{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:05:43Z","timestamp":1787069143874,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.yexcr.2021.112895","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:10:42Z","timestamp":1635379842000},"page":"112895","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Comprehensive analysis of differentially expressed mRNA and circRNA in Ankylosing spondylitis patients\u2019 platelets"],"prefix":"10.1016","volume":"409","author":[{"given":"Tingting","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhui","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laiyou","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuilian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donge","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongzhou","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2062-8394","authenticated-orcid":false,"given":"Xiaoping","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2021.112895_bib1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41413-019-0057-8","article-title":"Ankylosing spondylitis: etiology, pathogenesis, and treatments","volume":"7","author":"Zhu","year":"2019","journal-title":"Bone Res."},{"key":"10.1016\/j.yexcr.2021.112895_bib2","first-page":"501653","article-title":"Ankylosing spondylitis: from cells to genes","volume":"2013","author":"Zambrano-Zaragoza","year":"2013","journal-title":"Int. J. Inflamm."},{"issue":"4","key":"10.1016\/j.yexcr.2021.112895_bib3","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/01.bor.0000163447.44037.c4","article-title":"Pathogenesis of ankylosing spondylitis and reactive arthritis","volume":"17","author":"Kim","year":"2005","journal-title":"Curr. Opin. Rheumatol."},{"issue":"6","key":"10.1016\/j.yexcr.2021.112895_bib4","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1083\/jcb.201304054","article-title":"The incredible journey: from megakaryocyte development to platelet formation","volume":"201","author":"Machlus","year":"2013","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.yexcr.2021.112895_bib5","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1182\/blood-2014-08-531582","article-title":"Platelets at the interface of thrombosis, inflammation, and cancer","volume":"126","author":"Franco","year":"2015","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.yexcr.2021.112895_bib6","first-page":"449","article-title":"The role of platelets in inflammation","volume":"114","author":"Thomas","year":"2015","journal-title":"Thromb. Haemostasis"},{"issue":"6","key":"10.1016\/j.yexcr.2021.112895_bib7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.pbj.2017.05.005","article-title":"Role of platelets in immune system and inflammation","volume":"2","author":"Sonmez","year":"2017","journal-title":"Porto Biomed. J."},{"issue":"2","key":"10.1016\/j.yexcr.2021.112895_bib8","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/CIRCRESAHA.117.310795","article-title":"Circulating platelets as mediators of immunity, inflammation, and thrombosis","volume":"122","author":"Koupenova","year":"2018","journal-title":"Circ. Res."},{"issue":"7","key":"10.1016\/j.yexcr.2021.112895_bib9","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/eci.12101","article-title":"Platelets and autoimmunity","volume":"43","author":"Habets","year":"2013","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.yexcr.2021.112895_bib10","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.3389\/fimmu.2019.01453","article-title":"Platelets in skin autoimmune diseases","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.yexcr.2021.112895_bib11","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nrrheum.2012.118","article-title":"Platelets: active players in the pathogenesis of arthritis and SLE","volume":"8","author":"Boilard","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.yexcr.2021.112895_bib12","doi-asserted-by":"crossref","first-page":"559593","DOI":"10.3389\/fphar.2020.559593","article-title":"Associations of platelet count with inflammation and response to anti-TNF-alpha therapy in patients with ankylosing spondylitis","volume":"11","author":"Qian","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.yexcr.2021.112895_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-14-1","article-title":"The complex transcriptional landscape of the anucleate human platelet","volume":"14","author":"Bray","year":"2013","journal-title":"BMC Genom."},{"issue":"7","key":"10.1016\/j.yexcr.2021.112895_bib14","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1111\/jth.13720","article-title":"Platelet RNA as a circulating biomarker trove for cancer diagnostics","volume":"15","author":"Best","year":"2017","journal-title":"J. Thromb. Haemostasis"},{"issue":"7441","key":"10.1016\/j.yexcr.2021.112895_bib15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.yexcr.2021.112895_bib16","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12943-020-01286-3","article-title":"Circular RNA: metabolism, functions and interactions with proteins","volume":"19","author":"Zhou","year":"2020","journal-title":"Mol. Cancer"},{"issue":"6","key":"10.1016\/j.yexcr.2021.112895_bib17","first-page":"3119","article-title":"Circular RNAs: crucial regulators in the human body (Review)","volume":"40","author":"Wang","year":"2018","journal-title":"Oncol. Rep."},{"issue":"15","key":"10.1016\/j.yexcr.2021.112895_bib18","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1089\/ars.2020.8139","article-title":"The landscape of coding and noncoding RNAs in platelets","volume":"34","author":"Gutmann","year":"2021","journal-title":"Antioxidants Redox Signal."},{"issue":"4","key":"10.1016\/j.yexcr.2021.112895_bib19","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780270401","article-title":"Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria","volume":"27","author":"van der Linden","year":"1984","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.yexcr.2021.112895_bib20","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41569-018-0110-0","article-title":"Platelet biology and functions: new concepts and clinical perspectives","volume":"16","author":"van der Meijden","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.yexcr.2021.112895_bib21","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.2741\/1939","article-title":"The role of ADP receptors in platelet function","volume":"11","author":"Murugappa","year":"2006","journal-title":"Front. Biosci."},{"issue":"47","key":"10.1016\/j.yexcr.2021.112895_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3001001","article-title":"Platelet CD154 potentiates interferon-alpha secretion by plasmacytoid dendritic cells in systemic lupus erythematosus","volume":"2","author":"Duffau","year":"2010","journal-title":"Sci. Transl. Med."},{"issue":"7","key":"10.1016\/j.yexcr.2021.112895_bib23","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1182\/blood-2007-05-091728","article-title":"Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge","volume":"111","author":"Elzey","year":"2008","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.yexcr.2021.112895_bib24","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.3892\/mmr.2014.2374","article-title":"Plateletderived growth factor promotes osteoblast proliferation by activating Gproteincoupled receptor kinase interactor1","volume":"10","author":"Wu","year":"2014","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.yexcr.2021.112895_bib25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.14715\/cmb\/2020.66.6.23","article-title":"PDGFRB as a potential therapeutic target of ankylosing spondylitis: validation following bioinformatics analysis","volume":"66","author":"Feng","year":"2020","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"issue":"8","key":"10.1016\/j.yexcr.2021.112895_bib26","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1172\/JCI119742","article-title":"Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor","volume":"100","author":"Weber","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.yexcr.2021.112895_bib27","doi-asserted-by":"crossref","first-page":"E618","DOI":"10.1097\/BRS.0000000000001328","article-title":"Association between intercellular adhesion molecule-1, -2, -3 plasma levels and disease activity of ankylosing spondylitis in the Chinese han population","volume":"41","author":"Liu","year":"2016","journal-title":"Spine"},{"issue":"6","key":"10.1016\/j.yexcr.2021.112895_bib28","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s11373-006-9107-5","article-title":"Involvement of platelet glycoprotein Ib in platelet microparticle mediated neutrophil activation","volume":"13","author":"Lo","year":"2006","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.yexcr.2021.112895_bib29","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fcvm.2019.00085","article-title":"Platelet-neutrophil interplay: insights into neutrophil extracellular trap (NET)-Driven coagulation in infection","volume":"6","author":"Zucoloto","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.yexcr.2021.112895_bib30","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12929-020-00634-1","article-title":"Enhanced NETosis generation in radiographic axial spondyloarthritis: utility as biomarker for disease activity and anti-TNF-alpha therapy effectiveness","volume":"27","author":"Ruiz-Limon","year":"2020","journal-title":"J. Biomed. Sci."},{"issue":"3","key":"10.1016\/j.yexcr.2021.112895_bib31","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/1756-185X.14057","article-title":"Neutrophil extracellular traps and inflammatory response: implications for the immunopathogenesis of ankylosing spondylitis","volume":"24","author":"Zambrano-Zaragoza","year":"2021","journal-title":"Int. J. Rheum Dis."},{"issue":"7","key":"10.1016\/j.yexcr.2021.112895_bib32","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1161\/01.ATV.0000170133.43608.37","article-title":"Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium","volume":"25","author":"Mause","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.yexcr.2021.112895_bib33","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3109\/09537104.2015.1064881","article-title":"The role of platelets in the recruitment of leukocytes during vascular disease","volume":"26","author":"Ed Rainger","year":"2015","journal-title":"Platelets"},{"issue":"7","key":"10.1016\/j.yexcr.2021.112895_bib34","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1073\/pnas.78.7.4584","article-title":"Platelet factor 4 is chemotactic for neutrophils and monocytes","volume":"78","author":"Deuel","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.yexcr.2021.112895_bib35","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1177\/0961203319830493","article-title":"RNA-seq of circular RNAs identified circPTPN22 as a potential new activity indicator in systemic lupus erythematosus","volume":"28","author":"Miao","year":"2019","journal-title":"Lupus"},{"issue":"6","key":"10.1016\/j.yexcr.2021.112895_bib36","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s10067-014-2663-6","article-title":"Wnt signaling in ankylosing spondylitis","volume":"33","author":"Corr","year":"2014","journal-title":"Clin. Rheumatol."},{"issue":"4","key":"10.1016\/j.yexcr.2021.112895_bib37","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/BOR.0000000000000399","article-title":"Janus kinase\/signal transducer and activator of transcription pathways in spondyloarthritis","volume":"29","author":"Raychaudhuri","year":"2017","journal-title":"Curr. Opin. Rheumatol."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482721004511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482721004511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:19:26Z","timestamp":1762147166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482721004511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S0014482721004511"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2021.112895","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive analysis of differentially expressed mRNA and circRNA in Ankylosing spondylitis patients\u2019 platelets","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2021.112895","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112895"}}