{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:15:14Z","timestamp":1789046114377,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.yexcr.2020.112245","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T11:06:03Z","timestamp":1598871963000},"page":"112245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["CSN6 aggravates Ang II-induced cardiomyocyte hypertrophy via inhibiting SIRT2"],"prefix":"10.1016","volume":"396","author":[{"given":"Zhi-liang","family":"Mei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-hua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.yexcr.2020.112245_bib1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.hfc.2017.02.001","article-title":"Epidemiology, pathophysiology, and prognosis of heart failure in older adults","volume":"13","author":"Dharmarajan","year":"2017","journal-title":"Heart Fail. Clin."},{"issue":"9970","key":"10.1016\/j.yexcr.2020.112245_bib2","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/S0140-6736(14)61889-4","article-title":"The war against heart failure: the Lancet lecture","volume":"385","author":"Braunwald","year":"2015","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.yexcr.2020.112245_bib3","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112245_bib4","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0092-8674(93)90541-W","article-title":"Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro","volume":"75","author":"Sadoshima","year":"1993","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.yexcr.2020.112245_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yexcr.2019.01.019","article-title":"CSN5 attenuates Ang II-induced cardiac hypertrophy through stabilizing LKB1","volume":"376","author":"Sheng","year":"2019","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112245_bib6","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol. Rev."},{"issue":"16","key":"10.1016\/j.yexcr.2020.112245_bib7","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1161\/CIRCULATIONAHA.115.013894","article-title":"Inhibition of hypertrophy is a good therapeutic strategy in ventricular pressure overload","volume":"131","author":"Schiattarella","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.yexcr.2020.112245_bib8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.yjmcc.2013.10.008","article-title":"Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond","volume":"71","author":"Cui","year":"2014","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"issue":"7","key":"10.1016\/j.yexcr.2020.112245_bib9","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1161\/CIRCRESAHA.112.300521","article-title":"Role of the ubiquitin proteasome system in the heart","volume":"112","author":"Pagan","year":"2013","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.yexcr.2020.112245_bib10","doi-asserted-by":"crossref","first-page":"H1283","DOI":"10.1152\/ajpheart.00249.2012","article-title":"The ubiquitin proteasome system in human cardiomyopathies and heart failure","volume":"304","author":"Day","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yexcr.2020.112245_bib11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1146\/annurev-biochem-061516-044916","article-title":"Mechanisms of deubiquitinase specificity and regulation","volume":"86","author":"Mevissen","year":"2017","journal-title":"Annu. Rev. Biochem."},{"issue":"9","key":"10.1016\/j.yexcr.2020.112245_bib12","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1161\/ATVBAHA.117.309859","article-title":"CYLD deubiquitinates nicotinamide adenine dinucleotide phosphate oxidase 4 contributing to adventitial remodeling","volume":"37","author":"Yu","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.yexcr.2020.112245_bib13","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1159\/000488230","article-title":"Deubiquitinase inhibitor auranofin attenuated cardiac hypertrophy by blocking NF-kappaB activation","volume":"45","author":"Hu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112245_bib14","doi-asserted-by":"crossref","first-page":"112004","DOI":"10.1016\/j.yexcr.2020.112004","article-title":"CSN6 inhibition suppresses pancreatic adenocarcinoma metastasis via destabilizing the c-Fos protein","volume":"391","author":"Ma","year":"2020","journal-title":"Exp. Cell Res."},{"issue":"6","key":"10.1016\/j.yexcr.2020.112245_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/biom9060217","article-title":"Role of the COP9 signalosome (CSN) in cardiovascular diseases","volume":"9","author":"Milic","year":"2019","journal-title":"Biomolecules"},{"issue":"6","key":"10.1016\/j.yexcr.2020.112245_bib16","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0092-8674(03)00722-0","article-title":"COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases","volume":"114","author":"Cope","year":"2003","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.yexcr.2020.112245_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043980","article-title":"The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain","volume":"7","author":"Pick","year":"2012","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.yexcr.2020.112245_bib18","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.21037\/jtd.2018.02.09","article-title":"COP9 signalosome subunit CSN5, but not CSN6, is upregulated in lung adenocarcinoma and predicts poor prognosis","volume":"10","author":"Xiao","year":"2018","journal-title":"J.\u00a0Thorac. Dis."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112245_bib19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1747-1028-8-14","article-title":"The COP9 signalosome subunit 6 (CSN6): a potential oncogene","volume":"8","author":"Zhang","year":"2013","journal-title":"Cell Div."},{"issue":"21","key":"10.1016\/j.yexcr.2020.112245_bib20","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1161\/CIRCULATIONAHA.117.028728","article-title":"SIRT2 acts as a cardioprotective deacetylase in pathological cardiac hypertrophy","volume":"136","author":"Tang","year":"2017","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.yexcr.2020.112245_bib21","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/emmm.201302451","article-title":"SIRT1 and SIRT2: emerging targets in neurodegeneration","volume":"5","author":"Donmez","year":"2013","journal-title":"EMBO Mol. Med."},{"issue":"11","key":"10.1016\/j.yexcr.2020.112245_bib22","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.tips.2015.08.001","article-title":"Emerging role of sirtuin 2 in the regulation of mammalian metabolism","volume":"36","author":"Gomes","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"issue":"14","key":"10.1016\/j.yexcr.2020.112245_bib23","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1074\/jbc.RA117.000915","article-title":"SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis","volume":"293","author":"Sarikhani","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"issue":"6","key":"10.1016\/j.yexcr.2020.112245_bib24","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/jmcb\/mjr009","article-title":"Sirt2 is a novel in vivo downstream target of Nkx2.2 and enhances oligodendroglial cell differentiation","volume":"3","author":"Ji","year":"2011","journal-title":"J.\u00a0Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.yexcr.2020.112245_bib25","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1161\/CIRCULATIONAHA.105.559005","article-title":"No evidence of transdifferentiation of human endothelial progenitor cells into cardiomyocytes after coculture with neonatal rat cardiomyocytes","volume":"113","author":"Gruh","year":"2006","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.yexcr.2020.112245_bib26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/jmcb\/mjr009","article-title":"Sirt2 is a novel in vivo downstream target of Nkx2.2 and enhances oligodendroglial cell differentiation","volume":"3","author":"Ji","year":"2011","journal-title":"J.\u00a0Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.yexcr.2020.112245_bib27","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1080\/15384101.2019.1609818","article-title":"Sirt2 epigenetically down-regulates PDGFRalpha expression and promotes CG4 cell differentiation","volume":"18","author":"Fang","year":"2019","journal-title":"Cell Cycle"},{"issue":"1","key":"10.1016\/j.yexcr.2020.112245_bib28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.pharmthera.2010.04.005","article-title":"Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies","volume":"128","author":"Bernardo","year":"2010","journal-title":"Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.yexcr.2020.112245_bib29","doi-asserted-by":"crossref","first-page":"R143","DOI":"10.1530\/JME-16-0086","article-title":"The role of autophagy in angiotensin II-induced pathological cardiac hypertrophy","volume":"57","author":"Zhou","year":"2016","journal-title":"J.\u00a0Mol. Endocrinol."},{"key":"10.1016\/j.yexcr.2020.112245_bib30","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1017\/S1462399411001815","article-title":"Angiotensin II and the vascular phenotype in hypertension","volume":"13","author":"Savoia","year":"2011","journal-title":"Expet Rev. Mol. Med."},{"issue":"9","key":"10.1016\/j.yexcr.2020.112245_bib31","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/01.RES.0000017629.70769.CC","article-title":"Angiotensin II induces myocyte enhancer factor 2- and calcineurin\/nuclear factor of activated T cell-dependent transcriptional activation in vascular myocytes","volume":"90","author":"Suzuki","year":"2002","journal-title":"Circ. Res."},{"issue":"8","key":"10.1016\/j.yexcr.2020.112245_bib32","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1161\/CIRCRESAHA.111.260729","article-title":"Interaction between NFkappaB and NFAT coordinates cardiac hypertrophy and pathological remodeling","volume":"110","author":"Liu","year":"2012","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112245_bib33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00395-016-0599-5","article-title":"MD2 mediates angiotensin II-induced cardiac inflammation and remodeling via directly binding to Ang II and activating TLR4\/NF-kappaB signaling pathway","volume":"112","author":"Han","year":"2017","journal-title":"Basic Res. Cardiol."},{"issue":"19","key":"10.1016\/j.yexcr.2020.112245_bib35","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1016\/j.febslet.2008.07.016","article-title":"SIRT2 is a negative regulator of anoxia-reoxygenation tolerance via regulation of 14-3-3 zeta and BAD in H9c2 cells","volume":"582","author":"Lynn","year":"2008","journal-title":"FEBS Lett."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112245_bib36","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.bbrc.2017.01.027","article-title":"SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth","volume":"483","author":"Luo","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112245_bib37","first-page":"943","article-title":"miR 150 promotes the proliferation and migration of nonsmall cell lung cancer cells by regulating the SIRT2\/JMJD2A signaling pathway","volume":"40","author":"Jiang","year":"2018","journal-title":"Oncol. Rep."},{"issue":"3","key":"10.1016\/j.yexcr.2020.112245_bib38","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.bbrc.2018.01.127","article-title":"HBx-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis","volume":"496","author":"Cheng","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112245_bib39","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2174\/1568009618666180102111539","article-title":"Novel homeodomain transcription factor Nkx2.2 in the brain tumor development","volume":"20","author":"Mariyath","year":"2020","journal-title":"Curr. Cancer Drug Targets"},{"issue":"17","key":"10.1016\/j.yexcr.2020.112245_bib40","first-page":"3067","article-title":"NKX2-2 suppresses osteosarcoma metastasis and proliferation by downregulating multiple target genes","volume":"9","author":"Chen","year":"2018","journal-title":"J.\u00a0Canc."},{"issue":"4","key":"10.1016\/j.yexcr.2020.112245_bib41","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.bbrc.2016.12.065","article-title":"Nuclear import of Nkx2-2 is mediated by multiple pathways","volume":"482","author":"Lin","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482720304948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482720304948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:34:52Z","timestamp":1757997292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482720304948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0014482720304948"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2020.112245","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CSN6 aggravates Ang II-induced cardiomyocyte hypertrophy via inhibiting SIRT2","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2020.112245","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112245"}}