{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:58:45Z","timestamp":1793066325141,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019397","name":"University Grants Commission South Eastern Regional Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007920","name":"University of Massachusetts Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["598\/OBC-CSIR UGC NET-DEC 2016"],"award-info":[{"award-number":["598\/OBC-CSIR UGC NET-DEC 2016"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.yexcr.2025.114460","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T23:31:37Z","timestamp":1740094297000},"page":"114460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["H50Q mutation in alpha-Synuclein impairs the insulin signaling pathway and induces neuroinflammation in the Drosophila model"],"prefix":"10.1016","volume":"447","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1085-3990","authenticated-orcid":false,"given":"Pooja","family":"Rai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2025.114460_bib1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s12035-012-8369-3","article-title":"The central theme of Parkinson's disease: \u03b1-synuclein","volume":"47","author":"Ozansoy","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.yexcr.2025.114460_bib2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/13813450902949012","article-title":"Insulin and the brain","volume":"115","author":"Laron","year":"2009","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.yexcr.2025.114460_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12035-012-8339-9","article-title":"Insulin in the brain: sources, localization and functions","volume":"47","author":"Ghasemi","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.yexcr.2025.114460_bib4","first-page":"681","article-title":"Increased risk of severe coronary heart disease events in patients with insulin resistance","volume":"4","author":"Havulinna","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.yexcr.2025.114460_bib5","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009191","article-title":"Insulin receptor signaling in normal and insulin-resistant states","volume":"6","author":"Boucher","year":"2014","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.yexcr.2025.114460_bib6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev.pathol.3.121806.151529","article-title":"Drosophila models of neurodegenerative diseases","volume":"4","author":"Lu","year":"2009","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.yexcr.2025.114460_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajogmf.2021.100537","article-title":"Treatment of acute respiratory distress syndrome from COVID-19 with extracorporeal membrane oxygenation in obstetrical patients","volume":"4","author":"Shih","year":"2022","journal-title":"American Journal of Obstetrics & Gynecology MFM"},{"key":"10.1016\/j.yexcr.2025.114460_bib8","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.3389\/fcimb.2022.1089991","article-title":"Fecal microbiota transplantation reverses insulin resistance in type 2 diabetes: a randomized, controlled, prospective study","volume":"12","author":"Wu","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.yexcr.2025.114460_bib9","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.3390\/ijms22126517","article-title":"\u0391-Syn as a prominent actor in the inflammatory synaptopathy of Parkinson's disease","volume":"22","author":"Cardinale","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexcr.2025.114460_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2023.152000","article-title":"Mitochondria-associated endoplasmic reticulum membranes: a promising toxicity regulation target","volume":"125","author":"Hu","year":"2023","journal-title":"Acta Histochem."},{"key":"10.1016\/j.yexcr.2025.114460_bib11","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3389\/fnins.2019.00560","article-title":"Linking the endoplasmic reticulum to Parkinson's disease and \u03b1-Syn opathy","volume":"13","author":"Colla","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.yexcr.2025.114460_bib12","doi-asserted-by":"crossref","first-page":"6459585","DOI":"10.1155\/2022\/6459585","article-title":"Mitochondrial-endoplasmic reticulum communication-mediated oxidative stress and autophagy","volume":"1","author":"Liu","year":"2022","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.yexcr.2025.114460_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130219","article-title":"Exploring the therapeutic potential of Rab11: a comprehensive study on its effectiveness in alleviating rotenone-induced molecular pathogenesis of Parkinson's disease in SH-SY5Y cells and its synergistic application with L-DOPA in Drosophila models","volume":"263","author":"Rai","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.yexcr.2025.114460_bib14","first-page":"2143","article-title":"Endoplasmic reticulum stress associated responses in cancer","volume":"10","author":"Wang","year":"2015","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.yexcr.2025.114460_bib15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1534\/genetics.115.179457","article-title":"Drosophila as an in vivo model for human neurodegenerative disease","volume":"201","author":"McGurk","year":"2015","journal-title":"Genetics"},{"key":"10.1016\/j.yexcr.2025.114460_bib16","first-page":"1","article-title":"Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease","volume":"4","author":"Chouhan","year":"2016","journal-title":"Acta Neuropathological Communications"},{"key":"10.1016\/j.yexcr.2025.114460_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47227-z","article-title":"\u0391-Syn is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders","volume":"9","author":"Schaser","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexcr.2025.114460_bib18","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3233\/JPD-212566","article-title":"Effects of \u03b1-Syn targeted antisense oligonucleotides on Lewy body-like pathology and behavioral disturbances induced by injections of pre-formed fibrils in the mouse motor cortex","volume":"11","author":"Boutros","year":"2021","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.yexcr.2025.114460_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbrc.2022.08.027","article-title":"Rab11 regulates mitophagy signaling pathway of Parkin and Pink1 in the Drosophila model of Parkinson's disease","volume":"626","author":"Rai","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexcr.2025.114460_bib20","doi-asserted-by":"crossref","first-page":"148442","DOI":"10.1016\/j.brainres.2023.148442","article-title":"Rab11 rescues muscle degeneration and synaptic morphology in the park13\/+ Parkinson model of Drosophila melanogaster","volume":"1816","author":"Rai","year":"2023","journal-title":"Brain Res."},{"key":"10.1016\/j.yexcr.2025.114460_bib21","article-title":"Interplay between \u0391-syn and oxidative stress in Parkinson' s disease cell models (doctoral dissertation","author":"Perfeito","year":"2012","journal-title":"Universidade de Coimbra (Portugal)"},{"key":"10.1016\/j.yexcr.2025.114460_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1574","article-title":"Effect of Parkin on methamphetamine\u2010induced \u03b1\u2010synuclein degradation dysfunction in vitro and in vivo","volume":"10","author":"Meng","year":"2020","journal-title":"Brain and Behavior"},{"key":"10.1016\/j.yexcr.2025.114460_bib23","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/780179","article-title":"Mitochondrial dysfunction: different routes to Alzheimer's disease therapy","volume":"2014","author":"Picone","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.yexcr.2025.114460_bib24","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s12640-019-00116-9","article-title":"\u03b2-Amyloid peptide: the cell compartment multi-faceted interaction in Alzheimer's disease","volume":"37","author":"Picone","year":"2020","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.yexcr.2025.114460_bib25","first-page":"20","article-title":"Drosophila models of insulin signaling: from molecular genetics to precision medicine","volume":"406","author":"Liu","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.yexcr.2025.114460_bib26","doi-asserted-by":"crossref","first-page":"E79","DOI":"10.1152\/ajpendo.1992.263.1.E79","article-title":"Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity","volume":"263","author":"Groop","year":"1992","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"key":"10.1016\/j.yexcr.2025.114460_bib27","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/414799a","article-title":"Insulin signalling and the regulation of glucose and lipid metabolism","volume":"414","author":"Saltiel","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2025.114460_bib28","first-page":"1958","article-title":"Synergistic dopaminergic neurotoxicity of microglial NADPH oxidase-derived free radicals and TNF-\u03b1","volume":"13","author":"Gao","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.yexcr.2025.114460_bib29","article-title":"Insulin signaling and resistance in sepsis","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.yexcr.2025.114460_bib30","first-page":"79","article-title":"Intranasal insulin as a treatment for neurodegenerative diseases: current state of research and future development","volume":"1","author":"Freiherr","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.yexcr.2025.114460_bib31","first-page":"2730","article-title":"Exenatide and the treatment of patients with Parkinson's disease","volume":"6","author":"Aviles-Olmos","year":"2014","journal-title":"J. Clin. Investig."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482725000564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482725000564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T01:57:43Z","timestamp":1744509463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482725000564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0014482725000564"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2025.114460","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"H50Q mutation in alpha-Synuclein impairs the insulin signaling pathway and induces neuroinflammation in the Drosophila model","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2025.114460","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114460"}}