{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:38:23Z","timestamp":1790746703565,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T00:00:00Z","timestamp":1587859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["2617H04338"],"award-info":[{"award-number":["2617H04338"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.yexcr.2020.112011","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T20:57:15Z","timestamp":1587761835000},"page":"112011","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Filopodia play an important role in the trans-mesothelial migration of ovarian cancer cells"],"prefix":"10.1016","volume":"392","author":[{"given":"Masato","family":"Yoshihara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Yamakita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kajiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Senga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Koya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Nawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitaka","family":"Kikkawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.yexcr.2020.112011_bib1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2353\/ajpath.2010.100105","article-title":"Ovarian cancer development and metastasis","volume":"177","author":"Lengyel","year":"2010","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.yexcr.2020.112011_bib2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.21873\/cgp.20004","article-title":"Mechanisms and targets involved in dissemination of ovarian cancer","volume":"13","author":"Weidle","year":"2016","journal-title":"CANCER GENOMICS PROTEOMICS"},{"issue":"1","key":"10.1016\/j.yexcr.2020.112011_bib3","first-page":"7","article-title":"Cancer statistics","volume":"68","author":"Siegel","year":"2018","journal-title":"Ca - Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112011_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1357-2725(03)00242-5","article-title":"The mesothelial cell","volume":"36","author":"Mutsaers","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.yexcr.2020.112011_bib5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fonc.2017.00024","article-title":"The unique molecular and cellular microenvironment of ovarian cancer","volume":"7","author":"Worzfeld","year":"2017","journal-title":"Frontiers in oncology"},{"issue":"14","key":"10.1016\/j.yexcr.2020.112011_bib6","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1016\/j.febslet.2008.03.039","article-title":"Lamellipodia and filopodia in metastasis and invasion","volume":"582","author":"Machesky","year":"2008","journal-title":"FEBS Lett."},{"issue":"11","key":"10.1016\/j.yexcr.2020.112011_bib7","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1016\/j.cellsig.2013.07.006","article-title":"Filopodia as sensors","volume":"25","author":"Heckman","year":"2013","journal-title":"Cell. Signal."},{"issue":"6","key":"10.1016\/j.yexcr.2020.112011_bib8","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nrm2406","article-title":"Filopodia: molecular architecture and cellular functions","volume":"9","author":"Mattila","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yexcr.2020.112011_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ceb.2015.06.007","article-title":"Filopodia in cell adhesion, 3D migration and cancer cell invasion","volume":"36","author":"Jacquemet","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.yexcr.2020.112011_bib10","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1741-7015-11-52","article-title":"Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis","volume":"11","author":"Tan","year":"2013","journal-title":"BMC Med."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112011_bib11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yexcr.2015.03.014","article-title":"Myosin-X and disease","volume":"334","author":"Courson","year":"2015","journal-title":"Exp. Cell Res."},{"issue":"9","key":"10.1016\/j.yexcr.2020.112011_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074923","article-title":"FHOD1, a formin upregulated in epithelial-mesenchymal transition, participates in cancer cell migration and invasion","volume":"8","author":"Gardberg","year":"2013","journal-title":"PloS One"},{"issue":"5","key":"10.1016\/j.yexcr.2020.112011_bib13","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.bbamcr.2006.07.001","article-title":"Regulation of the actin cytoskeleton in cancer cell migration and invasion","volume":"1773","author":"Yamaguchi","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"issue":"9","key":"10.1016\/j.yexcr.2020.112011_bib14","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrm3861","article-title":"Steering cell migration: lamellipodium dynamics and the regulation of directional persistence","volume":"15","author":"Krause","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112011_bib15","first-page":"403","article-title":"N-WASP promotes invasion and migration of cervical cancer cells through regulating p38 MAPKs signaling pathway","volume":"9","author":"Hou","year":"2017","journal-title":"Am. J. Tourism Res."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112011_bib16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ygyno.2012.06.008","article-title":"High level of WAVE1 expression is associated with tumor aggressiveness and unfavorable prognosis of epithelial ovarian cancer","volume":"127","author":"Zhang","year":"2012","journal-title":"Gynecol. Oncol."},{"issue":"50","key":"10.1016\/j.yexcr.2020.112011_bib17","doi-asserted-by":"crossref","first-page":"88232","DOI":"10.18632\/oncotarget.21088","article-title":"Cortactin in cancer cell migration and invasion","volume":"8","author":"Yin","year":"2017","journal-title":"Oncotarget"},{"issue":"7","key":"10.1016\/j.yexcr.2020.112011_bib18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nrm3141","article-title":"The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function","volume":"12","author":"Murphy","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yexcr.2020.112011_bib19","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fcell.2015.00004","article-title":"The regulation of MMP targeting to invadopodia during cancer metastasis","volume":"3","author":"Jacob","year":"2015","journal-title":"Frontiers in cell and developmental biology"},{"issue":"2","key":"10.1016\/j.yexcr.2020.112011_bib20","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1083\/jcb.103.2.631","article-title":"Intracellular localization of the 55-kD actin-bundling protein in cultured cells: spatial relationships with actin, alpha-actinin, tropomyosin, and fimbrin","volume":"103","author":"Yamashiro-Matsumura","year":"1986","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.yexcr.2020.112011_bib21","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cub.2009.12.035","article-title":"The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion","volume":"20","author":"Li","year":"2010","journal-title":"Curr. Biol. : CB (Curr. Biol.)"},{"issue":"10","key":"10.1016\/j.yexcr.2020.112011_bib22","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.biocel.2010.06.019","article-title":"Fascin: a key regulator of cytoskeletal dynamics","volume":"42","author":"Jayo","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"21","key":"10.1016\/j.yexcr.2020.112011_bib23","doi-asserted-by":"crossref","first-page":"12632","DOI":"10.1074\/jbc.271.21.12632","article-title":"Phosphorylation of human fascin inhibits its actin binding and bundling activities","volume":"271","author":"Yamakita","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112011_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1155\/2008\/284382","article-title":"Association of cortactin, fascin-1 and epidermal growth factor receptor (EGFR) expression in ovarian carcinomas: correlation with clinicopathological parameters","volume":"25","author":"Lin","year":"2008","journal-title":"Dis. Markers"},{"issue":"2","key":"10.1016\/j.yexcr.2020.112011_bib25","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ygyno.2019.01.020","article-title":"Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis","volume":"153","author":"McGuire","year":"2019","journal-title":"Gynecol. Oncol."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112011_bib26","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ncb762","article-title":"Myosin-X is an unconventional myosin that undergoes intrafilopodial motility","volume":"4","author":"Berg","year":"2002","journal-title":"Nat. Cell Biol."},{"issue":"33","key":"10.1016\/j.yexcr.2020.112011_bib27","doi-asserted-by":"crossref","first-page":"12411","DOI":"10.1073\/pnas.0602443103","article-title":"Myosin-X is a molecular motor that functions in filopodia formation","volume":"103","author":"Bohil","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"6","key":"10.1016\/j.yexcr.2020.112011_bib28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/ncb1136","article-title":"Myosin-X provides a motor-based link between integrins and the cytoskeleton","volume":"6","author":"Zhang","year":"2004","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112011_bib29","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1172\/JCI67280","article-title":"Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis","volume":"124","author":"Arjonen","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112011_bib30","doi-asserted-by":"crossref","first-page":"10449","DOI":"10.1038\/s41598-018-28717-y","article-title":"Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis","volume":"8","author":"Tokuo","year":"2018","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112011_bib31","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1074\/jbc.M607174200","article-title":"Calmodulin-like protein increases filopodia-dependent cell motility via up-regulation of myosin-10","volume":"282","author":"Bennett","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112011_bib32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1749-0774.2007.00030.x","article-title":"Establishment of a new cell line of endometrioid carcinoma of the ovary and its chemosensitivity","volume":"20","author":"Umezu","year":"2007","journal-title":"Hum. Cell"},{"issue":"8","key":"10.1016\/j.yexcr.2020.112011_bib33","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1158\/1535-7163.MCT-14-0135","article-title":"Expression of the miR200 family of microRNAs in mesothelial cells suppresses the dissemination of ovarian cancer cells","volume":"13","author":"Sugiyama","year":"2014","journal-title":"Mol. Canc. Therapeut."},{"issue":"66","key":"10.1016\/j.yexcr.2020.112011_bib34","doi-asserted-by":"crossref","first-page":"32609","DOI":"10.18632\/oncotarget.25975","article-title":"Hematopoietic lineage cell-specific protein 1 (HS1), a hidden player in migration, invasion, and tumor formation, is over-expressed in ovarian carcinoma cells","volume":"9","author":"Koya","year":"2018","journal-title":"Oncotarget"},{"issue":"8","key":"10.1016\/j.yexcr.2020.112011_bib35","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1016\/S0021-9258(18)89183-9","article-title":"Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells","volume":"260","author":"Yamashiro-Matsumura","year":"1985","journal-title":"J. Biol. Chem."},{"issue":"41","key":"10.1016\/j.yexcr.2020.112011_bib36","doi-asserted-by":"crossref","first-page":"43843","DOI":"10.18632\/oncotarget.5983","article-title":"CSIOVDB: a microarray gene expression database of epithelial ovarian cancer subtype","volume":"6","author":"Tan","year":"2015","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.yexcr.2020.112011_bib37","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1053\/j.gastro.2014.01.046","article-title":"Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes","volume":"146","author":"Li","year":"2014","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.yexcr.2020.112011_bib38","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/cm.20356","article-title":"Fascin1 is dispensable for mouse development but is favorable for neonatal survival","volume":"66","author":"Yamakita","year":"2009","journal-title":"Cell Motil Cytoskeleton"},{"issue":"6","key":"10.1016\/j.yexcr.2020.112011_bib39","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1083\/jcb.200603013","article-title":"Role of fascin in filopodial protrusion","volume":"174","author":"Vignjevic","year":"2006","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112011_bib40","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4161\/cam.5.2.14773","article-title":"Cortactin: a multifunctional regulator of cellular invasiveness","volume":"5","author":"Kirkbride","year":"2011","journal-title":"Cell Adhes. Migrat."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112011_bib41","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1083\/jcb.200909113","article-title":"Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia","volume":"189","author":"Schoumacher","year":"2010","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112011_bib42","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.203661","article-title":"Tks adaptor proteins at a glance","volume":"131","author":"Saini","year":"2018","journal-title":"J. Cell Sci."},{"issue":"326","key":"10.1016\/j.yexcr.2020.112011_bib43","article-title":"Myosin X regulates neuronal radial migration through interacting with N-cadherin","volume":"9","author":"Lai","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"4","key":"10.1016\/j.yexcr.2020.112011_bib44","doi-asserted-by":"crossref","DOI":"10.1111\/eci.12903","article-title":"Upregulated N-cadherin expression is associated with poor prognosis in epithelial-derived solid tumours: a meta-analysis","volume":"48","author":"Luo","year":"2018","journal-title":"Eur. J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.yexcr.2020.112011_bib45","doi-asserted-by":"crossref","first-page":"15588","DOI":"10.3390\/ijms131215588","article-title":"Elevated levels of Lewis y and integrin alpha5beta1 correlate with chemotherapeutic drug resistance in epithelial ovarian carcinoma","volume":"13","author":"Hu","year":"2012","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112011_bib46","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1091\/mbc.9.5.993","article-title":"Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells","volume":"9","author":"Yamashiro","year":"1998","journal-title":"Mol. Biol. Cell"},{"issue":"8","key":"10.1016\/j.yexcr.2020.112011_bib47","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.tcb.2017.03.003","article-title":"Tumor cell invadopodia: invasive protrusions that orchestrate metastasis","volume":"27","author":"Eddy","year":"2017","journal-title":"Trends Cell Biol."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112011_bib48","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4161\/cam.5.5.17723","article-title":"Filopodia and adhesion in cancer cell motility","volume":"5","author":"Arjonen","year":"2011","journal-title":"Cell Adhes. Migrat."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112011_bib49","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1158\/2159-8274.CD-11-0010","article-title":"Ovarian cancer spheroids use myosin-generated force to clear the mesothelium","volume":"1","author":"Iwanicki","year":"2011","journal-title":"Canc. Discov."},{"issue":"9","key":"10.1016\/j.yexcr.2020.112011_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075577","article-title":"Filopodia and membrane blebs drive efficient matrix invasion of macrophages transformed by the intracellular parasite Theileria annulata","volume":"8","author":"Ma","year":"2013","journal-title":"PloS One"}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482720302330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482720302330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:31:06Z","timestamp":1757997066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482720302330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0014482720302330"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2020.112011","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Filopodia play an important role in the trans-mesothelial migration of ovarian cancer cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2020.112011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112011"}}