{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:44:22Z","timestamp":1791895462081,"version":"4.3.4"},"reference-count":68,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.yexcr.2020.112093","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T03:41:15Z","timestamp":1590118875000},"page":"112093","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["The effect and mechanism of 19S proteasome PSMD11\/Rpn6 subunit in D-Galactose induced mimetic aging models"],"prefix":"10.1016","volume":"394","author":[{"given":"Han","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuhong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9491","key":"10.1016\/j.yexcr.2020.112093_bib1","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0140-6736(05)67423-5","volume":"366","author":"Gates","year":"2005","journal-title":"Presbycusis. Lancet"},{"issue":"10","key":"10.1016\/j.yexcr.2020.112093_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006371","article-title":"A large genome-wide association study of age-related hearing impairment using electronic health records","volume":"12","author":"Hoffmann","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.yexcr.2020.112093_bib3","unstructured":"1.Presbycusis."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112093_bib4","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/geront\/43.5.661","article-title":"The impact of hearing loss on quality of life in older adults","volume":"43","author":"Dalton","year":"2003","journal-title":"Gerontol."},{"issue":"211","key":"10.1016\/j.yexcr.2020.112093_bib5","first-page":"188","article-title":"Ageing and hearing loss","author":"Yan","year":"2007","journal-title":"J. Pathol."},{"issue":"23","key":"10.1016\/j.yexcr.2020.112093_bib6","first-page":"154","article-title":"A review of causal mechanisms underlying the link between age-related hearing loss and cognitive decline","author":"Rachel","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.yexcr.2020.112093_bib7","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.redox.2017.04.031","article-title":"The role of sodium hydrosulfide in attenuating the aging process via PI3K\/AKT and CaMKKbeta\/AMPK pathways","volume":"12","author":"Chen","year":"2017","journal-title":"Redox Biol"},{"issue":"3","key":"10.1016\/j.yexcr.2020.112093_bib8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1568-1637(02)00004-1","article-title":"Molecular mechanisms of age-related hearing loss","volume":"1","author":"Seidman","year":"2002","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.yexcr.2020.112093_bib9","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.1749-6632.2009.03931.x","article-title":"Age-related hearing loss: ear and brain mechanisms","volume":"1170","author":"Frisina","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.yexcr.2020.112093_bib10","first-page":"a033217","volume":"vol. 9","author":"Dawson","year":"2019"},{"issue":"14","key":"10.1016\/j.yexcr.2020.112093_bib11","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1111\/febs.13324","article-title":"Age-related changes in mitochondrial antioxidant enzyme Trx2 and TXNIP-Trx2-ASK1 signal pathways in the auditory cortex of a mimetic aging rat model: changes to Trx2 in the auditory cortex","volume":"282","author":"Sun","year":"2015","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112093_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10522-013-9475-y","article-title":"The role of mitochondria in age-related hearing loss","volume":"15","author":"Chen","year":"2014","journal-title":"Biogerontology"},{"issue":"1\u20132","key":"10.1016\/j.yexcr.2020.112093_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.heares.2006.06.004","article-title":"Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss","volume":"226","author":"Yamasoba","year":"2007","journal-title":"Hear. Res."},{"issue":"5733","key":"10.1016\/j.yexcr.2020.112093_bib14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1112125","article-title":"Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging","volume":"309","author":"Kujoth","year":"2005","journal-title":"Science"},{"issue":"Suppl 1","key":"10.1016\/j.yexcr.2020.112093_bib15","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1471-2091-8-S1-S3","article-title":"Role of proteasomes in disease","volume":"8","author":"Dahlmann","year":"2007","journal-title":"BMC Biochem."},{"key":"10.1016\/j.yexcr.2020.112093_bib16","series-title":"Increased burden of mitochondrial DNA deletions and point mutations in. Experimental Gerontology","author":"Mi-Jung Kima","year":"2019"},{"issue":"4","key":"10.1016\/j.yexcr.2020.112093_bib17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.mam.2009.04.001","article-title":"The proteasomal system","volume":"30","author":"Jung","year":"2009","journal-title":"Mol. Aspect. Med."},{"issue":"24","key":"10.1016\/j.yexcr.2020.112093_bib18","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1007\/s00018-014-1699-8","article-title":"Proteasome assembly","volume":"71","author":"Gu","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"issue":"11","key":"10.1016\/j.yexcr.2020.112093_bib19","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/s41580-018-0040-z","article-title":"Regulation of proteasome assembly and activity in health and disease","volume":"19","author":"Rousseau","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yexcr.2020.112093_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/sj.cdd.4401709","article-title":"Early work on the ubiquitin proteasome system","author":"Hershko","year":"2005","journal-title":"an. Cell Death and Different."},{"key":"10.1016\/j.yexcr.2020.112093_bib21","article-title":"Regulation of proteasome activity in health and disease\u2606","author":"Marion Schmidt A","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexcr.2020.112093_bib22","article-title":"Proteasome activation as a novel antiaging StrategyProteasome activation as a novel antiaging strategy","author":"Gonos","year":"2008","journal-title":"IUBMB Life"},{"issue":"11","key":"10.1016\/j.yexcr.2020.112093_bib23","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1007\/s10495-010-0466-z","article-title":"Ubiquitin\/proteasome pathway impairment in neurodegeneration: therapeutic implications","volume":"15","author":"Huang","year":"2010","journal-title":"Apoptosis"},{"issue":"4","key":"10.1016\/j.yexcr.2020.112093_bib24","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.mam.2012.04.001","article-title":"Roles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degeneration","volume":"33","author":"Shang","year":"2012","journal-title":"Mol. Aspect. Med."},{"issue":"49","key":"10.1016\/j.yexcr.2020.112093_bib25","doi-asserted-by":"crossref","first-page":"13285","DOI":"10.1523\/JNEUROSCI.4393-08.2008","article-title":"Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons","volume":"28","author":"Tydlacka","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yexcr.2020.112093_bib26","article-title":"Aging in mouse brain is a CellTissue-level phenomenon","author":"Lei Mao","year":"2010","journal-title":"J. Proteome Res."},{"issue":"36","key":"10.1016\/j.yexcr.2020.112093_bib27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1365-2990.2010.01063.x","article-title":"Review: the ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration","author":"Rogers","year":"2010","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112093_bib28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1073\/pnas.1117648108","article-title":"The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together","volume":"109","author":"Pathare","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7415","key":"10.1016\/j.yexcr.2020.112093_bib29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nature11315","article-title":"RPN-6 determines C. elegans longevity under proteotoxic stress conditions","volume":"489","author":"Vilchez","year":"2012","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.yexcr.2020.112093_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101970","article-title":"A functional genomic screen for evolutionarily conserved genes required for lifespan and immunity in germline-deficient C. elegans","volume":"9","author":"Sinha","year":"2014","journal-title":"PloS One"},{"issue":"7415","key":"10.1016\/j.yexcr.2020.112093_bib31","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nature11468","article-title":"Increased proteasome activity in human embryonic stem cells is regulated by PSMD11","volume":"489","author":"Vilchez","year":"2012","journal-title":"Nature"},{"issue":"7415","key":"10.1016\/j.yexcr.2020.112093_bib32","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nature11468","article-title":"Increased proteasome activity in human embryonic stem cells is regulated by PSMD11","volume":"489","author":"Vilchez","year":"2012","journal-title":"Nature"},{"issue":"52","key":"10.1016\/j.yexcr.2020.112093_bib33","doi-asserted-by":"crossref","first-page":"E7176","DOI":"10.1073\/pnas.1522332112","article-title":"cAMP-induced phosphorylation of 26S proteasomes on Rpn6\/PSMD11 enhances their activity and the degradation of misfolded proteins","volume":"112","author":"Lokireddy","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"31","key":"10.1016\/j.yexcr.2020.112093_bib34","doi-asserted-by":"crossref","first-page":"22460","DOI":"10.1074\/jbc.M702439200","article-title":"Proteasome function is regulated by cyclic AMP-dependent protein kinase through phosphorylation of Rpt6","volume":"282","author":"Zhang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2020.112093_bib35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1152\/physiol.00026.2007","article-title":"Metabolic control of proteasome function","volume":"22","author":"Zhang","year":"2007","journal-title":"Physiology"},{"key":"10.1016\/j.yexcr.2020.112093_bib36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.anaerobe.2014.03.003","article-title":"Lactobacillus pentosus var. plantarum C29 ameliorates memory impairment and inflammaging in a D-galactose-induced accelerated aging mouse model","volume":"27","author":"Woo","year":"2014","journal-title":"Anaerobe"},{"issue":"5","key":"10.1016\/j.yexcr.2020.112093_bib37","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1179\/016164105X25126","article-title":"D-galactose injured neurogenesis in the hippocampus of adult mice","volume":"27","author":"Zhang","year":"2005","journal-title":"Neurol. Res."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112093_bib38","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/jnr.20899","article-title":"Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid","volume":"84","author":"Cui","year":"2006","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112093_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10522-013-9475-y","article-title":"The role of mitochondria in age-related hearing loss","volume":"15","author":"Chen","year":"2014","journal-title":"Biogerontology"},{"key":"10.1016\/j.yexcr.2020.112093_bib40","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.2147\/TCRM.S117491","article-title":"The potential role for use of mitochondrial DNA copy number as predictive biomarker in presbycusis","volume":"12","author":"Falah","year":"2016","journal-title":"Therapeut. Clin. Risk Manag."},{"issue":"1\u20132","key":"10.1016\/j.yexcr.2020.112093_bib41","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.heares.2006.06.004","article-title":"Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss","volume":"226","author":"Yamasoba","year":"2007","journal-title":"Hear. Res."},{"key":"10.1016\/j.yexcr.2020.112093_bib42","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, oxidants, and aging","volume":"120","author":"Robert","year":"2005","journal-title":"Cell"},{"issue":"5733","key":"10.1016\/j.yexcr.2020.112093_bib43","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1112125","article-title":"Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging","volume":"309","author":"Kujoth","year":"2005","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.yexcr.2020.112093_bib44","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/em.20050","article-title":"Development of a quantitative PCR (TaqMan) assay for relative mitochondrial DNA copy number and the common mitochondrial DNA deletion in the rat","volume":"44","author":"Nicklas","year":"2004","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.yexcr.2020.112093_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2012.09.001","article-title":"Protein damage, repair and proteolysis","volume":"35","author":"Chondrogianni","year":"2014","journal-title":"Mol. Aspect. Med."},{"issue":"4\u20136","key":"10.1016\/j.yexcr.2020.112093_bib46","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.mam.2011.10.010","article-title":"Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA","volume":"32","author":"Radak","year":"2011","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.yexcr.2020.112093_bib47","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev-genet-110711-155456","article-title":"Probing mechanisms that underlie human neurodegenerative diseases in Drosophila","volume":"46","author":"Jaiswal","year":"2012","journal-title":"Annu. Rev. Genet."},{"issue":"4","key":"10.1016\/j.yexcr.2020.112093_bib48","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cmet.2014.01.016","article-title":"Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin\/proteasome system","volume":"19","author":"Segref","year":"2014","journal-title":"Cell Metabol."},{"issue":"4","key":"10.1016\/j.yexcr.2020.112093_bib49","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/brain\/awz060","article-title":"Tau suppresses neuronal activity in vivo, even before tangles form","volume":"142","author":"Busche","year":"2019","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.yexcr.2020.112093_bib50","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.abb.2010.05.008","article-title":"Tau protein degradation is catalyzed by the ATP\/ubiquitin-independent 20S proteasome under normal cell conditions","volume":"500","author":"Grune","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.yexcr.2020.112093_bib51","doi-asserted-by":"crossref","first-page":"42","DOI":"10.12703\/P7-42","article-title":"Mitochondria and apoptosis: emerging concepts","volume":"7","author":"Li","year":"2015","journal-title":"F1000Prime Rep"},{"issue":"1","key":"10.1016\/j.yexcr.2020.112093_bib52","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0006-8993(97)01361-9","article-title":"Developmental and aging changes of Bak expression in the human brain","volume":"783","author":"Obonai","year":"1998","journal-title":"Brain Res."},{"issue":"46","key":"10.1016\/j.yexcr.2020.112093_bib53","doi-asserted-by":"crossref","first-page":"19432","DOI":"10.1073\/pnas.0908786106","article-title":"Age-related hearing loss in C57BL\/6J mice is mediated by Bak-dependent mitochondrial apoptosis","volume":"106","author":"Someya","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"38","key":"10.1016\/j.yexcr.2020.112093_bib54","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1038\/onc.2013.413","article-title":"The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a","volume":"33","author":"Sparks","year":"2014","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.yexcr.2020.112093_bib55","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.18632\/oncotarget.1797","article-title":"Dissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activity","volume":"5","author":"Pant","year":"2014","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.yexcr.2020.112093_bib56","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1439-0388.2005.00522.x","article-title":"Partial molecular characterization, polymorphism and chromosomal localization of the porcine PSMD4 gene","volume":"122","author":"Wang","year":"2005","journal-title":"J. Anim. Breed. Genet."},{"issue":"12","key":"10.1016\/j.yexcr.2020.112093_bib57","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1016\/j.celrep.2016.02.068","article-title":"Assembly of an evolutionarily conserved alternative proteasome isoform in human cells","volume":"14","author":"Padmanabhan","year":"2016","journal-title":"Cell Rep."},{"issue":"1\u20133","key":"10.1016\/j.yexcr.2020.112093_bib58","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.febslet.2004.05.067","article-title":"The alpha 4 and alpha 7 subunits and assembly of the 20S proteasome","volume":"569","author":"Apcher","year":"2004","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112093_bib59","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00441-017-2786-6","article-title":"Modifications of the 26S proteasome during boar sperm capacitation","volume":"372","author":"Zigo","year":"2018","journal-title":"Cell Tissue Res."},{"issue":"331","key":"10.1016\/j.yexcr.2020.112093_bib60","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.bbrc.2005.03.149","article-title":"P53 in neuronal apoptosis","author":"Carsten Culmsee","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112093_bib61","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13024-017-0220-x","article-title":"Modulating the catalytic activity of AMPK has neuroprotective effects against alpha-synuclein toxicity","volume":"12","author":"Bobela","year":"2017","journal-title":"Mol. Neurodegener."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112093_bib62","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physiol.00050.2013","article-title":"AMPK: regulating energy balance at the cellular and whole body levels","volume":"29","author":"Hardie","year":"2014","journal-title":"Physiology"},{"issue":"6","key":"10.1016\/j.yexcr.2020.112093_bib63","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1007\/s12035-018-1352-x","article-title":"AMPK activation of PGC-1alpha\/NRF-1-dependent SELENOT gene transcription promotes PACAP-induced neuroendocrine cell differentiation through tolerance to oxidative stress","volume":"56","author":"Abid","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.yexcr.2020.112093_bib64","first-page":"3371","article-title":"Age-associated decline in Nrf 2 signaling and associated mtDNA damage may be involved in the degeneration of the auditory cortex: implications for central presbycusis","volume":"42","author":"Li","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"128","key":"10.1016\/j.yexcr.2020.112093_bib65","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.neuropharm.2017.10.027","article-title":"P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer's disease","author":"Francisco S\u00e1ez-Orellana","year":"2018","journal-title":"Neuropharmacology"},{"issue":"11","key":"10.1016\/j.yexcr.2020.112093_bib66","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/gt.2015.63","article-title":"The spread of adenoviral vectors to central nervous system through pathway of cochlea in mimetic aging and young rats","volume":"22","author":"Chen","year":"2015","journal-title":"Gene Ther."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112093_bib67","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bbrc.2014.01.154","article-title":"Down regulated connexin 26 at different postnatal stage displayed different types of cellular degeneration and formation of organ of Corti","volume":"445","author":"Chen","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112093_bib68","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.bbrc.2014.09.118","article-title":"Mitochondrial DNA common deletion increases susceptibility to noise-induced hearing loss in a mimetic aging rat model","volume":"453","author":"Yu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482720303360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482720303360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:31:19Z","timestamp":1757997079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482720303360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S0014482720303360"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2020.112093","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect and mechanism of 19S proteasome PSMD11\/Rpn6 subunit in D-Galactose induced mimetic aging models","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2020.112093","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112093"}}