","volume":"39","author":"Kim","year":"2006","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.yexcr.2020.112005_bib78","doi-asserted-by":"crossref","first-page":"C969","DOI":"10.1152\/ajpcell.00168.2019","article-title":"Inhibition of osteoclastogenesis by mechanically stimulated osteoblasts is attenuated during estrogen deficiency","volume":"317","author":"Allison","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112005_bib79","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/jcb.21089","article-title":"Osteoblasts and osteocytes respond differently to oscillatory and unidirectional fluid flow profiles","volume":"100","author":"Ponik","year":"2007","journal-title":"J. Cell. Biochem."},{"issue":"12","key":"10.1016\/j.yexcr.2020.112005_bib80","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1359\/jbmr.1997.12.12.2014","article-title":"Establishment of an osteocyte\u2010like cell line, MLO\u2010Y4","volume":"12","author":"Kato","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.yexcr.2020.112005_bib81","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jmbbm.2014.11.001","article-title":"The role of integrin \u03b1 V \u03b2 3 in osteocyte mechanotransduction","volume":"42","author":"Haugh","year":"2015","journal-title":"Journal of the mechanical behavior of biomedical materials"},{"issue":"2","key":"10.1016\/j.yexcr.2020.112005_bib82","first-page":"505","article-title":"Ultrastructure of the osteocyte process and its pericellular matrix. The anatomical record Part A: discoveries in molecular, cellular, and evolutionary biology","volume":"278","author":"You","year":"2004","journal-title":"An Official Publication of the American Association of Anatomists"},{"issue":"75","key":"10.1016\/j.yexcr.2020.112005_bib83","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1098\/rsif.2012.0286","article-title":"Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes","volume":"9","author":"Verbruggen","year":"2012","journal-title":"J. R. Soc. Interface"},{"issue":"3","key":"10.1016\/j.yexcr.2020.112005_bib84","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0021-9290(94)90010-8","article-title":"A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses","volume":"27","author":"Weinbaum","year":"1994","journal-title":"J. Biomech."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112005_bib85","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jbiomech.2011.10.037","article-title":"Effect of oscillating fluid flow stimulation on osteocyte mRNA expression","volume":"45","author":"Li","year":"2012","journal-title":"J. Biomech."},{"key":"10.1016\/j.yexcr.2020.112005_bib86","series-title":"Estrogen Withdrawal from Osteoblasts and Osteocytes Causes Increased Mineralization and Apoptosis","author":"Brennan","year":"2014"},{"issue":"7","key":"10.1016\/j.yexcr.2020.112005_bib87","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1096\/fj.201601280R","article-title":"Estrogen deficiency attenuates fluid flow-induced [Ca2+]i oscillations and mechanoresponsiveness of MLO-Y4 osteocytes","volume":"31","author":"Deepak","year":"2017","journal-title":"Faseb. J."},{"issue":"Suppl","key":"10.1016\/j.yexcr.2020.112005_bib88","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/0378-5122(96)01015-8","article-title":"Estrogen and bone metabolism","volume":"23","author":"Vaananen","year":"1996","journal-title":"Maturitas"},{"issue":"2","key":"10.1016\/j.yexcr.2020.112005_bib89","first-page":"143","article-title":"Oestrogen action on bone cells","volume":"2","author":"Krassas","year":"2001","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"10.1016\/j.yexcr.2020.112005_bib90","series-title":"Advances in Osteoporosis","article-title":"Estrogen deficiency and osteoporosis","author":"Okman-Kilic","year":"2015"},{"issue":"Suppl 1","key":"10.1016\/j.yexcr.2020.112005_bib91","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1007\/BF01673415","article-title":"Osteocytes, strain detection, bone modeling and remodeling","volume":"53","author":"Lanyon","year":"1993","journal-title":"Calcif. Tissue Int."},{"issue":"10","key":"10.1016\/j.yexcr.2020.112005_bib92","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1138\/20060233","article-title":"Mechanosensation and transduction in osteocytes","volume":"3","author":"Bonewald","year":"2006","journal-title":"BoneKEy-Osteovision"},{"issue":"6274","key":"10.1016\/j.yexcr.2020.112005_bib93","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/345442a0","article-title":"The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene","volume":"345","author":"Yoshida","year":"1990","journal-title":"Nature"},{"issue":"6717","key":"10.1016\/j.yexcr.2020.112005_bib94","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/16852","article-title":"OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis","volume":"397","author":"Kong","year":"1999","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.yexcr.2020.112005_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021462","article-title":"M-CSF potently augments RANKL-induced resorption activation in mature human osteoclasts","volume":"6","author":"Hodge","year":"2011","journal-title":"PloS One"},{"issue":"14","key":"10.1016\/j.yexcr.2020.112005_bib96","doi-asserted-by":"crossref","first-page":"7829","DOI":"10.1073\/pnas.130200197","article-title":"Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression","volume":"97","author":"Shevde","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"24","key":"10.1016\/j.yexcr.2020.112005_bib97","doi-asserted-by":"crossref","first-page":"13960","DOI":"10.1073\/pnas.251534698","article-title":"Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo","volume":"98","author":"Roggia","year":"2001","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"issue":"10","key":"10.1016\/j.yexcr.2020.112005_bib98","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI11066","article-title":"Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-\u03b1","volume":"106","author":"Cenci","year":"2000","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112005_bib99","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/0006-291X(91)92015-C","article-title":"Macrophage colony stimulating factor (M-CSF) is essential for osteoclast formation in vitro","volume":"177","author":"Hattersley","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112005_bib100","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/oxfordjournals.jhered.a108657","article-title":"Osteopetrosis, a new recessive skeletal mutation on chromosome 12 of the mouse","volume":"67","author":"Marks","year":"1976","journal-title":"J. Hered."},{"issue":"12","key":"10.1016\/j.yexcr.2020.112005_bib101","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1073\/pnas.87.12.4828","article-title":"Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op\/op) mouse","volume":"87","author":"Wiktor-Jedrzejczak","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112005_bib102","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1172\/JCI116179","article-title":"Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors","volume":"91","author":"Tanaka","year":"1993","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.yexcr.2020.112005_bib103","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1172\/JCI4561","article-title":"Estrogen blocks M-CSF gene expression and osteoclast formation by regulating phosphorylation of Egr-1 and its interaction with Sp-1","volume":"102","author":"Srivastava","year":"1998","journal-title":"J. Clin. Invest."},{"issue":"27","key":"10.1016\/j.yexcr.2020.112005_bib104","doi-asserted-by":"crossref","first-page":"24458","DOI":"10.1074\/jbc.M111.223297","article-title":"Inhibition of osteoclast differentiation and bone resorption by N-methylpyrrolidone","volume":"286","author":"Ghayor","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.yexcr.2020.112005_bib105","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1074\/jbc.M805280200","article-title":"Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption","volume":"284","author":"Wilson","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112005_bib106","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1210\/me.2014-1365","article-title":"HDAC9 inhibits osteoclastogenesis via mutual suppression of PPAR\u03b3\/RANKL signaling","volume":"29","author":"Jin","year":"2015","journal-title":"Mol. Endocrinol."},{"issue":"9","key":"10.1016\/j.yexcr.2020.112005_bib107","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185441","article-title":"Class II and IV HDACs function as inhibitors of osteoclast differentiation","volume":"12","author":"Blixt","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.yexcr.2020.112005_bib108","series-title":"Studies on the Role of Two Proteins in Breast Cancer-Histone Deacetylase 11 in Estrogen Receptor Positive Breast Cancer and the Redox Protein Memo in Metastasis and Tumorigenesis","author":"Frei","year":"2015"},{"issue":"3","key":"10.1016\/j.yexcr.2020.112005_bib109","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3109\/03008207.2014.989320","article-title":"Inhibitory effects of eugenol on RANKL-induced osteoclast formation via attenuation of NF-\u03ba B and MAPK pathways","volume":"56","author":"Deepak","year":"2015","journal-title":"Connect. Tissue Res."},{"issue":"7","key":"10.1016\/j.yexcr.2020.112005_bib110","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.cellbi.2006.12.008","article-title":"Morphological analysis of osteoclastogenesis induced by RANKL in mouse bone marrow cell cultures","volume":"31","author":"Gardner","year":"2007","journal-title":"Cell Biol. Int."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112005_bib111","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00441-007-0450-2","article-title":"Comparison of morphological effects of PGE2 and TGF\u03b2 on osteoclastogenesis induced by RANKL in mouse bone marrow cell cultures","volume":"330","author":"Gardner","year":"2007","journal-title":"Cell Tissue Res."},{"issue":"7","key":"10.1016\/j.yexcr.2020.112005_bib112","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.3390\/nu6072584","article-title":"Effects of \u03c93-and \u03c96-polyunsaturated fatty acids on RANKL-induced osteoclast differentiation of RAW264. 7 cells: a comparative in vitro study","volume":"6","author":"Boeyens","year":"2014","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.yexcr.2020.112005_bib113","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.bone.2006.02.070","article-title":"Strength of cancellous bone trabecular tissue from normal, ovariectomized and drug-treated rats over the course of ageing","volume":"39","author":"McNamara","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.yexcr.2020.112005_bib114","doi-asserted-by":"crossref","first-page":"396","DOI":"10.22203\/eCM.v021a30","article-title":"Site specific increase in heterogeneity of trabecular bone tissue mineral during oestrogen deficiency","volume":"21","author":"Brennan","year":"2011","journal-title":"Eur. Cell. Mater."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112005_bib115","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jbiomech.2010.10.023","article-title":"The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis","volume":"44","author":"Brennan","year":"2011","journal-title":"J. Biomech."},{"key":"10.1016\/j.yexcr.2020.112005_bib116","doi-asserted-by":"crossref","DOI":"10.1007\/s00223-012-9657-7","article-title":"Temporal changes in bone composition, architecture and strength following estrogen deficiency in osteoporosis","author":"Brennan","year":"2012","journal-title":"Calcif. Tissue Int."},{"issue":"6","key":"10.1016\/j.yexcr.2020.112005_bib117","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.bone.2006.06.008","article-title":"Bone tissue compositional differences in women with and without osteoporotic fracture","volume":"39","author":"McCreadie","year":"2006","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.yexcr.2020.112005_bib118","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.trsl.2008.05.003","article-title":"Expression characteristic and significance of interleukin-6, nuclear factor kappa beta, and bone formation markers in rat models of osteoporosis","volume":"152","author":"Zhu","year":"2008","journal-title":"Transl. Res."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112005_bib119","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jbiomech.2010.10.023","article-title":"The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis","volume":"44","author":"Brennan","year":"2011","journal-title":"J. Biomech."},{"issue":"7","key":"10.1016\/j.yexcr.2020.112005_bib120","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.bpj.2015.02.031","article-title":"Altered mechanical environment of bone cells in an animal model of short- and long-term osteoporosis","volume":"108","author":"Verbruggen","year":"2015","journal-title":"Biophys. J."},{"key":"10.1016\/j.yexcr.2020.112005_bib121","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jmbbm.2016.05.004","article-title":"Mechanisms of osteocyte stimulation in osteoporosis","volume":"62","author":"Verbruggen","year":"2016","journal-title":"J Mech Behav Biomed Mater"},{"issue":"1","key":"10.1016\/j.yexcr.2020.112005_bib122","doi-asserted-by":"crossref","DOI":"10.1115\/1.4028986","article-title":"Multiscale modeling of trabecular bone marrow: understanding the micromechanical environment of mesenchymal stem cells during osteoporosis","volume":"137","author":"Vaughan","year":"2015","journal-title":"J. Biomech. Eng."},{"issue":"7","key":"10.1016\/j.yexcr.2020.112005_bib123","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.bpj.2015.02.031","article-title":"Altered mechanical environment of bone cells in an animal model of short- and long-term osteoporosis","volume":"108","author":"Verbruggen","year":"2015","journal-title":"Biophys. J."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482720302275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482720302275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:30:32Z","timestamp":1757997032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482720302275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":123,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0014482720302275"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2020.112005","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alterations in osteocyte mediated osteoclastogenesis during estrogen deficiency and under ROCK-II inhibition: An in vitro study using a novel postmenopausal multicellular niche model","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2020.112005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112005"}}