{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T17:05:07Z","timestamp":1779728707889,"version":"3.53.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.yexcr.2026.115047","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:44:00Z","timestamp":1777445040000},"page":"115047","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["CircRNA_38959 protects liver cells from intermittent hypoxia-triggered injury and suppresses ferroptosis by interacting with IGF2BP3"],"prefix":"10.1016","volume":"460","author":[{"given":"Chaowei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhuang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanta","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiyong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.yexcr.2026.115047_bib1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","article-title":"Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis","volume":"7","author":"Benjafield","year":"2019","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.yexcr.2026.115047_bib2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.smrv.2016.07.002","article-title":"Prevalence of obstructive sleep apnea in the general population: a systematic review","volume":"34","author":"Senaratna","year":"2017","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.yexcr.2026.115047_bib3","article-title":"A systematic review of risk factors for sleep apnea","volume":"42","author":"Yayan","year":"2024","journal-title":"Prev. Med. Rep."},{"issue":"4","key":"10.1016\/j.yexcr.2026.115047_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/diseases9040088","article-title":"Association and risk factors for obstructive sleep apnea and cardiovascular diseases: a systematic review","volume":"9","author":"Mitra","year":"2021","journal-title":"Diseases"},{"issue":"1","key":"10.1016\/j.yexcr.2026.115047_bib5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1378\/chest.14-0500","article-title":"Intermittent hypoxemia and OSA: implications for comorbidities","volume":"147","author":"Dewan","year":"2015","journal-title":"Chest"},{"issue":"7","key":"10.1016\/j.yexcr.2026.115047_bib6","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1164\/rccm.201806-1109TR","article-title":"Obstructive sleep apnea, hypoxia, and nonalcoholic fatty liver disease","volume":"199","author":"Mesarwi","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"4","key":"10.1016\/j.yexcr.2026.115047_bib7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.yexcr.2026.115047_bib8","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of mitochondria in ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.yexcr.2026.115047_bib9","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1007\/s11325-020-02091-4","article-title":"The role of ferroptosis in chronic intermittent hypoxia-induced liver injury in rats","volume":"24","author":"Chen","year":"2020","journal-title":"Sleep Breath."},{"issue":"41","key":"10.1016\/j.yexcr.2026.115047_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202402241","article-title":"IL6 derived from macrophages under intermittent hypoxia exacerbates NAFLD by promoting ferroptosis via MARCH3-Led ubiquitylation of GPX4","volume":"11","author":"Cai","year":"2024","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115047_bib11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12943-020-01286-3","article-title":"Circular RNA: metabolism, functions and interactions with proteins","volume":"19","author":"Zhou","year":"2020","journal-title":"Mol. Cancer"},{"issue":"12","key":"10.1016\/j.yexcr.2026.115047_bib12","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s41581-021-00465-9","article-title":"Circular RNAs in kidney disease and cancer","volume":"17","author":"van Zonneveld","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.yexcr.2026.115047_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.00428","article-title":"Biogenesis and function of circular RNAs in health and in disease","volume":"10","author":"Haddad","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.yexcr.2026.115047_bib14","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ebiom.2018.07.036","article-title":"Circular RNAs: promising biomarkers for human diseases","volume":"34","author":"Zhang","year":"2018","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.yexcr.2026.115047_bib15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s11325-023-02920-2","article-title":"The role of exosomal circular RNA ZNF292 in intermittent hypoxia-induced AC16 cardiomyocytes injury","volume":"28","author":"Xie","year":"2024","journal-title":"Sleep Breath."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115047_bib16","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/s41598-024-51471-3","article-title":"Hsa_circ_0081065 exacerbates IH-induced EndMT via regulating miR-665\/HIF-1\u03b1 signal axis and HIF-1\u03b1 nuclear translocation","volume":"14","author":"Jiang","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexcr.2026.115047_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.972407","article-title":"Expression profiling and functional analysis of circular RNAs in vitro model of intermittent hypoxia-induced liver injury","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.yexcr.2026.115047_bib18","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41417-023-00698-9","article-title":"Circular RNA RHBDD1 regulates tumorigenicity and ferroptosis in colorectal cancer by mediating the ELAVL1\/SCD mRNA interaction","volume":"31","author":"Long","year":"2024","journal-title":"Cancer Gene Ther."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115047_bib19","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41420-020-00306-x","article-title":"Circular RNA cIARS regulates ferroptosis in HCC cells through interacting with RNA binding protein ALKBH5","volume":"6","author":"Liu","year":"2020","journal-title":"Cell Death Discov."},{"issue":"7","key":"10.1016\/j.yexcr.2026.115047_bib20","first-page":"6262","article-title":"Identification and characterization of circular RNAs expression profiles in obstructive sleep apnea-induced liver injury","volume":"16","author":"Li","year":"2024","journal-title":"Aging (Albany NY)"},{"issue":"2","key":"10.1016\/j.yexcr.2026.115047_bib21","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1073\/pnas.91.2.674","article-title":"Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha","volume":"91","author":"Wu","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2026.115047_bib22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-4939-8766-5_3","article-title":"ChIRP-MS: RNA-directed proteomic discovery","volume":"1861","author":"Chu","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.yexcr.2026.115047_bib23","series-title":"Physiology, Albumin. StatPearls","author":"Moman","year":"2025"},{"issue":"4","key":"10.1016\/j.yexcr.2026.115047_bib24","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/hep.21593","article-title":"Chronic intermittent hypoxia predisposes to liver injury","volume":"45","author":"Savransky","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2026.115047_bib25","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3389\/fcell.2019.00363","article-title":"IGF2BP3 from physiology to cancer: novel discoveries, unsolved issues, and future perspectives","volume":"7","author":"Mancarella","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"issue":"11","key":"10.1016\/j.yexcr.2026.115047_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24119423","article-title":"Targeting IGF2BP3 in cancer","volume":"24","author":"Liu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115047_bib27","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s13046-022-02466-3","article-title":"CircARID1A binds to IGF2BP3 in gastric cancer and promotes cancer proliferation by forming a circARID1A-IGF2BP3-SLC7A5 RNA\u2013protein ternary complex","volume":"41","author":"Ma","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"12","key":"10.1016\/j.yexcr.2026.115047_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1512","article-title":"circRARS synergises with IGF2BP3 to regulate RNA methylation recognition to promote tumour progression in renal cell carcinoma","volume":"13","author":"Liu","year":"2023","journal-title":"Clin. Transl. Med."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115047_bib29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12943-017-0647-2","article-title":"IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis","volume":"16","author":"Zhou","year":"2017","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.yexcr.2026.115047_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bbrc.2020.05.112","article-title":"Ubiquitination of IGF2BP3 by E3 ligase MKRN2 regulates the proliferation and migration of human neuroblastoma SHSY5Y cells","volume":"529","author":"Jia","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"36","key":"10.1016\/j.yexcr.2026.115047_bib31","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2407016121","article-title":"Oncofetal IGF2BP3-mediated control of microRNA structural diversity in the malignancy of early-stage lung adenocarcinoma","volume":"121","author":"Fujiwara","year":"2024","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"9","key":"10.1016\/j.yexcr.2026.115047_bib32","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1016\/j.celrep.2016.04.083","article-title":"IGF2BP3 modulates the interaction of invasion-associated transcripts with RISC","volume":"15","author":"Ennajdaoui","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.yexcr.2026.115047_bib33","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fendo.2018.00178","article-title":"Insulin-like growth factor 2 mRNA-Binding protein 3 influences sensitivity to Anti-IGF system agents through the translational regulation of IGF1R","volume":"9","author":"Mancarella","year":"2018","journal-title":"Front. Endocrinol."},{"issue":"6","key":"10.1016\/j.yexcr.2026.115047_bib34","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1002\/hep.29340","article-title":"Pericentral hepatocytes produce insulin-like growth factor-2 to promote liver regeneration during selected injuries in mice","volume":"66","author":"Liu","year":"2017","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.yexcr.2026.115047_bib35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s10020-023-00752-0","article-title":"IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling in d-galactose-induced aging mice","volume":"29","author":"Zhou","year":"2023","journal-title":"Mol. Med."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726001643?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726001643?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:41:38Z","timestamp":1779727298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482726001643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0014482726001643"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.115047","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CircRNA_38959 protects liver cells from intermittent hypoxia-triggered injury and suppresses ferroptosis by interacting with IGF2BP3","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.115047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115047"}}