{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:27:07Z","timestamp":1775482027304,"version":"3.50.1"},"reference-count":63,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["2020\u20130107\/CMB\/ADHOC-BMS"],"award-info":[{"award-number":["2020\u20130107\/CMB\/ADHOC-BMS"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["ECR\/2016\/001475"],"award-info":[{"award-number":["ECR\/2016\/001475"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.yexcr.2022.113273","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T09:32:24Z","timestamp":1657877544000},"page":"113273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["The intraflagellar transport protein IFT52 associated with short-rib thoracic dysplasia is essential for ciliary function in osteogenic differentiation in vitro and for sensory perception in Drosophila"],"prefix":"10.1016","volume":"418","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2650-9142","authenticated-orcid":false,"given":"Vishal Singh","family":"Guleria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Parit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Quadri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5308-3477","authenticated-orcid":false,"given":"Ranajit","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4319-7283","authenticated-orcid":false,"given":"Priyanka","family":"Upadhyai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2022.113273_bib1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028290","article-title":"Evolution of cilia","volume":"9","author":"Mitchell","year":"2017","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.yexcr.2022.113273_bib2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1146\/annurev-biochem-013118-111153","article-title":"Mechanism and regulation of centriole and cilium biogenesis","volume":"88","author":"Breslow","year":"2019","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.yexcr.2022.113273_bib3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/jb\/mvx087","article-title":"Ciliary protein trafficking mediated by IFT and BBSome complexes with the aid of kinesin-2 and dynein-2 motors","volume":"163","author":"Nakayama","year":"2018","journal-title":"J. Biochem."},{"key":"10.1016\/j.yexcr.2022.113273_bib4","doi-asserted-by":"crossref","first-page":"773","DOI":"10.15252\/embj.201593164","article-title":"Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin-binding IFT-B2 complex","volume":"35","author":"Taschner","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.yexcr.2022.113273_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11491","article-title":"An organelle-specific protein landscape identifies novel diseases and molecular mechanisms","volume":"7","author":"Boldt","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yexcr.2022.113273_bib6","doi-asserted-by":"crossref","first-page":"10962","DOI":"10.1074\/jbc.M116.713883","article-title":"Overall architecture of the intraflagellar transport (IFT)-B complex containing cluap1\/IFT38 as an essential component of the IFT-B peripheral subcomplex","volume":"291","author":"Katoh","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2022.113273_bib7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1083\/jcb.201408002","article-title":"Crystal structures of IFT70\/52 and IFT52\/46 provide insight into intraflagellar transport B core complex assembly","volume":"207","author":"Taschner","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2022.113273_bib8","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrm.2017.60","article-title":"Genes and molecular pathways underpinning ciliopathies","volume":"18","author":"Reiter","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yexcr.2022.113273_bib9","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201846589","article-title":"Mixed signals from the cell's antennae: primary cilia in cancer","volume":"19","author":"Eguether","year":"2018","journal-title":"EMBO Rep."},{"key":"10.1016\/j.yexcr.2022.113273_bib10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/humu.23362","article-title":"Expanding the genetic architecture and phenotypic spectrum in the skeletal ciliopathies","volume":"39","author":"Zhang","year":"2018","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.yexcr.2022.113273_bib11","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41580-020-00279-w","article-title":"Mechanisms of bone development and repair","volume":"21","author":"Salhotra","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yexcr.2022.113273_bib12","doi-asserted-by":"crossref","first-page":"13325","DOI":"10.1073\/pnas.0700636104","article-title":"Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism","volume":"104","author":"Malone","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2022.113273_bib13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s12195-010-0127-x","article-title":"The role of primary cilia in mesenchymal stem cell differentiation: a pivotal switch in guiding lineage commitment","volume":"3","author":"Tummala","year":"2010","journal-title":"Cell. Mol. Bioeng."},{"key":"10.1016\/j.yexcr.2022.113273_bib14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.reth.2014.10.002","article-title":"Signaling pathways regulating the specification and differentiation of the osteoblast lineage","volume":"1","author":"Hojo","year":"2015","journal-title":"Regen. Ther."},{"key":"10.1016\/j.yexcr.2022.113273_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aan5748","article-title":"Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes","volume":"10","author":"Lyons","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/j.yexcr.2022.113273_bib16","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1002\/stem.1235","article-title":"Primary cilia-mediated mechanotransduction in human mesenchymal stem cells","volume":"30","author":"Hoey","year":"2012","journal-title":"Stem Cell."},{"key":"10.1016\/j.yexcr.2022.113273_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ydbio.2021.12.004","article-title":"Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice","volume":"482","author":"Yamaguchi","year":"2022","journal-title":"Dev. Biol."},{"key":"10.1016\/j.yexcr.2022.113273_bib18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1242\/dev.02732","article-title":"Intraflagellar transport is essential for endochondral bone formation","volume":"134","author":"Haycraft","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2022.113273_bib19","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1093\/hmg\/ddr013","article-title":"An Ift80 mouse model of short rib polydactyly syndromes shows defects in hedgehog signalling without loss or malformation of cilia","volume":"20","author":"Rix","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2022.113273_bib20","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1093\/hmg\/ddw241","article-title":"C. University of Washington Center for Mendelian Genomics, D. Krakow, D.H. Cohn, IFT52 mutations destabilize anterograde complex assembly, disrupt ciliogenesis and result in short rib polydactyly syndrome","volume":"25","author":"Zhang","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2022.113273_bib21","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1093\/hmg\/ddz091","article-title":"Human IFT52 mutations uncover a novel role for the protein in microtubule dynamics and centrosome cohesion","volume":"28","author":"Dupont","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2022.113273_bib22","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/cge.12762","article-title":"A homozygous nonsense variant in IFT52 is associated with a human skeletal ciliopathy","volume":"90","author":"Girisha","year":"2016","journal-title":"Clin. Genet."},{"key":"10.1016\/j.yexcr.2022.113273_bib23","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1167\/iovs.17-23351","article-title":"IFT52 as a novel candidate for ciliopathies involving retinal degeneration","volume":"59","author":"Chen","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.yexcr.2022.113273_bib24","doi-asserted-by":"crossref","first-page":"26344","DOI":"10.1074\/jbc.M111.254920","article-title":"Biochemical mapping of interactions within the intraflagellar transport (IFT) B core complex: IFT52 binds directly to four other IFT-B subunits","volume":"286","author":"Taschner","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2022.113273_bib25","doi-asserted-by":"crossref","first-page":"21508","DOI":"10.1074\/jbc.M110.106997","article-title":"Direct interactions of intraflagellar transport complex B proteins IFT88, IFT52, and IFT46","volume":"285","author":"Lucker","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2022.113273_bib26","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1083\/jcb.201801039","article-title":"Interaction of heterotrimeric kinesin-II with IFT-B-connecting tetramer is crucial for ciliogenesis","volume":"217","author":"Funabashi","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2022.113273_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000568","article-title":"The gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons","volume":"9","author":"Cachero","year":"2011","journal-title":"PLoS Biol."},{"key":"10.1016\/j.yexcr.2022.113273_bib28","doi-asserted-by":"crossref","first-page":"e9799","DOI":"10.7717\/peerj.9799","article-title":"Characterization of primary cilia features reveal cell-type specific variability in in vitro models of osteogenic and chondrogenic differentiation","volume":"8","author":"Upadhyai","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.yexcr.2022.113273_bib29","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0091-679X(08)60927-9","article-title":"Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes","volume":"44","author":"Patel","year":"1994","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.yexcr.2022.113273_bib30","doi-asserted-by":"crossref","first-page":"12980","DOI":"10.1073\/pnas.0403493101","article-title":"An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster","volume":"101","author":"Bauer","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2022.113273_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004577","article-title":"HEATR2 plays a conserved role in assembly of the ciliary motile apparatus","volume":"10","author":"Diggle","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.yexcr.2022.113273_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21186665","article-title":"Hedgehog signaling in skeletal development: roles of Indian hedgehog and the mode of its action","volume":"21","author":"Ohba","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexcr.2022.113273_bib33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ijos.2015.14","article-title":"The Hedgehog signalling pathway in bone formation","volume":"7","author":"Yang","year":"2015","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.yexcr.2022.113273_bib34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fcell.2018.00008","article-title":"Signaling through the primary cilium","volume":"6","author":"Wheway","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.yexcr.2022.113273_bib35","doi-asserted-by":"crossref","first-page":"D265","DOI":"10.1093\/nar\/gkz991","article-title":"CDD\/SPARCLE: the conserved domain database in 2020","volume":"48","author":"Lu","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yexcr.2022.113273_bib36","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.cub.2003.08.034","article-title":"Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm","volume":"13","author":"Han","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2022.113273_bib37","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1073\/pnas.79.8.2700","article-title":"Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos","volume":"79","author":"Jan","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2022.113273_bib38","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1083\/jcb.201502032","article-title":"Rootletin organizes the ciliary rootlet to achieve neuron sensory function in Drosophila","volume":"211","author":"Chen","year":"2015","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2022.113273_bib39","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.bone.2012.06.021","article-title":"The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesis","volume":"51","author":"Yang","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.yexcr.2022.113273_bib40","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1083\/jcb.200905103","article-title":"Electron-tomographic analysis of intraflagellar transport particle trains in situ","volume":"187","author":"Pigino","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2022.113273_bib41","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1126\/science.aaf4594","article-title":"Microtubule doublets are double-track railways for intraflagellar transport trains","volume":"352","author":"Stepanek","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2022.113273_bib42","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1242\/jcs.183244","article-title":"Two classes of short intraflagellar transport train with different 3D structures are present in Chlamydomonas flagella","volume":"129","author":"Vannuccini","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2022.113273_bib43","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.cell.2012.10.010","article-title":"The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis","volume":"151","author":"Goetz","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2022.113273_bib44","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1101\/gad.1194004","article-title":"Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport","volume":"18","author":"Blacque","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.yexcr.2022.113273_bib45","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2046-2530-2-13","article-title":"The Small GTPase Rsg1 is important for the cytoplasmic localization and axonemal dynamics of intraflagellar transport proteins","volume":"2","author":"Brooks","year":"2013","journal-title":"Cilia"},{"key":"10.1016\/j.yexcr.2022.113273_bib46","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1091\/mbc.E20-08-0556","article-title":"Cooperation of the IFT-A complex with the IFT-B complex is required for ciliary retrograde protein trafficking and GPCR import","volume":"32","author":"Kobayashi","year":"2021","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yexcr.2022.113273_bib47","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/S0960-9822(01)00484-5","article-title":"Localization of intraflagellar transport protein IFT52 identifies basal body transitional fibers as the docking site for IFT particles","volume":"11","author":"Deane","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2022.113273_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043118","article-title":"Dissecting the sequential assembly and localization of intraflagellar transport particle complex B in Chlamydomonas","volume":"7","author":"Richey","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.yexcr.2022.113273_bib49","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1242\/jcs.200758","article-title":"Intraflagellar transport protein IFT52 recruits IFT46 to the basal body and flagella","volume":"130","author":"Lv","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2022.113273_bib50","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0960-9822(01)00485-7","article-title":"The bld1 mutation identifies the Chlamydomonas osm-6 homolog as a gene required for flagellar assembly","volume":"11","author":"Brazelton","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2022.113273_bib51","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/0012-1606(86)90314-3","article-title":"Mutant sensory cilia in the nematode Caenorhabditis elegans","volume":"117","author":"Perkins","year":"1986","journal-title":"Dev. Biol."},{"key":"10.1016\/j.yexcr.2022.113273_bib52","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0896-6273(04)00268-5","article-title":"Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons","volume":"42","author":"Tsujikawa","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.yexcr.2022.113273_bib53","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1242\/dev.01894","article-title":"Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors","volume":"132","author":"Liu","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2022.113273_bib54","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.cub.2003.09.025","article-title":"Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tails","volume":"13","author":"Sarpal","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexcr.2022.113273_bib55","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1534\/genetics.104.029934","article-title":"Expression level of sarah, a homolog of DSCR1, is critical for ovulation and female courtship behavior in Drosophila melanogaster","volume":"168","author":"Ejima","year":"2004","journal-title":"Genetics"},{"key":"10.1016\/j.yexcr.2022.113273_bib56","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0925-4773(01)00427-0","article-title":"Comparative biological responses to human Sonic, Indian, and Desert hedgehog","volume":"106","author":"Pathi","year":"2001","journal-title":"Mech. Dev."},{"key":"10.1016\/j.yexcr.2022.113273_bib57","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1210\/edrv.21.4.0403","article-title":"Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1","volume":"21","author":"Yamaguchi","year":"2000","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.yexcr.2022.113273_bib58","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nature04117","article-title":"Vertebrate Smoothened functions at the primary cilium","volume":"437","author":"Corbit","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2022.113273_bib59","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1126\/science.1139740","article-title":"Patched1 regulates hedgehog signaling at the primary cilium","volume":"317","author":"Rohatgi","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2022.113273_bib60","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1371\/journal.pgen.0010053","article-title":"Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function","volume":"1","author":"Haycraft","year":"2005","journal-title":"PLoS Genet."},{"key":"10.1016\/j.yexcr.2022.113273_bib61","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ng0393-241","article-title":"A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene","volume":"3","author":"Hui","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yexcr.2022.113273_bib62","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1242\/dev.124.1.113","article-title":"Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development","volume":"124","author":"Mo","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2022.113273_bib63","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.chembiol.2014.10.013","article-title":"The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation","volume":"21","author":"Fan","year":"2014","journal-title":"Chem. Biol."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448272200266X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448272200266X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:20:56Z","timestamp":1762147256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448272200266X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S001448272200266X"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2022.113273","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The intraflagellar transport protein IFT52 associated with short-rib thoracic dysplasia is essential for ciliary function in osteogenic differentiation in vitro and for sensory perception in Drosophila","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2022.113273","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113273"}}