{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:06:33Z","timestamp":1785215193925,"version":"3.55.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.yexcr.2020.112135","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T12:57:38Z","timestamp":1591880258000},"page":"112135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Crk1\/2 and CrkL play critical roles in maintaining podocyte morphology and function"],"prefix":"10.1016","volume":"394","author":[{"given":"Jialin","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.yexcr.2020.112135_bib1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1083\/jcb.201410017","article-title":"Review series: the cell biology of renal filtration","volume":"209","author":"Scott","year":"2015","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.yexcr.2020.112135_bib2","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0002-9440(10)64421-5","article-title":"Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation","volume":"161","author":"Saleem","year":"2002","journal-title":"Am. J. Pathol."},{"issue":"11","key":"10.1016\/j.yexcr.2020.112135_bib3","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1681\/ASN.2015121303","article-title":"Intravital and kidney slice imaging of podocyte membrane dynamics","volume":"27","author":"Brahler","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112135_bib4","doi-asserted-by":"crossref","first-page":"F46","DOI":"10.1152\/ajprenal.00184.2016","article-title":"The podocyte as a direct target for treatment of glomerular disease?","volume":"311","author":"Mallipattu","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"9","key":"10.1016\/j.yexcr.2020.112135_bib5","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/ncb3402","article-title":"Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation","volume":"18","author":"Sun","year":"2016","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.yexcr.2020.112135_bib6","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1681\/ASN.2017091039","article-title":"The role of palladin in podocytes","volume":"29","author":"Artelt","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112135_bib7","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1172\/JCI69778","article-title":"Podocyte-associated talin 1 is critical for glomerular filtration barrier maintenance","volume":"124","author":"Tian","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"44","key":"10.1016\/j.yexcr.2020.112135_bib8","doi-asserted-by":"crossref","first-page":"6348","DOI":"10.1038\/sj.onc.1204779","article-title":"Crk family adaptors-signalling complex formation and biological roles","volume":"20","author":"Feller","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2020.112135_bib9","doi-asserted-by":"crossref","first-page":"34349","DOI":"10.1038\/srep34349","article-title":"A pre-metazoan origin of the CRK gene family and co-opted signaling network","volume":"6","author":"Shigeno-Nakazawa","year":"2016","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.yexcr.2020.112135_bib10","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/nchembio.954","article-title":"Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII","volume":"8","author":"Jankowski","year":"2012","journal-title":"Nat. Chem. Biol."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112135_bib11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1385\/IR:28:2:79","article-title":"Involvement of crk adapter proteins in regulation of lymphoid cell functions","volume":"28","author":"Gelkop","year":"2003","journal-title":"Immunol. Res."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112135_bib12","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2017.1376155","article-title":"Crk adaptor protein promotes PD-L1 expression, EMT and immune evasion in a murine model of triple-negative breast cancer","volume":"7","author":"Kumar","year":"2017","journal-title":"OncoImmunology"},{"issue":"Suppl 1","key":"10.1016\/j.yexcr.2020.112135_bib13","first-page":"E35","article-title":"CRKL promotes lung cancer cell invasion through ERK-MMP9 pathway","volume":"54","author":"Lin","year":"2015","journal-title":"Mol. Carcinog."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112135_bib14","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1039\/C7MD00619E","article-title":"Structure-guided design of a potent peptide inhibitor targeting the interaction between CRK and ABL kinase","volume":"9","author":"Shen","year":"2018","journal-title":"Medchemcomm"},{"issue":"10","key":"10.1016\/j.yexcr.2020.112135_bib15","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1038\/s41388-018-0546-z","article-title":"Regulation of human glioma cell migration, tumor growth, and stemness gene expression using a Lck targeted inhibitor","volume":"38","author":"Zepecki","year":"2019","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.yexcr.2020.112135_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nbt.1513","article-title":"Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy","volume":"27","author":"Du","year":"2009","journal-title":"Nat. Biotechnol."},{"issue":"16","key":"10.1016\/j.yexcr.2020.112135_bib17","doi-asserted-by":"crossref","first-page":"6272","DOI":"10.1128\/MCB.00472-06","article-title":"Cardiovascular and craniofacial defects in Crk-null mice","volume":"26","author":"Park","year":"2006","journal-title":"Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112135_bib18","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/85855","article-title":"Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome","volume":"27","author":"Guris","year":"2001","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.yexcr.2020.112135_bib19","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1056\/NEJMoa1609009","article-title":"Genetic drivers of kidney defects in the DiGeorge syndrome","volume":"376","author":"Lopez-Rivera","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.yexcr.2020.112135_bib20","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1002\/ajmg.a.35996","article-title":"The duplication 17p13.3 phenotype: analysis of 21 families delineates developmental, behavioral and brain abnormalities, and rare variant phenotypes","volume":"161a","author":"Curry","year":"2013","journal-title":"Am. J. Med. Genet."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112135_bib21","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.tjog.2018.08.031","volume":"57","author":"Chen","year":"2018","journal-title":"Taiwan. J. Obstet. Gynecol."},{"issue":"51","key":"10.1016\/j.yexcr.2020.112135_bib22","doi-asserted-by":"crossref","first-page":"26273","DOI":"10.1074\/jbc.M116.764613","article-title":"Fibroblast growth requires CT10 regulator of kinase (crk) and crk-like (CrkL)","volume":"291","author":"Park","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"43","key":"10.1016\/j.yexcr.2020.112135_bib23","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1038\/onc.2013.453","article-title":"Essential roles of Crk and CrkL in fibroblast structure and motility","volume":"33","author":"Park","year":"2014","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.yexcr.2020.112135_bib24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1158\/1541-7786.MCR-17-0242","article-title":"Crk tyrosine phosphorylation regulates PDGF-BB-inducible Src activation and breast tumorigenicity and metastasis","volume":"16","author":"Kumar","year":"2018","journal-title":"Mol. Canc. Res."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112135_bib25","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1172\/JCI60070","article-title":"Crk1\/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease","volume":"122","author":"George","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.yexcr.2020.112135_bib26","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1038\/ki.2013.556","article-title":"Crk1\/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis","volume":"85","author":"George","year":"2014","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112135_bib27","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1172\/JCI27414","article-title":"Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization","volume":"116","author":"Verma","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.yexcr.2020.112135_bib28","first-page":"4648","article-title":"Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts","volume":"13","author":"Birge","year":"1993","journal-title":"Mol. Cell Biol."},{"issue":"23","key":"10.1016\/j.yexcr.2020.112135_bib29","doi-asserted-by":"crossref","first-page":"10678","DOI":"10.1073\/pnas.92.23.10678","article-title":"Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas","volume":"92","author":"Polte","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"49","key":"10.1016\/j.yexcr.2020.112135_bib30","doi-asserted-by":"crossref","first-page":"29145","DOI":"10.1074\/jbc.270.49.29145","article-title":"CRKL links p210BCR\/ABL with paxillin in chronic myelogenous leukemia cells","volume":"270","author":"Salgia","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112135_bib31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.tcb.2006.03.003","article-title":"p130Cas: a versatile scaffold in signaling networks","volume":"16","author":"Defilippi","year":"2006","journal-title":"Trends Cell Biol."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112135_bib32","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/jcmm.13001","article-title":"FAK contributes to proteinuria in hypercholesterolaemic rats and modulates podocyte F-actin re-organization via activating p38 in response to ox-LDL","volume":"21","author":"Hu","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.yexcr.2020.112135_bib33","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1146\/annurev-physiol-020911-153238","article-title":"Cell biology and pathology of podocytes","volume":"74","author":"Greka","year":"2012","journal-title":"Annu. Rev. Physiol."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112135_bib34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/mc.22262","article-title":"Crk and CrkL are required for cell transformation by v-fos and v-ras","volume":"55","author":"Koptyra","year":"2016","journal-title":"Mol. Carcinog."},{"issue":"4","key":"10.1016\/j.yexcr.2020.112135_bib35","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.immuni.2012.03.007","article-title":"The adaptor protein Crk controls activation and inhibition of natural killer cells","volume":"36","author":"Liu","year":"2012","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.yexcr.2020.112135_bib36","doi-asserted-by":"crossref","first-page":"F1376","DOI":"10.1152\/ajprenal.00075.2008","article-title":"Dissociation of NEPH1 from nephrin is involved in development of a rat model of focal segmental glomerulosclerosis","volume":"295","author":"Otaki","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"6","key":"10.1016\/j.yexcr.2020.112135_bib37","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.kint.2016.01.012","article-title":"Podocyte injury and its consequences","volume":"89","author":"Nagata","year":"2016","journal-title":"Kidney Int."},{"key":"10.1016\/j.yexcr.2020.112135_bib38","doi-asserted-by":"crossref","first-page":"8031039","DOI":"10.1155\/2019\/8031039","article-title":"Anemoside B4 protects rat kidney from adenine-induced injury by attenuating inflammation and fibrosis and enhancing podocin and nephrin expression","volume":"2019","author":"Gong","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.yexcr.2020.112135_bib39","doi-asserted-by":"crossref","first-page":"112078","DOI":"10.1016\/j.jep.2019.112078","article-title":"Rhodojaponin II attenuates kidney injury by regulating TGF-beta 1\/Smad pathway in mice with adriamycin nephropathy","volume":"243","author":"Qiu","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"7\u20138","key":"10.1016\/j.yexcr.2020.112135_bib40","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s00424-017-1993-z","article-title":"Podocytes from the diagnostic and therapeutic point of view","volume":"469","author":"Muller-Deile","year":"2017","journal-title":"Pfl\u00fcgers Archiv"},{"issue":"1","key":"10.1016\/j.yexcr.2020.112135_bib41","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13045-017-0418-y","article-title":"Paxillin: a crossroad in pathological cell migration","volume":"10","author":"Lopez-Colome","year":"2017","journal-title":"J. Hematol. Oncol."},{"issue":"10","key":"10.1016\/j.yexcr.2020.112135_bib42","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1016\/j.ajpath.2014.06.027","article-title":"Glycogen synthase kinase 3 beta dictates podocyte motility and focal adhesion turnover by modulating paxillin activity: implications for the protective effect of low-dose lithium in podocytopathy","volume":"184","author":"Xu","year":"2014","journal-title":"Am. J. Pathol."},{"issue":"7","key":"10.1016\/j.yexcr.2020.112135_bib43","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s00467-011-1831-z","article-title":"Plasma from a case of recurrent idiopathic FSGS perturbs non-muscle myosin IIA (MYH9 protein) in human podocytes","volume":"26","author":"Babayeva","year":"2011","journal-title":"Pediatr. Nephrol."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112135_bib44","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.kint.2017.09.021","article-title":"Vinculin is required to maintain glomerular barrier integrity","volume":"93","author":"Lausecker","year":"2018","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112135_bib45","doi-asserted-by":"crossref","first-page":"F603","DOI":"10.1152\/ajprenal.00234.2007","article-title":"Bradykinin modulates focal adhesions and induces stress fiber remodeling in renal papillary collecting duct cells","volume":"294","author":"Marquez","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"8","key":"10.1016\/j.yexcr.2020.112135_bib46","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.4049\/jimmunol.1303485","article-title":"Immunophilins control T lymphocyte adhesion and migration by regulating CrkII binding to C3G","volume":"193","author":"Nath","year":"2014","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112135_bib47","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0092-8674(00)81280-5","article-title":"Cell migration: a physically integrated molecular process","volume":"84","author":"Lauffenburger","year":"1996","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.yexcr.2020.112135_bib48","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/jcb.24749","article-title":"Crk at the quarter century mark: perspectives in signaling and cancer","volume":"115","author":"Kumar","year":"2014","journal-title":"J. Cell. Biochem."},{"issue":"7","key":"10.1016\/j.yexcr.2020.112135_bib49","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/mc.20745","article-title":"Crk and CrkL present with different expression and significance in epithelial ovarian carcinoma","volume":"50","author":"Wang","year":"2011","journal-title":"Mol. Carcinog."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112135_bib50","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1083\/jcb.201612069","article-title":"Rho GTPase signaling complexes in cell migration and invasion","volume":"217","author":"Lawson","year":"2018","journal-title":"J. Cell Biol."},{"issue":"27","key":"10.1016\/j.yexcr.2020.112135_bib51","doi-asserted-by":"crossref","first-page":"42683","DOI":"10.18632\/oncotarget.7977","article-title":"MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia","volume":"7","author":"Chakraborty","year":"2016","journal-title":"Oncotarget"},{"issue":"10","key":"10.1016\/j.yexcr.2020.112135_bib52","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1182\/blood-2005-04-1388","article-title":"Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways","volume":"106","author":"Salameh","year":"2005","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.yexcr.2020.112135_bib53","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/jb\/mvn176","article-title":"Signalling pathway involving GULP, MAPK and Rac1 for SR-BI-induced phagocytosis of apoptotic cells","volume":"145","author":"Osada","year":"2009","journal-title":"J. Biochem."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112135_bib54","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ydbio.2005.06.038","article-title":"Organization of the pronephric filtration apparatus in zebrafish requires Nephrin, Podocin and the FERM domain protein Mosaic eyes","volume":"285","author":"Kramer-Zucker","year":"2005","journal-title":"Dev. Biol."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482720303827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482720303827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:32:18Z","timestamp":1757997138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482720303827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S0014482720303827"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2020.112135","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crk1\/2 and CrkL play critical roles in maintaining podocyte morphology and function","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2020.112135","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112135"}}