{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:04:16Z","timestamp":1786115056147,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2022LSW005"],"award-info":[{"award-number":["ZR2022LSW005"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.yexcr.2026.115118","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:02:29Z","timestamp":1782774149000},"page":"115118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["MiR-1281 downregulates LMX1B to inhibit gastric cancer development"],"prefix":"10.1016","volume":"461","author":[{"given":"Shenshuo","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqiu","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuguang","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyong","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10494","key":"10.1016\/j.yexcr.2026.115118_bib1","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/S0140-6736(25)00052-2","article-title":"Gastric cancer","volume":"405","author":"Sundar","year":"2025","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.yexcr.2026.115118_bib2","first-page":"10","article-title":"Cancer statistics","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J. Clin."},{"issue":"2","key":"10.1016\/j.yexcr.2026.115118_bib3","first-page":"140","article-title":"Gastric cancer: rapid evidence review","volume":"111","author":"Mott","year":"2025","journal-title":"Am. Fam. Physician"},{"issue":"1","key":"10.1016\/j.yexcr.2026.115118_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.suc.2024.06.005","article-title":"Lymphadenectomy for gastric cancer","volume":"105","author":"Hwang","year":"2025","journal-title":"Surg. Clin. North Am."},{"issue":"3","key":"10.1016\/j.yexcr.2026.115118_bib5","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1056\/NEJMe2507207","article-title":"New perioperative strategy in gastric cancer","volume":"393","author":"Shitara","year":"2025","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.yexcr.2026.115118_bib6","first-page":"212","article-title":"Advances and challenges in gastric cancer testing: the role of biomarkers","volume":"22","author":"Sun","year":"2025","journal-title":"Cancer Biol. Med."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115118_bib7","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41419-025-07466-7","article-title":"MiR-769-5p of macrophage exosomes induced by GRP78 promotes stemness and chemoresistance in colorectal cancer","volume":"16","author":"Tian","year":"2025","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115118_bib8","doi-asserted-by":"crossref","first-page":"7076","DOI":"10.1038\/s41598-025-91665-x","article-title":"MiR-365-3p inhibits lung cancer proliferation and migration via CPT1A-mediated fatty acid oxidation","volume":"15","author":"Xu","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115118_bib9","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/s42003-025-08441-w","article-title":"Exo-miR-1911-5p regulates ferroptosis to promote macrophages M2 polarization-mediated gastric cancer cisplatin resistance via MYB\/AKR1B10\/ACC","volume":"8","author":"Kong","year":"2025","journal-title":"Commun. Biol."},{"issue":"8","key":"10.1016\/j.yexcr.2026.115118_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107522","article-title":"miR-107 reverses the multidrug resistance of gastric cancer by targeting the CGA\/EGFR\/GATA2 positive feedback circuit","volume":"300","author":"Wang","year":"2024","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.yexcr.2026.115118_bib11","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1007\/s12033-023-00877-x","article-title":"miR-181-5p\/KLHL5 promoted proliferation and migration of gastric cancer through activating METTL3-Mediated m6A process","volume":"66","author":"Li","year":"2024","journal-title":"Mol. Biotechnol."},{"issue":"3","key":"10.1016\/j.yexcr.2026.115118_bib12","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s10120-013-0313-3","article-title":"Prognostic significance of miR-34a and its target proteins of FOXP1, p53, and BCL2 in gastric MALT lymphoma and DLBCL","volume":"17","author":"He","year":"2014","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.yexcr.2026.115118_bib13","article-title":"The role of microRNA-21 (miR-21) in pathogenesis, diagnosis, and prognosis of gastrointestinal cancers: a review","volume":"316","author":"Farasati","year":"2023","journal-title":"Life Sci."},{"issue":"14","key":"10.1016\/j.yexcr.2026.115118_bib14","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2411716122","article-title":"LMX1B missense-perturbation of regulatory element footprints disrupts serotonergic forebrain axon arborization","volume":"122","author":"Eastman","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2026.115118_bib15","article-title":"Molecular landscape of endometrial stromal tumors","volume":"9","author":"Brunetti","year":"2025","journal-title":"JCO Precis. Oncol."},{"issue":"8","key":"10.1016\/j.yexcr.2026.115118_bib16","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1093\/neuonc\/noaf085","article-title":"SOX2 commands LIM homeobox transcription factors in choroid plexus development and tumorigenesis","volume":"27","author":"Faltings","year":"2025","journal-title":"Neuro Oncol."},{"issue":"33","key":"10.1016\/j.yexcr.2026.115118_bib17","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1038\/onc.2013.375","article-title":"Identification of LMX1B as a novel oncogene in human ovarian cancer","volume":"33","author":"He","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.yexcr.2026.115118_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109174","article-title":"LMX1B mRNA expression and its gene body CpG methylation are valuable prognostic biomarkers for laryngeal squamous cell carcinoma","volume":"117","author":"Fan","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.yexcr.2026.115118_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7375879","article-title":"LMX1B activated circular RNA GFRA1 modulates the tumorigenic properties and immune escape of prostate cancer","volume":"2022","author":"Meng","year":"2022","journal-title":"J. Immunol. Res."},{"issue":"5","key":"10.1016\/j.yexcr.2026.115118_bib20","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.12421","article-title":"LncRNA LINC00963 promotes colorectal cancer cell proliferation and metastasis by regulating miR-1281 and TRIM65","volume":"24","author":"Lv","year":"2021","journal-title":"Mol. Med. Rep."},{"issue":"24","key":"10.1016\/j.yexcr.2026.115118_bib21","first-page":"10842","article-title":"LncRNA GIHCG regulates microRNA-1281 and promotes malignant progression of breast cancer","volume":"23","author":"Fan","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"6","key":"10.1016\/j.yexcr.2026.115118_bib22","article-title":"Lnc-GIHCG promotes cell proliferation and migration in gastric cancer through miR- 1281 adsorption","volume":"7","author":"Liu","year":"2019","journal-title":"Mol. Genet. Genom. Med."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115118_bib23","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.yexcr.2008.10.012","article-title":"The LIM-homeodomain transcription factor LMX1B regulates expression of NF-kappa B target genes","volume":"315","author":"Rascle","year":"2009","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexcr.2026.115118_bib24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.freeradbiomed.2025.07.022","article-title":"Exosomes from tumor-associated neutrophils suppress ferroptosis and confer chemoresistance in gastric cancer via miR-9-3p\/ACSL4 axis","volume":"239","author":"Dong","year":"2025","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.yexcr.2026.115118_bib25","doi-asserted-by":"crossref","first-page":"327","DOI":"10.32604\/or.2024.050431","article-title":"Exosomal miR-224-3p promotes lymphangiogenesis and lymph node metastasis by targeting GSK3B in gastric cancer","volume":"33","author":"Zhou","year":"2025","journal-title":"Oncol. Res."},{"issue":"9","key":"10.1016\/j.yexcr.2026.115118_bib26","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1001\/jamasurg.2025.2493","article-title":"Exosomal liquid biopsy for the early detection of gastric cancer: the DESTINEX multicenter study","volume":"160","author":"Sui","year":"2025","journal-title":"JAMA Surg."},{"issue":"10","key":"10.1016\/j.yexcr.2026.115118_bib27","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100294RR","article-title":"Expression, regulation, and function of exosome-derived miRNAs in cancer progression and therapy","volume":"35","author":"Li","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.yexcr.2026.115118_bib28","article-title":"Comprehensive roles and future perspectives of exosomes in peritoneal metastasis of gastric cancer","volume":"11","author":"Chen","year":"2021","journal-title":"Front. Oncol."},{"issue":"11","key":"10.1016\/j.yexcr.2026.115118_bib29","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1093\/neuonc\/noaf162","article-title":"Lipid nanoparticle formulation for gene editing and RNA-based therapies for glioblastoma","volume":"27","author":"Zhang","year":"2025","journal-title":"Neuro Oncol."},{"issue":"8","key":"10.1016\/j.yexcr.2026.115118_bib30","doi-asserted-by":"crossref","first-page":"741","DOI":"10.2174\/138920101708160517234941","article-title":"Lipid nanoparticles to deliver miRNA in cancer","volume":"17","author":"Campani","year":"2016","journal-title":"Curr. Pharm. Biotechnol."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726002351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726002351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T23:53:37Z","timestamp":1785974017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482726002351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0014482726002351"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.115118","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MiR-1281 downregulates LMX1B to inhibit gastric cancer development","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.115118","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115118"}}