{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:18:02Z","timestamp":1790713082571,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.yexcr.2022.113277","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T07:59:44Z","timestamp":1657267184000},"page":"113277","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Propofol enhances the sensitivity of glioblastoma cells to temozolomide by inhibiting macrophage activation in tumor microenvironment to down-regulate HIF-1\u03b1 expression"],"prefix":"10.1016","volume":"418","author":[{"given":"Wenbo","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keming","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2022.113277_bib1","first-page":"69","article-title":"Neuro-oncology in 2015: progress in glioma diagnosis, classification and treatment, Nature reviews","volume":"12","author":"Wen","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.yexcr.2022.113277_bib2","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.21873\/anticanres.13315","article-title":"Immune phenotype correlates with survival in patients with GBM treated with standard temozolomide-based therapy and immunotherapy","volume":"39","author":"Antonopoulos","year":"2019","journal-title":"Anticancer Res."},{"key":"10.1016\/j.yexcr.2022.113277_bib3","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41582-019-0220-2","article-title":"Genetic and molecular epidemiology of adult diffuse glioma","volume":"15","author":"Molinaro","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.yexcr.2022.113277_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010351","article-title":"Molecular mechanisms of treatment resistance in glioblastoma","volume":"22","author":"Ou","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexcr.2022.113277_bib5","first-page":"5846","article-title":"Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine","volume":"47","author":"Stevens","year":"1987","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexcr.2022.113277_bib6","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1093\/neuonc\/noy072","article-title":"Temozolomide for immunomodulation in the treatment of glioblastoma","volume":"20","author":"Karachi","year":"2018","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.yexcr.2022.113277_bib7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12943-020-1137-5","article-title":"DNA-methylation-mediated activating of lncRNA SNHG12 promotes temozolomide resistance in glioblastoma","volume":"19","author":"Lu","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.yexcr.2022.113277_bib8","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s40262-018-0672-3","article-title":"Clinical pharmacokinetics and pharmacodynamics of propofol","volume":"57","author":"Sahinovic","year":"2018","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.yexcr.2022.113277_bib9","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1097\/ALN.0000000000002357","article-title":"Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in colon cancer surgery","volume":"129","author":"Wu","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1016\/j.yexcr.2022.113277_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12967-018-1389-7","article-title":"Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence","volume":"16","author":"Kim","year":"2018","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.yexcr.2022.113277_bib11","article-title":"Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery","volume":"16","author":"Huang","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.yexcr.2022.113277_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12867","article-title":"Effects of propofol on the development of cancer in humans","volume":"53","author":"Xu","year":"2020","journal-title":"Cell Prolif"},{"key":"10.1016\/j.yexcr.2022.113277_bib13","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1002\/tox.22458","article-title":"Evaluation of cytotoxicity of propofol and its related mechanism in glioblastoma cells and astrocytes","volume":"32","author":"Hsu","year":"2017","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.yexcr.2022.113277_bib14","doi-asserted-by":"crossref","first-page":"356","DOI":"10.2174\/1871520621666210708094328","article-title":"In vitro effects of propofol on cytotoxic, apoptotic and PI3K-akt signaling pathway genes on brain cancer cells","volume":"22","author":"Edgunlu","year":"2022","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.yexcr.2022.113277_bib15","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.3892\/mmr.2015.4014","article-title":"Propofol suppresses proliferation and invasion of glioma cells by upregulating microRNA-218 expression","volume":"12","author":"Xu","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.yexcr.2022.113277_bib16","doi-asserted-by":"crossref","first-page":"8858","DOI":"10.1038\/s41598-020-65649-y","article-title":"Anesthetic propofol epigenetically regulates breast cancer trastuzumab resistance through IL-6\/miR-149-5p axis","volume":"10","author":"Tian","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexcr.2022.113277_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4174232","article-title":"Propofol reversed hypoxia-induced docetaxel resistance in prostate cancer cells by preventing epithelial-mesenchymal transition by inhibiting hypoxia-inducible factor 1alpha","volume":"2018","author":"Qian","year":"2018","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.yexcr.2022.113277_bib18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.canlet.2016.01.043","article-title":"Tumor microenvironment and therapeutic response","volume":"387","author":"Wu","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.yexcr.2022.113277_bib19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cmet.2019.06.001","article-title":"Macrophages and metabolism in the tumor microenvironment","volume":"30","author":"Vitale","year":"2019","journal-title":"Cell Metabol."},{"key":"10.1016\/j.yexcr.2022.113277_bib20","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12929-019-0568-z","article-title":"Tumor-associated macrophages: an accomplice in solid tumor progression","volume":"26","author":"Chen","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.yexcr.2022.113277_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molimm.2018.12.027","article-title":"IL-16 regulates macrophage polarization as a target gene of mir-145-3p","volume":"107","author":"Huang","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.yexcr.2022.113277_bib22","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/s12015-019-09947-7","article-title":"Dimethyloxalyl Glycine regulates the HIF-1 signaling pathway in mesenchymal stem cells","volume":"16","author":"Zhou","year":"2020","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.yexcr.2022.113277_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s40880-019-0424-2","article-title":"Bortezomib inhibits growth and sensitizes glioma to temozolomide (TMZ) via down-regulating the FOXM1-Survivin axis","volume":"39","author":"Tang","year":"2019","journal-title":"Cancer Commun."},{"key":"10.1016\/j.yexcr.2022.113277_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113071","article-title":"Xihuang pill potentiates the anti-tumor effects of temozolomide in glioblastoma xenografts through the Akt\/mTOR-dependent pathway","volume":"261","author":"Fu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.yexcr.2022.113277_bib25","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/s12967-014-0279-x","article-title":"Propofol exerts anti-hepatocellular carcinoma by microvesicle-mediated transfer of miR-142-3p from macrophage to cancer cells","volume":"12","author":"Zhang","year":"2014","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.yexcr.2022.113277_bib26","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s13311-017-0519-x","article-title":"Glioma subclassifications and their clinical significance","volume":"14","author":"Chen","year":"2017","journal-title":"Neurotherapeutics : J. Am. Soc. Exper. NeuroTherap."},{"key":"10.1016\/j.yexcr.2022.113277_bib27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.semcancer.2017.11.010","article-title":"Glioma epigenetics: from subclassification to novel treatment options","volume":"51","author":"Gusyatiner","year":"2018","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.yexcr.2022.113277_bib28","first-page":"299","article-title":"Management of glioblastoma: state of the art and future directions","volume":"70","author":"Tan","year":"2020","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.yexcr.2022.113277_bib29","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.tiv.2012.04.024","article-title":"Investigation of 2,6-diisopropylphenol (propofol)-evoked Ca2+ movement and cell death in human glioblastoma cells","volume":"26","author":"Liang","year":"2012","journal-title":"Toxicol. Vitro : Int. J. Publ. Assoc. BIBRA"},{"key":"10.1016\/j.yexcr.2022.113277_bib30","article-title":"Elucidating the mechanisms of Temozolomide resistance in gliomas and the strategies to overcome the resistance, Biochimica et biophysica acta","author":"Tomar","year":"2021","journal-title":"Rev. Canc."},{"key":"10.1016\/j.yexcr.2022.113277_bib31","first-page":"619","article-title":"CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1\/2 signaling, Laboratory investigation","volume":"100","author":"Zhang","year":"2020","journal-title":"J. Techn. Methods Pathol."},{"key":"10.1016\/j.yexcr.2022.113277_bib32","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.trecan.2020.02.010","article-title":"MGMT status as a clinical biomarker in glioblastoma","volume":"6","author":"Butler","year":"2020","journal-title":"Trends Canc."},{"key":"10.1016\/j.yexcr.2022.113277_bib33","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1158\/1078-0432.CCR-14-0618","article-title":"Livin contributes to tumor hypoxia-induced resistance to cytotoxic therapies in glioblastoma multiforme","volume":"21","author":"Hsieh","year":"2015","journal-title":"Clin. Cancer Res. : Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.yexcr.2022.113277_bib34","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/s41419-018-1176-7","article-title":"Hypoxia-mediated mitochondria apoptosis inhibition induces temozolomide treatment resistance through miR-26a\/Bad\/Bax axis","volume":"9","author":"Ge","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.yexcr.2022.113277_bib35","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejphar.2018.04.009","article-title":"Effects of propofol on cancer development and chemotherapy: potential mechanisms","volume":"831","author":"Jiang","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.yexcr.2022.113277_bib36","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.3892\/or.2017.5514","article-title":"Propofol suppresses LPS-induced nuclear accumulation of HIF-1\u03b1 and tumor aggressiveness in non-small cell lung cancer","volume":"37","author":"Yang","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.yexcr.2022.113277_bib37","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8978704","article-title":"Propofol attenuates hypoxia-induced inflammation in BV2 microglia by inhibiting oxidative stress and NF-\u03baB\/Hif-1\u03b1 signaling","volume":"2020","author":"Peng","year":"2020","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.yexcr.2022.113277_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116644","article-title":"Glioma-associated microglia\/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1","volume":"10","author":"Szulzewsky","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.yexcr.2022.113277_bib39","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1919538","article-title":"Effect of propofol on the production of inflammatory cytokines by human polarized macrophages","volume":"2019","author":"Kochiyama","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.yexcr.2022.113277_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6852857","article-title":"Metabolic profiles of propofol and fospropofol: clinical and forensic interpretative aspects","volume":"2018","author":"Dinis-Oliveira","year":"2018","journal-title":"BioMed Res. Int."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482722002701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482722002701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:42:43Z","timestamp":1757997763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482722002701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0014482722002701"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2022.113277","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Propofol enhances the sensitivity of glioblastoma cells to temozolomide by inhibiting macrophage activation in tumor microenvironment to down-regulate HIF-1\u03b1 expression","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2022.113277","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113277"}}