{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:46:35Z","timestamp":1784029595105,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173026"],"award-info":[{"award-number":["82173026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MH268"],"award-info":[{"award-number":["ZR2020MH268"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.yexcr.2023.113458","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T12:16:56Z","timestamp":1672748216000},"page":"113458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["KNTC1, regulated by HPV E7, inhibits cervical carcinogenesis partially through Smad2"],"prefix":"10.1016","volume":"423","author":[{"given":"Wei","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2534-147X","authenticated-orcid":false,"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10167","key":"10.1016\/j.yexcr.2023.113458_bib1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0140-6736(18)32470-X","article-title":"Cervical cancer","volume":"393","author":"Cohen","year":"2019","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.yexcr.2023.113458_bib2","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/cncr.32003","article-title":"The distribution and prevalence of human papillomavirus in women in mainland China","volume":"125","author":"Li","year":"2019","journal-title":"Cancer"},{"key":"10.1016\/j.yexcr.2023.113458_bib3","doi-asserted-by":"crossref","first-page":"h2372","DOI":"10.1136\/bmj.h2372","article-title":"HPV testing as a screen for cervical cancer","volume":"350","author":"Goodman","year":"2015","journal-title":"BMJ"},{"issue":"17","key":"10.1016\/j.yexcr.2023.113458_bib4","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1042\/CS20160786","article-title":"The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review","volume":"131","author":"Graham","year":"2017","journal-title":"Clin. Sci."},{"issue":"2","key":"10.1016\/j.yexcr.2023.113458_bib5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/rmv.488","article-title":"Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity","volume":"16","author":"Hebner","year":"2006","journal-title":"Rev. Med. Virol."},{"issue":"Pt 17","key":"10.1016\/j.yexcr.2023.113458_bib6","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1242\/jcs.114.17.3103","article-title":"The Zw10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore","volume":"114","author":"Sca\u00ebrou","year":"2001","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.yexcr.2023.113458_bib7","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.str.2010.02.014","article-title":"Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery","volume":"18","author":"Civril","year":"2010","journal-title":"Structure"},{"key":"10.1016\/j.yexcr.2023.113458_bib8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1471-2334-9-125","article-title":"Modulations of cell cycle checkpoints during HCV associated disease","volume":"9","author":"Sarfraz","year":"2009","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.yexcr.2023.113458_bib9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/1471-2407-10-181","article-title":"Array-based gene expression, CGH and tissue data defines a 12q24 gain in neuroblastic tumors with prognostic implication","volume":"10","author":"Wolf","year":"2010","journal-title":"BMC Cancer"},{"issue":"6","key":"10.1016\/j.yexcr.2023.113458_bib10","first-page":"1004","article-title":"Novel somatic frameshift mutations of genes related to cell cycle and DNA damage response in gastric and colorectal cancers with microsatellite instability","volume":"96","author":"Kim","year":"2010","journal-title":"Tumori"},{"key":"10.1016\/j.yexcr.2023.113458_bib11","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.3389\/fonc.2019.01210","article-title":"The olfactory receptor family 2, subfamily T, member 6 (OR2T6) is involved in breast cancer progression via initiating epithelial-mesenchymal transition and MAPK\/ERK pathway","volume":"9","author":"Li","year":"2019","journal-title":"Front. Oncol."},{"issue":"12","key":"10.1016\/j.yexcr.2023.113458_bib12","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/s41419-020-03244-9","article-title":"HPV E7-mediated NCAPH ectopic expression regulates the carcinogenesis of cervical carcinoma via PI3K\/AKT\/SGK pathway","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.yexcr.2023.113458_bib13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1470-2045(08)70103-7","article-title":"Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study","volume":"9","author":"McCredie","year":"2008","journal-title":"Lancet Oncol."},{"issue":"5","key":"10.1016\/j.yexcr.2023.113458_bib14","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.bpobgyn.2011.04.005","article-title":"Histology of cervical intraepithelial neoplasia and the role of biomarkers","volume":"25","author":"Martin","year":"2011","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"issue":"7","key":"10.1016\/j.yexcr.2023.113458_bib15","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1083\/jcb.201412085","article-title":"A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochores","volume":"208","author":"Moudgil","year":"2015","journal-title":"J. Cell Biol."},{"issue":"7","key":"10.1016\/j.yexcr.2023.113458_bib16","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/s41556-018-0130-3","article-title":"Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis","volume":"20","author":"Sacristan","year":"2018","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.yexcr.2023.113458_bib17","doi-asserted-by":"crossref","first-page":"10069","DOI":"10.1002\/jcb.28290","article-title":"Identification of core genes and outcomes in hepatocellular carcinoma by bioinformatics analysis","volume":"120","author":"Shen","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.yexcr.2023.113458_bib18","first-page":"3637","article-title":"Bioinformatics analysis identifies hub genes and pathways in nasopharyngeal carcinoma","volume":"18","author":"Liu","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.yexcr.2023.113458_bib19","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2147\/CMAR.S185205","article-title":"Importance of gene expression signatures in pancreatic cancer prognosis and the establishment of a prediction model","volume":"11","author":"Yan","year":"2019","journal-title":"Cancer Manag. Res."},{"issue":"1","key":"10.1016\/j.yexcr.2023.113458_bib20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1615\/CritRevEukaryotGeneExpr.2021037301","article-title":"Knockdown of KNTC1 inhibits the proliferation, migration and tumorigenesis of human bladder cancer cells and induces apoptosis","volume":"31","author":"Huang","year":"2021","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"issue":"12","key":"10.1016\/j.yexcr.2023.113458_bib21","doi-asserted-by":"crossref","first-page":"9717","DOI":"10.1007\/s13277-015-3735-1","article-title":"Association between cell cycle gene transcription and tumor size in oral squamous cell carcinoma","volume":"36","author":"Diniz","year":"2015","journal-title":"Tumour Biol"},{"issue":"3","key":"10.1016\/j.yexcr.2023.113458_bib22","first-page":"1053","article-title":"shRNA-mediated knockdown of KNTC1 suppresses cell viability and induces apoptosis in esophageal squamous cell carcinoma","volume":"54","author":"Liu","year":"2019","journal-title":"Int. J. Oncol."},{"issue":"3","key":"10.1016\/j.yexcr.2023.113458_bib23","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.yexcr.2023.113458_bib24","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s12094-020-02409-4","article-title":"CDKN2A inhibits cell proliferation and invasion in cervical cancer through LDHA-mediated AKT\/mTOR pathway","volume":"23","author":"Luan","year":"2021","journal-title":"Clin. Transl. Oncol."},{"issue":"6","key":"10.1016\/j.yexcr.2023.113458_bib25","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1158\/1078-0432.CCR-08-2667","article-title":"Enhancement of lexatumumab-induced apoptosis in human solid cancer cells by cisplatin in caspase-dependent manner","volume":"15","author":"Wu","year":"2009","journal-title":"Clin. Cancer Res."},{"issue":"15","key":"10.1016\/j.yexcr.2023.113458_bib26","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1038\/sj.onc.1208403","article-title":"TRAIL is a key target in S-phase slowing-dependent apoptosis induced by interferon-beta in cervical carcinoma cells","volume":"24","author":"Vannucchi","year":"2005","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.yexcr.2023.113458_bib27","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/35046598","article-title":"Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores","volume":"2","author":"Chan","year":"2000","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.yexcr.2023.113458_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006211","article-title":"The role of integration in oncogenic progression of HPV-associated cancers","volume":"13","author":"McBride","year":"2017","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.yexcr.2023.113458_bib29","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s13046-016-0454-4","article-title":"HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability","volume":"35","author":"Zhao","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.yexcr.2023.113458_bib30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1101\/gr.164806.113","article-title":"Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability","volume":"24","author":"Akagi","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.yexcr.2023.113458_bib31","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.meegid.2018.03.003","article-title":"Understanding the HPV integration and its progression to cervical cancer","volume":"61","author":"Oyervides-Mu\u00f1oz","year":"2018","journal-title":"Infect. Genet. Evol."},{"issue":"6","key":"10.1016\/j.yexcr.2023.113458_bib32","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.devcel.2016.10.023","article-title":"Living in CIN: mitotic infidelity and its consequences for tumor promotion and suppression","volume":"39","author":"Funk","year":"2016","journal-title":"Dev. Cell"},{"issue":"6","key":"10.1016\/j.yexcr.2023.113458_bib33","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.cell.2018.08.027","article-title":"The multifaceted role of chromosomal instability in cancer and its microenvironment","volume":"174","author":"Bakhoum","year":"2018","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.yexcr.2023.113458_bib34","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/wdev.86","article-title":"The TGFbeta superfamily signaling pathway","volume":"2","author":"Weiss","year":"2013","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"issue":"23","key":"10.1016\/j.yexcr.2023.113458_bib36","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1101\/gad.1350705","article-title":"Smad transcription factors","volume":"19","author":"Massagu\u00e9","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.yexcr.2023.113458_bib35","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000324949","article-title":"Transforming growth factor-\u03b2 and Smads","volume":"170","author":"Lan","year":"2011","journal-title":"Contrib. Nephrol."},{"issue":"10","key":"10.1016\/j.yexcr.2023.113458_bib37","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1007\/s00705-006-0768-1","article-title":"E7 proteins from high- and low-risk human papillomaviruses bind to TGF-beta-regulated Smad proteins and inhibit their transcriptional activity","volume":"151","author":"Habig","year":"2006","journal-title":"Arch. Virol."},{"issue":"41","key":"10.1016\/j.yexcr.2023.113458_bib38","doi-asserted-by":"crossref","first-page":"38557","DOI":"10.1074\/jbc.M206786200","article-title":"The human papilloma virus E7 oncoprotein inhibits transforming growth factor-beta signaling by blocking binding of the Smad complex to its target sequence","volume":"277","author":"Lee","year":"2002","journal-title":"J. Biol. Chem."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482723000058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482723000058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:44:15Z","timestamp":1757997855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482723000058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S0014482723000058"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2023.113458","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"KNTC1, regulated by HPV E7, inhibits cervical carcinogenesis partially through Smad2","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2023.113458","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113458"}}