{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:04:00Z","timestamp":1788174240875,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Health Commission of Hebei Province","award":["20190058"],"award-info":[{"award-number":["20190058"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.yexcr.2020.112059","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T04:13:10Z","timestamp":1588565590000},"page":"112059","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["FBXW7 promotes pathological cardiac hypertrophy by targeting EZH2-SIX1 signaling"],"prefix":"10.1016","volume":"393","author":[{"given":"Weinian","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2020.112059_bib1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0140-6736(12)60397-3","article-title":"Hypertrophic cardiomyopathy","volume":"381","author":"Maron","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.yexcr.2020.112059_bib2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.pharmthera.2016.03.005","article-title":"Epigenetics and obesity cardiomyopathy: from pathophysiology to prevention and management","volume":"161","author":"Zhang","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.yexcr.2020.112059_bib3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nrcardio.2011.159","article-title":"Mechanisms of disease: hypertrophic cardiomyopathy","volume":"9","author":"Frey","year":"2012","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.yexcr.2020.112059_bib4","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3389\/fendo.2020.00280","article-title":"Cardiomyocyte senescence and cellular communications within myocardial microenvironment","volume":"11","author":"Tang","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.yexcr.2020.112059_bib5","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMra072139","article-title":"Cardiac plasticity","volume":"358","author":"Hill","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yexcr.2020.112059_bib6","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1161\/CIRCULATIONAHA.115.013894","article-title":"Inhibition of hypertrophy is a good therapeutic strategy in ventricular pressure overload","volume":"131","author":"Schiattarella","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.yexcr.2020.112059_bib7","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.yexcr.2020.112059_bib8","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1042\/CS20200128","article-title":"Short-chain fatty acid, acylation and cardiovascular diseases","volume":"134","author":"Chen","year":"2020","journal-title":"Clin. Sci."},{"key":"10.1016\/j.yexcr.2020.112059_bib9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00018-008-8335-4","article-title":"The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease","volume":"66","author":"Kumar","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.yexcr.2020.112059_bib10","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s00246-017-1744-0","article-title":"In silico analyses reveal the relationship between SIX1\/EYA1 mutations and conotruncal heart defects","volume":"39","author":"Li","year":"2018","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.yexcr.2020.112059_bib11","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1161\/CIRCRESAHA.111.252205","article-title":"Polycomb repressive complex 2 regulates normal development of the mouse heart","volume":"110","author":"He","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.yexcr.2020.112059_bib12","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.yjmcc.2019.01.017","article-title":"Role of the PRC2-Six1-miR-25 signaling axis in heart failure","volume":"129","author":"Oh","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yexcr.2020.112059_bib13","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nature13073","article-title":"Inhibition of miR-25 improves cardiac contractility in the failing heart","volume":"508","author":"Wahlquist","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2020.112059_bib14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ng.1068","article-title":"Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis","volume":"44","author":"Delgado-Olgu\u00edn","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yexcr.2020.112059_bib15","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/ehf2.12017","article-title":"Six1 is down-regulated in end-stage human dilated cardiomyopathy independently of Ezh2","volume":"1","author":"Tschirner","year":"2014","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.yexcr.2020.112059_bib16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12943-018-0857-2","article-title":"FBXW7: a critical tumor suppressor of human cancers","volume":"17","author":"Yeh","year":"2018","journal-title":"Mol. Canc."},{"key":"10.1016\/j.yexcr.2020.112059_bib17","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1172\/JCI123374","article-title":"Fbxw7 increases CCL2\/7 in CX3CR1hi macrophages to promote intestinal inflammation","volume":"130","author":"He","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexcr.2020.112059_bib18","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1182\/blood-2018-12-891507","article-title":"FBXW7 is a biologically validated cancer driver gene for CLL","volume":"133","author":"Rossi","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.yexcr.2020.112059_bib19","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1172\/JCI40725","article-title":"Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver","volume":"121","author":"Onoyama","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexcr.2020.112059_bib20","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1038\/s41467-019-10881-y","article-title":"Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7","volume":"10","author":"Harty","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yexcr.2020.112059_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041116","article-title":"Fbxw7 controls angiogenesis by regulating endothelial Notch activity","volume":"7","author":"Izumi","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.yexcr.2020.112059_bib22","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1091\/mbc.E18-04-0259","article-title":"FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB","volume":"30","author":"Pronk","year":"2019","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yexcr.2020.112059_bib23","first-page":"1389","article-title":"SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity","volume":"38","author":"Luo","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.yexcr.2020.112059_bib24","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s11427-014-4687-1","article-title":"Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure","volume":"57","author":"Mu","year":"2014","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.yexcr.2020.112059_bib25","doi-asserted-by":"crossref","first-page":"36576","DOI":"10.1038\/srep36576","article-title":"SIRT1 deacetylates the cardiac transcription factor Nkx2.5 and inhibits its transcriptional activity","volume":"6","author":"Tang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexcr.2020.112059_bib26","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1161\/CIRCULATIONAHA.117.028728","article-title":"SIRT2 acts as a cardioprotective deacetylase in pathological cardiac hypertrophy","volume":"136","author":"Tang","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.yexcr.2020.112059_bib27","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1002\/jcb.23314","article-title":"D-galactose induces necroptotic cell death in neuroblastoma cell lines","volume":"112","author":"Li","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.yexcr.2020.112059_bib28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ng.1068","article-title":"Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis","volume":"44","author":"Delgado-Olguin","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yexcr.2020.112059_bib29","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1161\/CIRCGENETICS.115.001134","article-title":"Eya4 induces hypertrophy via regulation of p27kip1","volume":"8","author":"Williams","year":"2015","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.yexcr.2020.112059_bib30","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.yjmcc.2011.12.002","article-title":"Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy","volume":"52","author":"Lee","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yexcr.2020.112059_bib31","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.jhep.2019.05.027","article-title":"Loss of Fbxw7 synergizes with activated Akt signaling to promote c-Myc dependent cholangiocarcinogenesis","volume":"71","author":"Wang","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.yexcr.2020.112059_bib32","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1073\/pnas.1909879116","article-title":"FBXW7-mediated stability regulation of signal transducer and activator of transcription 2 in melanoma formation","volume":"117","author":"Lee","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2020.112059_bib33","first-page":"2271","article-title":"Expression of FBXW7 in diabetic cardiomyopathy","volume":"34","author":"Tu Lu-mei","year":"2018","journal-title":"Chin. J. Pathophysiol."},{"key":"10.1016\/j.yexcr.2020.112059_bib34","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s10495-018-1484-5","article-title":"Inhibition of the ubiquitination of HSF1 by FBXW7 protects the intestine against ischemia-reperfusion injury","volume":"23","author":"Tan","year":"2018","journal-title":"Apoptosis"},{"key":"10.1016\/j.yexcr.2020.112059_bib35","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/HYPERTENSIONAHA.119.13173","article-title":"Transcribed ultraconserved regions, Uc.323, ameliorates cardiac hypertrophy by regulating the transcription of CPT1b (carnitine palmitoyl transferase 1b)","volume":"75","author":"Sun","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.yexcr.2020.112059_bib36","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.bbrc.2013.05.079","article-title":"MicroRNA-214 provokes cardiac hypertrophy via repression of EZH2","volume":"436","author":"Yang","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482720302913?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482720302913?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:31:04Z","timestamp":1757997064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482720302913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0014482720302913"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2020.112059","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FBXW7 promotes pathological cardiac hypertrophy by targeting EZH2-SIX1 signaling","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2020.112059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112059"}}