{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:15:47Z","timestamp":1790716547086,"version":"4.1.0"},"reference-count":127,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003789","name":"Helwan University","doi-asserted-by":"publisher","award":["Call 2 \\u20132023"],"award-info":[{"award-number":["Call 2 \\u20132023"]}],"id":[{"id":"10.13039\/501100003789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.yexcr.2026.115170","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:07:50Z","timestamp":1788995270000},"page":"115170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cuproptosis and copper metabolism regulate hepatocellular carcinoma progression and therapeutic response to sorafenib"],"prefix":"10.1016","volume":"462","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8894-530X","authenticated-orcid":false,"given":"Ahmed S.","family":"Elkateb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa B.","family":"Atya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar A.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2026.115170_bib1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jhep.2019.11.016","article-title":"The chances of hepatic resection curing hepatocellular carcinoma","volume":"72","author":"Cucchetti","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.yexcr.2026.115170_bib2","first-page":"87","article-title":"Hepatocellular carcinoma (HCC) in Egypt: prevalence, risk factors, diagnosis and prevention: a review","volume":"10","author":"Abdelhalim Yameny","year":"2024","journal-title":"J. Biosci. Appl. Res."},{"key":"10.1016\/j.yexcr.2026.115170_bib3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jconrel.2021.11.041","article-title":"Glutathione-responsive copper-disulfiram nanoparticles for enhanced tumor chemotherapy","volume":"341","author":"Chen","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexcr.2026.115170_bib4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41392-025-02192-0","article-title":"The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer","volume":"10","author":"Guo","year":"2025","journal-title":"Signal Transduct. Target. Ther"},{"issue":"7","key":"10.1016\/j.yexcr.2026.115170_bib5","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41392-022-01229-y","article-title":"Copper homeostasis and cuproptosis in health and disease","author":"Chen","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.yexcr.2026.115170_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103302","article-title":"FDX1 downregulation activates mitophagy and the PI3K\/AKT signaling pathway to promote hepatocellular carcinoma progression by inducing ROS production","volume":"75","author":"Sun","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.yexcr.2026.115170_bib7","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.yexcr.2026.115170_bib8","series-title":"Hepatocellular Carcinoma (HCC) in Egypt: a Comprehensive Overview","author":"Rashed","year":"2020"},{"key":"10.1016\/j.yexcr.2026.115170_bib9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/hep.29466","article-title":"Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease","volume":"67","author":"Estes","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.yexcr.2026.115170_bib10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.livres.2025.09.002","article-title":"Hepatitis B virus integration and hepatocarcinogenesis","volume":"9","author":"Ma","year":"2025","journal-title":"Liver Res"},{"key":"10.1016\/j.yexcr.2026.115170_bib11","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s42003-025-08369-1","article-title":"HBV DNA integration gene CCDC91 is oncogenic and a potential therapeutic target for hepatocellular carcinoma","volume":"8","author":"Li","year":"2025","journal-title":"Commun. Biol"},{"key":"10.1016\/j.yexcr.2026.115170_bib12","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.3390\/ijms25094753","article-title":"Wilson disease: copper-mediated cuproptosis, iron-related ferroptosis, and clinical highlights, with comprehensive and critical analysis update","volume":"25","author":"Teschke","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexcr.2026.115170_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers12102729","article-title":"Hepatocellular carcinoma: updates in pathogenesis, detection and treatment","volume":"12","author":"Mart\u00ednez-Chantar","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.yexcr.2026.115170_bib14","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1016\/j.csbj.2025.11.020","article-title":"Stratification of telomerase activity in cancer reveals associations with senescence and genomic instability","volume":"27","author":"Noureen","year":"2025","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.yexcr.2026.115170_bib15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/dgd.12718","article-title":"Wnt\/\u03b2\u2010catenin signaling: structure, assembly and endocytosis of the signalosome","volume":"63","author":"Colozza","year":"2021","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.yexcr.2026.115170_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/mmr.2024.13163","article-title":"Essential contribution of the JAK\/STAT pathway to carcinogenesis, lytic infection of herpesviruses and pathogenesis of COVID-19","volume":"29","author":"Li","year":"2024","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.yexcr.2026.115170_bib17","first-page":"1","article-title":"Vascular endothelial growth factor in relation to the development of hepatocellular carcinoma in hepatitis C virus patients treated by direct-acting antivirals, Egypt","volume":"11","author":"ElGhandour","year":"2021","journal-title":"Liver J"},{"key":"10.1016\/j.yexcr.2026.115170_bib18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1158\/1055-9965.EPI-24-1096","article-title":"Anti-FDX1 autoantibody as a potential biomarker for non\u2013small cell lung cancer detection","volume":"34","author":"Li","year":"2025","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.yexcr.2026.115170_bib19","first-page":"27","article-title":"Targeting the JAK\/STAT pathway in solid tumors","volume":"6","author":"Qureshy","year":"2020","journal-title":"J. Cancer Metastasis Treat."},{"key":"10.1016\/j.yexcr.2026.115170_bib20","first-page":"1151","article-title":"State-of-the-art review on the correlations between pathological and magnetic resonance features of cirrhotic nodules","volume":"37","author":"Renzulli","year":"2022","journal-title":"Histol. Histopathol."},{"issue":"71","key":"10.1016\/j.yexcr.2026.115170_bib21","first-page":"1","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat. Rev. Dis. Prim. 2021"},{"key":"10.1016\/j.yexcr.2026.115170_bib22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ncrna.2025.05.002","article-title":"The emerging role of miRNAs in biological aging and age-related diseases","volume":"13","author":"Turko","year":"2025","journal-title":"Non-Coding RNA Res"},{"key":"10.1016\/j.yexcr.2026.115170_bib23","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.freeradbiomed.2025.01.047","article-title":"Fasting enhances the efficacy of Sorafenib in breast cancer via mitophagy mediated ROS-driven p53 pathway","volume":"229","author":"Li","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yexcr.2026.115170_bib24","article-title":"BCLC strategy for prognosis prediction and treatment recommendations: the 2025 update","author":"Reig","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.yexcr.2026.115170_bib25","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"EASL clinical practice guidelines: Management of hepatocellular carcinoma","volume":"69","author":"Galle","year":"2018","journal-title":"J. Hepatol."},{"issue":"185","key":"10.1016\/j.yexcr.2026.115170_bib26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41575-020-00395-0","article-title":"Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma","volume":"18","author":"Llovet","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol. 2021"},{"key":"10.1016\/j.yexcr.2026.115170_bib27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.17998\/jlc.21.1.25","article-title":"External beam radiotherapy for hepatocellular carcinoma: a review of the current guidelines in the east and the west","volume":"21","author":"Yoon","year":"2021","journal-title":"J. Liver Cancer"},{"key":"10.1016\/j.yexcr.2026.115170_bib28","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1016\/S0140-6736(17)31046-2","article-title":"Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1\/2 dose escalation and expansion trial","volume":"389","author":"El-Khoueiry","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.yexcr.2026.115170_bib29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1200\/JCO.19.01307","article-title":"Pembrolizumab as second-line therapy in patients with advanced hepatocellular carcinoma in KEYNOTE-240: a randomized, Double-Blind, phase III trial","volume":"38","author":"Finn","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.yexcr.2026.115170_bib30","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jhep.2017.06.026","article-title":"Prognostic factors and predictors of sorafenib benefit in patients with hepatocellular carcinoma: analysis of two phase III studies","volume":"67","author":"Bruix","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.yexcr.2026.115170_bib31","article-title":"Effectiveness of regorafenib in second-line therapy for advanced hepatocellular carcinoma: a systematic review and meta-analysis","volume":"104","author":"Shen","year":"2025","journal-title":"Med. (United States)"},{"key":"10.1016\/j.yexcr.2026.115170_bib32","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMoa1717002","article-title":"Cabozantinib in patients with advanced and progressing hepatocellular carcinoma","volume":"379","author":"Abou-Alfa","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yexcr.2026.115170_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000549355","article-title":"Rechallenge with immune checkpoint inhibitors in patients with hepatocellular carcinoma: a narrative review","author":"Li","year":"2025","journal-title":"Liver Cancer"},{"key":"10.1016\/j.yexcr.2026.115170_bib34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/14737140.2019.1559058","article-title":"Sorafenib: key lessons from over 10 years of experience","volume":"19","author":"Escudier","year":"2019","journal-title":"Expert Rev. Anticancer Ther."},{"key":"10.1016\/j.yexcr.2026.115170_bib35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.14218\/JCTH.2017.00031","article-title":"Current and future treatment of hepatocellular carcinoma: an updated comprehensive review","volume":"6","author":"Daher","year":"2018","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.yexcr.2026.115170_bib36","first-page":"1","article-title":"The advantages and challenges of sorafenib combination therapy: drug resistance, toxicity and future directions","volume":"30","author":"Wei","year":"2025","journal-title":"Oncol. Lett."},{"issue":"101","key":"10.1016\/j.yexcr.2026.115170_bib37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41392-024-02075-w","article-title":"Hepatocellular carcinoma: signaling pathways and therapeutic advances","volume":"10","author":"Zheng","year":"2025","journal-title":"Signal Transduct. Target. Ther. 2025"},{"key":"10.1016\/j.yexcr.2026.115170_bib38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/cam4.5105","article-title":"Use of multikinase inhibitors\/lenvatinib concomitant with radioiodine for the treatment of radioiodine refractory differentiated thyroid cancer","volume":"11","author":"Herranz","year":"2022","journal-title":"Cancer Med."},{"key":"10.1016\/j.yexcr.2026.115170_bib39","first-page":"1","article-title":"The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects","volume":"5","author":"Tang","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.yexcr.2026.115170_bib40","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.annonc.2020.02.002","article-title":"Epigenetic modulations and lineage plasticity in advanced prostate cancer","volume":"31","author":"Ge","year":"2020","journal-title":"Ann. Oncol. Off. J. Eur. Soc. Med. Oncol."},{"key":"10.1016\/j.yexcr.2026.115170_bib41","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s12943-025-02434-3","article-title":"Epigenetic modification of cuproptosis by non-coding RNAs in cancer drug resistance","volume":"24","author":"Du","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.yexcr.2026.115170_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109025","article-title":"Triterpenoid corosolic acid modulates global CpG methylation and transcriptome of tumor promotor TPA induced mouse epidermal JB6 P+ cells","volume":"321","author":"Hudlikar","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.yexcr.2026.115170_bib43","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s12272-025-01545-1","article-title":"Targeting vascular endothelial growth receptor-2 (VEGFR-2): structural biology, functional insights, and therapeutic resistance","volume":"48","author":"Shah","year":"2025","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.yexcr.2026.115170_bib44","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.neo.2021.11.002","article-title":"ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma","volume":"23","author":"Huang","year":"2021","journal-title":"Neoplasia"},{"key":"10.1016\/j.yexcr.2026.115170_bib45","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1007\/s00018-016-2207-0","article-title":"Mechanisms and consequences of entosis","volume":"73","author":"Krishna","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.yexcr.2026.115170_bib46","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1134\/S0006297919120010","article-title":"When and how can death be an adaptation?","volume":"84","author":"Galimov","year":"2019","journal-title":"Biochemistry. (Mosc)"},{"key":"10.1016\/j.yexcr.2026.115170_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1383456","article-title":"Targeting PD-1\/PD-L-1 immune checkpoint inhibition for cancer immunotherapy: success and challenges","volume":"15","author":"Javed","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.yexcr.2026.115170_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/nu12010236","article-title":"A review of micronutrients and the immune system-working in harmony to reduce the risk of infection","volume":"12","author":"Gombart","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.yexcr.2026.115170_bib49","article-title":"Copper-binding proteins genes set predicting the overall survival and immune infiltration in hepatocellular carcinoma by bioinformatic analysis","volume":"34","author":"Liao","year":"2023","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.yexcr.2026.115170_bib50","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1053\/j.gastro.2024.02.025","article-title":"TGF-\u03b21-Induced SOX18 elevation promotes hepatocellular carcinoma progression and metastasis through transcriptionally upregulating PD-L1 and CXCL12","volume":"167","author":"Chen","year":"2024","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yexcr.2026.115170_bib51","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.jconrel.2024.06.059","article-title":"Biomimetic gold nanocages incorporating copper-human serum albumin for tumor immunotherapy via cuproptosis-lactate regulation","volume":"372","author":"Zafar","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexcr.2026.115170_bib52","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41568-021-00417-2","article-title":"Connecting copper and cancer: from transition metal signalling to metalloplasia","volume":"22","author":"Ge","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.yexcr.2026.115170_bib53","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000499261","article-title":"Serum levels of selenium, zinc, copper, manganese, and iron in prostate cancer patients","volume":"14","author":"Saleh","year":"2020","journal-title":"Curr. Urol."},{"key":"10.1016\/j.yexcr.2026.115170_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-017-1099-7","article-title":"Trace element and heavy metal levels in colorectal cancer: comparison between cancerous and non-cancerous tissues","volume":"183","author":"Sohrabi","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.yexcr.2026.115170_bib55","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.3390\/cancers17162628","article-title":"Nanoparticle-based delivery strategies for combating drug resistance in cancer therapeutics","volume":"17","author":"Park","year":"2025","journal-title":"Cancers"},{"key":"10.1016\/j.yexcr.2026.115170_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110401","article-title":"The contribution of copper efflux transporters ATP7A and ATP7B to chemoresistance and personalized medicine in ovarian cancer","volume":"129","author":"Lukanovi\u0107","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.yexcr.2026.115170_bib57","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1080\/15548627.2023.2165323","article-title":"Copper-dependent autophagic degradation of GPX4 drives ferroptosis","volume":"19","author":"Xue","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.yexcr.2026.115170_bib58","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1007\/s00424-020-02412-2","article-title":"The molecular mechanisms of copper metabolism and its roles in human diseases","volume":"472","author":"Chen","year":"2020","journal-title":"Pfl\u00fcgers Arch. - Eur. J. Physiol"},{"key":"10.1016\/j.yexcr.2026.115170_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2022.100916","article-title":"Overcoming cancer chemotherapy resistance by the induction of ferroptosis","volume":"66","author":"Wang","year":"2023","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.yexcr.2026.115170_bib60","doi-asserted-by":"crossref","first-page":"11683","DOI":"10.1021\/acsami.1c01006","article-title":"A three-in-one ZIFs-Derived CuCo(O)\/GOx@PCNs hybrid Cascade nanozyme for immunotherapy\/enhanced starvation\/photothermal therapy","volume":"13","author":"Wang","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.yexcr.2026.115170_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109518","article-title":"Copper transporter gene ATP7A: a predictive biomarker for immunotherapy and targeted therapy in hepatocellular carcinoma","volume":"114","author":"Shao","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.yexcr.2026.115170_bib62","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s40364-024-00677-8","article-title":"Copper homeostasis and copper-induced cell death in tumor immunity: implications for therapeutic strategies in cancer immunotherapy","volume":"12","author":"Zhang","year":"2024","journal-title":"Biomark. Res."},{"key":"10.1016\/j.yexcr.2026.115170_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2022.106319","article-title":"Blood-brain barrier permeable and multi-stimuli responsive nanoplatform for orthotopic glioma inhibition by synergistic enhanced chemo-\/chemodynamic\/photothermal\/starvation therapy","volume":"180","author":"Cao","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.yexcr.2026.115170_bib64","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41568-023-00568-4","article-title":"Dissecting metastasis using preclinical models and methods","volume":"23","author":"Hebert","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.yexcr.2026.115170_bib65","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41568-021-00353-1","article-title":"Long noncoding RNAs in cancer metastasis","volume":"21","author":"Liu","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.yexcr.2026.115170_bib66","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41416-020-01178-9","article-title":"EMTome: a resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signatures","volume":"124","author":"Vasaikar","year":"2021","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.yexcr.2026.115170_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102122","article-title":"Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram\/copper-induced ferroptosis","volume":"46","author":"Ren","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.yexcr.2026.115170_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114391","article-title":"Copper's dual role: reviewing its impact on liver health and disease","volume":"152","author":"Pan","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.yexcr.2026.115170_bib69","doi-asserted-by":"crossref","first-page":"C186","DOI":"10.1152\/ajpcell.00132.2018","article-title":"Copper transporters and copper chaperones: roles in cardiovascular physiology and disease","volume":"315","author":"Fukai","year":"2018","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.yexcr.2026.115170_bib70","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s12282-019-01044-4","article-title":"Evaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer","volume":"27","author":"Blockhuys","year":"2020","journal-title":"Breast Cancer"},{"key":"10.1016\/j.yexcr.2026.115170_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188435","article-title":"LOXL2 in cancer: regulation, downstream effectors and novel roles","volume":"1874","author":"Wen","year":"2020","journal-title":"Biochim. Biophys. Acta - Rev. Cancer"},{"key":"10.1016\/j.yexcr.2026.115170_bib72","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.3390\/cells8091080","article-title":"Activity and trafficking of copper-transporting ATPases in tumor development and defense against platinum-based drugs","volume":"8","author":"Petruzzelli","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.yexcr.2026.115170_bib73","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1158\/0008-5472.CAN-20-0471","article-title":"Intratumoral copper modulates PD-L1 expression and influences tumor immune evasion","volume":"80","author":"Voli","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexcr.2026.115170_bib74","first-page":"375","author":"Tsvetkov","year":"2022","journal-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins"},{"key":"10.1016\/j.yexcr.2026.115170_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216348","article-title":"Copper in hepatocellular carcinoma: a double-edged sword with therapeutic potentials","volume":"571","author":"Wu","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.yexcr.2026.115170_bib76","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.711227","article-title":"Role of copper on mitochondrial function and metabolism","volume":"8","author":"Ruiz","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.yexcr.2026.115170_bib77","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10495-023-01928-z","article-title":"Ferroptosis and cuproptposis in kidney diseases: dysfunction of cell metabolism","volume":"29","author":"Chen","year":"2023","journal-title":"Apoptosis"},{"key":"10.1016\/j.yexcr.2026.115170_bib78","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s43556-025-00347-7","article-title":"Targeting ferroptosis and cuproptosis in gastrointestinal cancers: molecular mechanisms, metabolic vulnerabilities, and therapeutic interventions","volume":"6","author":"Zhang","year":"2025","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.yexcr.2026.115170_bib79","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41420-025-02553-2","article-title":"Cuproptosis and cuproptosis-related cell death and genes: mechanistic links to spermatogenic cell death","volume":"11","author":"Li","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.yexcr.2026.115170_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122701","article-title":"A strategy of \u201cadding fuel to the flames\u201d enables a self-accelerating cycle of ferroptosis-cuproptosis for potent antitumor therapy","volume":"311","author":"Huang","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.yexcr.2026.115170_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2024.105958","article-title":"Curcumin-loaded emulsome nanoparticles induces apoptosis through p53 signaling pathway in pancreatic cancer cell line PANC-1","volume":"102","author":"Demirci","year":"2025","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.yexcr.2026.115170_bib82","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3390\/cells15151394","article-title":"Ferroptosis inducers combined with copper ionophores aggravate lung cancer-related fatigue via GSH depletion and FKBP5-Associated impairment of Nrf2\/HO-1 signaling","volume":"15","author":"Chen","year":"2026","journal-title":"Cells"},{"key":"10.1016\/j.yexcr.2026.115170_bib83","article-title":"Tumor lysate-cloaked CuMOF-sorafenib nanoassembler: a synergistic cuproptosis-ferroptosis nanoweapon against tumors","volume":"36","author":"Zhang","year":"2026","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.yexcr.2026.115170_bib84","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.240523","article-title":"Dynamic and cell-specific transport networks for intracellular copper ions","volume":"134","author":"Lutsenko","year":"2021","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexcr.2026.115170_bib85","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s13046-022-02485-0","article-title":"Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy","volume":"41","author":"Zheng","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.yexcr.2026.115170_bib86","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12885-022-10461-2","article-title":"Cuproptosis regulatory genes greatly contribute to clinical assessments of hepatocellular carcinoma","volume":"23","author":"Ke","year":"2023","journal-title":"BMC Cancer"},{"key":"10.1016\/j.yexcr.2026.115170_bib87","article-title":"Pan-cancer analysis reveals copper transporters as promising potential targets","volume":"10","author":"Li","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.yexcr.2026.115170_bib88","volume":"42","author":"Wang","year":"2023","journal-title":"Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer"},{"key":"10.1016\/j.yexcr.2026.115170_bib89","volume":"vol. 9","author":"Lu","year":"2022"},{"key":"10.1016\/j.yexcr.2026.115170_bib90","article-title":"Cuproptosis-related gene FDX1 as a prognostic biomarker for kidney renal clear cell carcinoma correlates with immune checkpoints and immune cell infiltration","volume":"14","author":"Yao","year":"2023","journal-title":"Front. Genet."},{"key":"10.1016\/j.yexcr.2026.115170_bib91","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.4240\/wjgs.v16.i6.1803","article-title":"FDX1 as a novel biomarker and treatment target for stomach adenocarcinoma","volume":"16","author":"Xie","year":"2024","journal-title":"World J. Gastrointest. Surg."},{"key":"10.1016\/j.yexcr.2026.115170_bib92","first-page":"1","article-title":"Role of KCNQ1OT1\/miR-27b-5p in modulating dihydrolipoamide S-acetyltransferase (DLAT): insights into cuproptosis in hepatocellular carcinoma","volume":"2026","author":"Elkateb","year":"2026","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.yexcr.2026.115170_bib93","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41420-024-01863-1","article-title":"Ferroptosis: a new hunter of hepatocellular carcinoma","volume":"10","author":"Jiang","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.yexcr.2026.115170_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102139","article-title":"Elesclomol elevates cellular and mitochondrial iron levels by delivering copper to the iron import machinery","volume":"298","author":"Garza","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexcr.2026.115170_bib100","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-26795-7","article-title":"A novel cuproptosis-related LncRNA signature to predict prognosis in hepatocellular carcinoma","volume":"12","author":"Zhang","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexcr.2026.115170_bib103","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1007\/s10238-022-00892-3","article-title":"Cuproptosis-related lncRNAs predict the prognosis and immune response in hepatocellular carcinoma","volume":"23","author":"Zhang","year":"2023","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.yexcr.2026.115170_bib101","article-title":"Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.yexcr.2026.115170_bib102","article-title":"A novel cuproptosis-related prognostic lncRNA signature for predicting immune and drug therapy response in hepatocellular carcinoma","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.yexcr.2026.115170_bib104","article-title":"A noval established cuproptosis-associated LncRNA signature for prognosis prediction in primary hepatic carcinoma, evidence-based complement","volume":"2022","author":"Luo","year":"2022","journal-title":"Altern. Med."},{"key":"10.1016\/j.yexcr.2026.115170_bib105","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4694323","article-title":"Prognostic implication of a cuproptosis-related miRNA signature in hepatocellular carcinoma","volume":"2022","author":"Jin","year":"2022","journal-title":"J. Healthc. Eng."},{"key":"10.1016\/j.yexcr.2026.115170_bib95","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrg.2015.10","article-title":"Unique features of long non-coding RNA biogenesis and function","volume":"17","author":"Quinn","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.yexcr.2026.115170_bib96","first-page":"379","article-title":"Non-coding rnas in caenorhabditis elegans aging","volume":"42","author":"Kim","year":"2019","journal-title":"Mol. Cells"},{"key":"10.1016\/j.yexcr.2026.115170_bib97","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12943-016-0524-4","article-title":"Circulating long non-coding RNAs in cancer: current status and future perspectives","volume":"15","author":"Qi","year":"2016","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.yexcr.2026.115170_bib98","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.yexcr.2026.115170_bib99","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nrg.2015.17","article-title":"Role of non-coding sequence variants in cancer","volume":"17","author":"Khurana","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.yexcr.2026.115170_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2026.153461","article-title":"Cuproptosis and lncRNAs: interplay in cancer immunity, prognosis, and chemotherapy sensitivity","volume":"811","author":"Huang","year":"2026","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexcr.2026.115170_bib107","article-title":"Identification of a long non-coding RNA signature associated with cuproptosis for prognosis and immunotherapy response prediction in patients with lung adenocarcinoma","volume":"16","author":"Zeng","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.yexcr.2026.115170_bib108","doi-asserted-by":"crossref","first-page":"6607","DOI":"10.2147\/JIR.S515647","article-title":"MiR-133a-5p facilitates cuproptosis in hepatocellular carcinoma through targeting of ATP7B","volume":"18","author":"Ren","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.yexcr.2026.115170_bib109","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2026.5729","article-title":"ZG16B: a key regulator of tumor progression and immune microenvironment modulation in cancer","volume":"57","author":"Chen","year":"2026","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.yexcr.2026.115170_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121659","article-title":"Cuproptosis illustrates tumor micro-environment features and predicts prostate cancer therapeutic sensitivity and prognosis","volume":"325","author":"Cheng","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.yexcr.2026.115170_bib111","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.724","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"5","author":"Yang","year":"2024","journal-title":"MedComm"},{"key":"10.1016\/j.yexcr.2026.115170_bib112","first-page":"226","article-title":"Targeting cuproptosis for cancer therapy: focus on the anti-tumor immune system, Cancer Pathog","volume":"3","author":"Zhang","year":"2025","journal-title":"Ther"},{"key":"10.1016\/j.yexcr.2026.115170_bib113","doi-asserted-by":"crossref","DOI":"10.1007\/s12072-026-11097-1","article-title":"Immune-checkpoint inhibitors for advanced hepatocellular carcinoma in Child-Turcotte-Pugh-B cirrhosis: a liver-centric approach to outcomes beyond tumor progression","author":"Agrawal","year":"2026","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.yexcr.2026.115170_bib114","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.3390\/cancers17081274","article-title":"Usefulness of the early increase of peripheral blood lymphocyte count in predicting clinical outcomes for patients with advanced hepatocellular carcinoma treated with durvalumab plus tremelimumab","volume":"17","author":"Honma","year":"2025","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.yexcr.2026.115170_bib115","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1180625","article-title":"A novel prognostic prediction model of cuprotosis-related genes signature in hepatocellular carcinoma","volume":"11","author":"Shao","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.yexcr.2026.115170_bib116","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.ccell.2025.02.015","article-title":"Hypoxia inducible factor-1\u03b1 drives cancer resistance to cuproptosis","volume":"43","author":"Yang","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.yexcr.2026.115170_bib117","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s10495-026-02266-6","article-title":"Harnessing Cuproptosis resistance to advance cancer therapeutics","volume":"31","author":"Li","year":"2026","journal-title":"Apoptosis"},{"key":"10.1016\/j.yexcr.2026.115170_bib118","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41423-026-01387-x","article-title":"Tackling cuproptosis: from metabolic rewiring to therapeutic exploitation in cancer","volume":"23","author":"Hao","year":"2026","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.yexcr.2026.115170_bib119","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12943-023-01732-y","article-title":"Cuproptosis: mechanisms and links with cancers","volume":"22","author":"Xie","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.yexcr.2026.115170_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.101018","article-title":"Cuproptosis: a novel therapeutic target for overcoming cancer drug resistance","volume":"72","author":"Wang","year":"2024","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.yexcr.2026.115170_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2025.217519","article-title":"Cuproptosis and its cooperative role in cancer therapy: exploring new treatment strategies","volume":"552","author":"Xu","year":"2026","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.yexcr.2026.115170_bib122","doi-asserted-by":"crossref","first-page":"874","DOI":"10.3390\/molecules31050874","article-title":"Copper complexes: main mechanisms as anticancer agents","volume":"31","author":"Hangan","year":"2026","journal-title":"Molecules"},{"key":"10.1016\/j.yexcr.2026.115170_bib123","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2025.1578693","article-title":"Copper metabolism in hepatocellular carcinoma: from molecular mechanisms to therapeutic opportunities","volume":"12","author":"Pang","year":"2025","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.yexcr.2026.115170_bib124","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12050466","article-title":"Development and in vivo application of a water-soluble anticancer copper ionophore system using a temperature-sensitive liposome formulation","volume":"12","author":"Ga\u00e1l","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexcr.2026.115170_bib125","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1596","article-title":"Ammonium tetrathiomolybdate in the decoppering phase treatment of Wilson's disease with neurological symptoms: a case series","volume":"10","author":"De Fabregues","year":"2020","journal-title":"Brain Behav"},{"key":"10.1016\/j.yexcr.2026.115170_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2026.102629","article-title":"Orchestrating mitochondrial catastrophe: mechanistic insights and therapeutic frontiers of cuproptosis in precision pharmacology","volume":"88","author":"El-Nablaway","year":"2026","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.yexcr.2026.115170_bib127","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.7150\/ijbs.105575","article-title":"Disulfiram\/copper triggers cGAS-STING innate immunity pathway via ROS-induced DNA damage that potentiates antitumor response to PD-1 checkpoint blockade","volume":"21","author":"Yuan","year":"2025","journal-title":"Int. J. Biol. Sci."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726002879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726002879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:34:40Z","timestamp":1790714080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482726002879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":127,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0014482726002879"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.115170","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cuproptosis and copper metabolism regulate hepatocellular carcinoma progression and therapeutic response to sorafenib","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.115170","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115170"}}