{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:49:50Z","timestamp":1790621390131,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.yexcr.2020.112292","type":"journal-article","created":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T02:39:47Z","timestamp":1600483187000},"page":"112292","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Lipopolysaccharide-induced DC-SIGN\/TLR4 crosstalk activates NLRP3 inflammasomes via MyD88-independent signaling in gastric epithelial cells"],"prefix":"10.1016","volume":"396","author":[{"given":"Yufan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiebin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chundi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.yexcr.2020.112292_bib1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/1574-6976.12027","article-title":"Survival in hostile territory: the microbiota of the stomach","volume":"37","author":"Yang","year":"2013","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.yexcr.2020.112292_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-540-71029-5_1","article-title":"Activation of dendritic cells by toll-like receptors and C-type lectins","volume":"188","author":"Diebold","year":"2009","journal-title":"Handb. Exp. Pharmacol."},{"issue":"8","key":"10.1016\/j.yexcr.2020.112292_bib3","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/cbin.10804","article-title":"KH-type splicing regulatory protein mediate inflammatory response in gastric epithelial cells induced by lipopolysaccharide","volume":"41","author":"Chen","year":"2017","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.yexcr.2020.112292_bib4","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","article-title":"Immunobiology of dendritic cells","volume":"18","author":"Banchereau","year":"2000","journal-title":"Annu. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.yexcr.2020.112292_bib5","first-page":"279","article-title":"DC-SIGN and immunoregulation","volume":"3","author":"Zhou","year":"2006","journal-title":"Cell. Mol. Immunol."},{"issue":"8","key":"10.1016\/j.yexcr.2020.112292_bib6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1471-4906(01)01974-3","article-title":"DC-SIGN and LFA-1: a battle for ligand","volume":"22","author":"Bleijs","year":"2001","journal-title":"Trends Immunol."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112292_bib7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0092-8674(00)80693-5","article-title":"Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses","volume":"100","author":"Geijtenbeek","year":"2000","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.yexcr.2020.112292_bib8","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1189\/jlb.0503208","article-title":"The role of dendritic cell C-type lectin receptors in HIV pathogenesis","volume":"74","author":"Turville","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.yexcr.2020.112292_bib9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev.immunol.22.012703.104558","article-title":"Self- and nonself-recognition by C-type lectins on dendritic cells","volume":"22","author":"Geijtenbeek","year":"2004","journal-title":"Annu. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.yexcr.2020.112292_bib10","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1084\/jem.20021787","article-title":"Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2","volume":"197","author":"Gantner","year":"2003","journal-title":"J. Exp. Med."},{"issue":"10","key":"10.1016\/j.yexcr.2020.112292_bib11","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.cellsig.2010.03.018","article-title":"C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity","volume":"22","author":"Svajger","year":"2010","journal-title":"Cell. Signal."},{"issue":"8","key":"10.1016\/j.yexcr.2020.112292_bib12","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.4049\/jimmunol.1103212","article-title":"Caspase-1 has both proinflammatory and regulatory properties in Helicobacter infections, which are differentially mediated by its substrates IL-1beta and IL-18","volume":"188","author":"Hitzler","year":"2012","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.yexcr.2020.112292_bib13","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1002\/eji.201243281","article-title":"The Cag pathogenicity island and interaction between TLR2\/NOD2 and NLRP3 regulate IL-1beta production in Helicobacter pylori infected dendritic cells","volume":"43","author":"Kim","year":"2013","journal-title":"Eur. J. Immunol."},{"issue":"7","key":"10.1016\/j.yexcr.2020.112292_bib14","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.4049\/jimmunol.1400362","article-title":"Helicobacter pylori-induced IL-1beta secretion in innate immune cells is regulated by the NLRP3 inflammasome and requires the cag pathogenicity island","volume":"193","author":"Semper","year":"2014","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.yexcr.2020.112292_bib15","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.4049\/jimmunol.1601629","article-title":"The importance of dendritic cells in maintaining immune tolerance","volume":"198","author":"Audiger","year":"2017","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112292_bib16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3109\/08830185.2013.834897","article-title":"DC-SIGN, DC-SIGNR and LSECtin: C-type lectins for infection","volume":"33","author":"Zhang","year":"2014","journal-title":"Int. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.yexcr.2020.112292_bib17","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/MOG.0000000000000316","article-title":"Gastrointestinal defense mechanisms","volume":"32","author":"Said","year":"2016","journal-title":"Curr. Opin. Gastroenterol."},{"issue":"5","key":"10.1016\/j.yexcr.2020.112292_bib18","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"issue":"7273","key":"10.1016\/j.yexcr.2020.112292_bib19","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nature08533","article-title":"Forcing cells to change lineages","volume":"462","author":"Graf","year":"2009","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.yexcr.2020.112292_bib20","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1053\/j.gastro.2009.11.043","article-title":"Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice","volume":"138","author":"Kao","year":"2010","journal-title":"Gastroenterology"},{"issue":"7\u20138","key":"10.1016\/j.yexcr.2020.112292_bib21","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.molimm.2010.01.014","article-title":"Schistosoma mansoni worm glycolipids induce an inflammatory phenotype in human dendritic cells by cooperation of TLR4 and DC-SIGN","volume":"47","author":"van Stijn","year":"2010","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.yexcr.2020.112292_bib22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/19490976.2015.1116673","article-title":"Systems-wide analyses of mucosal immune responses to Helicobacter pylori at the interface between pathogenicity and symbiosis","volume":"7","author":"Kronsteiner","year":"2016","journal-title":"Gut Microb."},{"issue":"6","key":"10.1016\/j.yexcr.2020.112292_bib23","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.yexcr.2020.112292_bib24","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/hel.12292","article-title":"The importance of toll-like receptors in NF-kappaB signaling pathway activation by Helicobacter pylori infection and the regulators of this response","volume":"21","author":"Hu","year":"2016","journal-title":"Helicobacter"},{"issue":"2","key":"10.1016\/j.yexcr.2020.112292_bib25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cyto.2015.02.025","article-title":"Toll-like receptors: activation, signalling and transcriptional modulation","volume":"74","author":"De Nardo","year":"2015","journal-title":"Cytokine"},{"issue":"6","key":"10.1016\/j.yexcr.2020.112292_bib26","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/icb.2016.18","article-title":"The molecular mechanisms of TLR-signaling cooperation in cytokine regulation","volume":"94","author":"Liu","year":"2016","journal-title":"Immunol. Cell Biol."},{"issue":"7\u20138","key":"10.1016\/j.yexcr.2020.112292_bib27","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1034\/j.1600-0463.2003.11107803.x","article-title":"Pathogens target DC-SIGN to influence their fate DC-SIGN functions as a pathogen receptor with broad specificity","volume":"111","author":"Geijtenbeek","year":"2003","journal-title":"APMIS"},{"issue":"8","key":"10.1016\/j.yexcr.2020.112292_bib28","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1084\/jem.20041061","article-title":"Helicobacter pylori modulates the T helper cell 1\/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN","volume":"200","author":"Bergman","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.yexcr.2020.112292_bib29","doi-asserted-by":"crossref","first-page":"6978936","DOI":"10.1155\/2016\/6978936","article-title":"The role of toll-like receptor 4 in infectious and noninfectious inflammation","volume":"2016","author":"Molteni","year":"2016","journal-title":"Mediat. Inflamm."},{"issue":"2","key":"10.1016\/j.yexcr.2020.112292_bib30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jmb.2017.03.031","article-title":"Consequences of epithelial inflammasome activation by bacterial pathogens","volume":"430","author":"Sellin","year":"2018","journal-title":"J. Mol. Biol."},{"issue":"7","key":"10.1016\/j.yexcr.2020.112292_bib31","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat. Med."},{"issue":"8","key":"10.1016\/j.yexcr.2020.112292_bib32","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1172\/JCI79337","article-title":"Helicobacter urease-induced activation of the TLR2\/NLRP3\/IL-18 axis protects against asthma","volume":"125","author":"Koch","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.yexcr.2020.112292_bib33","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1136\/gutjnl-2014-307175","article-title":"The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome","volume":"65","author":"Ng","year":"2016","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.yexcr.2020.112292_bib34","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J. Immunol."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482720305413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482720305413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:35:33Z","timestamp":1757997333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482720305413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0014482720305413"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2020.112292","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipopolysaccharide-induced DC-SIGN\/TLR4 crosstalk activates NLRP3 inflammasomes via MyD88-independent signaling in gastric epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2020.112292","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112292"}}