{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:43:53Z","timestamp":1776141833021,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","award":["801481"],"award-info":[{"award-number":["801481"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF17CC0027852"],"award-info":[{"award-number":["NNF17CC0027852"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019854","name":"Greater Copenhagen Health Science Partners","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Danish Cancer Society","doi-asserted-by":"publisher","award":["R223-A13071"],"award-info":[{"award-number":["R223-A13071"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.yexcr.2026.114982","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:41:20Z","timestamp":1773160880000},"page":"114982","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Loss of splicing factor RBM25 promotes the collapse of murine hematopoiesis"],"prefix":"10.1016","volume":"458","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9070-8103","authenticated-orcid":false,"given":"Mafalda Ara\u00fajo","family":"Pereira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1742-5550","authenticated-orcid":false,"given":"Mikkel Bruhn","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Tapia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9372-8265","authenticated-orcid":false,"given":"Pedro","family":"Aragon-Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3117-7832","authenticated-orcid":false,"given":"Erwin M.","family":"Schoof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6043-0844","authenticated-orcid":false,"given":"Bo Torben","family":"Porse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.yexcr.2026.114982_bib1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2008.01.025","article-title":"Hematopoiesis: an evolving paradigm for stem cell biology","volume":"132","author":"Orkin","year":"2008","journal-title":"Cell."},{"issue":"6","key":"10.1016\/j.yexcr.2026.114982_bib2","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/wsbm.86","article-title":"Hematopoietic stem cell: self-renewal versus differentiation","volume":"2","author":"Seita","year":"2010","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"issue":"7","key":"10.1016\/j.yexcr.2026.114982_bib3","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00109-017-1535-3","article-title":"Dysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia","volume":"95","author":"Basilico","year":"2017","journal-title":"J. Mol. Med."},{"issue":"7","key":"10.1016\/j.yexcr.2026.114982_bib4","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a003707","article-title":"Spliceosome structure and function","volume":"3","author":"Will","year":"2011","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"12","key":"10.1016\/j.yexcr.2026.114982_bib5","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ng.259","article-title":"Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing","volume":"40","author":"Pan","year":"2008","journal-title":"Nat. Genet."},{"issue":"D1","key":"10.1016\/j.yexcr.2026.114982_bib6","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gky955","article-title":"GENCODE reference annotation for the human and mouse genomes","volume":"47","author":"Frankish","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yexcr.2026.114982_bib7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-biochem-060614-034316","article-title":"Mechanisms and regulation of alternative Pre-mRNA splicing","volume":"84","author":"Lee","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.yexcr.2026.114982_bib8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.csbj.2020.12.009","article-title":"Alternative splicing: human disease and quantitative analysis from high-throughput sequencing","volume":"19","author":"Jiang","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"9","key":"10.1016\/j.yexcr.2026.114982_bib9","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1038\/leu.2014.73","article-title":"Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia","volume":"28","author":"Matsunawa","year":"2014","journal-title":"Leukemia"},{"issue":"8","key":"10.1016\/j.yexcr.2026.114982_bib10","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1038\/s41375-020-01116-x","article-title":"U2af1 is required for survival and function of hematopoietic stem\/progenitor cells","volume":"35","author":"Dutta","year":"2021","journal-title":"Leukemia"},{"issue":"17","key":"10.1016\/j.yexcr.2026.114982_bib11","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1128\/MCB.00202-15","article-title":"SRSF2 is essential for hematopoiesis, and its myelodysplastic syndrome-related mutations dysregulate alternative Pre-mRNA splicing","volume":"35","author":"Komeno","year":"2015","journal-title":"Mol. Cell Biol."},{"issue":"7367","key":"10.1016\/j.yexcr.2026.114982_bib12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature10496","article-title":"Frequent pathway mutations of splicing machinery in myelodysplasia","volume":"478","author":"Yoshida","year":"2011","journal-title":"Nature"},{"issue":"23","key":"10.1016\/j.yexcr.2026.114982_bib13","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1056\/NEJMoa1516192","article-title":"Genomic classification and prognosis in acute myeloid leukemia","volume":"374","author":"Papaemmanuil","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yexcr.2026.114982_bib14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.21037\/sci.2017.01.06","article-title":"Aberrant RNA splicing and mutations in spliceosome complex in acute myeloid leukemia","volume":"4","author":"Zhou","year":"2017","journal-title":"Stem Cell Invest."},{"issue":"16","key":"10.1016\/j.yexcr.2026.114982_bib15","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1016\/j.febslet.2007.05.066","article-title":"Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3\u2032\u2010end formation","volume":"581","author":"Fortes","year":"2007","journal-title":"FEBS (Fed. Eur. Biochem. Soc.) Lett."},{"issue":"19","key":"10.1016\/j.yexcr.2026.114982_bib16","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.1128\/MCB.00560-08","article-title":"Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection","volume":"28","author":"Zhou","year":"2008","journal-title":"Mol. Cell Biol."},{"issue":"32","key":"10.1016\/j.yexcr.2026.114982_bib17","doi-asserted-by":"crossref","first-page":"13381","DOI":"10.1074\/jbc.M117.784371","article-title":"RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation","volume":"292","author":"Carlson","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.yexcr.2026.114982_bib18","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/CIRCULATIONAHA.111.044495","article-title":"Role of RBM25\/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure","volume":"124","author":"Gao","year":"2011","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.yexcr.2026.114982_bib19","doi-asserted-by":"crossref","DOI":"10.4172\/1747-0862.1000183","article-title":"Whole-exome sequencing identifies novel somatic mutations in Chinese breast cancer patients","volume":"9","author":"Zhang","year":"2015","journal-title":"J. Mol. Genet. Med."},{"issue":"14","key":"10.1016\/j.yexcr.2026.114982_bib20","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1038\/s41388-018-0602-8","article-title":"Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway","volume":"38","author":"Yang","year":"2018","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.yexcr.2026.114982_bib21","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/s41467-018-08076-y","article-title":"The splicing factor RBM25 controls MYC activity in acute myeloid leukemia","volume":"10","author":"Ge","year":"2019","journal-title":"Nat. Commun."},{"issue":"5229","key":"10.1016\/j.yexcr.2026.114982_bib22","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.7660125","article-title":"Inducible gene targeting in mice","volume":"269","author":"K\u00fchn","year":"1995","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.yexcr.2026.114982_bib23","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41375-023-01810-6","article-title":"The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes","volume":"37","author":"Trempenau","year":"2023","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.yexcr.2026.114982_bib24","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.stem.2007.07.005","article-title":"Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy","volume":"1","author":"Pronk","year":"2007","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.yexcr.2026.114982_bib25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.stem.2015.05.003","article-title":"Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions","volume":"17","author":"Pietras","year":"2015","journal-title":"Cell Stem Cell"},{"issue":"7128","key":"10.1016\/j.yexcr.2026.114982_bib26","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05541","article-title":"Restoration of p53 function leads to tumour regression in vivo","volume":"445","author":"Ventura","year":"2007","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.yexcr.2026.114982_bib27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.stemcr.2016.07.009","article-title":"Embryonic stem cell culture conditions support distinct states associated with different developmental stages and potency","volume":"7","author":"Martin Gonzalez","year":"2016","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.yexcr.2026.114982_bib28","article-title":"Unraveling the proteome landscape of mouse hematopoietic stem and progenitor compartment with high sensitivity low-input proteomics","author":"\u00dcresin","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.yexcr.2026.114982_bib29","author":"Gatto"},{"issue":"2","key":"10.1016\/j.yexcr.2026.114982_bib30","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1074\/mcp.M115.055897","article-title":"Peptide-level robust ridge regression improves estimation, sensitivity, and specificity in data-dependent quantitative label-free shotgun","volume":"15","author":"Goeminne","year":"2016","journal-title":"Proteomics Molecular & Cellular Proteomics"},{"issue":"41","key":"10.1016\/j.yexcr.2026.114982_bib31","doi-asserted-by":"crossref","first-page":"17413","DOI":"10.1073\/pnas.0909296106","article-title":"Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis","volume":"106","author":"Chen","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"3","key":"10.1016\/j.yexcr.2026.114982_bib32","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.stem.2012.02.003","article-title":"Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration","volume":"10","author":"Park","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.yexcr.2026.114982_bib33","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3389\/fpls.2017.00292","article-title":"RBM25 mediates abiotic responses in plants","volume":"8","author":"Cheng","year":"2017","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.yexcr.2026.114982_bib34","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2023019620","article-title":"RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice","author":"Bramlett","year":"2023","journal-title":"Blood"},{"issue":"21","key":"10.1016\/j.yexcr.2026.114982_bib35","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1182\/blood-2013-12-544544","article-title":"Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia","volume":"123","author":"Wang","year":"2014","journal-title":"Blood"},{"issue":"21","key":"10.1016\/j.yexcr.2026.114982_bib36","doi-asserted-by":"crossref","DOI":"10.1172\/JCI141401","article-title":"U2af1 is a haplo-essential gene required for hematopoietic cancer cell survival in mice","volume":"131","author":"Wadugu","year":"2021","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.yexcr.2026.114982_bib37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1101\/gr.181016.114","article-title":"U2AF1 mutations alter splice site recognition in hematological malignancies","volume":"25","author":"Ilagan","year":"2015","journal-title":"Genome Res."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726000996?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726000996?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T03:49:06Z","timestamp":1776138546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482726000996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0014482726000996"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.114982","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of splicing factor RBM25 promotes the collapse of murine hematopoiesis","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.114982","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114982"}}