{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:40:07Z","timestamp":1790019607324,"version":"4.0.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003847","name":"Ningbo Municipal People's Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo Municipality","doi-asserted-by":"publisher","award":["2024A232"],"award-info":[{"award-number":["2024A232"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.yexcr.2026.115129","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:12:12Z","timestamp":1785337932000},"page":"115129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["NOP2-regulated m5C methylation of FKBP4 in promoting lung adenocarcinoma progression"],"prefix":"10.1016","volume":"462","author":[{"given":"Yong","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.yexcr.2026.115129_bib1","first-page":"10","article-title":"Cancer statistics","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.yexcr.2026.115129_bib2","doi-asserted-by":"crossref","DOI":"10.1101\/2024.12.06.24318630","article-title":"Lung cancer and risk of cardiovascular mortality","volume":"11","author":"Wang","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"issue":"3","key":"10.1016\/j.yexcr.2026.115129_bib3","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3390\/cancers13030384","article-title":"Immune resistance in lung adenocarcinoma","volume":"13","author":"Spella","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.yexcr.2026.115129_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10555-024-10172-z","article-title":"Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance","volume":"43","author":"Bhat","year":"2024","journal-title":"Cancer Metastasis Rev."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115129_bib5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12943-025-02321-x","article-title":"Emerging artificial intelligence-driven precision therapies in tumor drug resistance: recent advances, opportunities, and challenges","volume":"24","author":"Mao","year":"2025","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.yexcr.2026.115129_bib6","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s12943-024-02093-w","article-title":"Multi-omics and clustering analyses reveal the mechanisms underlying unmet needs for patients with lung adenocarcinoma and identify potential therapeutic targets","volume":"23","author":"Asada","year":"2024","journal-title":"Mol. Cancer"},{"issue":"Pt 4","key":"10.1016\/j.yexcr.2026.115129_bib7","article-title":"mRNA expression profile and prognostic values of the CDHR family genes in lung adenocarcinoma","volume":"281","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.yexcr.2026.115129_bib8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41575-023-00884-y","article-title":"RNA modification-mediated mRNA translation regulation in liver cancer: mechanisms and clinical perspectives","volume":"21","author":"Lin","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115129_bib9","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12943-024-02089-6","article-title":"Writers, readers, and erasers RNA modifications and drug resistance in cancer","volume":"23","author":"Chen","year":"2024","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.yexcr.2026.115129_bib10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12943-023-01841-8","article-title":"m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism","volume":"22","author":"Yue","year":"2023","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.yexcr.2026.115129_bib11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s12943-024-02132-6","article-title":"RNA m6A modification in ferroptosis: implications for advancing tumor immunotherapy","volume":"23","author":"Shi","year":"2024","journal-title":"Mol. Cancer"},{"issue":"5","key":"10.1016\/j.yexcr.2026.115129_bib12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.21037\/atm-22-500","article-title":"5-methylcytosine RNA methylation regulators affect prognosis and tumor microenvironment in lung adenocarcinoma","volume":"10","author":"Liu","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.yexcr.2026.115129_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154621","article-title":"Comprehensive analyses of genome-wide methylation and RNA epigenetics identify prognostic biomarkers, regulating the tumor immune microenvironment in lung adenocarcinoma","volume":"248","author":"Liu","year":"2023","journal-title":"Pathol. Res. Pract."},{"issue":"10","key":"10.1016\/j.yexcr.2026.115129_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.70970","article-title":"NOP2-Mediated m5C methylation modification of LMNB2 mRNA facilitates colorectal cancer progression","volume":"14","author":"Bi","year":"2025","journal-title":"Cancer Med."},{"key":"10.1016\/j.yexcr.2026.115129_bib15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.34133\/research.0184","article-title":"NOP2-mediated m5C modification of c-Myc in an EIF3A-Dependent manner to reprogram glucose metabolism and promote hepatocellular carcinoma progression","volume":"6","author":"Zhang","year":"2023","journal-title":"Research"},{"key":"10.1016\/j.yexcr.2026.115129_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/cac2.70023","article-title":"Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2-mediated increase of SOAT2 RNA methylation","author":"Jiang","year":"2025","journal-title":"Cancer Commun."},{"issue":"2","key":"10.1016\/j.yexcr.2026.115129_bib17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41419-023-05661-y","article-title":"M 5 C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6\/TK1 mRNAs splicing and stabilization","volume":"14","author":"Wang","year":"2023","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.yexcr.2026.115129_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115661","article-title":"The m 5 C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism","volume":"44","author":"Li","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.yexcr.2026.115129_bib19","doi-asserted-by":"crossref","first-page":"6520","DOI":"10.3390\/ijms24076520","article-title":"Prognostic value and genome signature of m6A\/m5C regulated genes in early-stage lung adenocarcinoma","volume":"24","author":"Tian","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.yexcr.2026.115129_bib20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.21037\/atm-22-500","article-title":"5-methylcytosine RNA methylation regulators affect prognosis and tumor microenvironment in lung adenocarcinoma","volume":"10","author":"Liu","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.yexcr.2026.115129_bib21","volume":"15","author":"Jiang","year":"2025"},{"key":"10.1016\/j.yexcr.2026.115129_bib22","volume":"14","author":"Zou","year":"2024"},{"key":"10.1016\/j.yexcr.2026.115129_bib23","first-page":"125","volume":"14","author":"Yang","year":"2023"},{"key":"10.1016\/j.yexcr.2026.115129_bib24","first-page":"962","volume":"63","author":"Du","year":"2024"},{"key":"10.1016\/j.yexcr.2026.115129_bib25","first-page":"506","volume":"15","author":"Yang","year":"2024"},{"issue":"3","key":"10.1016\/j.yexcr.2026.115129_bib26","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4149\/neo_2023_230110N17","article-title":"NOP2-mediated m5C methylation of XPD is associated with hepatocellular carcinoma progression","volume":"70","author":"Sun","year":"2023","journal-title":"Neoplasma"},{"issue":"1","key":"10.1016\/j.yexcr.2026.115129_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-78383-6","article-title":"FKBP4 promotes glycolysis and hepatocellular carcinoma progression via p53\/HK2 axis","volume":"14","author":"Zeng","year":"2024","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.yexcr.2026.115129_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e29098","article-title":"Pan-cancer analysis of the prognostic and immunological role of FKBP4","volume":"10","author":"Xiong","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.yexcr.2026.115129_bib29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.7150\/thno.35561","article-title":"FKBP4 connects mTORC2 and PI3K to activate the PDK1\/Akt-dependent cell proliferation signaling in breast cancer","volume":"9","author":"Mang\u00e9","year":"2019","journal-title":"Theranostics"},{"issue":"2","key":"10.1016\/j.yexcr.2026.115129_bib30","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s10142-024-01337-8","article-title":"Nuclear protein NOP2 serves as a poor-prognosis predictor of LUAD and aggravates the malignancy of lung adenocarcinoma cells","volume":"24","author":"Qin","year":"2024","journal-title":"Funct. Integr. Genomics"},{"issue":"3","key":"10.1016\/j.yexcr.2026.115129_bib31","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1089\/gtmb.2024.0416","article-title":"Exploration of the prognostic value of m5C methylation protein NOP2 and NSUN6 in Colon cancer","volume":"29","author":"Jiang","year":"2025","journal-title":"Genet. Test. Mol. Biomark."},{"issue":"11","key":"10.1016\/j.yexcr.2026.115129_bib32","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1111\/cas.14190","article-title":"NOP2\/Sun RNA methyltransferase 2 promotes tumor progression via its interacting partner RPL6 in gallbladder carcinoma","volume":"110","author":"Gao","year":"2019","journal-title":"Cancer Sci."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115129_bib33","doi-asserted-by":"crossref","DOI":"10.1080\/15384047.2023.2263921","article-title":"Function of m 5 C RNA methyltransferase NOP2 in high-grade serous ovarian cancer","volume":"24","author":"Yang","year":"2023","journal-title":"Cancer Biol. Ther."},{"issue":"6","key":"10.1016\/j.yexcr.2026.115129_bib34","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/s41419-021-03857-8","article-title":"FKBP4 integrates FKBP4\/Hsp90\/IKK with FKBP4\/Hsp70\/RelA complex to promote lung adenocarcinoma progression via IKK\/NF-\u03baB signaling","volume":"12","author":"Zong","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.yexcr.2026.115129_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6021602","article-title":"FKBP4 accelerates malignant progression of non-small-cell lung cancer by activating the Akt\/mTOR signaling pathway","volume":"2020","author":"Meng","year":"2020","journal-title":"Anal. Cell Pathol."},{"issue":"7","key":"10.1016\/j.yexcr.2026.115129_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2025.167974","article-title":"Nop2\/Sun domain family member 5 contributes to tumorigenic properties in prostate cancer by engaging the PI3K-AKT pathway and tumor-associated macrophages","volume":"1871","author":"Huang","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115129_bib37","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5152\/tjg.2024.23684","article-title":"NOP2\/Sun RNA methyltransferase 4 regulates the mammalian target of rapamycin signaling pathway to promote hepatocellular carcinoma progression","volume":"36","author":"Wang","year":"2024","journal-title":"Turk. J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115129_bib38","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","article-title":"PI3K\/AKT\/mTOR signaling transduction pathway and targeted therapies in cancer","volume":"22","author":"Glaviano","year":"2023","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.yexcr.2026.115129_bib39","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4149\/neo_2024_230907N476","article-title":"The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K\/AKT\/VEGFA signaling pathway","volume":"71","author":"Qian","year":"2024","journal-title":"Neoplasma"},{"key":"10.1016\/j.yexcr.2026.115129_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-026-49053-6","article-title":"USP7-dependent stabilization of FKBP4 contributes to acquired osimertinib resistance through glycolytic remodeling in NSCLC","volume":"16","author":"Pang","year":"2026","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115129_bib41","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11010-025-05378-w","article-title":"The oncogenic role of NSUN2 in lung adenocarcinoma by stabilizing CCT5 mRNA via a YBX1-dependent m5C modification","volume":"481","author":"Li","year":"2026","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.yexcr.2026.115129_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinsp.2025.100662","article-title":"Inhibition of NSUN3 suppresses immune escape in non-small cell lung cancer through stabilizing PD-L1 in a 5-methyladenosine dependent way","volume":"80","author":"Huang","year":"2025","journal-title":"Clinics"},{"key":"10.1016\/j.yexcr.2026.115129_bib43","volume":"16","author":"Li","year":"2025"},{"key":"10.1016\/j.yexcr.2026.115129_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2026.104193","article-title":"Oxidative stress-driven m(5)C methylation by NSUN5 confers cisplatin resistance in lung adenocarcinoma through promoting glycolysis","volume":"94","author":"Wang","year":"2026","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115129_bib45","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000535479","article-title":"NSUN6 regulates NM23-H1 expression in an m5C manner to affect epithelial-mesenchymal transition in lung cancer","volume":"33","author":"Lu","year":"2024","journal-title":"Med. Princ. Pract."},{"issue":"4","key":"10.1016\/j.yexcr.2026.115129_bib46","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s00262-025-03986-5","article-title":"NSUN2\/ALYREF axis-driven m(5)C methylation enhances PD-L1 expression and facilitates immune evasion in non-small-cell lung cancer","volume":"74","author":"Yang","year":"2025","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.yexcr.2026.115129_bib47","first-page":"1","volume":"17","author":"Li","year":"2026"},{"issue":"1","key":"10.1016\/j.yexcr.2026.115129_bib48","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s13148-025-01992-z","article-title":"Peripheral blood mononuclear cell DNA methylation biomarkers for prognostic stratification in Chinese lung adenocarcinoma: a genome-wide epigenetic profiling study","volume":"17","author":"Li","year":"2025","journal-title":"Clin. Epigenet."},{"issue":"1","key":"10.1016\/j.yexcr.2026.115129_bib49","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13072-025-00617-2","article-title":"TET1 functions as a tumor suppressor in lung adenocarcinoma through epigenetic remodeling and immune modulation","volume":"18","author":"Rahim","year":"2025","journal-title":"Epigenetics Chromatin"}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726002466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726002466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:09:33Z","timestamp":1788538173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482726002466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0014482726002466"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.115129","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NOP2-regulated m5C methylation of FKBP4 in promoting lung adenocarcinoma progression","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.115129","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115129"}}