{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:15:27Z","timestamp":1790716527175,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2022SF-276"],"award-info":[{"award-number":["2022SF-276"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2022ZDLSF01-10"],"award-info":[{"award-number":["2022ZDLSF01-10"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.yexcr.2026.115157","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T23:20:26Z","timestamp":1787095226000},"page":"115157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["CircUBE2I regulates YAP\/TAZ signaling pathway through miR-659-3p\/PSMA1 axis to promote human lung adenocarcinoma cell progression"],"prefix":"10.1016","volume":"462","author":[{"given":"Peini","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongheng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faguang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2607-0943","authenticated-orcid":false,"given":"Xian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2026.115157_bib1","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.cell.2018.12.040","article-title":"Commensal microbiota promote lung cancer development via \u03b3\u03b4 T cells","volume":"176","author":"Jin","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2026.115157_bib2","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41419-022-04943-1","article-title":"Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer","volume":"13","author":"Zhu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.yexcr.2026.115157_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41571-026-01165-8","article-title":"Cancer burden and control in China: landscape, trends and challenges","author":"Xia","year":"2026","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.yexcr.2026.115157_bib4","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.yexcr.2026.115157_bib5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ctrv.2015.02.008","article-title":"Molecular histology of lung cancer: from targets to treatments","volume":"41","author":"Wood","year":"2015","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.yexcr.2026.115157_bib6","doi-asserted-by":"crossref","first-page":"14542","DOI":"10.1073\/pnas.1402814111","article-title":"Novel coding, translation, and gene expression of a replicating covalently closed circular RNA of 220 nt","volume":"111","author":"AbouHaidar","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexcr.2026.115157_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135659","article-title":"Circular RNAs in programmed cell death: regulation mechanisms and potential clinical applications in cancer: a review","volume":"280","author":"Gao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.yexcr.2026.115157_bib8","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1093\/nar\/gkv1367","article-title":"Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor","volume":"44","author":"Enuka","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yexcr.2026.115157_bib9","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1158\/0008-5472.CAN-22-1923","article-title":"CircPDIA4 induces gastric cancer progression by promoting ERK1\/2 activation and enhancing biogenesis of oncogenic circRNAs","volume":"83","author":"Shen","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexcr.2026.115157_bib10","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1186\/s13046-023-02915-7","article-title":"CircGPRC5A enhances colorectal cancer progress by stabilizing PPP1CA and inducing YAP dephosphorylation","volume":"42","author":"Chen","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.yexcr.2026.115157_bib11","doi-asserted-by":"crossref","first-page":"D1179","DOI":"10.1093\/nar\/gkab830","article-title":"CSCD2: an integrated interactional database of cancer-specific circular RNAs","volume":"50","author":"Feng","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yexcr.2026.115157_bib12","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1097\/CM9.0000000000004120","article-title":"Circulating circRNAs at the frontier of cancer detection, prognosis, and therapy","volume":"139","author":"Zhang","year":"2026","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.yexcr.2026.115157_bib13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12943-024-01944-w","article-title":"ZNF460-mediated circRPPH1 promotes TNBC progression through ITGA5-induced FAK\/PI3K\/AKT activation in a ceRNA manner","volume":"23","author":"Zhang","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.yexcr.2026.115157_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12943-023-01888-7","article-title":"CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis","volume":"22","author":"Cui","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.yexcr.2026.115157_bib15","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1053\/j.gastro.2023.09.050","article-title":"A circulating panel of circRNA biomarkers for the noninvasive and early detection of pancreatic ductal adenocarcinoma","volume":"166","author":"Xu","year":"2024","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yexcr.2026.115157_bib16","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13073-021-01009-3","article-title":"The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer","volume":"14","author":"Hansen","year":"2022","journal-title":"Genome Med."},{"key":"10.1016\/j.yexcr.2026.115157_bib17","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1146\/annurev-biochem-062917-011931","article-title":"Structure and function of the 26S proteasome","volume":"87","author":"Bard","year":"2018","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.yexcr.2026.115157_bib18","doi-asserted-by":"crossref","first-page":"11840","DOI":"10.3748\/wjg.v20.i33.11840","article-title":"Identification of differential proteins in colorectal cancer cells treated with caffeic acid phenethyl ester","volume":"20","author":"He","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.yexcr.2026.115157_bib19","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3389\/fonc.2020.01113","article-title":"Proteomic profiling of serum exosomes from patients with metastatic gastric cancer","volume":"10","author":"Ding","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.yexcr.2026.115157_bib20","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/s41419-022-05417-0","article-title":"PSMA1 mediates tumor progression and poor prognosis of gastric carcinoma by deubiquitinating and stabilizing TAZ","volume":"13","author":"Yang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.yexcr.2026.115157_bib21","first-page":"9","article-title":"YAP\/TAZ as master regulators in cancer: modulation, function and therapeutic approaches","volume":"4","author":"Piccolo","year":"2023","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.yexcr.2026.115157_bib22","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ccell.2016.05.005","article-title":"YAP\/TAZ at the roots of cancer","volume":"29","author":"Zanconato","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.yexcr.2026.115157_bib23","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s42255-022-00584-y","article-title":"A YAP\/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth","volume":"4","author":"Ong","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.yexcr.2026.115157_bib24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.canlet.2020.11.037","article-title":"YAP\/TAZ and EZH2 synergize to impair tumor suppressor activity of TGFBR2 in non-small cell lung cancer","volume":"500","author":"Lo Sardo","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.yexcr.2026.115157_bib25","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/embj.201386082","article-title":"Tumor-propagating cells and Yap\/Taz activity contribute to lung tumor progression and metastasis","volume":"33","author":"Lau","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.yexcr.2026.115157_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.118330","article-title":"Targeting YAP\/TAZ-TEAD and their protein-protein interaction for precision cancer therapy","volume":"302","author":"Chen","year":"2026","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.yexcr.2026.115157_bib27","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41571-021-00585-y","article-title":"The emerging roles of circRNAs in cancer and oncology","volume":"19","author":"Kristensen","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.yexcr.2026.115157_bib28","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41568-024-00721-7","article-title":"Circular RNA in cancer","volume":"24","author":"Conn","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.yexcr.2026.115157_bib29","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.trecan.2020.01.012","article-title":"Circular RNAs in cancer: biogenesis, function, and clinical significance","volume":"6","author":"Li","year":"2020","journal-title":"Trends Cancer"},{"key":"10.1016\/j.yexcr.2026.115157_bib30","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1016\/j.apsb.2026.04.019","article-title":"In vitro transcribed circRNA as a therapeutic agent for cancer","volume":"16","author":"Shi","year":"2026","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.yexcr.2026.115157_bib31","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1038\/s41467-019-11162-4","article-title":"circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1","volume":"10","author":"Cheng","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yexcr.2026.115157_bib32","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/cas.16067","article-title":"Circular RNA circWNK1 inhibits the progression of gastric cancer via regulating the miR-21-3p\/SMAD7 axis","volume":"115","author":"Dai","year":"2024","journal-title":"Cancer Sci."},{"key":"10.1016\/j.yexcr.2026.115157_bib33","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1007\/s12094-020-02485-6","article-title":"The emerging roles of exosomal circRNAs in diseases","volume":"23","author":"Guo","year":"2021","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.yexcr.2026.115157_bib34","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41418-022-00948-7","article-title":"Specific expression and functions of circular RNAs","volume":"29","author":"Misir","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.yexcr.2026.115157_bib35","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cell.2014.09.001","article-title":"Complementary sequence-mediated exon circularization","volume":"159","author":"Zhang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2026.115157_bib36","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2026.115157_bib37","article-title":"circRNA-0015004 act as a ceRNA to promote RCC2 expression in hepatocellular carcinoma","volume":"14","author":"Zhao","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexcr.2026.115157_bib38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12943-022-01598-6","article-title":"The circSPON2\/miR-331-3p axis regulates PRMT5, an epigenetic regulator of CAMK2N1 transcription and prostate cancer progression","volume":"21","author":"Yao","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.yexcr.2026.115157_bib39","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1101\/gad.1184404","article-title":"Specificity of microRNA target selection in translational repression","volume":"18","author":"Doench","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.yexcr.2026.115157_bib40","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1186\/s12885-022-10029-0","article-title":"MiR-659-3p inhibits osteosarcoma progression and metastasis by inhibiting cell proliferation and invasion via targeting SRPK1","volume":"22","author":"Gong","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.yexcr.2026.115157_bib41","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/s41419-024-07245-w","article-title":"RON receptor tyrosine kinase as a critical determinant in promoting tumorigenic behaviors of bladder cancer cells through regulating MMP12 and HIF-2\u03b1 pathways","volume":"15","author":"Wang","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.yexcr.2026.115157_bib42","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2026.115157_bib43","doi-asserted-by":"crossref","first-page":"13497","DOI":"10.1002\/cam4.6007","article-title":"Overexpression of RAB31 in gastric cancer is associated with released exosomes and increased tumor cell invasion and metastasis","volume":"12","author":"Wu","year":"2023","journal-title":"Cancer Med."},{"key":"10.1016\/j.yexcr.2026.115157_bib44","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/5386635","article-title":"PSMA1, a poor prognostic factor, promotes tumor growth in lung squamous cell carcinoma","volume":"2023","author":"Liu","year":"2023","journal-title":"Dis. Markers"}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726002740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726002740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:34:46Z","timestamp":1790714086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482726002740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0014482726002740"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.115157","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CircUBE2I regulates YAP\/TAZ signaling pathway through miR-659-3p\/PSMA1 axis to promote human lung adenocarcinoma cell progression","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.115157","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115157"}}