{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:27:34Z","timestamp":1776205654068,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.yexcr.2024.114397","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T23:52:17Z","timestamp":1735257137000},"page":"114397","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["ALDH2 plays a role in spermatogenesis and male fertility by regulating oxidative stress in mice"],"prefix":"10.1016","volume":"444","author":[{"given":"Ying","family":"Lv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linxiao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zexin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huatao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-9614","authenticated-orcid":false,"given":"Zongzhuang","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.yexcr.2024.114397_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/diseases12090201","article-title":"The Effect of COVID-19 and COVID-19 vaccination on assisted human reproduction outcomes: a systematic review and meta-analysis","volume":"12","author":"Milostic-Srb","year":"2024","journal-title":"Diseases"},{"issue":"14","key":"10.1016\/j.yexcr.2024.114397_bib2","doi-asserted-by":"crossref","DOI":"10.1242\/dev.202838","article-title":"Development of functional spermatozoa in mammalian spermiogenesis","volume":"151","author":"Miyata","year":"2024","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.yexcr.2024.114397_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41585-023-00837-9","article-title":"Molecular mechanisms of cellular dysfunction in testes from men with non-obstructive azoospermia","volume":"21","author":"Piechka","year":"2024","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.yexcr.2024.114397_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2147\/IJGM.S241099","article-title":"Some of the factors involved in male infertility: a prospective review","volume":"13","author":"Babakhanzadeh","year":"2020","journal-title":"Int. J. Gen. Med."},{"issue":"7","key":"10.1016\/j.yexcr.2024.114397_bib5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11934-016-0605-3","article-title":"In vitro spermatogenesis: how far from clinical application?","volume":"17","author":"Galdon","year":"2016","journal-title":"Curr. Urol. Rep."},{"issue":"4","key":"10.1016\/j.yexcr.2024.114397_bib6","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.beem.2015.04.006","article-title":"Androgen receptor roles in spermatogenesis and infertility","volume":"29","author":"O'Hara","year":"2015","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"issue":"12","key":"10.1016\/j.yexcr.2024.114397_bib7","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202201144R","article-title":"Hadh deficiency induced oligoasthenoteratozoospermia through the TNF-alpha\/Bcl-2 pathway in male mice","volume":"36","author":"Zhu","year":"2022","journal-title":"Faseb. J."},{"key":"10.1016\/j.yexcr.2024.114397_bib8","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.chemosphere.2017.01.056","article-title":"Semen quality and insulin-like factor 3: associations with urinary and seminal levels of phthalate metabolites in adult males","volume":"173","author":"Chang","year":"2017","journal-title":"Chemosphere"},{"issue":"13","key":"10.1016\/j.yexcr.2024.114397_bib9","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1073\/pnas.1422371112","article-title":"Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation","volume":"112","author":"Zhang","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.yexcr.2024.114397_bib10","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/humupd\/1.5.515","article-title":"The anatomical preparations of the human testis and epididymis in the Glasgow Hunterian Anatomical Collection","volume":"1","author":"Hirsh","year":"1995","journal-title":"Hum. Reprod. Update"},{"issue":"15","key":"10.1016\/j.yexcr.2024.114397_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21155377","article-title":"The role of the epididymis and the contribution of epididymosomes to mammalian reproduction","volume":"21","author":"James","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.yexcr.2024.114397_bib12","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/humrep\/deac015","article-title":"Sperm acquire epididymis-derived proteins through epididymosomes","volume":"37","author":"Barrachina","year":"2022","journal-title":"Hum. Reprod."},{"issue":"2","key":"10.1016\/j.yexcr.2024.114397_bib13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1530\/jrf.0.0720509","article-title":"Resorption versus secretion in the rat epididymis","volume":"72","author":"Turner","year":"1984","journal-title":"J. Reprod. Fertil."},{"issue":"5","key":"10.1016\/j.yexcr.2024.114397_bib14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/andr.12630","article-title":"Orchestrating the antioxidant defenses in the epididymis","volume":"7","author":"O'Flaherty","year":"2019","journal-title":"Andrology"},{"issue":"2","key":"10.1016\/j.yexcr.2024.114397_bib15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/humupd\/dmn055","article-title":"New insights into epididymal biology and function","volume":"15","author":"Cornwall","year":"2009","journal-title":"Hum. Reprod. Update"},{"issue":"8","key":"10.1016\/j.yexcr.2024.114397_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/cells11081277","article-title":"Deletion of hnrnpk gene causes infertility in male mice by disrupting spermatogenesis","volume":"11","author":"Xu","year":"2022","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.yexcr.2024.114397_bib17","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1530\/REP-17-0507","article-title":"Murine sperm capacitation, oocyte penetration and decondensation following moderate alcohol intake","volume":"155","author":"Sanchez","year":"2018","journal-title":"Reproduction"},{"issue":"5\u20136","key":"10.1016\/j.yexcr.2024.114397_bib18","first-page":"265","article-title":"[The metabolism of alcohol]","volume":"74","author":"Paquot","year":"2019","journal-title":"Rev. Med. Liege"},{"issue":"6","key":"10.1016\/j.yexcr.2024.114397_bib19","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.049601","article-title":"ALDH2 variance in disease and populations","volume":"15","author":"Chen","year":"2022","journal-title":"Dis Model Mech"},{"issue":"6","key":"10.1016\/j.yexcr.2024.114397_bib20","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.apsb.2021.02.008","article-title":"The role of ALDH2 in tumorigenesis and tumor progression: targeting ALDH2 as a potential cancer treatment","volume":"11","author":"Zhang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"12","key":"10.1016\/j.yexcr.2024.114397_bib21","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1016\/j.jprot.2011.05.013","article-title":"Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications","volume":"74","author":"Song","year":"2011","journal-title":"J. Proteonomics"},{"issue":"39","key":"10.1016\/j.yexcr.2024.114397_bib22","doi-asserted-by":"crossref","first-page":"33048","DOI":"10.1074\/jbc.M112.366690","article-title":"Electrophilic aldehydes generated by sperm metabolism activate mitochondrial reactive oxygen species generation and apoptosis by targeting succinate dehydrogenase","volume":"287","author":"Aitken","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.yexcr.2024.114397_bib23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S1534-5807(03)00093-5","article-title":"H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis","volume":"4","author":"Fernandez-Capetillo","year":"2003","journal-title":"Dev. Cell"},{"issue":"12","key":"10.1016\/j.yexcr.2024.114397_bib24","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41419-023-06359-x","article-title":"Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice","volume":"14","author":"Zhu","year":"2023","journal-title":"Cell Death Dis."},{"issue":"14","key":"10.1016\/j.yexcr.2024.114397_bib25","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1021\/bi9521093","article-title":"Possible role of liver cytosolic and mitochondrial aldehyde dehydrogenases in acetaldehyde metabolism","volume":"35","author":"Klyosov","year":"1996","journal-title":"Biochemistry"},{"issue":"8","key":"10.1016\/j.yexcr.2024.114397_bib26","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1089\/ars.2019.7832","article-title":"Oxidative stress dysregulates protein homeostasis within the male germ line","volume":"32","author":"Cafe","year":"2020","journal-title":"Antioxidants Redox Signal."},{"issue":"2","key":"10.1016\/j.yexcr.2024.114397_bib27","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/JU.0000000000002682","article-title":"ALDH2 expression, alcohol intake and semen parameters among east Asian men","volume":"208","author":"Greenberg","year":"2022","journal-title":"J. Urol."},{"issue":"1","key":"10.1016\/j.yexcr.2024.114397_bib28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00018-019-03253-8","article-title":"Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management","volume":"77","author":"Barati","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.yexcr.2024.114397_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/frph.2022.822257","article-title":"Oxidative stress and male infertility: Evidence from a research perspective","volume":"4","author":"Ayad","year":"2022","journal-title":"Front Reprod Health"},{"issue":"18","key":"10.1016\/j.yexcr.2024.114397_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221810043","article-title":"Oxidative stress, testicular inflammatory pathways, and male reproduction","volume":"22","author":"Dutta","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.yexcr.2024.114397_bib31","doi-asserted-by":"crossref","first-page":"346","DOI":"10.5534\/wjmh.190145","article-title":"Coenzyme Q10 improves sperm parameters, oxidative stress markers and sperm DNA fragmentation in infertile patients with idiopathic oligoasthenozoospermia","volume":"39","author":"Alahmar","year":"2021","journal-title":"World J Mens Health"},{"issue":"8","key":"10.1016\/j.yexcr.2024.114397_bib32","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrurol.2017.69","article-title":"Oxidative stress and male infertility","volume":"14","author":"Bisht","year":"2017","journal-title":"Nat. Rev. Urol."},{"issue":"9","key":"10.1016\/j.yexcr.2024.114397_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18091943","article-title":"Molecular mechanisms of acetaldehyde-mediated carcinogenesis in squamous epithelium","volume":"18","author":"Mizumoto","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.yexcr.2024.114397_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-14374-9","article-title":"Polyphenols from persimmon fruit attenuate acetaldehyde-induced DNA double-strand breaks by scavenging acetaldehyde","volume":"12","author":"Matsuzaki","year":"2022","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.yexcr.2024.114397_bib35","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1080\/00365520902912563","article-title":"Acetaldehyde as a common denominator and cumulative carcinogen in digestive tract cancers","volume":"44","author":"Salaspuro","year":"2009","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.yexcr.2024.114397_bib36","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.freeradbiomed.2016.11.010","article-title":"Pro-apoptotic effects of lipid oxidation products: HNE at the crossroads of NF-kappaB pathway and anti-apoptotic Bcl-2","volume":"111","author":"Timucin","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yexcr.2024.114397_bib37","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1746-6148-9-101","article-title":"Oxidative stress in cancer-bearing dogs assessed by measuring serum malondialdehyde","volume":"9","author":"Macotpet","year":"2013","journal-title":"BMC Vet. Res."},{"issue":"1","key":"10.1016\/j.yexcr.2024.114397_bib38","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s11689-021-09379-w","article-title":"Oxidative stress indices in ASD children in Sub-Sahara Africa","volume":"13","author":"Omotosho","year":"2021","journal-title":"J. Neurodev. Disord."},{"key":"10.1016\/j.yexcr.2024.114397_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2023.156144","article-title":"Antioxidant and anti-inflammatory effects of curcumin\/turmeric supplementation in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials","volume":"164","author":"Dehzad","year":"2023","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.yexcr.2024.114397_bib40","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1007\/s10787-023-01323-9","article-title":"The effects of L-carnitine supplementation on inflammatory and anti-inflammatory markers in adults: a systematic review and dose-response meta-analysis","volume":"31","author":"Rastgoo","year":"2023","journal-title":"Inflammopharmacology"}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482724004889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482724004889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T11:01:38Z","timestamp":1737284498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482724004889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0014482724004889"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2024.114397","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ALDH2 plays a role in spermatogenesis and male fertility by regulating oxidative stress in mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2024.114397","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114397"}}